Document NG4XjQ5kyyO2mpD8er8vxz6Jg

imttCY95% KSEMCl5% IESIABCN 65% BraCinDN 35% --iii . Tankersley, Hoechst Celanese Corporation^ CHARTERED: 1991. TASK GROUP: Toxicology'WMeT MANAGER: Kathleen Roberts. MISSION: To address the regulatory concerns of manufacturers, processers, and users of acetone. GREATEST ACCOM PLISHMENT: Successfully advocated OSHA PEL of 750 ppm. LATEST ACCOMPLISHMENT: Completed and submitted petitions to reclassify acetone as a vola tile organic compound of negligible reactivity and to delist from SARA 313. MOST PRESSING ISSUE: To proceed with neurotoxicity testing program outlined in a recent consent order. DETAILS: Page . CHAIRMAN: Connie E. Carroll, Union Carbide Corporation. CHAR-________________ TIRED: 1987. TASK GROUP: Toxi cology Research. PANEL MANAGER: Fernando Leiva. MIS SION: To determine the health and environmental effects of alkylphenols and ethoxylates in manufacture and use. GREATESTACCOMPLISHMENT: Completed all testing required under TSCA Section 4 for nonylphenol. LATEST ACCOM PLISHMENT: Held a facilitated planning session in which communication and research needs were identified as fur ther priorities. MOST PRESSING ISSOE: To initiate a risk assessment ofalkylphenols and ethoxylates. DETAILS: Page. MVtGICr 50% KSEMCI 50% CHAIRMAN: Ray Papciak, Texaco Chemical Company. CHARTERED: _ 1982. TASK GROUP: Toxicology Research. PANEL MANAGER: Jonathon Busch. MISSION: To address toxicology regulatory issues of alkanolamines. GREATESTACCOMPLISHMENT: Completed voluntary research program relating to the dermal absorption, developmental toxicity, and pharmacokinetics studies of MEAand DEA. LATEST ACCOMPLISHMENT: Initiated a literature review cov ering the use, chemical and physical properties, toxicol ogy and pharmacokinetics of alkanolamines. MOSTPRESS ING ISSUE: Advocating an increase in the Reportable Quan tity for DEA with EPA. DETAILS: Page . CHAIRMAN; Roy Roseberry, FMC Corporation. CHARTERED: 1991. TASK GROUP: Toxicology Research. PANEL MANAGER: Kathleen Roberts. MISSION: To address TSCA Section 4 test ing issues for aryl phosphates. LATEST ACCOMPLISH MENT: Proposed a testing program which was aceepted under EPA's "open season." MOST PRESSING ISSUES: To reach final agreement on TSCA testing program and begin testing. DETAILS: Page . .... n CMA 054542 KINKY100% IHKKY 20% 1001070% BMOWI10% CHAIRMAN: John Stewart, Courtaulds Fibers, Inc. CHARTERED: 1991. TASK GROUP: TSCA Testing. PANEL MANAGER: Elizabeth Moran. MISSION: Interact with regulatory agencies on safety, health, and environmental is sues. GREATEST ACCOMPLISHMENT: Completed a re view of the literature on CS2 effects that will form the basis of the Panel's advocacy activities. LAYESTACCOMPLISHMENT: Convinced EPA to issue a stay of the effectiveness of listing H2S on SARA 313. MOST PRESSING ISSUE: Appropriate setting ofthe ref erence concentration for Carbon Disulfide. NEIAILS: Page. mucky in KSfjua m acunwm H 11 L A..I.X m Y >j: ...YYi CHAIRMAN: Bruce Jacobsen, Olin Corporation. CHARTERED; 1989. TASK GROUPS: Transportation; Re search; DCCA Dihydrate Reclassification. PANELMANAGER: Kathleen Roberts. MISSION: To promote safety practices in the processing, packaging, warehousing, transportation and use of chlorinated pool chemicals. GREATEST ACCOM PLISHMENT: Developed bulletins on safe handling, storage and transportation of CPCs, including a video for emer gency response personnel. LATEST ACCOMPLISHMENT: Sub mitted a research report on chloroform releases from swim ming pools to the California Air Resources Board. MOST PRESSING ISSUE: withDOTmdthe U^Expe^Co^ mutee on/fie Transport ofDangen^Us Gqdds onme "kelf- nractivel'classifftation m certaii^CPCi DETAILS: Page CHAIRMAN: Earl Smith, Vulcan Chemicals. CHARTERED 1987. TASK GROUPS: Administration; Ad- -------------------------vocacy; Regulatory, Technical. PANEL MANAGER: Robert Romano. MISSION: To gather, review, generate and disseminate information on chlorine dioxide. GREAT ESTACCOMPLISHMENT: Educated EPAjesp chlorine dioxide, ? sodium