Document Ne8RyB3GvJ1jvDeXVkZdm52ED

eRe fuEiaDngH7c03a59041C55o.n0 AR 6 3 TWO YEAR ORAL (DIET) TOXICITY / CARCINOGENICITY . STUDY OF FLUOROCHEMICAL FC-143 IN RATS (RIKER ExperiMeNT No. 0281CRO012) Vouue 3 of 4 ConpucTep DURING Aerie, 1981 - Mav, 1383 RIKER LABORATORIES, Inc. / 3M Company ST. 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O1:L EBaEse Ffeome afali mmnE. hh S=E ToPmeEeerAnaTss LPeniti 22 SmmaenEiml 1kiohm aSwsimenan mE FHroeienrisss spezsst(oEis TN SRL kL zc So=Roesafo smov eeBawesseemasnas::S mesmnlanl oin 4h =2EEFr3E PfPooeissetiaaErse Sens riEGeanEr.cC doLim BS2 a5sS3l FPoGeneemasaili ote dis ermmamnaaco. dohha 7= 5a= BEST COPY AVAILABLE Hfaedit5e2 iPw Spien EpoEsRsesnsl =samrEis La conan 6a 601530 FaEoReiMe esifi fMeaoEmNaai fi ae nBieaeE. Lnim MmeELii HR L mm MmoeoemE mia mm EDEERRaE WTTHohEiEeSEmiiEsx Hm pfriEteRmEiE med DHmaeienmeai3E5 Rosoee as HERE pFHDrorhuEteeE12s EmmSaHeRmEeaEEns mDTFS eoEmoAsEae e DmaUmTk ReAEs rt me pSetAtiE DEm CRRRmEE BEmmaEEEl Lhb ERC MEEEL mEdmmCEaCF3iLL EBmEaEC E Ob mS kb PEEECCLi ame i: WER snoWade0R5ecs:ow aoa EmLWEEEECR L4 *. MmamueEl Lo5:d2 REmCSSRl Lh 2 HEEECGL EMmFEEEEC LLo3g mE on. 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PDPoeoonon aasaai ei: as emssen.. 3 sme. 3 PmaEdma M EINEL roRoonsoennn 132 PFPjFOsroOoDniIoAieR g$1122fs5 spezes3a6teTi3.Eae8o4zldss}w1e2 ass fefooiaoe Pom 1a32e es mWlrmae.'l} sigs. 3 aoitai ia MN ikh rtToor%oo0ssemmn Reset i32 3 [FRo0a3s3h :32 o[R000%5ems i? =meEsadEn - Fs"Hiaa aHE3EE EuE3Eaa4 wmomaeaE .i a HwTday %fa ea mRse BS=Ei mrEi 2 mE3 fSSrikd mBeEd5 ae 1B9i5.t8]5 -- ihh3e6o3er.o8n4 stv : wfSmeieeate =E1.eg3% BEST COPY AVAILABLE im26u0n.s9 : 1Sa3og3t Sa iaedl. 643 01032 Fo1Ro0r3T5e3e4 21255 4m4e33100 122 FOO-De3I6R35 025 212 F1oPo0n3T63e5 102255 sreeezs 0co 122 F1oP0903I5A3R7 1@2255 3sa2te7s0 21)2 F1opnabzaeAzee 212s5 Sr3i0e3z 00 12)2 F1oe9oinigaese 16225s 2S5m5.s2e4 0 12)2 FsopoeozsAsee 1e22s5 aassesc0 212 F1Tp"AeD2IeRaEs e1o2s5 470s 2 eeez 0 a2 Foo3n5R4e2 @12255 5s.a3e4:0 122 F1opooozizAeps 1e2s5 2a02m083c70 122 F1opoeo3asRaes 162255 sSies z530 12)2 F1oPoap3Jceees o1z2s5 Se0s1e7 0 122 F1oFooo2I5R4es a12s5 sseiaes c0 312 F1o0o0p3I5R4e7 1a335 es7sazees 0c 13]3 F1oroeb3asmaes 1ea3s5 732842s0 00 13]3 F1opeoapsJeese 1e3s5 S821431400 13]3 F1opoonzsAsee 1e23s5 7m.r4s5s cg)13 F1opoeC3IsAsRy 1ea3s5 afiesses 0 13]3 Fpoe0zbsIsA2R 1e3a5s Tsiaezs 0 172)2 F1opooD3IEAseT 1ea3s5 e234874s 0 133 pFoaozesanRsR 313s5 S3e7i4e4s8 co 213 F1oroebzreeses 1e3a5s sSeee ses 0+ 13]2 F1op0o0aTsRsEs e113s5 sasiese 0 132 F1opeozDeIsA7R x13s5 sa3%c0 123 F1opoeb3isAsRe 1e3ds5 4Ss8e26d1e 0 31]3 F1opooo2JeRsPe 163355 38625..4244 13)3 t 1Fpoeoacssea 1e3a5s 0sa34.6530 13]3 Fpooosbieese e1i3s5 2832..5514 00-133] F1rooozrsReez 1e3a5s a4s6s22e8s co 123 428239..4633 w4a98ar .7d5 2s717.002s S4s2e2331 E3r71e ez 421687..5284 419.9 s38a97..0632 S3e0e.53843 3se8a19333 25818.65032 261708.3247 338757.2265 e57s1 269 27328083s e2123441 25577..432 3se8s25s03 357733.4262 358234..8746 s37s4i.4683 3s8c5e 051 438165.588 E38731.315 sa2es01 26552.2444 3se4355 RB EST 359222.3914 4a2s.265s COPY AVAILABLE Fpoaozpsaees 1e3x5s F1opoaozJsAeRs 1e3s5 PpAaTss&es eas FonolRe 135 esm.seers+ #sse7l2ec1rezsecseesss 6.04 c 133 s2e7r6. 261 a313 358358.6722 3 ~8.04 -NeOTesON STUDY 13 -e.04 644 01033 mDemmmE = omnn = =7 Demi am mac mn oL =a #13 BESTCOPY AVAILABLE 645 01034 . 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F3 melon FCEhSoacnid iE 125 150355D8See8r2l5 oF 1 eles Hp PoEwE aE S SweEn. FFmoeooaotr Pom iE a1 MEpgneensC ae. OiiBe PeHloEieRsaEa M MmeedEl. L5 FhTeoeroessre a3asst foie 3: dsdeeaes.d}if Mees. PFpoooirnn a1a3s daeesre:i D PSFkooo ieoei1l sk3 mam airn R m.. 12 HDwoeidNivieene: a E m az nOd CRoFh HfiDoioEnieoRc ao E mad3Bi2. lul0fkib EErazaze BHGeeed wBEeey SGSdEE ESGeetie EfEorlH SBEeodE3s EHHeEE FEaern] Epeee EwErFe E3horHon stow a SEees qS53ki BBSeeid EEEEoe] e5Mddl EfZoaan SnmaeE Ei 5e8 . EE= 32334422 BEST COPY AVAILABLE HBeEl 654 01043 HERE mEon Eo mm ES Hew SIA muon wr Eg PORE mE OL oy ww Fa muon $i tresE Bs ace hor ow smr LowmeemaE mMpIdL LSE DEE EE oH mud wpeug i222 BEST COPY AVAILABLE BE 655 601044 ment =H 0 52 & BESTCOPY AVAILABLE FiFoorotocdiseier 1oa2zs5 esdenemecarrtc ii1z2 fvseeeerar J FiFoootesueo o12ss daamraassc 1in E= mey FFIorleGiiee s112a5 dsiremenin i3Ln sWaisee5 fFiorPoeatsiisnasg: o18z23s isEairi.EL3 fES=aes FFiooPooottidinsee oa1z2=s GfFaerrih iii.. 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ENE 3 b 1% RESTCOPYY AVAAVIALIALABBLE 5 01139 . Fuusleirnsk 6132s5 f3e0w6e0r 313 e00ee81 FRoiueils 1o2i5s umge 3a3 Emrr7 . rTheins 03s FuoL ine 135 eo Fae:8 sis az 20 ze ses digns i13s5 im i3 373255.5571 FwOrGoCzIeRrEe 0133s3 TSasses 212 i7sasa76s Frueli16r8 6133s5 iFoners ois GTaezaes 13 fe 1lc 3 GSEaz3e5 512 FEORTOOTRR 135 pUsET protege Eo 13 "ez eNOT OW STUDY 3 see FToHoeIRe 125 resi a arc 8a3 maa 3 37427.a32 rFuoobiaae 133 FooLiee 135 sEiziescon3) ise 13 G3a8s s1e Eh pees: eis 3 541.09 ep00r0 Ree 1g25 iFOkGeOzIsRsRd Iw e1i3s3 FrFUOoCsIiRnetE e1133r55 FrOoUzCsIiRsR o12n2s FReosleakr B1i2s3 FpolrIk 125 FiukeelisTseks 0132s2 Feosostiee 013235 ForoeriTseee 1633s5 FFooozoeesr: 1o335s FiOrUe0zIeRsRs 013355 FFooelissese 013255 t keezeeresssee sonis aT2sress 31]3 T3e3esseec az mac 81 2Z2isg 313 T3i%2ers iz2 F siet : E ITTin:13 ddeesesze 3iz 8 es2szaoi 13 8 sss 3 31): 6ss03..785%00 31]3 Sie 2 f=o) eemimsa o 13x ss efliosss 313 a71275 0512 2Ers 297.4214 E75r2.88 E3r6 7 E255t76 a3s7e7 7326 40262. a5.z 23553o7r kFoerd s6i06 275 361.51 3S5E.513s 7R8E3a 01140 A Bt ce LITE dF wae BE mse ERI #8 lt A DcRoSiIrrA RL:3 BomFOODJAR 115 aay Jus me. 387.63 11 BESTCOPY AVAILABLE 3e7.63 BD FEI I "am: l= i. 01141 fFloirece0hwe a11ss pr sSeeew3 Sos wSoreesson sew MCaehmeea 4n: awesSlSs aiEls lLi ees EheerEeon stun Se=EdReEuDs o RLEeT wm S2es oGHigedeetnaei sEWraEsHc ne OL rafaays LEFalEoiics ais 11s ssesadSSeeosl 3 wn een c otOoeotou sry iHDoietaea:nil:f esSapEeuC. db1OL EEaSen HLEeeyewdeanu31:2 seessCalGWeGiIs oin oes ots5tgon stupor FDiooel d11s o E LEdw:n Soese FDHieomtoeaanriis sBMIsEsEL Lha 3SF34.Eg73 pfFaeotoanl 32 11s sressaNSt eebils i wm o.05 hataeson stu roracitineegdtr i = seraDE ch pBfEaaRd HPHienetenau:l memsEEl hiLho mwEEed LHFeEiecsoe siz 11s ssesssSsSee1ls wu ese horArson stow FLHoEoeoudasii f.esciECbis n8 sero sen i ohoreon sow 0Si0s1ter FFj0oe0oonra us ssa dihn BWHenHi DHGieeveetwtaii EE wrEiCGbn SSSEnE . feioiee rui o EMeEe. bh S=E TGeoeoomame auasi E msmaeualrs na oh mBaraef aof DmfReeeLaattss a3sr2 EwSRnaC fw 2%SEoie FFfillieotsohr i12ss sressiSFE Geas wm ose h:or on stov awTeeolfer H12E5 1ness0edTBGeas 3wn es - ooprsoon stu HOR WE 4 SE i Y AVAILABLE - 01142 PRY ant ePEse A"Baf T. 