Document NNEoYOX48y9ReBqqvrL0n4EZE

July 9, 1949 Mr. k. L. Milstead, Chief Cincinnati District , Food and Bru^ AdminIsoration, 501 Post Office Building.? Cincinnati 2, Ohio. Dear Mr. Milstead: I regret ay tardiness in replying to your letter of May 26 concerning the problem of spray residues , but a number of matters have interfered seriously with my correspondence, and I shall have co rely upon your indulgence. tie, of courset have reason to be very much concerned with the hygienic problem of spray residues of various kinds on fruits and other food materials. We have studied various aspects of this problem, sometimes more or less indirectly, in connection with our principal work which relates to industrial hazards rather than to hazards to the general public. Some of our- data, therefore, are pertinent, with particular reference to load,fluorides and DDT. So far as I know, there is no wholly satisfactory information on arsenic, end ire have none worth mentioning on parathion. I shall have to .'.'hit frankly that at the present time I do not know the facts with reference to the use of these materials on various food products, not do X know the proportional representation of various food products likely to be sprayed with these materials, so as to be able to appraise their overall significance in the dietary. The latter, to my way of thinking, is the most difficult problem that is faced by any investigator or authority responsible .for the public health in these matters. I have been told x-ecently, that the use of lead and arsenic on apples and pears is at the vanishing point in a number of sections of the country. Despite the apparent reliability of ny source of information I do not know that this is true, nor do I know how extensive has been the shift country-wide from these to other insecticides. If the facts are as reported, the need for a tolerance on these compounds is very greatly diminished. The problem of DDT is somewhat confused by the present differences in the s !T.t Taints of investigators with reference to the effects of low concentrations of DDT on experimental animals. I should be disposed to feel that.the level of J as indicated in your letter, should be well within safe limits, but X think this opinion will be disagreed with in certain governmental circles. N9717 Returning to the subject of lead and fluorine, we have conducted experimental work on human beings that is highly significant. Our observations relate to the fate of these materials in the human body, and they enable us to express an opinion as to the levels of dosage which are compatible with safety and well being when taken day by day over long periods of tame. If it were possible to relate lu. orances to these physiological data, X would have no hesitation Hr. K. L. Milstead - (2) - July 9, 19^9 in expressing opinions based on sound, evidence. The real diffi culty* resides in the fact that it is very difficult, if not impossible, to determine the precise contribution made to the daily intake of these materials by individual items of food stuff, he do not have field information on the extent of the contamination of various articles of food in various areas of the country. e do not know anything,factually, about the quantitative occurrence of lead, arsenic, or fluorine on apples or pears as they now appear on the market. Kor do ve know whether methods of washing now employed remove these materials effectively or to any measurable extent All that we can say is that the available evidence, so far as we have seen it,-is that the representation of these materials in the dietary, as we have seen it, would appear to be within sate limits at present. Specifically, with reference to lead, our* evidence would snow that the daily dosage in the food must not exceed a figure somewhere between 0.5 and.1.0 mg./day. The fact is that the figurcBW^proximates 0.2 rag./day in the case of the ave^s-rvaaQgr*er i? ndrNi*?vt ri^dnuVaJOl' overr\ \Trs'Vi ad f*Pai-i r*v>lTyit pv%*rvaoa lT onged period, fTT>Vh, ere is no question of risk of life or heal h, so long as individuals conduct themselves with respect to tb ir diets within this limit of lead intake. There are many other things that may bo said on this subject, and you may be assured that I would be prepared to attend a hearing cn this subject, and would, in fact, consider it my duty to do so, I should hope that some conclusion,which could be substantiated by adequate evidence, could be arrived at with respect to these tolerances. I am not as certain as some other persons would seem to be, that the evidence is ouch that this can be done. Cordially yours, RAK ef Robert A. Kehoe, M. L. 0008461