chlorite and sodium chlorate are safe and effec- ' five chemicals that should be used in the strategy of treat ing water in the United States. LATEST ACCOMPLISHMENT: Completed all Phase 1 requirements for EPA's F1FRA Data Call-In and FIFRA Phase IV Reregistration. MOST PRESS ING ISSUES: Negotiating with EPA on Disinfectants and Disinfection By-Products Proposed Rule and the Enhanced Surface WaterTreatment Requirements Proposed Rule. DE TAILS: Page. 100% CNAIHMAN: James Bryant, Standard Chlorine Chemical Co., Inc. CHARTERED: 1974. TASK GROUPS: Toxicology Research, FIFRAData Call-In, 1,2,4-Trichlorobenzene. PANELMANAGER: Carol Stack. MISSIGN: Voluntary and mandated research on health and environmental ef fects. LATEST ACCOMPLISHMENT: Completion of eight year TSCA Section 4 testing program. MOST PRESS- d/M.5 CHAIRMAN: Allan Kushins, Lonza, Inc. CHARTERED: 1992. TASK GROUP: None. PANEL MANAGER: Cecilia Spearing. MISSION: To complete a Screening Information Data Set (SIDS) dossier. GREAIESTACCOMPLISHMENT: Comple tion of SIDS dossier. LATESTACCOMPLISHMENT: Work ing with EPA to ensure that all available data have been identified. MOST PRESSING ISSUE: Same. DE TAILS: Page . AmCACY 85% KSUM10% CtUMKICITlN 5% CHAIRMAN: William Snellings, Union Carbide Corporation. CHAR TERED: 1986. TASK GROUP: Toxi cology Research. PARE!MANAGER: ICuifiiylttVOuica. MS SION: To augment the database and address regulations affecting ethylene glycol. GREATEST ACCOMPLISHMENT: Ad vocated 5000 pound CERCLA RQ which EPA proposed in November 1993. LATESTACCOMPLISHMENT: Initiated fur ther research in determining mechanism of EG develop mental toxicity. MOST PRESSING ISSOE: Responding to in clusion of EG on HAPTSCA list. DETAILS: Page . 1'/1 * ' muetm MVMICT40% 140% 110% 10% CHAIRMAN: Vacant. CHARTERED: 1974. TASK GROUP: None. PANEL MANAGER: Kathleen Roberts. MIS SION: To address safety and health issues arising from the production, distribution, and use of EDC. LATEST ACC0MPUSHMENT: Submitted comments on draff ATSDR Toxi cology Profile. MOST PRESSING ISSOE: Tracking regula tory issues affecting EDC. DETAILS: Page . CHAIRMAN: Glenn Jones, Eastman Chemical Com pany. CHARTERED: 1980. TASKGDOHPS: Toxicology Research, Process Safety, Clean Air. PANEL MANAGER: Kathryn Rosica. MIS SION: Develop a data base, provide information, and promote sound regulatory action. GREATEST ACCOM PLISHMENT: Successfully advocated industry posi tions to federal, state and international bodies for more than 12 years. LATEST ACCOMPLISHMENT: Took opportunity to present over $1.8 million in Panel funded state-of-the-art research to an international audience of government regulators and researchers. M0STFRESSINGISS0E: Addressing continuous confu sion among individual members of the category and regulations that do not appropriately differentiate CMA 054544 MVOCICY 20% KSaiCH 75% mam s% CHAIRMAN: Ray Papciak, Texaco Chemical Company. CHARTERED: 1982. TASK BROUP: Toxicology Re----------------------------- search. PANEL MANAGER: Robert Romano. MISSION: To address regulatory and scientific activities in an effort to help agencies make sound decisions on ethylene oxide. 6REAIEST V, ACCOMPLISHMENT: The EOIC has established directly or indirectly a tremendous data base on ethylene toxide from toxicology, epidemidogy, and industrial ^ hygine to engineering safety which allows for a more s complete risk assessment on ethyene oxide. LAT EST ACCOMPLISHMENT: Participated in an IARC re I view and evaluated a mutagenicity risk assessment on ethylene oxide. MOSTPRESSING ISSUES: Work with EPA, academia and others on evaluating the carci nogenicity risk assessment on ethylene oxide and track the EO propagation study. DETAILS: Page . CHAIRMAN: Donald Lamb, Miles Inc. CHARTERED: 1988. TASKGROUP: Toxicology Research. PANEL MAN AGER: Kathleen Roberts. MISSION: To address TSCA Section 4 issues for HDI. GREATEST AC COMPLISHMENT: Advocated that TSCA testing should be conducted via inhalation route, as it is the most relevant exposure possibility. LATEST ACCOMPLISHMENT: Responded to the inclusion ofHDI on EPA's proposed Toxics Release Inventory expansion list. MOST PRESSING ISSUE: To pro ceed with the required TSCA Section 4 testing program when EPA issues final rule. DETAILS: Page . KSUC8100% ANOGACY 75% KSEAGCN 25% CHAIRMAN: Sharron Laas, DuPont. CHARTERED: 1987. TASK GROUPS: Specific Chemical Producers, Spe cific Chemicals Toxicology. PANEL , MANAGER: Kathleen Roberts. MIS SION: To address TSCA Section 4 issues on fluoroalkenes. GREATEST ACCOMPLISHMENT: Completed requirements for TSCA Section 4 test rule in 1992. LATESTACCOMPLISHMENT: Same. MOST PRESSING ISSUE: To respond to any issues regarding the results of the TSCA testing program. DE TAILS: Page . CHAIRMAN: Sherry Duff, Olin Corporation. CHAR TERED: 1991. TASK GROUP: Toxicology Research. PANEL MANAGER: Dee Kuhn. MISSION: To support hydrazine related product stew ardship activities. GREATESTACCOMPLISHMENT: Con tinued efforts to provide the ACGIH with toxicity information to aid in its evaluation of the TLV for hydrazine. LATEST ACCOMPLISHMENT: Same. MOST PRESSING ISSUE: Monitor regulatory response to out standing comments and petitions. DETAILS: Page . v --- Old *S4, MINIM 90% 15% 5% MINIM m M8MN7IS BN0IN5\ CO-CHAIRMEN: Vergil Perry and Jonathon Ramlow, The Dow Chemical Company. CHARTERED: 1971. TASK GROUPS: Vinyl Chloride Re search Coordinator Group, Vinyl Chloride Transporta tion Network (VCNet). PANELMANAGER: Has Shah. MIS SION: To assess health and safety data on vinyl chloride and to develop a mutual aid network for response to vi nyl chloride incidents. GREAILSI ACCOMPLISHMENT: For mation of VCNet to respond to vinyl chloride incidents, ensuring safety and effective response. LATEST ACCOM PLISHMENT: Investigating a physiologically based phar macokinetic model for vinyl chloride risk assessment. MOST PRESSING ISSOES: To work with EPA on the risk assessment of vinyl chloride. DETAILS: Page . CHAIRMAN: Randy Deskin, American Cyanamid Company. CHARTERED: 1985. TASK 6RQ0P: Specific Chemi cals. PANEL MANAGER: Robert ------------- ----------------Romano. MISSION: Address regula tions and gather, review, generate and dissemenate information on direct and indirect potable water additives. GREATEST AC COMPLISHMENT: Achieved National Sanitation Foundation ac ceptance of water additives certification packages for several chemicals. LATESTACCOMPLISHMENT: Worked with NSF to al low the certification process on three chemistries to be smooth, cost/effective and quick. MOST PRESSING ISSOES: Assure the NSF certification process is running smoothly and cost/effec tive for three water additive chemistries and that all company member products are NSF certified as soon as possible. DE TAILS: Page . MINIM 100% ; f **! | CHAIRMAN: James Barter, PPG Indus tries, Inc. CHARTERED: 1974. TASK GRODP: None. PANEL MANAGER: Kathleen Roberts. MISSION: To spon- --- sor research on the potential toxicologic effects and pharmaco kinetics ofVDC. GREATESTACCOMPUSNMENTyrracked the Calp fomia Air ftfcrvnrrps Board Compound Review of VD( ESTACCOMPLISHMENT: SameJMSTPRESSING ISSDL- To respond to potential regulations affe CMA 054546 n Acetone MISSION: The Acetone Task Group formed under the Ke tones Panel in 1990 to address regulatory concerns of manu facturers, processors, and users. Task Group members de cided to form a separate Panel because of the complexity and diversity of acetone issues, ACCOMPLISHMENTS: By submitting information on tox icity and environmental concentrations, the Acetone Panel successfully advocated the removal of acetone from the Ari zona Department of Environmental Quality's proposed list of hazardous air pollutants. After the Panel presentation at an ACGIH Committee Meeting in March 1993, and at the spe cific request of ACGIH members, the Panel developed a re view of available human data on acetone. The Panel report, "The Local and Systemic Health Effects of Acetone," was provided to ACGIH Committee members for consideration in the acetone threshold limit value review. The Acetone Panel also