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ESmIiERh oobb MmaeBe0r 3ob oTuo6po smo HpwgaY SBEeEEd Ha faEyE EE2id BmEE co1841 APPENDIX ITEM F | GROUP MEAN BODY WEIGHTS, INDIVIOUAL BODY WEIGHTS AND FEED JAR WEIGHTS OF FEMALE RATS RECEIVING FLUOROCHEHICAL FC-143 IN DIET FOR THO YEARS --e---- NOTES: Code 1 indicates a control group rat weight Code 2 indicates a FC-163 - 300 ppm group rat weight Code 3 indicates a FC-143 - 30 ppm group rat weight Codes 11, 12, 13 indicates the total feed jar weight for the previous rat(s) ANT weights are in grans e-- e ------------------ 846 01235 AvemDix tren vo Year OroaflPl(uDoierto)caTrobxoincFiCt.y14-3OnicnogRaantiscity Study Group Mean Body Weights (3) + Standard Deviation Females SWtuosky cMoonatnroBl 1-WS0Dppm() Mea3n00Bpp2mWSD (0) Mea30n B pm1W5D (0) 2 113509.2232 11000.17 ((6655)) 205% 148 (65) 11687..3031 190..06 ((6653)) 21383 11 (65) 116367..0232 1100..24 ((5300)) 214.9% 13.8 (30) s8 225769%3 2170036 ((6635)) 223574..4633 115..99 ((6633)) 22358.7%% 1179..98 ((5500)) 210 1 22699.52%% 222306 ((6653)) 8973 2007 (65) 226734.233% 0200.82 ((6633)) 6.43 2.0 (63) 27651..53%% 22030.82 ((5300)) 2w2.8% 25.9 (30) 118s 20 0269118835 22070.34 ((6655)) AT 201 (65) 229895..443% 2275..13 ((6635)) 307.6% 29.4 (65) 229085..09%5 2275..26 ((3300)) 304.1% 30.6 (30) 2226 33123.4153 30017s ((6655)) 32733 300 (60) 3224056X3 0330.93 ((6633)) 32600% M1 (63) e30l9e.9s% 3324.23 ((3500)) 323.6% 38.5 (50) 302 3M3T%T 3\/26 ((6600 E BETT W8.a3 ((6635)) 333.0.0443 06..51 ((3500)) 332 3 0M5753: 0 36l6 ((6644)) IST WA (64) B3a2a81F: 43299s ((6633)) ITNT 45.0 (63) 3s4s08s: 4424.s1 ((5300)) 8.0% 463 (30) 3"80 2 336933235 44000098 ((6634)) 72E al 6) 336662.303% 4466..24 ((6633)) IE 07 6) 3I1T5%F s45a.d8 ((3300)) sis x sas (9) pw" a 1B7133 745417 ((6633)) 9233 S11 (63) W309.4T: $521.4 ((6633)) 39163 5515 (64) 83692..70%% 5s6..82 ((4439)) 195.8% eat (da) s502 430966.13% 553365 ((6623)) 43G969.31Fx 5s6.58 ((6644)) 349096..72%% 6633.85 ((447)) 2+ SNuimgbneirfiocfanatnidmiaflfserveeniceghefdrom Control at the 5% level (Dunnettis Test; a = 0.05) 847 91236 aspeprx 17En vo Year OroaflFl(uDoierto)caTrobxoinciFCt-y14-3OnicnogReantsicity Study Group ean Body Weishts (9) +Standard Deviation Females Stpueesy MceoanntrBoWl 1- S0 ppm(K) Mea3n00wppem s (0) Mo3a0n Bprwa50 () ssse A40G1E% a4s6l9o W(4D6)) 2A1S2L% 663017 ((a99)) 4401027.36 s67e.z1 W(4D1)) 05s 430096%% sdeiles ((4466)) 44267.40T% 6654.67 ((4a88)) 442370..30%% 7s1.a2 ((4411)) psH @Ge6l6T:E a4ls ((4453)) 344109%% 6659.9 ((4411)) 4459.90%% T7e2n8 ((uann)) p6y 70 @Gliss%t il90r6 ((6433)) G1l4E sole (63) 35..05%% 772062 ((4411 asi: Ta (a1 ussesa:: 775648 ((a4nm) ls: Tes (4m 777" $We5l2s3: 5625.00 ((4432)) 5523 7613 (42) 4652.X8% 7T5a5s (W4n) M743 666 (43) s46a3.e3s% 7T5a5s ((4456)) asa: Tos (4s) a7 l"aslst: s65i.z6 ((430)) 445572..07%% 6666..98 ((4a30)) s47e1.x3% 7796..73 ((4455)) a02 56 w@aals0:F 76521 ((3387) 0273 710 (36) 746.16.8%3 6642.30 ((4412)) sez: 608 (42) 4ds7s6.3x% 880169 ((4403)) 19.7% sae (a0) a50 9590101633 7701053 ((345)) 64s.16.e%x 7T3e2. ((399)) edsase: s35o.n5 ((389)) 556 96 $50152.873% 7761.49 ((3382)) 506.9% 796 (31) w4s515..09F% 7763.07 ((368)) dees: 67.2 (0) 449826..03%% 10041.s9 ((3358)) 5043s s84 (31) 10508 550001.203% 7781.33 ((3206)) 4dseee.z0:x 7718.23 ((332)) 550055..65%%1060..75 ((2385)) 110042 5500320063F 7659.006 ((2255)) d4e5z0e.3x% 8s5a.s5 (O29N) 5s01a.8x% 8s6n..60 ((2204)) 2+ Suimgbneirficoafnatnidsiaflfserevneciegherdom Control at the St level (Dunnett's Test; & = 0.05) 01283478 THO YEAR OKRLCDIET) TOA-ONC STUDY OF FH-382EX4P.&0FC6-21E4i3CRION0ZRATS t TTEOCUHNRISCIDANATIENSITISoA7LTS.e:1S M4 : SWREEOYIOGMHOTFIMROAFTESF.ULSL0F-FE3OM4OA6DL,EJ0A-R3:3S8 SGOSRANS . weer RikoGaazs7TeT F1ORUSDITREE iFRoebaJsRtRs F1Re0a4S5EIe1 FFO0L4IA5G:E 1FOrOeUaIsReFs 1iRF0G4i5T6E4S FHOGC5aO4TJ5EA5EF7 FRUOO4DTIEAsR 1FFuGdIiSeEFE 1FFaGaizile FLOEORD4ISR:F RFOnCOdJH.E iFRao4izine FOODIRF iFFeoaissisr FiioRRoo0hseITsAssks F1OROGD4JSReRn 1FFOGOaDcIeR)E iGFaGcicee:: EGUsItnnE PFoEolSe 1ikreediecoesr F1oFoGu4l5n0k5 TFoucos e6i1sS osoerrizeeeeritdyi 161155.8e0o773z0o0010304c e11S5 O0oov7s6e0e0i0z8s0 0L1SS G0OTTEOE0OILZIIS 1G1155 0o0l7e3e6e6G6l0z8d 011155 6oi1o0i2e0e0i8s0z8 BGIiSf 0110034000010435 B01I11TF5 00c11o00r53o08v00i10z38a48 O111FS 001160356600103056. 0111S5 Gei11i0l000eI0%0En 06115S peiaiizlee0viitzie 01i1T5 6G1L1S3e0e0l0d0T0 0111F5 CGLLLi76S0e00A0E. 0G1IFS CGL11L%S000G1LSIT 115 @1206000C e0i1s5 eei1z2z1e0w0i1z4e5 o1e11ic5s GOoiiazszass0oeeeeioicczssi 1G1155 eGiazzsPeeeeaatcie 1E1155 0G1i2z3e6e0e0i0s0s 6611Ss 0e1i3i6t0e001i2i8i 1G115 6Z133626e6a00s8 611135 e611Z3d500001010s0 6Gi1f5 Eeil33vSeeo0ilzdis 1B1I5E e6i1i39s0e0e1e2s8e 015 Gasceoizs scno 41 630 111 e60n 411 S4O0 11 1700 111 460 111 4600 11 64200 111 1 00 111 60 111 4S0e 41 6S0111 100 111 S8E0 11 6S0O 111 12o0e0 1111 setn 111 2Tn 11 6S0 0111 2000 42d 4i6 11 ZGo0 111 teuo 111 1700. 11 11 16 1343 5 3 11343534. e1214.7 1eo324 . 114356.4& e134.4 1e24.2 1f5e3n A384 1 533 114478.6& e134.2 ae e 114354.13 p&ro 1eo 21s o 135572HRFQT zi3e12 120.4 ss speete2) 1e 37 i301 COPY AVAILABLE 849 01238 PFooitue G1L1E8 Gearaazs0e0c1ozeTs T6o0 a41 RFOeGaLIdW)e e1i16s ecllaiis0o0maodnte o0n0 111 FIiRrl0oIiiEcIniEz GG1Ii1Ff5 GGGliiiasctooosootloasorsn a62n00 1131 . 1eaSsicliaS FUL aGi5f 115 GGiescsoononiates 01000000 6s30u 1311 .TWfEoiEs . 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31577..65 . 1i730914 13614862 316173.24 - 113352566 131445..47 3s1e81 l13e0 s7 136272.34 313114s1 s55i.z6 311660.47 311663.44 31631 2 i31787.49 311659..11 14607 2 136145.23 3w1e616 1s5s3.68 135153.522 116.8.49 132600.11 71297'1s 31176565 6310654 m16e4?1 31 REST COPY A 13713162 1i5s4o8s 36182 4 sre 01249 LForooLsIeesEy o2z5t 1o111106000174130 6400 122 Fikheos0eJsks 1o2o5f 0er1i1c3e0v0i3e1s1 4300 122 FiSrokooasosgictnsrke e1oo2ss5 coeiiiiiissceoeeuciiirseay 244000 2122 Fi5onoc7odioSncko 0Gai%ts oeoliriaassreoocevsiaieedss 533000 4222 . 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Hpireaos d1 1671571 3162572 i 3s2o1e4 i3iszd G1i5i55e6.z17 3iisr1os1s? 7s5is5s 3 824s i 3fe24 FSres 1ap5ne5s)5 13i1e54e2e 6f3r1ee363 ie31see?5 E3i1ez8se? iS2ei0sz531s . 3i:r 5 BEST COPY AV) S2eiszsse bfirelos e ie 866 21255 MBSeiAbeeRl 1iE GGGreeReinElsEs 6 i1b3 rEiioyrewmwEEEIaaGGmmeEaEmNnnnnlne fwrSiiehls iSEE SAUhNeeESrRs nYLe F2L So RMeeassmEaAmmEmImDnR L wIreoouroremeaeassoissseeensn n0 33x . pGHaeroreadUfTraGnmaeeamnms nse 8nn EHMeoenetmseeEGGEELaaSamiNsmEeEemEeRelnaEfLi3L hmTreurwnitpGef aeEimsaeEenmntinE vo b33 mHfTreeeiim?EUG8ffIGSSgolenEmeeeeGirrtttner naateee 33 nefmismieaS GfmEtrme a emaenEs s Ena f31i maoSeutEmte Hw GEEE3oEEoimRomseeEeEinEtsnnLob : & nfmeEresmapSaarnmaalmnElndkofb mmPrmemmoEprEaaSmnhmeennen dnwrn 1 kb i s Taeafoffa Gcoemnent w ge n mrCuemmrasmEeimmdnaeEEnrE fF L EdIeememesm83tt% EaGrsmsemmanrnennse nL ErCooresnmc:ooetietEr smrpaeenat tis isa 3 kL FDmToeouEtmis 8E d135%iGomirsafeeEeansitrLetfoo 131Cd3 CFFoE elEixe Eg GE f ECraE RaeInnEkkif sirPeaairtnie 1GIrmShaaeemntssa 3k3L Rem nEmEne kb psHoezi . gHiii ii 2 BiHE.eo i31e6.s3i FHHeEeet] iiEri: iBiled iHFsHe mEeiid Hn2 5id1 EEBHei iEeaes FiFohi H#5i35e iiied ioE3e iiFsHe.e F$Fi3e.Hd2 BEST COPY AVAILABLE ffFpeedHrd) 5uia3id Es 867 01256 LiReesdTaa:z 0ei3E5 0o4zezl0o0o1l8s4z 4&06 FocLgnR 135 028300213 70 33 13 F4i7r4eds 0e3x5: 0oz2a5c0e001i8s4e 0S8U Fododer 135 ezarevizz on 33 13 `TiSsa4tTeerS OwIiFs e2z4a8s0e0o1z6e2s 8300 FODOJRK 135 e2see0iir. 0 33 13 1FReGaa7tass 63355 02510015: 20 23 1FFo0oaITeSR0 01o365 6o2zs5iEoRoLnTiZs 4z0a 313 FFooaoerl 1e3i5s oorzSSsoeceiiiecs s1o0 13 E1FReooaaiTStn: 0010D3555 eeGIcItSSsTEeObnGLiLIiTTiEA a$Zn0B 33 13 lGFAaiTtiSs b0i2s5 e6r2e5t0e0e0i1rSz0 s1o0 33 sForueppIeoikeer1e5 bez8e%uiid sa 13 1s5z4e4 1365476 3i2c2e e20z0 3er issisre2 137125.783 1782814 a3r1e8s% 5173433 117576.13 314% 01257 THO : VERE ORALCTTOIeEcTehTiORem-OMpGuerSTiUnsDYesGFmwF-35H23e6 FaE-16b3 1e0 RATS .: ESooAn TRuheELRSSE DheeroS-oEe coos . hee . 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S2eao0 2122 SFiRRooousoccrenss oo1c2ot%c 0eo1ii4srcce0oo0oz2se5sc3r 9400 60 2122 FiGrFoeeoaascseses: co12oc5fc ecaiiisjvscee0oeesaziszaee 8070a0 2122 [FiRoRooGsoaiacsne:es oicts 02% 0eeii1io5zs4ee0a0s22e5es1s e9a0 00 22 2 iiFoRPoeoossicenecwss cc1oa2ss5 08o1i15s59e70000007z25s48s0 383000 212 2 FiioRRooeosaicdmoemrr 1occc 62% e00i11s63e00e00a02s23i4r50 3600 80 122 2 iiFoRrooobsaicsnoeens 1oo5sss5 oeeii1ce6isze00ee0sz2v32e03 33S00 01222 iFiRrooeoesiccnosers doocssss GoGiiicecsdaoseae2tc6e3scse00io 2122 aFiro-ceo3gi5sn5:e4 Qe1z5is maeiiccccsroeeera2ideessr ss4a0o 2212 FiioRRceooaascdeeenss 1oo2azts5 aceiii7v7iezede0oasszsssere s33o06 1222 FiSofRoeoosagccessrer oo12ocsst 0ooi1ir7rdssa0002ez%%es1e 368000 2122 Foooink 125 e17ce0es 40 12 a336.1s oSims e f22i1es2 . Zfiaeez ZSSe2oa6e1 SF2e2ve3 27229 235257 5E2e%62 f6acse 2S0e7 z5 25276s4 22S25r21 a 22e5z538 25S25e5 2s 235674s 3E55e7 a2f2e0 2235564.1365 Sf257a5 3s :237a566s6 Se22e5es3s 2256.ss5 2zSeese+ REST COPY AVAILABLE 5703s 22S0a45s6 sl 881 01270 Fisfrooooierstosess aaozacs oemiiurrreerceeeecsszcaerrs 81s00o a22z 22S07e6.1e9 FiikoReoeaca7oronese: ao4zs2ss5 eooilaceaeiocsoeeszseizdss s730o0 1222 F3Eirs 0FDh7i747t766o3s aGcica:t oooiiicootssoeeoesszzeearr 2a30a0 2212 5= 20s5 Lheiren ox oiecooes 40 2 irvoosoreme os eaeveozsz 10 132 pr 54023.34 _ LFioRRoaiosrorameses i0133c%5 iGciissceesccoe0szsse7aid 4vsaaa 3313 52m03e54 FiiRfooaaaorroinso oo1z2xs5 eobiiicssssieocecmszsiiezcs 282a0 3133 ifeiril aif oisscesss 2a 3 22S2e32z5 222 iiFRRoeooihurorieasec 1ox2is6s aooisisrsceooeoeszssitas 333000 3133 E2a5e03)3 FiiofRseetsroriaises 1ooa3it5s oopziiesoseweceeszssisitss ea7o0 1333 37 25S6 7 iiFnfoaeoaubrroiaetce oo1ri2c:s esosroeozstecooesizzsszss 13200a 3313 F2=Ei: - FiiRRoooouag7rniiees oo2a3ft oobszzoopcsioeeezsssisss 667a8 1333 #aGa6er FSFrlOeasvU7ioRne aG3vcf: zoGoslooosvreeoczoasauesr 4Sz0oo 3133 Foutsek 13: oziooosar 60 13 FBSaieisz sre iFFRoeocaaorrssse 1oeii3:t: eoboarisizcovoeernsaceiss 02o0a 3313 EfHHoEt Fiiffoeesiurrisnes 3aoxf5: ooaarstiiacsoeooemcaesizse 281008 1333 F=2r2e5ee1e FfGorFdootarsrceiekt aG1ii3ff5 ooarraiic0eoo0usssesess s77oaa 3313 2fSe=5a7r Fiihorooeuuirsraeccss ae1xi2ts5 azbzeaiaierceoeoezcreriree s7sa0a 3133 Gres7se ois orzso0zis 7a 3 ESpeeesd is? iFikhoeasuurrssnis oe4zx2sc5 aobsrzssosetoceoesszersris s22a0 1333 ikeirss exc asereoess sa 3 22o75i52e: 1 iiFoRkoaebiayrrasswssk 0x133s55 ooozzsssseesceeoeesssezissr 30s0o 3313 Footsen 135 0z3i0034s 80 13 #2B53s5 52s SFiRkiaouaniraskc? 10013355% oo02rs7ad3so0eo0a2ss5es8ss. r%0a0 313.3 32S25i7s Bp EST COPY AVAILABLE FfLkoidToiins aG3i5Ff ooomrsdi7oeoocerasseeiss e2s0aa 3313 iRaren 023 oaesenz sa 3 3iS0al8s His FSifhoeeiaurraansc oo23ff3 ooozzxvaiicseceoeozszeeadar 01700a 3313 7EFgi7e - 882 01271 iFsoreopeoairrRasks 100332555 66o2224e43s20e00e03a23z55e3334000 1233 32385343 226 5 SiFkoRpuoabariranasec 001333255 oea2isscee0eeicze 280 3313 2S3ioi2e.662 riRoa4pai7rnaags 1c0a33s5: ooo22zsessceeoseeei2zceesss 425000 3133 S2ede5'42s SFikRoeoaarrssaeos o1oa3its eo0zzzssez3se0ec00s2se3e20s 333000 3313 53Ze66n2553 fFiRkooeoaahrrjssaosb c10a33s55 bo6esotics0oe0ae2zs0is3 8e20n0 3313 23Sa:s8e2 FiikoReooaoaru7smoses o0133s55 6oeo:cs3ossreeea0zr2issyi0 02200 3133 0i35z62 FSiPoootoasressgesses16s255 0e2zee0eee0sesdi sm 350 31.3 SBaiss .t 883 CO1272 Tho VER GRALCTTOIeEeTmTOcH-OtIE iSTUDaY OFsmF-39E24A6RFE-343 In RATS . C SLeneE honrE a br0taateoS-aEs sons . ee rmpsmmeeiasrrsgeuoigstroaewrmsneEezemmrleo 1L mLEdoEEetRmm6Ml%aAelmIeEEasRLsEre bih i mE E SeuRSL mEaME arNaAN eaEnNlnEdb4hhb rHmDeaeaEemmgeiiauamnaaenmmaeennd kii mm fP mnoeEiimU stesaa3t1R ifn aiumbS smNaeemeE nieena0 iLi Lo. pEm LreRtma ManIm ENsEn iikib Ec mFeOmmmae taeasieesNanEnzsRe 4 i GHmLeoeemeigtith:aiGGmneeReeennnaana ihibat rDmeuemlmm aanrtmmaanemmemmmneiensln ibih EpDmemeem gamdrrtraaonmiNmEnEEERERRnLRe iLib fsPmaeimsmasanrmeaaEinE REnREEsnnnhBii eEFCreeeemchmaaeAatNRiNnnmEEmRnnSa fb h mesa aEEEy BEwseeisre = FEor 3 E2B1H3i 1 E2uedd =B5E,He S=3 EaiIi 2i fno5s FFE=ert FB35rad%ge BEST COPY AVAILABLE 3 EHHiss 3 3 Fert 2 =NEES; =ail 884 01273 Fpoocordn So11sEwsGisReseEnssa Foie 3 thiaweier 6 11 ha a=5r,s3 EfLEoUESeS SNiMfIIU nAMiuMNseNINacEiEaRSEsEe b1L oBs3e = irGErmomlEEcTiUOnafEEif aSMNlhiiRiecnmeEeretnLave8 Lh =Ep=reP FfIRooiEttidIieamSS34iE4:% bosNilistaiaNmemeeeciNseiets tsea 2 h|t It =E=,Hi 5 roWFouitntivSioeffTrsiitnUeseeNeesstGsde Eh1t E5ErH:3 EfIEFENEeiRn fS0E4f2EsAodLNemiENveeEsSntIy Dn sa b11 22 EaA3e HEfmooLRdEiEe 1OI N4f:ItoUAhhAeewNmeNieAosaIE3wn0sD h1}La E2Fio3 52 - EORRouEeSllt ioN IEiuoSie mtimesese ns Ejdaa L1i 1 E= EeH EAH EPr mmEiaIIr uoma aEavnneEt ht gFii3H fTE froooiuRlte: GiaEiiff ibsNiiiasoTaens fae 1h1t hn E=1iH 1 NLmfFrouueesglitt0Ii1fIEsdiEcaacENesREse Easa 1L 5== E:2H mfLPoeiuitets 621% nNiiivteeessss nomae b11t 2=ii rirorooautncehs ozs sorsoozes 7a 31 2225.:28 , fIiRoeEiccReis 14o2z32s sI orosraeI sess:r aSa1R 12 2 1 = 257 3 BEST COPY AVAILABLE FEefoooRiRre EoE15f2NoRSTooeEmEeeeErRsse to na i 31a 2i E53H3 FSE MeuRaniRsE s A1355E%RR nSlioocsE eeEoessisssES3aEa )2312 E351H33 iPeifemislcmes:maaosiEx:naoesldaovrsmneeaEeiszmnL5se 21132 i2E53lHs r WEAoREiRS 5 EH 885 c01274 FiimRooaoessetsseet o1o5zi%s Gevalilisloeooeusseesst a3e0n 5ixz FSInnoeesodetsnts 16o33c5 oooiiillisisooenaesstcees? sw 3o z12 iFGhkeUafcESosr oGGif3s eonlrviisceeeeoesssseee ssrooo 51 iFiRhPGoaavesiicmesks o1So3if%f oooiiiitfseieeesssssseaitre z7ieaa 5152 FiioPFoaeussisin:ek 1oa5oi5ff oeciiisciiiaeesecessisiseee aseon 5312 iFiRoRooodvusisentsks o5osi:tf ieoiissfstveeeosssicirisrs 54v80e 32iz iFioRfoooteortntce 0o153i%%f ooeiiisssosseesseecszisesrr es@ea 3512 FIiRPooausccsscies ooiaif:s oGoiiLsrsisiooeeeesssrsesed a6B8o 3152 iFiokRoauusiictntika 5ii:ff oioiisstoeeessscsaeern vrsaon 3332 iiFRRooooiuiesarse: oo1s5st%t booiiii7seeeesesscssiess ssraoa 3312 iFiRRoooteiioissss o135s%%t eooiiisssiseceseeesssseesir osvaaa 1532 FIioRNootTsisEer Go13fF% oGbiiivvslsseeeseesssesssee srsaea 3312 F(ioFFooousuictmiskc 8o152f%5 booiiisassrseeesssisiaists 1s86e 1352 iFiofFooovuaizcnockss 5oosa5tt oooiiisssiesseeosessseetssi 3if0oo 1252 FiiRoRooasvsdicene:ks LGGiiiff: ooeiiissieieceeeessesesst sssaao 3512 iFiRRooobiucsrsaass oo1si%t: eooiiisssssveeaesscsseeiser rsaaa 2132 FiiorRooiousoceme:kr oo2aa5ct eooiiiSsoescceoeasssessssr sz0oa 2122 iFioRRooahueocgeoskes o1a3t55 oeoiiicssszie0ce0easssesiri v0sa0a | 3i5z iFioRRooovuuitcaoekss 3ooao%tf eooilisssssieocseesssirsaec sssooa E532 FLiR0gAi5cGe6s G1o3o3%f bGeiiiscccrsooeseesszsesose e8aa 3i2z FiiRFoaaouitcsiasess o185:f%5 oeG1ii7rvisaceseeessssisesirsceaa 3i2z RiFoRooovsticnaik: 1oo2xf5 ooiiCrrirsiseeoeeccscesessr 21caa0 1352 AEST RORY BUR BEL 0 scaense fFmerHts is5es 3 = = FSfr=ee 5Hbeeeh iFEotl aerrsee =Es?7 s2 fra? =EAeH2 na Eied SFEroee l i pSeid i5per8: F= ere P2#ids2 Saiitd 2FFrsHy 5F5l = FFel 5Fpia53 wi sUBH BEAT a86 01275 Porm ummna =, roan won, hemos 2 mam n : I: Soom i gas 3 1 Ee Dem b 3: ii 3 BESTCOPY AVAILABLE na ioe 3 487 C1276 Feesavta:z eo3nss Dv2z4e3zoenwzzessy e4a0 33 22615 4 1FROGOiDTJIASR O13355 0B22445d0v8e2i4s0e 0800 313 233460.8 F1FOeOaDrIaEs 1033%S eG2z4vce0d0i2z3z2 1100 133 32232211 11Re44774457 B6I3S5 B0224s8e8e822e3s3 3300 33 224365.33 FRu704l8R 01335% 0e22%7o1p0e0r2i5i0 6100 133 23610 1 FioRoeDaJ7AaRs 1b3i5f oB22SSszeeeeszsezs 4200 133 92028..32 i1RFEe4aTTSsO 0G335 0o2oS5s4e0n0z2e4s0 8800 33 220960 8 1FFOeCaO7JSAzR 613355 G02zSSTceeR0z3e7lS 7400 313 237451.73 1FRRooGoairoTsiS:es 1mG2ii5it o0G22zs3ee8on0ne0es2zs2is47 sSaa 10 13 3 3 3223485 #71 FFOeOaDItAsP 1033%S borzizieonezzezsr 2a0 133 G2a2s762 ssssssiess ss @ CO1277 To YER CHE CCIETS TOR-ONG STUY OF T Tomegi mateisn:5 F-35Ee4t FEe-A43dIN EATS . fF LrOoEE yaCcEE sS a Re SE canons . exe M mmspoeEucmrrsa eagoilsrn EaeonieezEn nsneiinsa ih1b EpI saEnEeegMErSi aoTeeeisnr ae ihb mEmTeOEesC LalsIIr aNnENeERk ERlReSbi1hb lmToeasaile enuNrer emeRdbi TmpeeEInwtGIaiiNaauNemeSemmnEitElRE |]hi1b mIpMrUeEomngRniriOAINESNAemReEEk h iob r MroSaeCmit GMgEiIimdap ReeEaEsEEaaST bi1h mtmpeeenirmsaaagrrlartnheeennei hb d eTpp eemssot nnsiimaamr imeaenntiinsh hb b) i meIoems tioisie iSuemieeeeeenna@ea h11b eposys Lis agrrSeaienneiemnnsd4ht Trl aeaeema aaarltaeoia lleeilminanLioib nmiees ogf saenenese i 2s2Ie2:s =w3 22i o= F=4i, F= B3es] 2B=2i:is =B=3HHi ==a 5:: BEST COPY AVAILABLE =P==isi 2n2 =s: x2 EH:Hd gB= zyel, f2 Bbreas =Bsi 889 01278 BEST COPY AVAll ABLE pMrosEesER EENE a Demian sd 2223 BEST COPY AVAILABLE E e puens n mea mn 1f EaH: ected of fi Bi 490 01279 FeC5STYCOCPOYRY RFuAl ARLE o EEEmmmsmESaE 2E:e ERTS Fe I. 01280 sf Lpoeisnzr sg o6isrwGirrsbe eezeerry ireates oo: irseestt 02 ooh S5 ifTrsrihteor 85% Gtditihaeeesnsesni0 2 ffP feoaiennE es 3S2E5FEdNSiR oSomeNonS n wEfaSa 23 2 Feoonnoemn oF GENIE iroaros es ciossezer sa 23b [Efhoretieanec ESoiffasoiimseeeeiietcse a8a 313 hofreeroiess ifnanis SofaeonlEismeesine sa b2 of sisseesir dn 3 FTireieentnioss igGE:E ioGitlsaeeassnes la}b3 fferoieiande? fone GB UElE biaod rimeenessene s 2k E}b b3 FiToreooitnnest elt 18G5%f% obSaaovvccmeeeeesssesss gInEGR Sa3a8 133 Ef UTfroikUnis psi 8GEi1fIietvrerNeeeencErettRSaa B3b HfTaeenve So GUaiFi ldotidhaeseecnmietawasa bb3 Feiroeiirnies Teenie UGGSlifISesionisetnnaeeseiissmngs Ea bb83 TFieeoerteio:e iiGfEf Soaiirldeeeessee ttdae ab33 TFireooietrEsos goGifff se Siiedeneeseeeiensn 4D3 Toirreeaotts 3iGi%f Stsiivseeeeassnces am 3a b33 oDireeierrsms GodfirSviameemassae:sa b3 eTireees SiofIsOSiEliIeeeNeEsRaa Femara 433bh aifritaie foie UUEGfIfIeSssEsemneanseessw na bb3b aTireesaetneiss D003:IiSOihNcoeeNaesEseieIaeEn 33b AHVUERIT Lalenaadd H2wr5ie 83 - = 2Fe31 =a=Ei 0Hp0 5s9e.0 i2FEo31 Ei #3H3 ia2:l3 Fi 85H3i 2mi5es aisH i==y 2= E5r E8 #r13] w=Ei3H EFFroH p=Hi3 =F2i. 5piE3H . i #a3 E2 HAe 892 01281 1pRee47a4Z 60335S FFOeOdDTJaAdR 163355 1FFOeOaDrIaRsR 613355 R1 ereasr e0a3s5 FiRuGuanreaks 1o3355 iFROeCdOrJaAsR 613355 RRATTIE 6G33S5 F1OROOO4JTRSE2 G1335% FFOeoaDtJsA:R o13i5i 1RReesa7tSsd B63255 FssOsCsDsJsAsRss1s35 0o224e3z0e0e2z7s5s 60224450000325582 oozzaas7oonozzes7e eozzasssaoanzzeeez eorzssiecaasziezre oo2osszieovezziess b02r5S4v0e0R25z4i B02tTe7000RsL7ezE oe2tseEovnezzzEzs 6ezrcfi0o0e0zZi5sA ezeezeeozte 2700 33 7200 133 Ssao 313 7100 33 s4a0 123 sSoo 313 2300 3 aEn 4313 S20 0513 eGo0 33 30 1e3 22755s.73 s25e237 2saa7.s5 . 22662071 E261h4 zese:e 52145.25 25475228 z38s32 2E3A8 576.3 893 01282 THNO VERR ORRLCUTIEECTH)NICTIOAX-NONICNISTTIUADLYS:OSFmiFH-392Ex4e.&w FCo-z1e4a3cRoInNtRzATS STELROFSRADTAST.E'SSFE7W/5A0L6E1 Fo0H NUMBER. 5 0-340, 0-338 i LETGHT OF FULL FOOD JAR'S GZSGRANS. - week i1Froeaassr7ss Foctdek oo1ii1ss5 ccoorvzeeeon2erzs oorseesiz 230a 20 11 41 iiFkepsassrTaE e0i1:5 @0w0s7e4o020s2z3 3380 Foo0Jek 115 0073003ze 60 11 11 ifFreeidsseesn aeiifs ceaurre7eeoczcezs0 340a 11 iFoRocLaIsRckr ikeise: o1l1f5 eit GGle6sGeee0izcees clowocrz S1a0 eu 111 1 iFRooodtSjieek Rosset 1811S5 ois CooLli0ac3zd0oo0oe2sz8es5ds e54a00 1111 iFiFoRaoaio4siseeerks 01115 ois 6G1i6o3s0e0n2s5iz9 oloreesse 040 10 141 4 Firoosisees iRoases e11i5: if eoaeessecnez3sers eilcozsz 1180 eo 141 1 iFPOoosLsIeRnE iFodser 1oi1f5 Gif eGr1ilz1e0u0zirtie eiisoered S2u0 50 111 1 fFRoooabsgoRze Fase: a1i1f5 eit ooinlistoeesscerdr olisverer ssou 10 111 4 iFPoocdbsieesk Reason 1b1l5s Gis Gbiillveeodoszs7Te eilseezes 5200 30 1411 FiiORROeoDi4IsSAseRrC ae1i1if5 e9611i22z81z00e00e23s75s63i.. e440Go i111 IFROeOaOsJcAeR 011155 6G1i2z5e0e6o3z1e5s 71a0 iReases eis oicseazer 20 111 1 IFROeos0sJoAnR Resor o1i1s5 ois 001122750000236450 oizseezrs 6100 su 111 4 rFoeosucioe:k iRaico: 011155 eis 0ea1z3s6e0e032s4r8. eiieze1 3s60aG 141 i S FOOLEIRR inodsos e1i1s5 615 e6i1i2e0e6z36s5 01306Z13 s3a0 40 1141 iFrooososdoeee iRascor G11155 oi5 eGiisivceeeeszsrez oiireesse ss7aaa 1A1t IFiRoRooesussaconoeks c1i1s5 ais c01l3i5s0e0e3s2s5e o14ceerss 2600 sa 141 1 : 237653..52 2557623 32220.s6 226290..54 230660.51 2 384.5 2269564 2G5i5z6a 2Ses11 7ez.1 7r6iz S2e6a4s3 22677s1 23776.25 2683 z2356e51.a63 FTSO T COPY AVAIL 23165317 32445126 72850.81 235478.3 32666133 226193.45 237870..78 z326s.6 22664.2 894 01283 iiFkboooeiiccsiaesn io1lcSf eGoirriisezaossceeissnvT0se0oH 1411 iiFfohouseuss io1l1ff% Leoiliiueotnnassiis:s e2Tr0 o:da ISFnoeltUtiiesEi11f% GSoauiesEeeorsEtess 3E fbo G1 iEiiirnoeeGdkitec gi11lf% MGoiidtiEeeoomsEseossR630 1is iLFRaOenMoEdiiks nG41f%aobiimttuieoeeoisieess n t5o0 d11 irFltoeoers 115 Gif Gr oiisooseee eersrees 20 80 11 EEioooEuditEmtr Eo1i1f5LooiiisEosseosNniee:s B4To0 31 d ijForsoispnk mr 15ie oincsig ecsmti s leso 11 1 dLFFroeseuilndt m1m1iI5s OooiiccEitaeRssicIosyo L3sN00 111 iiFFiooositicoccetss o03i14s35 oeoiiiccosemooonezsieeeyss d12a00 4111 EiFoouEnseo ao11i2sloiirariznenensaeassi dba i111 iiFeRoeeueciei:s ioGiff: oooiiirrdsaeeenssierrsse zfseoe 111 iiFReonsoaisEtesy 004111%:5 iooiareitnnsozeeiss s22o0 14dt iLFFonoosvfswlmte b0Si1it%S dibimicacaoaeoeezoiectsid f74o 411 iiFffooaoisiiiaicest noaii5fs oooiiicesoaseooooasrseessss ZSwaob 44it iFRoousirasn o1i1s% ooiictrseonncssses 226 1ia rofirroieossaisaasrnsg eozsgovseeeztsa so 2n iiRRoouscsadss o0p o3s% Goooe rssooerrse cays 23aa 23 iFt foeiicaeg s 0152%3 Fionn 12% br ooormceosr sssssrs ouoeres sa f1a6 iz 3iz iiRRoosuacsaaesr 00O52i%f: Goollloootssoeanceissitssst dsseaa 1332 FiLoFrouooairssesisss 01o23f:3 booiiieoosasosononsssseesrr s0soa 33iz FiihFFoooLeiiiinccks: 01a22i5fs ooeildooovdgeoecsacisezrss 4a 300 :332 TRoteS: aif oioseocer 0a 3 Zzsroee+ BEST COPY RAVAN ABLE : 2fHrel pE5oa r= eet 2fE:HH eFEois EeFieH EHEoea E2Er2i pePriiz FfEoHi s7Ee2eH2 = sE+e 22 EH7 = 22555 =$i2 F026E02. =25iss: =E?H1 2mesee S5foi3d 2E55H32 = id 895 001284 F1OaGsUsRsE 612255 bUililloebeeiziSid sSo 0212 123s44 Fedess bls BlizBeZiz SUL ze . FRoeoaUcItRsE x12f5 oeiillsboeezzsz:e sToo i2z 3e53r3 11RFOe4dSsSsTs 06325 eBiiiLsSeOsIsAsG 7T0Q 22 225a577 FInooanstss L63S GoLultseosNizsaes aTa 122 a35s40?3 FPoeosuacsee 1eiSt oGiiiiseeesuziiioe 0su 2iz mress 11RFeGs4sSsE:L eGcZtF mGiliizieoeozzsazr a80n 22 2r52e4 FRoeodbusn:e 61I5f Goiizzdeeeeszesse 7s0u 212 2358.575 F1OROeUdJsRsEs o1z2s5 mSiizzsoeosizeeds eSaa 122 26445.68 iLRReO44sSsEsS 00325% mGi1lizreecei2sas0 s4a0 22 s298s4 F1OFo6O4I5RSET 012255 BDaiz3sGoRnEsIeAe 6600 212 235846 1FROgOdLsIsRsE 612255 ceiuiizleoezieaei 4r0a i2z 328403..47 11RRGeassssnse 6025% eLailidioeoacztsir 6e0a 22 5a7r6e 1FFoGo4uSRTeL 6123S% BeIiZidsEe0mzsEesr 1100 212 236673.11 - FiOReOdDsJrA:R 1RE4STI 61335 63F ooiilrzeeseszess Giijeszsi sean zu 212 2 m366e 2812 iFkOGOdDsITRaE Z12F% 0Gl1a4l0e0s0i2e9s6 8s0u 212 2364384 iPASaTeSs e02i% Dc1i4i2e8s0s2e5s3 700 22 22585371 1FROEO4USITRTE 0122%5 0o1l4s3c0e0i2s5e5 6700 212 235347 F1OROGU4IERTES O1C2F5 GGil4arsouseizsee S7O0 242 s58e.s7 1iFf@e4sEsTsSe 0622 0G1l4a5s0e0o2s5r20a00 22 E282a F1oPoou4isREki 10:S5 8s1i5s1o6e0s2s5a5i s1a0 212 S56a1s FroeodIsR: 4o5f% eeiasczieeaznsisisaaa a2z 1Fedses 025 bisieezes 60 235633.84 26s & iFRUeodDsJtAdR o1z2f5 GDiisssseaezseers 3400 212 =36i6:4 BEST COPY AVAILABLE 11PFEe4dZs3sSs 0622s% oGilsSsTeeeezzes s0o0 22 eESse F1oROeDdJsReK? 102255 601155300800324591. 3800 212 235415.3 F1oRoe0sdsRsks 1oz2s5 veiic5i2e0e0z3e7s1 s3a0 212 e37s1s3 11RR0o445S3S0S 0622S5 o6i155d3c0e022s0z1 6300 22 22451256 FioFoOu4lEREkL 6133F5 6Gi1s5s0e0o0s25r5. 1100 a2z 26375.11 FiRuednsikz 1o5z5 cmiicsreeesniircad e7na 212 238744.7 11K4G3as3s:a 502385 oicseozes ea 22 2E6B1.3 F1RoGo4SdSsS O1I3F5 Geiirtiioeedssse 4100 212 2d3e2ad4 F1FOesIssEs 6122%5 obiirrzaeenezsssss s0a 212 23656.35 1R04557 625 virsenzel sa 2 ie : 896 091285 Fisfpooorssisecesss o1022z%:: cioiurrraeoneenveziirteis2se0 2iz iFiroRaceuourrrononel o152s5:t% oobiiirccsaieeseniieerssr ft0oo 32ie iFLUkFoodiTraotl GoIIsEF: Goiiicctasooeecitress dwtbae 331 FiPFooisrtoaosn 0o135f%5 Gbmiiiiccisreoesnoscseesss d33a %312 Fiiokkoeeniaarrnoonrr coofsf oGiscszeoosstseyr sao 253 FLiRRoooduirrooorrs o0132i%% oibisisaesoeeeeecsseassri vS0aa i33z FiifRoeoousvrriainsek 3o02f%% iblisasssgeeeverciisrs sdfeeo 3 3 Fiifrooooisrrsiiest oO1F2fF% obeaiiccsatcvoosetsstreisr s37a0a 333 Fiifkhooosaurrriiess 0o13o1%f% ooctoieoeeiccononississtye d33o00 i33n FiiRooonuoriincc i0133f%5 ocoscsooecsiosesaetssassnae s0so0e 13 FiihrRoeavasir7nsikst a01i33f55 ocosasooosaresaneseieieirrr wSaao S313 FLihaiuirekss B 0d3% oE m xloeRa scesN3r0e L33h Ffiporeosorseues 10O2F3%F% osSuthiaisoetsemtiiesrraesnan 3313 Fiiefloeousrrreicsss 100%33:%5 nbneiiidsueeososciseerss 2s300 n:133 FiiRhoeossorTrelrs 010%30:%% booautitossveoeoirstsesss s77eaa i33z FiiRfo0eesu7rIenEs 001533%:5 ooeaxxttciaicsoeoenssiaesds 2s10a0 1333 F1if5oo0di7or5r:5 03133%5% ocersamsrsaseveeeessrsezss 23da00 1333 FiiFRoeeoiurrss3esz 10a33i2s2 zooseictreaoesvoessosssss Sr5oaa 3133 FfioFFooebisirrnsikys 010323%%5 orrsiisgsecoearrissd sssaoa 3313 FiE Roouurriiee o1l1f%I oorsirsaeoeesseess 7eae 133 FfiFuRooeirtasirs o813i3%f5 nSbsiiidseoecssecirrrsas f8oaa =33 FiihreoesCiirraaor 1o035c%5 booiirszsnneoiertses zt0ae 1333 Foie 13% oxvieesor 30 13 HfSaoies EEEHiE EfarEr F=ti7 wi2rcy =7i87 $oEeiHs 1 =Fez =E=is : =H=ees f2=re7 p2 2e7d =iZs rE=sei ##=2sr7 E3zi5Y1 BEST COPY AVAILABLE 5p5o3 & pErad Seeetel E=i5s7 = 7oi faHose 53 897 01286 appt BETI AEE ARTS aiFwkluaosacrraeas wL3i5fs% bsSoiasvssiosevnegiosyn o330a us135 iboats 3% oscars 20 3 P82o0ss 252 FiifRoooasrTosasr 10033%% sbonsasesracesesetsss l3sae 3B3s Ian 3 ea32d: = PiGRaoieutreaa:s 63i35G%% aeoximssiteoiasssseerr as7oa 5B3b =e=Hd Fliffooeiaorrtreo o0130f%% rboriscaeicnoerssiseerss 4tsaaa 3133 . 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BEST COPY AVAILABLE =e3 i==s =32 - 899 C01288 LFSioonusdsso oeaiiisss obeiiitiizneoeoesassses 75300 14a bpdrhroeatniieSGins EsviSeenEt: e011 SL R I LrotE iaR ? EGifAiVteoE EnzesSwS0S Lh 1 .orMRmRamEeruNMiIIaNMmEmeSEEEREERSDS dLh EISieat S8a1]IaSNninRnaeSiarEvnelL7Da 14 i Thosintn G0e1IS NoritNveEt esIts SeEa 1BA E IFFooutiiim c 01i1c3m ooaitdooea sceasetde ne2na f111 iMiaimiw SiGsIoaainceENrsEy afGen L1 E FIrouEiiI tEoiLoAaEcNcsIeRcEssSoNn L41 LEpreEsmtiEgeiolfnogieehseemrees 26 L 4 . fPiRohoRiitEe IGIfaiSEroReTiEseEEre i14 FIeLoIdiRTEE 0111S5 0G1i7r4d0e6e3n7c5s. s8a0 111 FEpiOtrEiinf tNsTeiRreEED2A t 1 EEINmEEmETiNdfIaLinlEiSNeEiEeCDS7a 114 HpIiaNetEeeS GdilE EigcNaehEcrSytN8sA 14 FA one aiEf SSicseenieer fee Fds FFiUooomntRci aOofFs sSsooeztaeesoeozsnesrst ecrao a:uie FSpralotnsag t O12F% sSgeetvenessntsi oa a 1 iz C FRaEt n 1E25 sSion meE esss sR} a fiz f FWermEioaNnnEeStnEtESE fkL FILoesEtaiSeln 0OSFE3F SlHlaosNseeseMeereR72a0 i2Tz RsEotEei iOSiEE oGGdeSoenEstsvEe F2i TE GE SEE = =z2srs BEST COPY AVAI ABLE iEiie . : F=Eo.H i17 o 24 S0e =iFH =i1e. 1pw3he =Sai2e F2Eed7 E= =Yi = 375 BEfrii =E5?Y i H5se i=. PoEEoear.) 5==. 2E7H3 5EBrh. Bsmidi E22e1 EY 900 01289 EF pont oneal 2 wee BESTOOF] Liatiagn = Rum mr aEgiE EE po Ean 2 = een mameii 2 = foam Eman 3 EH I aA e rtma 1 o=e, Pon hang 1 = - 901 01290 Ffspiuoaacusts obLicissn mmwaiirrreseseeezareses 477a00 2212 iR ifRaiivreoe rn eoiztse moeiceast osecrrees 2S7U0aI 2 2 FifRooOiirEeet i6GfE GGacEeaeSeeEnrrEas R sdoe F322 Ht HioeTtiOEl mdieee isiee sle 212 moiBkoResuAreGr ocafs ociussaseeoocmsei Swoa 33n iSFfhoaoaaorroonss 031333%%% oooiiisaisceaesnrasacess Zdfoaa 331a FSiooRouotraoirnsie o0313f%3 bisseeser ousseozzz 2a io 3513 iFIFoooursrtiii:ec o03f3cf5: omsiiiasarceeonnrsarsree dsdaao 3312 FSiRelooouarrriiaes 0Gi1cfF: oOouzlmvosasesoeessiseeesds 3e70aa 332 iGFafRceAisTersEi o81i0%:% oCouzhoooscwoeessrisaseses 0asa 13 3 iSFfRoeouuurrtiaiest o3Aii%:5 oSorisooostdoaoonncsiaaotss 0a26 332 iTHxeuoirney GELifioordiei eecs cRa L33 fGFRarecarreelrsit612g5% Gbiiizeessisetefno :31a iGFeoriorevsiasm o31i3%f% oSosualsvfeoisdcnztsasissdeoa 3532 iGFFecoabarris:mt o0135s%% oSbsaiesleesvsocrneeasrd 0eene 3 3 iLFfooeuairricies 0ei1ii%t: obbriiisnsoeoveaanrsaeiss 03f0o 13 3 iiFkRooGoaTrsiseoi 0GLi5%5 o6bii2vs3da0eo0cm2ss4ra5ss 06s0o 13 3 iiFoooiorutsis:e eo1xi3cs5 ooossicetsoaoosvzsaeeesss r7fo0o 3313 iiFhFoeeoiasrresa o01i32:%5 ooosrrisdzeaeae0niensrieas 30a0 3313 SFRoeE uuTrE G4E i3f5 ooiiL iisoeaenseS egs 0200 331 Fip uokuist o35f% obsir iateeectss aRTeae 33 3 FiiRRoooasirraaeln 001155%% eoSrrsvoooooerreesrs 4s30aa 3333 Fockie 13% eiasoscie ab 13 : aZeomldr F+FHdd 25Eo513 = Ser8 0p06sn.0 a FFeed 2ir2ee Foeael = iFAd] 235%.3 s2$i6de2 H2Eey es5e00sr.e2 =iFrie = =e a eEisde F2Er5d BEST COPY AVAILABLE NS=eeer?r 22525388 F2ei =fiide 3Fe533 bi 01902291 ipFaeTiraazz e3355 o2z4a3d0o0e2z8e4s 1800 33 Foster 135 ozase0ies sa 1% 22656415 Sas Rivaoiatreass 303%5 Obzoeaceooezzeeez so 33 - 2262086 FiORGoOaTrRaEs 103355 602z4i5s0e003z5e4z 8100 133 1 i7ar eis ozsevezsd ea 3 23364218 254 iFuRseOdIrfdRs 1oz3s5 002255120000321717 4400 133 Feiss eis ozmioezze 6a 3 327171.44 256 FFoaoosieee 163355 b025s%d0e0e2sSess 61a0 ikairsy exs ezseveziz 30 133 3 essei 217.3 kFoiotDIsR:R 103355 ee22sssreeeerssiez oeno 133 s25a0re FiiOFFOaoUaa7JrsRo:Es BG1ii3Sf% beo2ozsedeteeeeenezzsissrse ss3oan 1333 2235550 s83 F1roeuaIresey o1n5s5 bbzriezseeeaziderd 1S0O 313 2e4a7.s1 sebspsssis 59 e : 903 01292 ;1 ve: CSo IETS TOKIO STUY OF FRSSEoYt6 FE-AA3 I TS : BTETeTmsrotheesEn,CnISRaET enon . ree 12 1R04T9S 01S 12500252 SO 1 2528 REST COPY 904 01293 IDioplmae S381133 eibaaieeteecsrss 36 4 FW eDdewdA smISDTanUmIeENeEEnNERiR RdLi AfSooauilss no8f3ftRSaemmiieneiie Wel UI Neat io 4f4 HF raekin It aine eaEnaL4 FHTeaeewmrdnaiinaaaumNenmmEEi oi0n D iFoaiee NGmi:EtmEitSeeEr RsRa fba rffieevteirGuei:adrNiNeeEsrmebEs bn EfriamitaihdsceneeNrumc edab1 Tifeeaetl BGGitiIbviEeeRnr EiBEa 1o1b PfRiEn abs ieerdeeessnza B1n aP Folnii e aG1ipaarme mesnnab mfa ienEeaLaTsraemarEreEmcmetaaLbBib HptaeitseeddNraienareluEetmttiEka bh Hr peosaiaIiaamEnNeAss IEnoL aHRuolmldGdiiaduemmeENrmemEe a b1 FiSrooeaaomineiss oOzfs sRoriecezzes snu n22 ifFeiendeen:s iiEsE: mesemseenenio 0da Fite Lit access sa 52i LfFroeeilirt:eiOSizF: oSGessrseeeimystaa eg er f3i LWPutEUeIa 15 ISi NhRoEen Rs RaE8 2812 friteiiaetna iret 3oa f vSilN ooweesiiss SE aeeni aEn L52 2 Hie iE ANIEEE Lk AEST Lu mie die H25E:I E2 =H 2 EFrA 2i2i1 ES=iid i f= i E= =i F= ZE l =x Bt: iosedsl B23Ii i52s: E2 