Document NGgMERpx07L4mNB9b08mvj9Ey

IN REPLY IN G A D D R E SS D ivision of Research G rants and Fellow ships FED ERA L SECU RI T Y A GEN CY PUBLIC HEALTH SERVICE N A T I O N A L I N ST I T U T ES O F H EA L T H B e t h e s d a 14, M a r y l a n d A p ril 4 , 1949 In reply re fe r to our RG--1970 OOKFIDMTIAL D r. R obert A. Kehoe D irecto r, K ettering lab o rato ry of A pplied Physiology U n iv e rs ity of C in cin n ati C ollege of Medicine C in c in n a ti , Ohio ' Dear D octor Kehoe: The re se a rc h p ro je c t o u tlin e d in th e accompanying a p p lic a tio n subm itted by Dr. Frank P r in c i, U n iv ersity o f Colorado M edical C enter, i s b e in g p rep ared fo r review by th e Hematology Study Section o f th e R a tio n a l I n s titu te s o f H ealth. Your opinion of th e s c ie n tif ic m erits of th e proposed research and the q u a lific a tio n s o f the in v e stig a to r would be of c o n sid e ra b le a s s is ta n c e to th e Study S e c tio n members in th e ir form ulation of a recommendation concerning the d e s ir a b ility of s u p p o rtin g D octor P r i n c i 1s p r o j e c t . A ll ap p licatio n s fo r research g rants are tre a te d as s t r i c t l y con fid e n tia l and, except in special circum stances, are not c irc u lated beyond the membership of the study sectio n s and co u n cils th a t review th e a p p l i c a t i o n s . Any in fo rm a tio n o r o p in io n t h a t you would be w i l l ing to fu rn ish also w ill be held in s tr ic t confidence. For your in fo rm atio n , the membership of th e Hematology Study S e c tio n .is given below: D r. Chas. A. Doan (Chairman) D r. K. I-i. B rinkhous D r. Edwin J . Cohn L t . Comdr. 3 . P . C ro n k ite D r. L ouis IC. Diamond D r. K enneth M. E n d ic o tt D r. Roy R. Kracke D r. C arl 7. Moore L t . C o l. Howard A. Tan Auken D r. Maxwell M. V in tro b e A self-ad d ressed envelope which req u ires no postage is enclosed fo r your convenience in re p ly in g . Sincerely yours, Enclosures 2 T ' ' r - ''* \ ^ r' ' ,.V ' J . Franklin Yeager, / executive Secretary Hematology Study S ectio n J APPLICATION FOR GRANT FOR RESEARCH PROJECT Received l/l7 /A 9 Page 1 RG 1970 Hematology I . APPLICANT: U n iv o rs ity o f C olorado M edical C en ter Denver 7, Colorado I I . DIRECTOR OF PROJECT: F rank P r i n c i , M .D., D ir e c to r , D ivision of In d u s tria l M edicinej A ssista n t P ro fe sso r o f Medicine I I I . SUBJECT: "The Value o f D if f e r e n t D ia g n o stic Methods in Lead A bsorption and Lead In to x ica tio n * " IV . FUNDS REQUESTED: (J u ly 1 , 19A9 - June 3 0 , 1950) P e rso n n e l: C hem ist $ 3,600. 2 Laboratory technicians 4.800* Consumable S u p p lie s : S tain s, glassw are, reagents T ravel: > 000 At *08 p e r m ile S u b to ta l 2*200* O verhead: To ua- , - /) V. FUNDS FROM OTHER SOURCES: Nonq $ 8,400 3,000. 1 ;000. $12,400. $13,39 2. V I. OTHER SUPPORT FOR THIS OR RELATED RESEARCH: None V H . EXPLANATION OF RESEARCH PROJECT: A. R e s u lts t o d a t e : 1 I n v e s t i g a t o r : - S tip p le c o ll counts are done ro u tin e ly in th is laboratory in a ll cases of occupational disease. Many to x ic su b sta n c e s do produce s t i p p l i n g o f th e re d c e l l s . However, th e re is -n o in fo rm atio n on th e de gree of stip p lin g in the vast m ajority of d iseases. 2. O thers: Joh n sto n e, R. T ., "O ccupational Medicine and I n d u s t r i a l H ygiene", C. V. Mosley Company, S t , L o u is, 194-8, pp. 237-242: " S tip p le c e l l s a re not pathognomonic of lead in to x ic a tio n " . ' D espite th is statem en t, no s tu d ie s have boon system atically carried out to prove th is point and th e m edical l i t e r a t u r e c o n tin u e s to recommend s tip p le c o ll counts as d ia g n o stic. /' ' / Page 2 RG 1970 Hematology B, Proposed research p la n ; S tip p le c e l l counts would be done on a l l p o ssib le h o s p ita l and o u tp a tie n t p a tie n ts . This work would be done in th e th ir te e n h o s p ita ls of th e M edical C en to r. At th e same tim e , blo o d and u rin e sam ples would be c o lle c te d and analyzed f o r le a d c o n te n t. P a rtic u la r a tte n tio n would be paid to attem pt to s tu d y p a t i e n t s who p r e s e n t a la r g e v a r i e t y o f d i s eases and the v ario u s stag es o f d ise a se , A number o f men who a re a c t u a l l y exposed to le a d would be stu d ie d in th e same m anner, and s im ila r s tu d ie s would be made on a group o f h e a lth y unexposed i n d i v id u a ls , . A fter the data is accum ulated, the follow ing in fo r mation should be d eriv ed : 1 , The in c id e n c e o f s t i p p l e c e l l s i n exposed and non-exposed in d iv id u a ls would be compared, 2 , The in c id e n c e o f s t i p p l e c e l l s in th e v a rio u s d ise a se s and in t h e i r d if f e r e n t stag e s would be estab lish ed , 3 , JThc amount o f s tip p lin g in th e d if f e r e n t s ta g e s o f le a d a b s o rp tio n would bo found, A, The s p e c i f i c i t y o f s ti p p l o c e l l s i n th e d ia g n o s is of le ad in to x ic a tio n would be determ ined, C, B ib lio g ra p h y su b m itted w ith a p p l i c a t i o n : None D, R e p rin ts su b m itte d w ith a p p l i c a t i o n : None E, A nticipated duration of study: