Document Ne2ngE98JarByOajd02By0zE

m AR226-2749 Copies to Haskell U b r ; i J Uf ^ ,' 02 c S r " y tor Toxicology r * an dh" I n du s t ri a l Medicine __ _______________ HASKELL LABORATORY REPORT NO. 160-69 Material Tested: Ammonium Perfluoro'octanoate Haskell No.: Other Codes ; # v l . (1) PeVilbls eenerat" "ere "sed -- alnm pertluorooctan.af erosols. achieve lower c o ,, c e ,, t r L P S L ' S" 1CaM a > l ,, e" I L s l r o 5 o c d"f ^ l * ` ' " * a l t < > delivered into a,. * * " " * ` ^ dld " fraction, the dost and .11 dust ^ -Hornberger Dust R w n m f -- x. . ' 616 2 - zi `^ - feceived^alnly 1 " TM * -- . 8 ^ Sttaa" "Ith b" "- th. S n a i a ^ d ' S T E ^ g E r " """ ~ ~ e ^ r e d * "" ^ f t mo r a t t i n g during exposure . ^ " S p I L ! ;,:- i n - r axpoaad- A u - p - TM " * d* - "" s : s ^ l s : n n - v : ; * soUda in a k"TM JZ ^P " " a i S t r t 8 a t l TM measurement ,, a s S T .'S ^ T L 'S E X S T " ' Company Sanitized. Does not contain T SCA CBI - 2- Results: Average Dust Concentration Generat - --- Ong/L) 1 5.7 4.8 Mortality Ratio 6/6 6/6 Mass Median Diameter fn^ 6.4 t 3.2 16 3.4 Gating, irregular breathing, red discharge around eyes and nose, salivation, death (1/6) Same as above, but no deaths 2.2* 6/6 7.6 t 3.8 Same as above 2 0.83* 1/6 1.8 t 2.5 Gasping, irregular breathing, red discharge around eyes and nose 0.81* 0.38 2/6 l/6 1.8 2.8 2.4 2.4 Same as above except one death Same as above t Whole body control exposure. * Sacrif ^ e d at 1, 7 and 14 days. * Sacrifi-ced at 27 and 42 days. Death not related to test material. 'ft fr0m 15 minutes to 48 hours Some rupture of eyes, all other eyes opaque; all dead in 48 hburs Same as above; fluorescein stain confirmed external eye damage Severe weight loss first day, mild loss the next day; normal growth thereafter; > 80% of rats have opaque and corroded appearing eyes; external damage confirmed with fluorescein stain; one death 2nd night Same as above; eyes appeared normal after 20 days Se v e r e weight losses f ,,t day; normal growth thereafter ' w Pathology (Cont'd.): -3- ^ ^ ^ S ^ n o ^ e s i d u a l ^ n j u r y ^ ^ o ^ u s ^ p a r t i c l e s ^ w e r e ^ e e n ^ i r ^ t h e ^ u ^ s 1"3 ^eve^Pe<^ Promptly but di.appea.ed in about the stomach which cleared in two weeks and irritation of the Q , . , n microscopical ly. There was irritation of s,,,ifl d d.y, at,, Citpo5ute. s viiri" i;r*4 J.2 - the ," t p*ir" ? in. enlargement was not apparent. microscopically normal at all times and the mechanism of Discussion: The time inhalation tern^ai^gnitude of rat liver enlargement caused by inhalatior to thos 0 Inhalation morpholog strictly comparable, s l j i c e ^ j o s u r ^ t ^ i B l M M ^ ^ ^ S S l ^ n0t*. **owver the exposures to the .two materials were not Thus effects from t h e f B J ^ ^ ^ xposu ^ ! o u l ^ e f l e c ^ n 5 . = r L Wh0e 7> whereas exPosure t < M f l w a s head only, pattern comparison c a ^ ^ S d ^ c liver enlargement .. "g*8.*10? of_greater apounts_o nateriaTros: Rooming. No strict recovery studies h a v ^ ot been carried out after ingestion o^ M I I | 7 0h f& ^ S / eri3US lnSestion since comparable lethal dose liver to bod wei ht " Z HowefcTr, 14 days after inhalation of a fractionally sublethal o r a l W T H v e r to body w i t f t 8 * " . ? l ? t S ^hest t(Au>; Orally, i T ^ u ~ been carried out for thej^___________ _ s^HliItiEiHoi!!?!!!!'"!^y xaciveiy constant for the rest of the study (last sacrifice 56 days after treatment). ^ ^halation. Summary: The exposure. It by ingesting 777 is -a c* * times normal) the test m a t e r i a l . Inhalation of the test m ^ t e r i a l ' c a u s e d * ? ? " " e r C ," pos,id to Iniiri.e c o m p l icating the study in The liver cell material i^ also hX-^SE caused corneal sopacity and nicer. TM T llll * lungs, liver, tr.chea, gastrointestinal tract ,,ere the only tissues examined microscopically. Company Sanitized. Does not contain T SC A CBf r# -4 - Summary (Cont'd.): any spilled on Jshould be handled with at least the the skin or eyes should be washed off same care asjjplp Ingestion and inhalation should be avoided and contact. immediately. T h e r e should be medical follow-up of any known eye Report by: ft ^ n/-- 0 Figen 0. Tayftlin Inhalation Toxicology Section FOT:RSW/jch Date: June 17. lQfiQ Richard_j8T Waritz Chief, Iphaiatipti^Toxicology Sectj A p p r o v e d by: a. John^ft. 2(kp,/Jr. Director Company Sanitized. Does not contain T SCA C S(