Document NedkKx2mmEGwb996B612gK6Rg

( MANUFACTURING CHEMISTS ASSOCIATION 182S CONNECTICUT AVENUE, N. W. WASHINGTON, D C. 20009 FOR RELEASE R-i Ai.V ...... ^ijPMLiNT APR 18 1974 For immediate Release W. M. SM " CONTACT: Richard F. Blewitt (202) 483-6126, ext. 282 WASHINGTON, D. C., April 16 ~ The,Manufacturing Chemists Association (MCA) announced today preliminary indications that vinyl chloride exposure has produced angiosarcoma -- a liver cancer -- in mice at several exposure levels. Industrial Bio-Test Laboratories, Inc., who are conducting the MCA-administered vinyl chloride animal exposure study, informed MCA that their work -- although very preliminary at this point -- tends to confirm the findings of professor Cesare Maltonl, an Italian scientist who found that vinyl chloride exposure in rats caused cancer. MCA immediately notified the Occupational Safety and Health Administration, the National Institute for Occupational Safety and Health and the Environmental protection Agency of the preliminary test results. In the MCA-administered study, rats, hamsters and mice are being exposed seven hours a day, five days a week, to 2500 parts per million (ppm), 200 ppm and 50 ppm. After seven months of exposure, angiosarcoma has been observed in mice at all levels, but not in rats or hamsters. (more) AP00006634 Page 2 of 2 Professor Ualtoni reported at the OSHA hearings on vinyl chloride February 15 that he had observed the liver cancer in rats exposed four hours a day, five days a week, to 250 ppm for up to 12 months. However, he did not find the cancer in testing at the 50 ppm level. The animal exposure study is continuing. Another MCAadministered study on the chemical, documenting the health experience of present and former employees who have worked with the material, the results of which also will be released, is expected to be completed in the near future. Further vinyl chloride testing is under consideration. MCA-3839 ### AP00006635 P^' * L. ' r* / SPONTANEOUS ANGIOSARCOMAS OF THE LIVER EJ AHS^LS * +Vr v .'. V. '* +We ^ ^ imVnnwi ' :. . ;_/ "- T^** K*H Sn"H *..va3rr.dj or 1 - animals has never seen this~leaicn. I have in m>n files records of over 10,000 rats with different strains and have never seen, this lesion* .. MICE--------In mice Angiosarcoma does spontaneously occur* This is irccikK in the Haired and Hairless strainmouse. Hemangio endotheliomas (Angiosarcomas) vere observed in 45 out of 251 iri the control groups * w- ( F 07 o Deringar, M. K.t J. of the National Erncer Institute* Vol: 12: 437-445, Oct. 1951. As would tea be expected when (C-amiroaaotoluene) was subcutaneously inoculated the Smcideroe 'of angiosarcomas increased. -------Ibid; 17: 533-53=^956 Swiss Albino mice have a spontaneous % occurrence of .angiosarcoma of the liver. EXPERIMENTAL ANGIOSARCOMAS IN ANIMALS D?S TO ^HOROTRAST c .1936------Capillary angiosarcomas were produced in mice by JOGS Selbie, F., Experimental Production d' Sarcoma with i4x Thorotrast. lancet 2 : 847* I955------Reticulosarcemas(angiosarcomas) of tte Liver wasproduced by intraveous injections. Qnufrio, Q, Su di un caso di . Reticulosarcoma sperirentale do rnoroirast. Folia ined* 24: 12^5- (probably used different spcies) ARSENIC EXPERIMENTAL IN ANIMALS A 80 ITS EJTZSTON MAN 'An excellent monograph on Arsenicals, has beenvritten by A. Furst and wall be published in the future by the World Health Organisation working group on Evaluation of Carcinogenic Rsks of Chemicals to Kan. j i I)S.* [-.* " ^ f ,"Jll_ | -' ^ i.. ' AP00006636 t3rr,v^; *'iTix**s; pr? 'vr jv'm t** \ jlitrosodinatViyliaoine-------^agee, P. ., Earne-s, J.K,, British -- * .. . ."' . *. i--------- --_* --_____.... ha*. i--aN i inr . 1" ?.. :ii- ,;"jx-" . .* cv2.^. ^ r .13* Ksrrold, K. Ml7 Journal of the NationAt* Cancer . Institute. 3?: 11";, 1?C?. Sibeut. n-ir.is t ration to Syrian Hamsters* * Otsuka, H. and Kwahara, A., Gann 62:147-156,1971* By oral administration and subcutaneous injection to DDD & BAX, b/e strain mice, ps-nthcm. Urethane ... .....- - Deranger, M. K., \'.S ' t * Journal of the National Cancer Institute 34: 641-847, 1965 Gave intraperitoneal injections ' to DBA/2eBDe strains of mice* 1 r.-*> F-v 1,2-Dimethylhydrazine Dihydrochloride--Syrian Golden Hamsters were given in water daily 0*156 mg* to the female and 0.161 mg* to the male. Angiosarcomas occurred in 89 f> of the females i>and 82 in the males* The tumors were in vVV' '* the livers', lungs, muscle, heart, and pancreas, No such .tumor is seen in the control* . Toth^ B,t Cancer Research, 32: 2818-2827, 1972. Ethylhydrazine hydrochloride--------o.ol25 was given in drinkihg * ' water and 38 $ vascular tumors were produced in Swiss Albipo strain mice* Toth, B*,- Scientific Proceedings, A.A.P.B* San Fran 1974* n,Butyl-hydrazine KCL--only lung cancer* - . l-carbamyl-2-phenylhydrazine--only lung cancer; - CONTROL INCIDENCE OF ANGIOSARCOMA IN THE SWISS ALBINO MOUSE IS 5#- Methylhydrazine--(A rocket fuel componentJ-^-Syrian Golden Hamsters received 0*01 $5 in drinking water* Angio- Sarcoma of the liver (Iiilignant Histiocytoma) . (Kupffer Cell Sarcoma)-was produced in 32 f> of the females and 54 # of the males* latency period 70 and 78 weeks,. No such tumor was seen in the controls, AP00006637