2i1 ga Bly ZS#ili. 32 wel znc'sl pres REST COPY AVAILABLE 2Z2l33 Bo5ey 5 @ii SE=EH E5=e3 B= 905 01294 kLedEcDsd obzo:n bGLaiuosubsezzeesn S1O0 22 F1FOG4CESIT 1O230F DBlli1Zlo0BaZseIs T70O 212 PFaOsLsIeA 1RG4SST Go1Iz2Fs: oGiuiisdeesezist:e Gr1%00253 2500 SO 212 P3 uadsime o12i5 eblliisreooezsseez s50o 12 AkFuRdEiSoH Botne uIZEs Lf oblilEoeoRnszisIe eineeiis s2lo0o 2iz APPe4desSsli FOODJRE oOiFsF 12% mmiiilineaeziessz oilieezez S7o0 So 22 12 RiRBeUaSsEsDs Foudee Gw3i:i 135 eDiazZsaoDn0z2sSzE oiZeoeite s2a0 ra 1222 1RRoBs4SeEsY 0o3i%s DeiaZiTseeaezzesrz 1200 22 F1UPGeL4ISMSET 61I3F5 o@iii2e%s0eez3stss 270a 122 FiOPeOaDsIeEs RGesei 01:2f5 03S DGeiiaii3Zizo00ee0zzisi7sz4 sSoO To 212 eFoarsee 1w2i5f ooliiiSiosmeizesas 2300 1=2 L1kPeOa4sETTcL FoooIRk B02I%E 12% aDiiilrdeosnziesss biisooiss 0B022 30 12 R1PeG4dETsT FrUIR B02Z5 125 Bpi1iis3o0a0z2s3a blatenise 7400 10 2212 11Re44S7TSS G023f5 peliiaizeeadzisees 4S0a 22 FAOROBL4TSATET 1B3IE5 G01l4a5dBmBeZsTzTz 470a 122 F1ROGO4DSITES LreaETe b12z% wzs boliiaceeneize7sE 0e0a 22ie FiOFUoOdJcAsEn LPO4SEL 012355 BIT 0611540300003350487100 815100264 50 2212 RFoeoiUsTsA:E 1R4SED o1z2s0 UIE ooiiSSziooanzieide 0I5408ZEI ssua 50 212 2 1FROeOdUsIsAsR 0122%5 pOiisSseopeezssees 0so 1P0455T 02% BiS7eOZSE 30 212 2 FiRoeodLsJsRs 10225% eeiis5ESeeeez3rssi a700 212 i1RFe0d4sssEs7 FOOUJAR 6022s5 125 GDiiccoipeoez2esrs oiczedszi B20 022 70 12 1iRFeE44ScESSE FOLIA 0022%5 125 boiiicid0p0a2z4s3e oistesste 6400 40 2212 1JRiGgSsE:L n02z%: OeaicGrioesEznsizz eSn 02 FAFuGd4SeSkC B132E0 ooilssssooanzsrssa 4200 212 FFoeodtse uIZIfS uoiir7oioaoeziscys 0a0n Pods oii oiTzoezes 80 2iz 2 FioFoeusidsesk u1z2s5 eeiiTriaoseezietrr a306 212 zas1 a3z77 8S2a2s m50s6 mezss3 zFroa m27s 63225 2ie287 224m2 eSse 72 2S76ae 26s5?3 r5a.z6 2858225 225.74 50315 22574 225778.4 2s70e.3 e35s417 554436 s26e53& 2s%ss5 E7so7 3z53e1 5727 25465.4 S3716264 Esae 4 72557 s 567s548 25777 3 906 01295 arm 1 AEELENEE | EET IPY AVAILABLE mnumEe Lo 1RO47HL 035 6cse0027E Sa 3 3s 907 01296 F1oRoGu4iTe4eZ G13I5F 8e2r4at2e0n0n2e7z6 e2a0 133 267202 1FFOaiITaEl 0135% 0B42adi0e0e3z5e3s S7Oa 313 1RG4TaS OD5 024580284 20 3 2i5d557 2842 iFFOeOaTTdEs O1I3F% o0zZeisTpeadzieisn 7700 313 3 4rds 03f ozesopzsa 20 3 33577 2542 rFOeOaUIdA?P 01335 0o22sseemeezzrzds 7100 313 2S7245.17 RiRee4aTTaaEs OoIiiF 6e2i5S1i0e0e2c3i2s 2e0n 33 FOoDIRR 13% o2mioesce So 13 2E2r ess : RiFeeaarTsSy o03i:: b0e2oSo4e0s0sziTis SsOo 33 227ma FRUGO4LTISRZE DOI5E 0022tSeTeoe0iZrEeT 3S0O 133 iRaTSS G15 wruzessis 10 3 32764725 Ze - FLHu0t4t7e5r4 1B51%5 apiiseaeuoeizztas 2800 133 iPedrss oii cieieezds ed Ssrsa z8 EY FseosoepsIsAsss1i35 ozi8osoiel 40 1@2 ois N1297 THO VEAR ORALCDL TTIeEcTes)ce TicOmXm-ONITC ieSTTntUDrsYSeSOF Ee FM-3924 & Cates FC-143 IN RATS : fMErREi nO30nSR,R casas . . ween 12 BirneoiTuceh ous tl aosesie sa eSieseae 1 1bt es ee 1 aEFneools] ue: mmmEeermniiSliaiGenmeteeneeni:nse hb int i F2B2Hi3 emFeees osiGetusitaenkmeNe i1hb men siusene i = 1 = =0 . TFLpSeeeTsaemsplaiittmaeeannemmnR 3h1b fot of Gian te 1 2E21:Hi Bi mm Dmeeoee rmoealnitinieeel men siUbeie i6hbb sE2B2e3iit es DmmLeeaesmmsalaiiiamatmmnieaEnnnneenbdfii men oiamenia i = 2fEsei u: emmLeaeeemTeaoNsifiiaeuanmmeeeansnEeinn iohbb el ae a 23u3e.3 EH R Tp Teonee SlSa ilSeneu eeesn ibt 1 mem sien hb 3 = 3 $57 BESTCOPY AVAILABLE 23 meoGeeeieOaolflttiueknkeenema a i3ht Tansee i o= FiaH ms LFmpocoustise sUneilieiumaeennee kh ibt Jeter 22E3,3 EH me gasEmn i 3 909 i ee 01298 rdTroeesldses Pro ai1psffrcvGriiedUssreoEennesiSer T7sS6s N13s i mImEtg aauaiIfiiSaamneesoRentleae b+}L o D RIrootiwiE s nGSisIasI AiisEeeGreR rIo Ra L44 TErFeoteoSshne h sndff eere seeonrasAze du i34 mrTTrrmieeEaert:smoasaliffsssSanicfaoEirmeEeeanndgae 1i + TE pfoarodmsim e E2sIuSaiccs emeeee ssa i1| ppmfoaosdrhie HGifISntNeteGtEsAa 1 4 ReCfrearsEimiasIinfGoaiNNsSeSeRErSa L44 hgppaaeetrepBtrtEAiTcS A 4 SmFEoeSiaG2traaSlamtssEeerRti Foie nis sissy Sdaa d131s mmMotRew ett bsMlErGaEnEnneSeeEemnIEeSte 4 L mHTieEie aGifalmmaoesnEeasLG3bt m rI ooexgs aamooznra esa :2u Co iEHHRoomuosonesEaStcEosiStnoeerecnnemertssis n7ssaae 122122 EpfforriEteeESeE t EnEetRe L)e m mileotEedets E83g5%abGEaemIeEneSnn eaTae :12 rHmiooeusesh) HESSER b:b:h EsFoiEs7 2 3 mi3 . . HE7 iieeH EesEooHe E2 EEHHH 32FE2dHHs =E= 2Hs s3EERo3s n5wESeii 2 E2 2H1 F2 ifred Hi 3e Ew5eHsr 2fB11aid7e BEST COPY AVAILABLE 7 FEoe3 1 HBweea 3e5ea EH 910 01299 : "FE pR BOoODEsIE sAERImZSEa0nn112Aea6L63Eim13.EeSG 12 1L ; EpeT meeeMeer lomBofessEeiiem ReeemeeSanm ::21 Lo opumihaiens p pBeaeceI erlgemrY e eneizeEeeN C3 Bpoeelaumems 2 E SEEM NIO NE L fEonr MIE 1 akin tl en ase bDT BoeUsaEeaaofmssaiirenmmey2 L213 Ty piohese se of siea e eesn2: 2: Bese ame aRepBuonesoon iamemssaeimeneeennseei:1bf PE puamriy aasnie eas :31 b TB=BBei=:is! . == ZEie]s. Biy oiwoHeil inet biss i=z:, Ei mn: nEEEagtHH] #3i=1n5, BESTCOPY AVAILABLE 22 = EnH2EeN FEaoH) 911 001300 Pm Baemsaaeran amneen enlse 24 2EE:HH . i IPrmeeiasommmser L at ol In spee orroset agrtue omemEe+I 3L p=2wH:e mheoapraamrens 33 ote meeramee = Eupataeene 2 ESEpeamapesmiigppnyfraspatseumsunmemeemmemenntres 331 225=2., Eniatanene 3 ie irmpemn 5 Er SBaamlitsaaammne 33 sEoeomsa1ts asmmeen 3 =m:e 2B3: BEST COPY AVAILABLE EfarowmnEnsaaeopasfmemrremmemeasmeess0no32 EABEEeHHH], Eopn aofssammeEeme n1L 4$e BHE m PuRmseui p sassma t maEmrn vb314 I21Bi:131 " 912 & 601301 F1ROeO4D7IaEs 6153S5 0622402100003297591200 iRgaraz 035 Gz430e267.20 133 3 327995.21 267.2 FikoeoaorJaese iRearas 013355 03 0Oz24d5o0e033e516 Ozcanzez 83a0 62 3313 33001.3 2626 FiokOe0aU7AaRs 013355 002244070000327677.. 6920 133 1Ro47ac 635 02400287. 30 3 327677..69 287.5 F1RROeD4I7AaR7 1e3355 0022551000003247198600 133 iRedas 035 025200294 60 3 23745186 254 F1Roeoap7iaese o133S5 6G225530o0e23378i 4e0a 313 1Paa7Se 035 ozosavzEd Q 3 253761.4 Ex Fiod4o7dsa:r iRea7s2 103355 035 0o:zsm7iee0s3z739s. 023800269. 