Document Ne574LyvdrEjvZGKjnnmjpkEV

UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS WESTERN SECTION PAUL M.CULLINAN, et al.,. * * * Plaintiffs, * * V. MONSANTO COMPANY, et al. , * * * * Defendants. * * ****************** CIVIL ACTION NO. 85--0378--F DEFENDANT THE 3.F. GOODRICH COMPANY'S RESPONSE TO PLAINTIFF'S REQUEST FOR SUPPLEMENTATION OF ANSWERS TO INTERROGATORIES (Set I) Defendant The-B.F. Goodrich Company ("BFG") -hereby supplements its answers to interrogatories numbered 2 through 5, set I. The following supplemental answers are intended to supplement and not replace the responses previously filed by BFG. By responding further to these interrogatories, BFG does not intend to waive its prior responses and objections, and states that the following supplemental responses are made subject to its specific objections and answers to each interrogatory contained in the Answers and Objections of Defendant The B.F. Goodrich Company to Interrogatories Propounded By the Plaintiff(s), Set I, filed on or about April 28, 1986. 21173001 Supplemental Answer to Interrogatories Nos. 2, 3, 4 and 5. BFG has no records showing that it supplied or sold PVC and/or VC to Monsanto's Texas City facility prior to 1979. The B.F. Goodrich Company By its attorneys, SVS-5500/B Joseph L. Cotter Timothy J. Langella GOODWIN, PROCTER & HOAR Exchange Place Boston, MA 02109 (617) 570-1000 2 UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS WESTERN SECTION ****************** * PAUL M.CULLINAN, et al., * * Plaintiffs, * * V. * * MONSANTO COMPANY, et al., * * Defendants. * * ****************** CIVIL ACTION NO. 85--0378-F DEFENDANT THE 3.F. GOODRICH COMPANY'S RESPONSE TO PLAINTIFF'S REQUEST FOR SUPPLEMENTATION OF ANSWERS TO INTERROGATORIES (Set II) Defendant The B.F. Goodrich Company ("BFG") hereby supplements its answers to certain interrogatories in plaintiffs' second set of interrogatories to BFd.- The following supplemental answers are intended to supplement and not replace the responses previously filed by BFG. By responding further to these interrogatories, BFG does not intend to waive its prior responses and objections, and states that the following supplemental responses are made subject to its specific objections and answers to each interrogatory contained in the Answers and Objections of Defendant The B.F. Goodrich Company to Plaintiffs' Second Set of Interrogatories, filed on or about September 26, 1986. Supplemental Answer to Interrogatory No. 9: BFG states that as a chemical manufacturer it makes reasonable efforts to 21173003 keep current as to the results of any research or other studies which are of interest to the chemical industry generally, including studies relating to the health effects of chemical exposure. Following is a partial list of publications and reports of which BFG was aware prior to 1980: Malignant Tumors of the Liver and Lungs in an Area with a PVC Industry Saric, M; Kulcar, Z; Zorica, M; Gelic, I Environmental Health Perspectives, Vol. 17, pp. 189-192 1976, October Pulmonary Changes Among Vinyl Chloride Polymerization Workers Lilis, R; Anderson, H; Miller, A; Selikoff, IJ Vol. 69, No. 2, pp. 299-303 1976, February Evaluation of Mortality in BF Goodrich Workers: Follow-Back Study of Medical Records and Death Certificates (Final Report) 1974, May 17 A Medical Records and Industrial Hygiene Studies for BFG 1974, March 20 Birth Defects and Vinyl Chloride Edmonds, CDCNIOSH, Conference on Women and the Workplace (Washington) 1976, June 17-19 Vinyl Chloride and Congenital Malformation CDC 1976 Working Conditions and Measures for their Sanitation in the Production and Utilization of Vinyl Chloride Plastics Tribukh, SL; Tikhomirova, NP; Levin, SV; Kozlov Arg. Sanit., Vol. 10, pp. 38-45 1949 The Toxicity of Vinyl Chloride as Determined by Repeated Exposure of Laboratory Animals tyWZLX'TZ 2 Torkelson, TR; Oyen, F; Rowe, VK American Industrial Hygiene Association, Vol. 22, No. 5, pp. 354-361 1961, October VCM