Document NVoYB2ywr4eVKmM1RQONVGxV

Katherine E . Reed, Ph .D . 3M Environmental, Health and 900 Bush Avenue, Buildmg '42-2E-26 Staff Vice President Safety Operations PO Box 3333 1 St. Paul, MN 55133-3331 ~ 651 778 4331 3M Certified Mai l July 28, 2006 Document Processing Center EPA East - Room 6428 Attn : Section 8(e) Office of Pollution Prevention and Toxic s US EP A 1200 Pennsylvania Avenue NW Washington DC 20460-000 1 , / f! ~ ~~4 ' ~ 3 l 00 37~ 36 No RE : TSCA 8(E) SUBSTANTIAL RISK NOTICE ON : PFHS and PFOS ; Supplemental to Sulfonate-based Fluorochemicals, Docket Nos . 8EHQ-1180-374 ; 8EHQ-0381-0394 ; 8EHQ0598-373 Dear Sir/Madam : Prelimina ry data from an on-going study sponsored by 3M th at is being conducted by TNO Laboratories in Leiden, Netherlands suggest an effect of perfluorooctanesulfonate (PFOS) and perfl uorohexanesulfonate (PFHS) on body weight, food consumption, and serum - ' cholesterol in 15% dietary fat fed E3 Leiden transgenic mice in vivo . Cholesterol was . reduced at dietary concentrations of 30 and 100 ppm for PFOS and 60 and 200 ppm for PFHS . Food consumption and body weight were reduced at dietary concentrations of .100 ppm PFOS and 200 ppm PFHS . On removal of the 100 ppm PFOS dosage-group mice frqm exposure through diet, food consumption and serum cholesterol showed recove ry , but-bodyweights remained low . On removal of the 200 ppm PFHS dosage-group mice from ~posure through diet, body weight an d food consumption showed recove ry , but serum cholesterol remained low . The lowered serum cholesterol in the 200 ppm PFHA dosage-group mice is being obse rv ed for recovering in the on-going study . 3M believes that this is the first observ ation in mice of cholesterol reduction as a result of treatment with PFOS and PFHS, and the first obse rv ations in mice treated with PFHS of reductions in body-weight and food consumption . PFOS and PFHS has previously been shown to have the effect of reducing body-weight and serum cholesterol in rats, and PFOS has been shown to produce the la tt er effects in monkeys . Therefore, 3M believes this information to be corroborative. A final repo rt will be forwarded to the EPA when it is received from the test facility . If there are questions, please contact Dayna Blomquist (651-736-5413) . Sincerely, Kathe ne E. Reed I li iI i II ~ I ~ 111hI ~i Il lI , l~~i~~?,~-~~, ~ Staff Vice President, Environmental Health and Safety OperationTsil 1s11a1n[ r, n 1u111n1111 n a n o l ~ 9~7 5Q .C~.