280a 70 133 3 327393.81 265.7 FiOrUaDdJ7RsRs 163355 602265090000326329 800 133 iRe47Se G35 026100233 10 3 326325 2531 FiRoeoaDrJsAsR 1o3:5c 0o2z8e3z0e0o327s22 7802 13% 3372287 ssessssess 99 : . { 913 01302 Attachments to Letter to C. Auer dated May 25, 2000 Toxicology Studies and Other Information on PFOA Repeated-Dose Toxicity 1) Final Report, Volumes 1-4, Two Year Oral (Diet) Toxicity / Carcinogenicity Study of FclounodruocctheedmdiucrailngFCA-pr1i4l3 1i9n8R1at-s,MaRiyke1r98L3a,boAruagtuorsites2,9,In1c9.,87S,tuwidtyhNoS.tu0d2y8R1eCpRoOrt012, Amendment No. 1, dated November 2, 1987 2) Ninety Day Subacute Rat Toxicity Study on Fluorad Fluorochemical FC-143 a) FFilnuaolroRcehpeormti.caNlinFeCt-y14D3a,yISnutbeamactuitoenaRlatReTsoxeiacricthyaSntdudDyevoenlFolpumoernatdCorporation, Study No. 137-089, 3M Reference No. T-3141, November 6, 1978 b) 930M-dIanytesmuablacCuotrersetsupdoyn,dfernocme JroenFCBe-l1i4sl3etaonalJyEsiLsoonfgs,edrautmedsMaamrpclehs2f0,ro1m9r7a8ts of ) 3M Intemal Correspondence re FC-143 analysisofliver samples from ratsof90day subacute study, from Jon Belisle to JE Long, dated March 31, 1978 3) Final Report, 28-Day Oral Toxicity Study with FC-143 in Albino Mice, Industrial Bio-Test Lot 269, Laboratories, Inc., Undated (1977) Study No. 8532-10655, 3M Reference No. T-1742CoC, 4) BFiinoa-lTeRsetpoLratb,or2a8t-orDiaeys,OrIancl.,ToSxtiucdiytyNoS.tu8d5y3w2i-t1h06F5C4-,1343MiRneAflebriennoceRaNtos., TI-nd1u7s4tr2iCaloC, Lot 269, September 29, 1977 5) Final Repon, Repeat Application 28 Day Percutaneous Absorption Study with T- 2618CoC Study No. in Albino Rabbits, Safety 09790AB04SS, 3M Ref. Evaluation Laboratory, No. FC-143, March 15, Riker 1981 Laboratories, Inc... 6) Ninety Day Subacute Rhesus Monkey Toxicity Study a) Final Report. Ninety Day Subacute Rhesus Monkey Toxicity Study, Intemational Research and Development Corporation, Study No. 137-090, November 10, 1978 b) Analytical data, FC-143 Analysis of IRDC 137-090 Samples [monkey serum and liver samples], 3M Central Research Laboratories, May 16, 1978 7) Final Report, Vol. II, 13-Week Dietary Toxicity Study with T-5180, Ammonium Perfluorooctanoate (CAS No. 325-26-1) in Male Rats, Hazelton Wisconsin, Inc. Study No. HWI 6329-100, May 17, 1993 8) Final Report, Daily Dose Oral Toxicity Study with T-6669 (FC-143) in Rats, Coming Hazelton, Inc. Study No. CHW 6329-197, April 30, 1997 4 01303 Attachments to Letter to C. Auer dated May 25, 2000 Toxicology Studies and Other Information on PFOA Ongoing: 26-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys, Covance Laboratories Inc., No. 6329-231, 3M Ref. No. T-6889.3. In progress. Protocol provided. Note: The study is sponsored by the Association of Plastic Manufacturersof Europe, APFO Toxicology Working Group. 3M has submitted a notice under TSCA Section 8(e) regarding preliminary data from this study. 3M and other Working Group members have received draft reports on the 4-week range-finding study and the full study, but these drafts are now obsolete. Final reports are in preparation and will be provided to the docket when available. In addition, the Working Group is still awaiting the hormonal measurements report covering cholecystokinin data; serum, urine, feces and liver APFO levels; palmitoyl CoA oxidase determinations; cell proliferation evaluations; and bile acid `and receptor level determinations. : 01304 Attachments to Letter to C. Auer dated May 25, 2000 Toxicology Studies and Other Information on PFOA Repeated-Dose Toxicity 1) FFilnuaolroRcehpoermti,caVloFlCu-m1e4s31i-n4,RTatws,oRYiekaerrOLraablor(aDtioerti)esT,oxInicc.,itSy/tuCdayrcNion.og0e2n8ic1iCtRyOS0t1u2d,y of conducted during April 1981 - May 1983, August 29, 1987, with Study Report Amendment No. 1, dated November 2, 1987 2) Ninety Day Subacute Rat Toxicity Study on Fluorad Fluorochemical FC-143 a) FFilnuaolroRcehpeormti,caNlinFeCt-y14D3a,yISnutbemaactuitoenaRlatReTsoexiacricthyaSntdudDyevoenlFolpumoernatdCorporation, Study No. 137-089, 3M Reference No. T-3141, November 6, 1978 b) 390M-dIanytesmuablacCuotrersetsupdoyn,dfernocmeJroenFCBe-l1i4sl3eatnoalJyEsiLsonogf,sedartuemdsMaamrpclehs2f0,ro1m97ra8ts of ) 3daMy IsnutbeamcaulteCostrurdeys,pfornodmenJcoenrBeelFiCs-l1e4t3o JanEalLyosnigs,ofdaltievedrMsaarmcphle3s1,fr1o9m78ratsof90- 3) BFiinoa-lTeRsetpoLratb,or2a8t-orDiaeys,OrIancl.,ToSxtiucdiytyNoS.tu8d5y3w2i-t1h06F5C5-,1343MiRneAflebriennoceMiNcoe.,TI-n1du7s4t2rCiaolC, Lot 269, Undated (1977) 4) FBiinoa-lTeRsetpoLratb,or2a8t-orDiaeys,OrInacl., ToSxtiucdiytyNoS.tu8d5y32w-i1th06F5C4-,1343MiRneAflebriennoceRaNtos., TIn-d1u7st4r2iCaloC, Lot 269, September 29, 1977 5) 2Fi6n1al8CRoeCpoinn,ARlebpienaotRAapbpbiltisc,atSiaofnet2y8EDvaalyuaPteirocnutLaanbeooruastoArbys,oRripkteironLaSbtourdaytowriitehs,T-Inc., Study No. 09790AB0485, 3M Ref. No. FC-143, March 15, 1981 6) Ninety Day Subacute Rhesus Monkey Toxicity Study 4) FRiensaelarRcehpoarnt,d NDienveetlyoDpmaeynStuCboarcpuotreatRihoens,uSstuMdoynNkoe.y 1T3o7x-i0c9i0t,y SNtouvdey,mbIentrem1a0,ti1o9n7al8 b) Analytical data, FC-143 Analysis of liver samples}, 3M Central Research IRDC 137-090 Samples [monkey Laboratories, May 16, 1978 serum and 7) FPienraflluRoerpooorctt,anVoola.teI(IC,A1S3N-oW.ee3k82D5i-e2t6a-r1y)ToinxiMcailtey SRattusd,yHwaiztehltTo-n51W8i0s,coAnmsimno,nIincu.m, Study No. HWI 6329-100, May 17, 1993 8) Final Report, Daily Dose Oral Toxicity Coming Hazelton, Inc., Study No. CHW Study with T-6669 6329-197, April 30, (FC-143) 1997 in Rats, 4 91305 ATtotxaiccohlmoegnytsSttuodLieetstaenrdtoOCt.heArueInrfdoartmeadtiMoanyon25P,F2O00A0 Ongoing 26-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys, Covance In progress. Protocol provided. Laboratories Inc., No. 6329-231, 3M Ref. No. T-6889.3. NAoPteF:O TTohxeicsotluodgyyisWsoproknisnogreGdrobuyp.the3AMssohcaisastuibomnoitftPeldaastnioctiMcaenuufnadcetruTreSrCsAofSEeucrtioopne,8() rreecgeairvdeidngdprraefltirmeipnoarrtys doantathfer4o-mwteheisksrtaundgy.e-f3inMdianngdsottuhdeyr aWnodrktihengfuGllrsotuupdym,ebmubtetrhsesheave ddroacfktestarwehnenowavoabisloalbeltee.. IFniandadlitrieopno,rttshearWeoirnkpirnegpaGrratoiuopn iasnsdilwlilalwbaietpirnogvtihdeedhotromtohneal `lemveealss;urpeamlemnittsoyrlepCorotAcooxviedraisneg cdheotleercmyisnattoikoinnsi;n cdealtla;prsoelriufemr,atuiroinnee,vafleucaetsiaonnsd;lainvedrbAilPeFaOcid and receptor level determinations. 5 013086