Document NezJjeJ63OzrX0DLpwNYyJEYR
AR226-2905
FOR DU FONT USE ONLY
E. I. du font de Nenours and Company
Haskeil Laboratory for Toxicology and Induetrial Medicine
Elkcon Road, Newark, Delaware 19711
CR&D Dept. Haskell Lab.
ORAl LD50 TEST IN RATS'
Procedure; The oral LD50 (>f|U|||^|lHH^^BH||RjiBing distilled water as the vehicle was found to be 12,196 ag/kg^H|||HBl To evaluate the effect. If any, of the vehicle used, the test material,"as a suspension In
corn oil, was administered by intragastric Incubation In single doses to 6
groups of 10 young adult CrI.'CD* male rats. The surviving rats were weighed and observed during a 14-day rejcovery period and then sacrificed. The LD50
value was calculated from the mortality data using the method of D. J.
Finney.**
'
Results:
Dose (nig/kg)
Average Body Weight (g)
Suspension CO
Average Dose (oL)
Mortality Ratio
LD50***
3,700
257
25
3.81
10/10
916 ing/kg
2,000
247
25
1.98
10/10
1,500
262
25
1.57
8/10
1,000
245
23
1.07
8/10
850
259
500
245
19
1.16
4/10
11
1.11
0/10
S^tod.DWsnoteon^TSCACBB
Company
Clinical Signs:
Stained and/or wet perifljeal area and weight loss at all levels tested. Diarrhea at all levels except 300 ng/kg.
Stained face at all levels except 500 and 850 ing/kg. Weakness at all levels except '5QO and 3,700 mg/kg.
Tremors at 1,500 and 2,000 mg/lkg. ChroBodacryorrhea at 1,000 and 2,000 ag/kg*
All deaths occurred within 5 djeys after dosing.
Sunnary:
i s yoi ,,
slightly toxic when administered orally to single doses; its LD50 is 916 mg/kg of body
weight. Clinical sign* observed at most dos levels included: stained
and/or wet perineal area, weight loss, diarrhea, stained face and weakness.
All deaths occurred within 5 cays after-dosing. The LD50 in corn oil was
approxiaately 1/2 that determined when the chemical was administered in
distilled water.
'
Purity;
Contaminants Synonym:
**
Finney, D. J., Probit analysis. 3rd Ed., 1971, Cambridge University
Press.
.
*** 952 Confidence Limits:
|Lowar: 746 mg/kg iUpper: 1,086 mg/kg
Slope: 6.5
Report by:
- /'9\ ,'?>v
ll- iQ tlL^^
1 Lon Hinckle Technician
Reviewed by:
0. Louis Dashiell Study Director
^T Approved by: 'SSit^JL J. ^y^w^ i Gerald L. Kennedy,'- J Chief, Acute InvestigatiiooiJs Section
LEH/jtd/WP:1.8 Date Isasuueecd; October^?, 1981
Report No.
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2 -
Company Sanitized. Does not contain TSCA CBi