from PVC During Thermal Decomposition 1975 Mortality Among Vinyl Chloride Workers: Monson, RR 1974, August 17 Abstract; Only Scientific and Technical Assessment Report on Vinyl Chloride and Polyvinyl Chloride SPA, 600/6-75-004 1975, June The Effects of Organic Compounds Used in the Manufacture of Plastics on the Responsitivity of Murine and Human Lymphocytes Thurman, GB; Simms, BG; Goldstein, AL; Kilian, DJ Tox. and Applied, Vol. 44, pp. 617-641 1978 Effects of - Inducers on the In Vivo Covalent Binding of a Vinyl Chloride Metabolite to Liver Fractions Pessayre, D; Wandscheer, JC; Descatoire, V; Dolder, A; Benhamou, JP Biochemical Pharmacology, Vol. 28, pp. 3667-3668 1979 Epidemiologic Considerations in the Design of Toxicologic Studies: An Approach to Risk Assessment in Humans Woods, JS, NIH Vol.. 38, No. 5, pp. 1892-1896 1979, April Oncogenic and Mutagenic Risks in Communities with Polyvinyl Chloride Production Facilities Infante, PF Annals of the New York Academy of Sciences 1976 Calculations of the Amount of VCM Metabolized at Various Concentrations Hinderer, RK 1978 Biochemical Alterations in Livers of Rats Exposed to Vinyl Chloride S O O S iT T Z 3 DU JT; Sandoz, JP; Tseng, MT; Tamburro, CH Journal of Toxicology and Environmental 5, pp. 1119-1132 1979 Health, Vol. Neoplastic Risk Among Workers Exposed to Vinyl Chloride Waxweiler, RJ; Stringer, W; Wagoner, JK; Jones, J; Falk, H; Carter, C Annals of the New York Academy of Sciences, pp. 40-48 1976 Epidemiological Study of Vinyl Chloride Workers: Final Report 1978, December Epidemiologic Study of Vinyl Chloride Workers Employed by Union Carbide Corporation, South Charleston Plant 1976, December Results of Prospective Mortality Study on Humans Exposed to VC/PVC Frentzel-Beyme, VR; Schmitz, T; Thiess, AM 1978, October Contemporary Pest Control Practices and Prospects Vol. I: Carcinogenesis in Man and Laboratory Animals 1975 Occupational Lung Disease--Agents of Inorganic Origin Wagner, JC pp. 213-220 1977, June An Epidemiologic Investigation of Lung Cancer in a Multixenobiotic Occupational Environment Waxweiler, RJ, University of North Carolina University of North Carolina 1978 The Medical Commission on the Production of PVC 1974, December Preliminary Report on the Medical Examination of 288 Employees at the PVC Plant, Norsk Hydro A.S., Porsgrunn Fabrikker Hillestad, L 1975, January 31 Occupational Acroosteolysis III. A Clinical Study Dodson, VN; Dinman, BD; Whitehouse, WM; Nasr, AHM; Magnuson, HJ 21173006 4 Arch. Environ. Health, Vol. 22 1971, January- Occupational Acroosteolysis II. An Industrial Hygiene Study Cook, WA; Giever, PM; Dinman, BD; Magnuson, HJ Arch. Environ. Health, Vol. 22 1971, January Occupational Acroosteolysis: I. An Epidemiological Study Dinman, DB; Cook, WA; Whitehouse, WM; Magnuson, HJ; Ditcheck, T Arch. Environ. Health, Vol. 22 1971, January Vinyl Chloride Content of Subcutaneous Adipose Tissue from Vinyl Chloride Polymerization Workers Knittle, J; Fontanares, P; Daum, S; Selikoff, IJ 1974, December Concerning the Principles and Methods of Toxicological Assessment of Volatile Substances Released by Synthetic Polymers . ...... Trakhtenberg, IM; Bartenev,_VD; Savitskii, IV; Balashov, VE Vol. 33, pp. 109-112 1968, January _ Vinyl Chloride: Code of Practice for Health Precautions Health and Safety Executive, pp. 1-41 1975, February Health Effects of Vinyl Chloride Monomer: An Annotated Literature Collection Warren, H; Huff, JE Environmental Health Perspectives, Vol. 11, pp. 1975, June '- 251-252 Vinyl Plastics: Their Dermatological and Chemical Aspects Morris, GE Archives of Industrial Hygiene & Occupational Medicine, Vol. 8, pp. 535-539 1953 Contact Dermatitis from Plastics containing Tri-Aryl Phosphates Pegum, JS British J. of Dermatology, Vol. 78, pp. 626-631 1966 i00S4TTZ 5 What's in PVC Little, K. Vol. 2, pp. 351-352 1968 Acropathy of the Extremities Associated with VC Polymerization--A New Occupational Disease Kovac, A.; Kurajica; L.; Juric-Ruzic, D.; Parac B. Vol. 91, No. 5, po. 5-17 1969 Contact Dermatitis Due to Table Cloth Cover of Vinyl Plastic Fabric Hitschmann, OB 1950 Angiosarcoma of the Liver in Vinyl Chloride/Polyvinyl Chloride Workers J. of Occupational Medicine, Vol. 16, No. 12 1974 Cytogenetic Studies of Bone Marrow Cells from Rats Exposed to Vinyl Chloride Johnston, RV; Mensik, DJ; Pinkerton, MN; Whorton, EB 1975 Carcinogenicity Bioassays of Vinyl Chloride: Research Plan and Early Results Lefemine, G; Maltoni, C Environmental Research, Vol. 7, pp. 387-405 1974 Vinyl Chloride Induced Liver Disease Thomas, LB; Popper, H; Berk, PD; Selikoff, I; Falk, H 1975 Experiments on the Chronic Toxicity of a Copolymer of Vinyl and Vinylidine Chloride Seeler, AO; Clinton, M; Boggs, J; Drinker, P Harvard Univ. 1947 Industry's Latest Cancer Scare 1974, February Properties and Essential Information for Safe Handling and Use of Vinyl Chloride 1972 Further Studies of Polymers as Carcinogenic Agents in Animals Oppenheimer, BS; Oppenheimer, ET; Danishefsky, I; Stout, AP; Eirich, FR 6 21173008 Cancer Research, Vol. 15, pp. 333-340 1955 Oncogenic Response of Rat Skin Lungs and 3ones to Vinyl Chloride Caputo, A; Sigotti, A; Viola, PL Cancer Research, Vol. 31, pp. 516-522 1971, May The Correlation of Clinical and Environmental Measurements for Workers Exposed to Vinyl Chloride Kramer, CG; Mutchier, JE AIHA, Vol. 33, No. 1, pp. 19-30 1972, January Working Conditions and Measures for their Sanitation in the Production and Utilization of Vinyl Chloride Plastics Tribukh, SL; Tikhomirova, NP; Levin, SV; Kozlov, LA 1949 Ten Canadian Cases of Angiosarcoma of the Liver in Vinyl Chloride Workers Delorme, F ....... 1978 Vinyl Chloride Content of Subcutaneous Adipose Tissue from Vinyl Chloride Polymerization Workers Knittle, JL; Fontanares, P; Daum, S; Selikoff, IJ 1974 Hemangiosarcoma and Hepatocellular Carcinoma of the Liver Following Vinyl Chloride Exposure Gokel, JM; Liebezeit, E; Eder, M 1976 Association of an Angiosarcoma of the Liver with a Hepatoma in a Vinyl Chloride Worker Delorme, F 1978 Scleroderma Like Skin Changes, Raynaud's Syndrome and Acroosteolyses in Workers in the Polyvinyl Chloride Producing Industry June, S; Lange, CE 1972 Toxic Trigeminal Disease and Polyvinylidene Chloride Krieger, J; Warter, JM; Mengus, M; Mehl, J; Isch, F 1971 21173009 7 Occupational Acroosteolysis (AOL): An Epidemiologic Investigation of a New Disease Among Polyvinyl Chloride Synthesis Workers Magnuson, J.; Dinman, 3D; Cook, WA; Giever, PM; Whitehouse, WM 1969, September 22-27 Occupational Acroosteolysis Markowitz, SS; McDonald CJ; Fethiere, W; Arch. Dermatol., Vol. 106, pp. 219-223 1972, August Kerzner, MS Occupational Lesions of the Skin due to PVC Sonneck, HJ 1962 Occupational Acroosteolysis Wilson, RH; McCormick, WE; Tatum, CF; JAMA, Vol. 210, No. 8, pp. 577-581 1967, August 21 Creech, JL Occupational Carcinogenesis Maltoni, C. 1973, April 9-12 Acute Inhalation Toxicity of Vinyl Chloride to Laboratory Animals Mastromatteo, E; Fisher, AM; Christie, H; Danziger, J. of AIHA, Vol. 21, pp. 394-398 1960 H Chronic Oral Toxicity to Rats of a Vinyl Chloride-Vinyl Acetate Copolymer Smyth, HF; Weil, CS Tox and Applied, Vol. 9, pp. 501-504 1966 One-Year Time Sequence Inhalation Toxicity Study of Vinyl Chloride in Rats: I. Growth, Mortality, Haematology, Clinical Chemistry and Organ Weights Feron, VJ; Kruysse, A; Til, HP Vol. 13, pp. 25-28 1979 Anesthesia XXVII: Narcosis with Vinyl Chloride Oster, RH; Carr, CJ; Krantz, JC Vol. 8, pp. 359-361 1947, July One-Year Time-Sequence Inhalation Toxicity Study of Vinyl Chloride in Rats: II. Morphological Changes in the Respiratory Tract, Ceruminous Glands, Brain, Kidneys, Heart and Spleen 21173010 8 Feron, VJ; Kroes, R Vol. 13, Dp. 131-141 1979 One-Year Time-Sequence Inhalation Toxicity Study of Vinyl Chloride in Rats: III. Morphological Changes the Liver Feron, VJ; Spit, BJ; Immel, HR; Kroes, R Vol. 13, pp. 143-154 1979 in Effects of Single