Document NgNjRvxnYXM9bx8ybj5QV20g

20 Sar (7) ears . AR a6 -- 1187 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON. D.C. 20460 SEP 27 22 PreveJ n Pearce mo ToC Suances MEMORANDUM SUBJECT: Revision of PFOA Hazard Assessment and Next Steps FROM: Charles M. Auer,Directo an) a. 7WB (use = Office of Pollution Prevention and Toxics 5 TO: ORsicskarAsHserensasnmdeenzt,DDiivriescitoonr T&owi Mary Ellen Economics, Weber, Director Exposure, and Technology Division CWhaermdicPaelnbCeorntthryo,lADcitviinsgioDnirector = = uw 3 understAansdphaeratlotfhtahnedeefnfovritrobnymtehnetaOlffiiscseuoefsPporlelsuetnitoend bPryefvleunotrioocnhaenmdicTaolxsiicnst(hOePwPaTk)etoof suunlefxopneacttesed(PtoFxOiSc)o,loOgiPcPalTahnadsbbieoeancciunmvuesltaitgiaotnindgipsecorvfelruioersoowcittahnoriecspaeccitdtaonpderiftslusaolrtosoe(tPyFlOA). dPaPteTd Freeblreuaasreyda20p,re2l0i0m2i,noarnyMDarracfht H2a8,za2r00d2A,sasnedssimsesntuoeafdPmerifnlourocroororcetcatnioonictoActihadtadnodcuImseSnatltos,n aApnrdilob1s5e,r2v0e0d2t.haTthabtlodordafmtoansisteosrsimnegndtaitnadsiucagtgeedstpeodtewnitidaelspsrysetaedmeixcptoosxuirceittyoatnhde cgaernceirnaolgenicity, uponpduelratwiaoyn,onalobtehietratenldopwoilnevteslsa.ndIt tahlastofnuorttehde,r dhaotwaevweoru,ltdhabteaadvdaiitliaobnlaelwtiotxhiicnitay smtautdtieersowfemroenths. data "The Agency has since submitted to the Agency received considerable suggesat potential for ardedpirtoidouncaltidvaeta/.deTvheleoapdmdeinttiaolnatloxtiocxitiyc,olaongdy aadrdeiutnieonxapllabilnoeoddastatmhpisletainmael.ysisdata indicate low level exposures to the general population that Toxic SuSbtsetpahnecneJso(hOnsPoPnT,S)A,ssmisettanwtitAhdmrienpirsesternattaotriovfetshferoOmfftihceemoafnuPfraevcetnutrieorns,aPnedstuisceirdesso,faPndFOA ` and related chemicals on August 13, 2002. He requested continued discussion with Recreateictih Vneegmeetatla1seasssduork)ReapynoamPesna (HOirNi T5A%IPNosisNnsOms c0ontr) | 2 `manufacturers and users ofPFOA raised the importance ofand need and related chemicals to for communicating with further investigate these issues, and the public. Following that meeting, OPTS met with toxicologists from industry on August 30, 2002, to discuss the recent study `smuabnmuifsascitounrseranrdeparensyenatdadtiitivoensaolnanSteipcitpeamtbeedrwo1r2k,.20O0P2PtTo ealxspolomreetexbiystcionngfeerxepnocseucraellinwfiotrhmation agennderiadelntpiofpyulgaatpiosn.in Stuhomsmeardaiteasothfatthmeasey mheeleptitnogsexaprleaibnetihneg pprleasceendcienotfhePpFuOblAicinadtmhienibsltoroadtoivfethe record for this investigation, AR-226: PFOS, PFAS, PFOA, Telomers, and Related Chemicals. incorporAanteinOtPePrTi'msrerveivsieedwhsaozfatrhdeassesdeastsamheantsbuepednatipnrgeptahreedo.riAgisnasloDornafastHtahizsadrodcuAmsesnestscmoemnptlteotes rinetveirsneadlhraezvairedwapsrsoecsesdmuernets,wiitthsihnoutlhde bneexptlfaocuerd tion sAiRx-2w2ee6k.s,Palteawsheipcrhotciemeedwtoefwiinlallipzleatcheisthienterim document in the public file. `monitor`iTnhgedraetparordeuvciteiwveed/dienvtehleopinmteenrtiamlrteovxiisceidtyhdaaztaar,dtahsesceasrscmiennotgernaiicsiettyhdeatpao,ssaibnidlitthyetbhaltooPdFOA. might meet the criteria for action under section 4()ofthe Toxic Substances Control Act. are met,`TahnedApguebnlcisyheedsttahbaltisphreodcaespsroinceasFseidner19a9l1RefgoirsdteetrenromtiinciencgownhceetmhienrgthreefTraScCtoAryc4(efr)amciricteria finiibteiraste(RaCpFri)or(i5t6y FreRvi5e8w6,9a3s;dNeoscvreimbbederin2t1h,at19n9o1t)i.ceW,ittohdtehtiesrmmeinmeot,heI asimgnriefqiucaenscteionfgtthhaetryioskusnow pfirneasleinztateidonboyftPhFeOAintaenrdimitrsesvailtsse.d Thhaizsarpdriaosrsiteyssrmeevnit.ewIsthiosumldybuengdienrswthainldeiynoguthpartoycoeuedhawivtehatlhseo initiated a request with the Science Advisory Board (SAB) for a peer reviewofthe preliminary tisk this assessment focused priority review. on developmental/reproductive toxicity that wil be developed based on Tt is myexpectationthat the hazard assessment priority review will be completed in the nAsesxitsftoanutr Atodmsiinxiwseterkast.or oPlneanseextbestperpespared to discuss these issues when we meet vith the eS. Johnson S. Hazen M. Schneider Administrative Record AR-226: PFOS, PFAS, PFOA, Telomers, and Related Chemicals R