Document Ne1YvOndRx1ann2DQBLwKjRmR

Monsanto Chemical Company.. .Foreign Department, St. Louis, Missouri, U. S. A. > SERVING INDUSTRY... WHICH SERVES MANKIND / LINDANEAAR0CL0R*C0MBINATI0NS BULLETIN NO ./EX-4, In recent news releases the Bureau of Entomology and Plant Quarantine, U.S. Department of Agriculture, Beltsville, Maryland, announced that results of laboratory and preliminary trial studies show marked in crease in the effective insecticidal life of lindane when chlorinated polyphenyls (Monsanto's Aroclors) are incorporated in-the toxicant formulation. A number of chlorinated polyphenyls were tested; best results were obtained with Aroclor 5460. For specific purposes where a very tacky deposit is desired, it may be possible that Aroclor 4465, also a resin, may be of interest. If a "wet" deposit is desired, perhaps chlorinated biphenyls such as Aroclors 1254, 1260 and 1262, which are viscous liquids, will give the desired effect. Lindane is a well established pestieidal chemical. When applied as a residue it may leave an unsightly crystalline deposit and because of its relatively high vapor pressure, its insecticidal value dis sipates within a few weeks. The Aroclors have good solvent action on lindane which results in improved appearance of the pestieidal residue. Moreover, the Aroclors function as relatively non-volatile, non-oxidizable, non-flammable bonding agents for lindane, imparting strong adhesion to all surfaces and reducing the evaporation of lindane to a marked degree. The high resistance of Aroclors to water and corrosive influences, no doubt, accounts for the unusually good weather durability of the lindane-Aroclor residue as noted in the preliminary work. Although the biphenyl Aroclors, and especially the lower chlorinated members of the series are knovm to possess activity as lousicides, miticides, larvicides and show synergistic action on nicotine, these properties seem to diminish with higher chlorination and also seem Trade name, (chlorinated biphenyl and chlorinated polyphenyls) Reg. U.S. Pat. Office. DSW 322122 STLCOPCB4073772 4i Page 2. i j -s t B prevalent in the terphenyl base Aroclors such as Aroclor 5460. -Tergism, however, cannot be readily predicted and the possibility or e^-nergism in this Aroclor-lindane mixture is at the present time being investigated by the Bureau of Entomology and Plant Quarantine. 1 1 I j Understanding of the dermatology and toxicology of Aroclors is important ` in their handling and use in insecticidal formulations. With reference to Monsanto's Technical Bulletin P-115, Page 19 reported data indicates that Aroclors 1254 and 5460 showed no primary irritancy or sensitization , when tested by standard skin patch tests. \ Although the vapor pressure of Aroclors is relatively low, if the materials are heated sufficiently to give off vapors it should be noted that such vapors bear a degree of toxicity and should not be breathed continuously, as indicated in greater detail in Bulletin P-115. Experimental Work and Formulations 50 to 200 milligrams of lindane per square foot of surface has given good insect control on nonporous surfaces. The ratio of lindane to Aroclor 5460 has been varied from 1:1 to 1:4. For most purposes a 1:1 or a 1:2 mixture is satisfactory. Formulations as used in the Bureau's experiments are: 1) For application as a solution Lindane Aroclor 5460 Carbon Tetrachloride* 5 5 750 pIaf rts 11 bft y ft weitight It 2) For application as an emulsion Lindane Aroclor 5460 Xylene Triton X-100 20 20 100 3 pIaI rts II tl bII y fl It we11ight n n To obtain a stable 1% lindane emulsion. mix 143 parts by weight of the above concentrate to 1857 parts by weight of water. 3) For use as a pressurized spray a) Lindane Aroclor 5460 Methylene chloride Freon 12 5 parts by weight 5" "" 40 " "" 50 " "" ps'N * Carbon tetrachloride is toxic and should be handled with extreme caution. Less toxic solvents are being studied. STLCOPCB4073773 i b) Lindane 5 parts by weight Aroclor 5460 5" " " Cyclohexanone 10 - " " " Ortho dichlorobenzene 35 " " " Freon 12 45 " " " l' I jt ? The Bureau people do not want these formulations or results with them to be construed as a recommendation for use as the work is in the laboratory stage and has not had extensive field testing. Experimental Results - American Roaches Using Formulas 3a or 3b, the toxicant was applied onto a painted wall depositing about 200 mg./sq.ft, of lindane and a like amount of Aroclor 5460. At the time of this writing, the toxicant coat is one month old, and it still gives 90-100$ kill of American roaches when the roaches contained in a petri dish are placed against the surface of the treated wall for two hours. ' . ; >. The research team found that the lindane-Aroclor 3460 mixture (used at the rate of 50 mg. of actual lindane per sq. ft.) would kill 80$ of all cockroaches exposed for 2 hours to a 60 day old treated surface. It remained lethal to 66$ of the roaches after 90 days. Regular lindane sprays used at the same rate, killed only 4$ of the roaches after 60 days. House Flies - Deposits of 25 mg. of lindane plus 25 mg. of Aroclor 5460 applied from carbon tetrachloride onto glass and aluminum (hard surfaces) give 100$ kill of normal house flies exposed for 2 hours to these treated surfaces after they had aged 18 weeks, the duration of the test. The surfaces are still equally active and the test is being continued. " Without the Aroclor the hard surfaces treated with Lindane alone would be effective only about one week. A lindane plus Aroclor mixture sprayed as an aerosol onto leaves of a willow tree continues to kill house flies after 2 months outdoor weathering, careful inspection of the treated leaves shows that the toxicant is held firmly to the surface and not withstanding rain and weather, the coating remains in good con dition. Also, within limits of a preliminary inspection there does not seem to be Injury to the willow leaves. DSW 322124 \ STLCOPCB4073774 s Page 4 Conclusion % According to these laboratory tests. It is believed that Aroclor increase the effective life* of lindane, 10 to 20 times. Since Aroclors are relatively very inexpensive, their use with Iir.lane would offer a great economic value. In addition to use Kith lindane, the Aroclors may be equally useful with a wide var iety of other insecticidal agents. FCM: r.d 2/3/53 osw 322125 STLCOPCB4073775