and Repeated Exposures of Humans and Rats ~o Vinyl Chloride Lester, D; Greenberg, LA; Adams, WR J. of AIHA, Vol. 24, pp. 265-275 1963, May-June Pharmacokinetics of Vinyl Chloride in the Rat Bolt, HM; Laib, RJ; Kappus, H; Buchter, A Vol. 7, pp. 179-188 1977 Disposition of (1,2-14C) Vinyl Chloride in Rat Bolt, HM; Kappus, H; Buchter, A; Bolt, W Vol. 35, No. 3, pp. 153-162 1976 Studies on the Metabolism of Vinyl Chloride Antweiler, H Vol. 17, pp. 217-219 1976 Metabolism of Vinyl Chloride Watanabe, PG; Hefner, RE; McGowan, GR; Gehring, PJ 1974, November 14 Vinyl Chloride Induced Depression of Hepatic Non-protein Sulfhydryl Content and Effects on Bromosulphalein (BSP) Watanabe, PG; Hefner, RE; Gehring, PJ 1976 Hepatic Macromolecular Binding Following Exposure to Vinyl Chloride 2X173011 -9- I" Watanabe, PG; Zempel, JA; Pegg, DG; Gehring, PJ Tox and Applied, Vol. 44, op. 571-579 1978 A Procedure for Preparing 14C-Labeled Vinyl Chloride Wagner, ER; Muelder, WW Vol. 246, pp. 152-153 1975, January 31 Cytochrome P-450 and the Metabolism of Vinyl Chloride Salmon, AG Vol. 2, No. 2, op. 109-114 1976 A Gas-Chromatographic Method for the Preparation of 14C-Labeled Vinyl Chloride Wagner, ER; Muelder, WM; Watanabe, PG; Hefner, RE; Braun, WH; Gehring, PJ Vol. 11, No. 4, pp. 535-542 1975 Activation of Vinyl Chloride to Covalently Bound Metabolities: Roles of 2-Chloroethylene Oxide and 2-Chloroacetaldehyde Guengerich, FP; Crawford, WM; Watanabe, PG Vol. 18, No. 23, pp. 5177-5182 1979 Testimony: Pharmacokinetics of Vinyl Chloride Gehring, PJ 1976, February 2 Acro-Osteolysis Occurring in Men Engaged in the Polymerization of Vinyl Chloride Harris, DK; Adams, WGF Vol. 3, pp. 712-714 1967 Percutaneous Absorption of Vinyl Chloride Hefner, RE; Watanabe, PG; Gehring, PJ Tox and Applied, Vol. 34, pp. 529-532 1975 Hepatic Lesions Caused by Vinyl Chloride Monomer in Humans: Study of Eight Clinicopathological Cases Pialat, J; Pasquier, B; Pahn, M; Kopp, N Vol. 27, No. 6, pp. 361-375 1979 Investigation of the Diseases Produced by Vinyl Chloride 10 fvj :k 5S !f-* a Suciu, I Vol. 15, pp. 967-978 1963, August Angiographic and Radionuclide Characteristics of Hepatic Angiosarcoma Found in Vinyl Chloride Workers Whelan, JG; University of Louisville; Creech, JL; Tamburro, CH Vol. 118, No. 3, pp. 549-557 1976, March The Pathology of 111 Cases of Primary Hepatic Malignancy Collected in the Liverpool Region Cruickshank, AH Vol. 14, pp. 120-131 1961, March Occupational Acroosteolysis - A Clinical Investigation of Polyvinyl Chloride Synthesis Workers Dinman, 3D; University of Michigan; Dodson, VN; Magnuson, HJ; Whitehouse, WM 1969 Occupational Acroosteolysis: Part ill. A Clinical Study Dodson, VN; Dinman, BD; Whitehouse, WM; Nasr, ANM; Magnuson, HJ Arch Environ Health, Vol. 22, pp. 83-91 1971, January Occupational Acroosteolysis: Part I. An Epidemiological Study Dinman, BD; Cook, WA; Whitehouse, WM; Magnuson, HJ; Ditcheck, T; Arch Environ Health, Vol. 22, pp. 61-73 1971, January Mutagenicity of Vinyl Chloride, Vinylidene Chloride and Chloroprene in V79 Chinese Hamster Cells Drevon, C; Kuroki, T Vol. 67, pp. 173-182 1979 Hepatic Macromolecular Binding Following Exposure to Vinyl Chloride Watanabe, PG; Zempel, JA; Pegg, DG; Gehring, PJ 1977, April 5 Mutagenicity in Vitro and Potential Carcinogenicity of Chlorinated Ethylenes as a Function of Metabolic Oxirane Formation I** H* Oi ll I' Greim, H; Bonse, G; Radwan, Z; Reichert, D; Henschler, D Vol. 24, pp. 2012-2017 1975, July Life-Span Oral Toxicity Study of Vinyl Chloride in Rats Feron, VJ; Hendriksen, CFM; Speek, AJ; Til, HP; Spit, BJ 1978, October: Final Report of Audit Task Group on Lifetime Inhalation Study on Vinyl Chloride at Industrial Bio-Test Labs, Inc. 1978 Vinyl Chloride Pathology Report 1979, January 9 Chronic Vapor Inhalation Toxicity Study with Vinyl Chloride (Ethylene Derived) in Albino Rats, Albino Mice and Golden Hamsters 1975, September 23 Chronic Vapor Inhalation Toxicity Study with Vinyl Chloride 1973, February Protocol Amendments and Communication for the VCM Long-Term Inhalation Study 1973 to 1978 Vinyl Halides Carcinogenicity NIOSH and OSHA Current Intelligence Bulletin No. 28 1978, September 21 Occupational Acroosteolysis: Report of 31 Cases Wilson, RH; McCormick, WE; Tatum, CF; Creech, JL JAMA, Vol. 201, pp. 577-581 1967, August 21 Cardiovascular Disease and Environmental Exposure Rosenman, KD Vol. 38, pp. 85-97 1979 Health Hazard Evaluation/Toxicity Determination Report: Gates Rubber Company Gunter, BJ; Lucas, JB NIOSH, Report No. H.H.E. 74-61-232 1975, November - 12 - r Volatile Materials from Geon Hi-Temp Crider, LB 1966, June 30 Oncogenic and Mutagenic Risks in Communities with Polyvinyl Chloride Production Facilities Infante, PF New York Academy of Science 1975 Mutagenicity of Vinyl Chloride Chloroethyleneoxide Chloroacetaldehvde and Chloroethanol Malaveilie, C.; Bartsch, H.; er al. Biochemical and Biophysical Research Communication 1975 Pneumoconiosis Formed After Inhaling Polyvinyl-Chloride Dust Szende, 3.; et al. Orvosis-Hetilap, Vol. 112 1971 Pharmacodynamics and Uptake of Vinyl-Chlorine Monomer Administered by Various Routes to Rats Withey, J., Jr. J. of Tox. and Envir. Health, Vol. I 1976 Proportional Mortality Among Vinyl Chloride Workers Monson, RR; et al. Lancet 1974, August 17 A Surface Active Agent Involved in PVC Induced Haemolysis Richards, RJ; Desai, R; Rose, FA Nature, Vol. 260 1976, March Genetic Risks of Vinyl Chloride Infante, PF; et al. Lancet, Vol. 1 No. 7978 1976, June Mutagenicity of Chloroacetalydehyde, A Possible Metabolic Product of 1,2-Dichloroethane (Ethylene-Dichloride), Chloroethanol (Ethylene Chlorohydrin). Vinyl Chloride, and Cyclophosphamide McCann, James; et al. Proc. Nat. Acad. Sci., USA, Vol. 72, No. 8 1975, August 13 S T O tA T T Z The Biological Fate in Rats of Vinyl Chloride in Relation to its Oncogenicity Green, T; Hathway, DE Chem. Biol. Interactions, Vol. 11 1975 Observations on the Oral Administration and Toxicity of Vinyl Chloride in Rats Feron, VJ; et al. Fd. Cosmet. Toxicol., Vol. 13 1975 Proportional Mortality Among Vinyl Chloride Workers Monson, RR; Peters, JM; Johnson, MN Environmental Health Perspectives, Vol. 11 1975, June Preliminary Studies on the Fate of Inhaled Vinyl Chloride Monomer (VCM) in Rats Hefner, RE; Watanabe, FG; Gehring, PJ Environmental Health Perspectives, Vol. 11 1975, June Biochemical Toxicology of Unsaturated Halogenated Monomers Jaeger, RJ, et al. Environmental Health Perspectives, Vol. 11 1975, June Pulmonary Function Defects in Non-Smoking Vinyl Chloride Workers Miller, A. Environmental Health Perspectives, Vol. 11 1975, June Vinyl Chloride Dependent Mutagenesis: Liver Extracts and Free Radicals Garro, AJ; et al. Mutation Research, Vol. 38 1976 Effects of Mutagenic and Carcinogenic Effects of Vinyl Chloride Bartsch, H; Montesano, R Mutation Research, Vol. 32 1975 Mortality Study of Workers in the Manufacture of Vinyl Chloride and its Polymers Tadershan, IR; Gaffey, WR JOM, Vol. 16, No. 8 1974 21173016 14 P- Final Report on Mortality Study Covering Employees of FVC Fabricators Chiazzi, et al. ORC: Mortality PVC Fabricators - Final Report 1976 Quantitative Risk Assessment for Community Exposure to Vinyl Chloride Kuzmack, AM; McGaug'ny, RE EPA: Risk of Living by VC-PVC Plants 1975 Hepatic Angiosarcoma Associated with Androgenic-Anabolic Steroids Falk, H; Popper, H; Thomas, LB; Ishak, KG Lancet 1979, November 24 Vinyl Chloride Exposure in a Controlled Industrial Environment Ott, NG; Langner, RR; Holder, 3B Archives of Environmental Health, Vol. 31 1975, July Ten Cases of Angiosarcoma of the Liver in Shawinigan, Quebec Delorme, F; Theriault, G Montreal Medical Society 1976 Malignant Tumors Resulting from Imbedding Plastics Rodents Oppenheimer, BS; Oppenheimer, ET; et al. Science, Vol. 129 1953, November 11 in Elevated CEA Levels in Polyvinyl Chloride Workers Theriault, L; Delorme, F Biomedicine, Vol. 25 1976 Fate of (14-C) Vinyl Chloride After Single Oral Administration in Rats Watanabe, PG; McGowan, GR; Gehring, PJ Toxicology and Applied Pharmacology, Vol. 36 1976 Proposal for a Council Directive on the Approximation of the Laws of the Member States Relating to Materials and Articles Containing Vinyl Chloride Monomer and Intended to come in contact with foodstuffs 211730IT 15 r European Economic Community Determination Official 1976 Risk 3enefit Analysis for Toxic Chemicals: Vinyl Chloride Wilson, R Harvard University 1976 Accidental Poisoning by Vinyl Chloride: Report of Two cases Danziger, R. Canadian Medical Association J., Vol. 82 I960 Vinyl Chloride Experiments on Small Animals Mastromatteo, E. 1959 Acute Response of Guinea Pigs to Vapors of Some New Commercial Organic Compounds Patty, PA; Yant, WP; Waite, CP Public Health Reports, Vol. 45, No. 34 1930 Ethylene Oxide Toxicity; A Biological Model for the Study of Tissue Reactions to Retained Ethylene Oxide Andersen, S. 1969 Pathology of Vinyl Chloride Viola, PL La Medicina Del Lavoro, Vol. 61, No. 31970 Effects of Vinyl Chloride in Man: A Cytogenetic Follow-up Study Hansteen, IL; Hillestad, L; Tmiisevensen, E; Heldaas, SS Mutation Research 1978 Angiosarcoma of the Liver Chloride Workers Spirtas, R; Kaminski, R. JOM, Vol. 20, No. 6 1977, June in Vinyl Chloride/Polyvinyl etoerrTz - 16 - I"* Carcinogenicity of Vinyl Chloride and Vinylidene Chloride Lee, CC; Bhandari, JC; Winston, JM; House, WB; Dixon, RL; Woods, JS Toxicology and Environmental Health, Vol. 4 1978 Smoking and Occupational Cancers Hoffmann, D.; Preventive Medicine, Vol. 5, No. 2 1976 Squamous cell Carcinoma of the Buccal Mucosa Associated with Chronic Oral Polyvinyl Chloride Exposure: Report of a Case Casterline, CL; Casterline, PF; Jaques, DA Cancer, Vol. 39 1977 In Vivo Observations of Skin Capillaries in Workers Exposed to Vinyl Chloride - An English American Comparison Maricg, MR; Darke, CS; Archibald, RM; Leroy, EC Brit. J. Indus. Med., Vol. 35 1978 Report on a Case Control Study Covering White Female Employees of PVC Fabricators 1977 Mortality Among Employees of PVC-Fabricators Chiazze, L; Nichols, WE; Wong, 0 JOM, Vol. 19, No. 9 1977 Angiosarcoma of the Liver: An Epidemiologic Survey Brady, J; Liberatore, F; Harper, P; Greenwald, P; Burnett, W; Davies, JNP; Bishop, M; Polan, A; Vianna, J-O-F NCI, Vol. 59, No. 5 1977 N Urinary Glycosamimoglycan Patterns in Angiosarcoma of the Liver Curran, KL; Kupchella, CE; Tamburro, CH 1977 *3 >- Q 17 Summary of the Studies Conducted on the Pharmacokinetics/Metabolism of Vinyl Chloride in Rats Watanabe, PG; Hefner, RE; Zempel, JA; Pegg, DG; Park, CN; Gehring, PJ 1977 Pulmonary Tumors Induced in Mice by Vinyl Chloride Monomer Suzuki, Y Envir. Research, Vol. 16 1978, July Living with Carcinogens Parkes, HG 1974 A Statistical Assessment of the Quantitative Uptake of Vinyl Chloride Monomer from Aqueous Solution Withey, JR; Collins, ST J. of Tox. and Envir. Health, Vol. 2 Congenital Central Nervous System Malformations and Vinyl Chloride Monomer Exposure: A Community Study Edmonds, LD; Anderson, CE; Flynt, JW Jr.; James, LM Teratology, Vol. 17 1978 Angiosarcoma of the Liver in PVC Fabricators Baxter, PJ Lancet 1976, Jan. 31 Fate of Vinyl Chloride Following Inhalation exposure in Rats Watanabe, PG; McGonan, GR; Madrid, EC; Gehring, PJ Tox. and Applied Pharm., Vol. 39 1976 Epidemiological Study of the Mortality of Workers Exposed to Vinyl Chloride VC in the FRG Reinl, W; Weber, N; Greiser, E 1977 Development of Hepatic Angiosarcoma in Man Induced by Vinyl Chloride, Thobotrast and Arsenic Popper, H; Thomas, LB; Telles, NC; Falk H; Selikoff, IJ Amer. J. of Pathology, Vol. 92, No. 2 1978, Aug. An Epidemiologic Investigation of an Excess Lung Cancer Risk in a Synthetic Chemicals Plant 18 21173020 Waxweiler, RJ; Smith, AH; Tyroler, HA; Falk, H 1978 Lung Cancer at a Polyvinyl Chloride PVC Polymerization Facility Falk, H; Waxweiler, RJ; Herbert, J; Kuschner, M; Auerbach, 