Document Nn2ynBgkqQnYoL3pZzGONjvR

October II, 1965 Mr. Fieri Hughes Chemistry Supervisor Chevrolet Forge Plant Tonawanda, New York Dear Mr. Hughes; O :h lb; 'A'lv CV^ \ w*. <tO Mack Nichols of our devexand office has asked me to forward toxicity and safe handling information forfPydraul A-2Q0.f ~~ .. . ___ Animal toxicity studies with this product have indicated)that the oral lethal dose (LDcq) to rats is 10,300 milligrams per kilogram. The lethal dose when the material was applied undiluted td the unbroken skin of rabbits is approximately 1230 milligrams per kilogram. i j ; : We conclude from the above that accidental ingestion on the part of humans is not a particular hazard In view of the high oral lethal dose in rats. Similarly, single massive skin exposures should not be immediately hazardous. The lethal dose obtained in skin penetration studies is such, however, that prolonged and repeated skin contact should be avoided because of possible systemic effects. In addition, prolonged and repeated skin contact may lead to skin irritation. I ' j ' 1 We also feel that vapor Inhalation should be avoided when ; the fluid is heated to elevated temperatures. Such exposure \ again relates to prolonged or repeated exposures rather .. ..... \ than short-term massive or acute exposures.J In the case of b \ thelatter, workraen irqxild nQt voluntarily expose themselves 1 -to concentrations that are hazardous because of irritation of j the respiratory tract. g- g The use of Pydraul A-200 in industrial hydraulic fluid appli-" cations should not present toxicity hazards during the trans fer of the fluid from original containers to the hydraulic j system. Obviously when the fluid is within the hydraulic j system, there should be no exposure and consequently, no ; hazard. In the event of rupture of hydraulic lines and j subsequent splashing or spraying of the fluid on the heated i DSW 586222 STLCOPCB4091555 Mr, Merle Hughes October 11, 1965 Page 2 surfaces, vapors of the fluid and possible decomposition products (depending on the temperature of the heated surface) may be irritating if inhaled to the degree that workmen will not voluntarily expose themselves to toxie concentrations. Ho hazardous exposure should result during the interval required to shut down the system and obtain suitable respiratory protective devices during repairs to the system. We would not anticipate any greater hazards during routine maintenance of a system containing Pydraul A-200 than would ce present If the system contained a phosphate case fluid. It would appear to be good practice to wipe dry any equipment before doing any welding on surfaces which slight be "wetted " with or have a film of either type fluid on them. If the above information does not/ answer your specific questions please let me know directly br through Mr./ Nichols. '' f!:'{/* ! Very truly yours, '. EPWjmJb n e k- Elmer ?/ Wheeler Manager, Environmental Health Medical Department cci R. Gaston, Safety Supervisor, Chevrolet Dr. J. J. Brandi, Medical Division, Chevrolet J. J. McNeil, Plant Engineer, Chevrolet Frank DiGlacomo, Purchasing Dept., Chevrolet Mack Nichols - Monsanto, Cleveland O. L .14* k i t-o CE Cu.1 o 0S\N 586221 STLCOPCB4091556