Document NVqk30Nx5pY5k3vgNwQ0n9Xy

RIKER LAU DRAT0131E S, IN C. Interoffice Carrespontience: CC:- M. T. Case D. C. Kvam March 319,.1977 APR044M19-797 7 03M C 0 Lz, TO: J4. N.-WELTER - ENVIRONMENTAL ENGINEERING & CONTROL.- 21-ZW FROM: S. R. RORLPING - RIKER RESEARCH - 218-2 SUBJECT': Salmonella/Mammalian-Microsome Mutagenicity Testing The Ames spot test for mutagenicity screening of chemical substances was used to-examine,the samples listed below. The equivalent of 10 mcg, based on percent composition, was tested against each of 3 indicator strains .(Ta 1537, TA 98, TA 100) together with arachlor-induced rat microsomes (S-9 mix). A'reference standard 2-aminof.luorene, which requires microsomal activation for significant mutagenicity, was highly active at 10 mcg and 1 mcg in this test. Three samples (marked with an asterisk) were incompatible with the standard test solvent dimethyl sulfoxide; the discs were therefore saturated with each sample in its undiluted state. The results of these tests do not indicate mutagenic activity in any of the samples submitted. Please inform me if the concentrations tested are inadequate for your needs. However, we are unable to.accomodate testing on additional samples.without prior approval from M. T. Case, Chairman of the Mutgenicity Committee. Samples Tested: 2-253* FC- 11.3 3-649 * Fc - 7 7 4-315 t:C.-9 8 5-730 Fc. 12$ 6-544 cc-- gly-3o 7-687 B-603 r@C- 2 (3 c c- .73 0^- 9-568* rc: 3JI 10-540 F C $C,'-@* 11-900 12-583 -.13-716 3Y 12. SRR:cb NB Ref. 45867-24,25