Document NevpweXRgRzJgGEM7ZJOvKZND

yA' ' ' -''1'"-,-j > V; v , Vj^._;' ' -,^e ! N J __ i__ Foreign Examinations - Tank v Cleaning C.^ses - (Organic Lead \ Cases and PbET Gasoline Complaints) N24594 \ Melbourne, u I , 1+**U O l>U J.nA Dear Sr. Tairley: It has been some time since ve have correspond to resume where ve left off last time. The spec this letter arises from the correspondence whic recently in connection vith tvo cases of tetrae treated by Dr. Blackburn and reported in some d pondence also contains a copy of your letter of Batchelor. It seems vi3e in view of this vhole you our reaction to the conclusions, arrived at tatively, concerning the efficacy of BAL in the ethyl lead poisoning. I am told that Dr. Black country and that I shall probably have an oppor u s matter vith him in person, meanwhile, I our1 opinion I n .sVo g_one. o ver the case records on the tvo me available, and I am frank to say chat I find no that would give me any great assurance that the SAL had materially influenced the outcome or t courses were in no vise to be regarded as unusu These cases always have their ups and downs, an their recovery has been such as to give one the virtually been snatched from the grave. A numb when one would have expected them to die, and o they were expected to survive. These vagaries and course of a disease are, therefore,characte and net of its treatment. I do not mean to pay been useful. I feel quite certain that a numbe virtue cf the judicious use of barbiturates par adequate supportive treatment. However, I see chat there Is any dramatically successful or s cases of Dr. Blackburn are no exception. There are a number of good experimental reasons usefulness of BAL in this condition. Experimen Gilman in this country when he was with the Che have been reported to me informally. They see clearly that BAL does not save the lives of ani dose of tetraethyl lead, whether the latter is after the intoxication has developed. Other, e ferred to in an article of ours in SCIENCE, of K f 0021485 0021486 3AL controls or decreases the symptomatology d We have a hope, which we are undertaking to In glucocide, which has low toxicity, may be empl some period of time to eliminate lead from the rapidity. If this is feasible, it might turn in dealing with certain types of men unduly ex occupations. However, even this type of thera used carefully, after thorough-going investiga release of lead from the erythrocytes of the b a maintained elevation of the lead in the plas injury to susceptible tissues. On the whole I a matter in which we should go slowly, being v courage the use of BAL in cases of this type, carefully controlled conditions. I am frank t hesitate very much to use BAL in the case of t unless I had reason to feel that the chances f patient were negligible. I have pointed this out to our people in Londo that they should avoid communicating to anyone ve have demonstrated an adequate method for th of poisoning. I should be glad to hear from you on any accou you care to comment on my remarks. With kindest personal regards, FAK ef . Copy by air mail. Original by steamer. f t E 0021487