0; Makk, L; Tamburo, C 1979 Capillary Abnormalities in Polyvinyl Chloride Production Workers Mariccr, HG; Johnson, MN; Whetsteon, CL; Leroy, JAMA,`Vol. 236, No. 12 1976 SC Hepatosplenic Angiosarcoma: Report of a Case and Review of the Literature Libeskind,-M; Lugagne, F; Malbran, J; Villemant, JF; Guyet-Rousset, P Gastroenterol. Clin. Biol., Vol. 1 1977 Chromosomal Analyses in Vinyl Chloride Exposed Workers Richardson, CR; Anderson, D; Paddle, GM; Adams, WGF Mutation Research, Vol. 57 1978 Comparison of the Fate of Vinyl Chloride Following Single and Repeated Exposure in Rats Watanabe, PG; Zempel, JA; Gehring, PJ Toxicology and Applied Pharmacology, Vol. 44 1978 Polyvinyl Chloride Pneumoconiosis: Epidemiological Study of Exposed Workers Dust, PVC; Mastrangelo, G; Manno, M; Marcer, F; Bartolucci, GB; Gemignani, C; Saladino, G; Simonato, L; Saia, B JOM, Vol. 21, No. 8 1979 Influence of Polyvinyl Chloride PVC Dust on Rat Respiratory System Popow, J. 1969 Toxicology, Carcinogenicity and Reproductive Effects of Single and Multiple Exposures to Vinyl Chloride in Rats and Mice Hehir, RM; McNamara, BP; McLaughlin, J, Jr.; Willigan, DA; Bierbower, G; Hardisty, JF 1980 TZOSIX1Z 19 Induction of Gene Mutations and Gene Conversions by Vinyl Chloride Metabolites in Yeast Am Cancer Research, Vol. 36 1977 Mortality Experience of Workers Exposed to Vinyl Chloride Monomer in the Manufacture of Polyvinyl Chloride in Great Britain Fox, AJ; Collier, PF Brit. J. of Indus. Med., Vol. 34 1977 Mortality and Cancer Morbidity in a Group of Swedish VCM and PVC Production Workers 3yren, D; Engholm, G; Englund, A; Westerholm, P Envir. Health Perspectives, Vol. 17 1976 Polyvinyl Chloride Pneumoconiosis Arnaud, A; DeSanti, P; Garbe, L; Payah, H; Charpin, J. Thorax, Vol. 33 1978 The Chemistry and Biogenesis of the S-Containing Metabolities of Vinyl Chloride in Rats Green, T; Hathway, DE Chem. Biol. Interactions, Vol. 17 1977 Comparative Mammalian Metabolism of Vinyl and Vinylidene Chlorides in Relation to Oncogenic Potential Hathway, DE Envir. Health Perspectives, Vol. 21 1977, December Monitoring Liver Disorders in Vinyl Chloride Monomer Workers Using Greyscale Ultrasonography Williams, DMJ; Smith, PM; Taylor, KJW; Crossley, IR; Duck, BW Brit. J. of Indus. Med., Vol. 33 1976 21173022 - 20 - r Angiosarcoma of the Liver Following Vinyl Chloride Exposure Block, JB JAMA, Vol. 229, No. 1 1974 Clinical and Morphologic Features of Hepatic Angiosarcoma in Vinyl Chloride Workers Makk, L; Delorme, F; Creech, JL; Ogden, II; Fadell, EF; Songster, CL; Clanton, J; Johnson, MN; Christopherson, WM Cancer, Vol. 37, No. 1 1976 Angiosarcoma of the Liver in the Liver Manufacture of Polyvinyl Chloride Creech, JL; Johnson, MN JOM, Vol. 16, No. 3 1974 in the Mortality Experience of a Cohort of Vinyl Chloride Polyvinyl Chloride Workers Holson, HJ; Hammond, EC; Seidman, M; Selikoff, IJ Annals NY Academy Sciences Characteristics of Cases of Angiosarcoma of the Liver Among Vinyl Chloride Workers in the U.S. Resolution of Dose Response Toxicity Data for Chemicals Requiring Metabolic Activation: Example Vinyl Chloride Gehring, PJ; Watanabe, PG; Park, CN Human Response 1977 Effect of Occupational and Nonoccupational Factors on the Respiratory System of Vinyl Chloride and Other Workers Gamble, J; Liu, S; McMichael, AJ; Waxweiler, RJ JOM, Vol. 13, No. 10 1976 $ o $ 21 Hemangiosarcoma of the. Liver Landrigan, PJ CDC 1974 Hepatic Angiosarcoma in a Vinyl Chloride Worker Williams, NJ; Evans, DMD New York Academy Med., Vol. 52, No. 4 1976 The Value of Predictive Experimental Environmental Carcinogeneses an Example: Vinyl Chloride Maltoni, C Ambio, Vol. 4, No. 1 1975 Vinyl Chloride and Angiosarcoma Block, JB J. of Kentucky Med. Assoc. 1974 On the So-called Vinyl Chloride Disease Juhe, S; Lange, GE; Stein, G; Veltman, G Deutsche-Medizihische-Wochenschrift, Vol. 98, No. 43 1973 Chronic Toxic Liver Damage in the Case of Workers PVC Production Teller, HJ, et al. Deut. Med. Wochenschr., Vol. 98, 2311-4 1973 in Vinyl Chloride Monomer Levels in Edible Fats Fuchs, G; Gawell, BM; Albanus, L; Slorach, S VAR FODA 27--(3)-134--145 1975 An Epidemiological Study of Vinyl Chloride Exposed Workers in Italy Bertazzi, PA; Villa, A; FOA, V; Saia, B; Fabbi, L; Mapp, C; Marcer, C; Manno, M; March, M; Mariani-Bottasso, F. Arh. Hig. Rada. Toxsikol, Vol. 30 1979 Polyvinyl Chloride Biomedical Products: Toxicity Testing and Identification of Additives Geertz, H; Dyer, K; Johnson, D; Miller, B; Taylor, Sharp, W Trans. Amer. Soc. Artif. Int. Organs, Vol. 20 1974 B; {sj 22 Angiosarcoma of the Liver in Workers Who have Prolonged Contact with Vinyl Chloroide: Epidemiology Program VC Workers Nakk, L; Delorme, F; Creech, JL TOME, Vol. 104 1975 Toxicology of Plastics Having Contact with Blood: Report Program Progress Josefhson, AM, 1975 Epidemiological Studies of Vinyl Chloride Health Effects in the United States Roy. Soc. Med., Vol 69 1976 Experimental Chronic Poisoning with Vinyl Chloride (Monochlorethene) Proban, L; Suciu, I; Pislaru, V; Ilea, E; Pascu, L Annals New York Academy of Sciences Pneumoconiosis Caused by the Inhalation of Polyvinyl Chloride Dust Szende, B; Lapis, K; Nemes, A; Pinter, A Med. Lavoro, Vol. 61, No. 8-9 1970 The Toxicity of Vinyl Chloride as Determined by Repeated Exposure of Laboratory Animals Torkelson, T; Oyen, F; Rowe, VK AIHA, Vol. 22, No. 5 1961 Investigation of the Diseases Produced by Vinyl Chloride Drejmin, I; Valaskai, M Med. Intern, Vol. 15 1963 Mortality and Cancer Morbidity in Workers in the Swedish PVC Processing Industry Monberg, B; Elofscoh, S; Holmlund, L; Maasing, R; Holima, G; Westerholm, P APME Mtg. Sweden 1979, June 8 Supplemental Answer to Interrogatory No. 15: BFG states that during the relevant time period (1969 to 1973), its liability insurance coverage is through Kemper. *3 23 Supplemental Answer to Interrogatory No. 34: BFG states that as a chemical manufacturer it makes reasonable efforts to keep current as to the results of any research or other studies which are of interest to the chemical industry generally, including studies relating to the health effects of chemical exposure. To the best of BFG's current knowledge, it first: became aware of the reports and studies at or about the time they were published. Supplemental Answer to Interrogatory No. 42: BFG states that since knowledge of angiosarcoma of the liver was a sudden discovery, information on all aspects of the potential danger or lack of danger attributed to VCM was delivered orally to BFG employees at the plants. Concurrent to these discussions with BFG employees, BFG customers were advised orally and by mail of developments as they occurred and became known by BFG. Non plant personnel of BFG received copies of the information mailed to BFG customers. Copies of the communications to BFG customers will be made available to plaintiff for review and inspection .in the- Health and Enviu-mntontaiU-Seryices Department at BFG's Corporate Headquarters in Bath, Ohio at a time mutually agreeable to the parties. Supplemental Answer to Interrogatory No. 54: BFG states that to the best of its knowledge Edward Begnaud, now deceased, was responsible for product labeling. In addition, see Supplemental Answer to Interrogatory No. 42. 21173026 - 24 - r Supplemental Answer to Interrogatory No. 55: BFG has many formal and informal relationships with various governmental agencies, trade associations, industry groups and universities. It is accordingly impossible to respond fully to this interrogatory as framed. To the extent the information sought by this interrogatory is contained in documents of BFG, those documents will be made available to plaintiff for review and inspection at BFG's Corporate Headquarters in Bath, Ohio at a time mutually agreeable to the parties. The B.F. Goodrich Company By its attorneys. SVS-5503/B Joseph L. Cotter Timothy J. Langella GOODWIN, PROCTER & HOAR Exchange Place Boston, MA 02109 (617) 570-1000 - 25 oa o