submitted a petition requesting EPA to reclassify acetone as a volatile organic compound of negligible reactivity. In conjunction with that petition, the Panel provided EPA with acetone reactivity data developed by Dr. William Carter of the University ofCalifornia at Riverside. Throughout the year, the group continued its communication with the EPA IRIS Work Group on establishing a reference dose for acetone, and with the National Sanitation Foundation on its accreditation of acetone as a potable water solvent. PLANS: The Panel will proceed with the scheduled-controlled operant behavior (SCOB) neurotoxicity testing pro gram, which was agreed upon during the settlement negotia tions in January, and will be outlined in a final consent order in the fall. In addition, the Acetone Panel will continue its communications with ACGIH regarding the acetone TLV re view process. The Acetone Toxicology Research Task Group will develop a dossier for Phase 4 of the OECD SIDS pro gram and address misinformation included in some publicly available databases. MISSION: The Panel formed initially to address toxicology issues associated with alkanolamines. Current Panel efforts are focused on voluntary research, publishing data, and regu latory advocacy. ACCOMPLISHMENTS: The Panel completed a number of studies on monoethanolamine and diethanolamine under its voluntary research program. Completed research includes an in vitro dermal absorption study and studies on develop mental toxicity in both rats and rabbits. Voluntary research in progress includes a pharmacokinetic study of DEA. The Panel initiated a literature review covering the use, chemical and physical properties, toxicology, and pharma cokinetics of alkanolamines. Once completed, the literature review will be published. Efforts also were initiated by the Panel to publish results of its voluntary research program. In 1993, EPA issued a proposed rule that would establish an RQ of 100 pounds for DEA. The Panel submitted comments to EPA indicating that the Agency incorrectly calculated the RQ, and that available scientific data support an RQ of 5,000 pounds. The Panel expects a response from EPA on the RQ issue in late 1994. PLANS: The Panel plans to: continue voluntary research activities; submit completed research studies to the National Toxicology Program; publish research results in various peerreviewed journals; publish a literature review of alkanolamines; develop a scientific position statement on the health effects of alkanolamines; continue advocating an in crease in the RQ of DEA; and, monitor and respond to new regulatory developments. MISSION; The Panel formed to determine the health and environmental effects of alkylphenols and ethoxylates in manufacture and use. Initial efforts focused on responding to EPA concerns about the chemical fate and environmental effects of nonylphenol. The Panel maintains liaison with the Soap and Detergent Association on scientific and regulatory issues. ACCOMPLISHMENTS: The Panel completed all testing under TSCA Section 4 for nonylphenol. In April, the Panel participated in an OECD-sponsored Risk Reduction Work shop hosted by the Swedish EPA. The Panel held a facili tated planning session in which communication and research needs were identified as further priorities. The Panel contin ued to work with the state of North Carolina and the Wiscon sin Department of National Resources on alkylphenols and ethoxylates on water treatability issues. PLANS: The Panel will continue to educate the U.S. regula tory community on the results of Panel research. A risk as sessment of APEs will be performed by the Panel by early 1994. The Panel also will continue to work with the Swed ish EPA and agencies of other ^onducteg)Countries. Biodeg radation and treatability studies will be investigated by the Panel to assist North Carolina and other states in assessing potential risks of these chemicals to the environment. The Panel will continue to identify research and communication needs. In addition, the Panel will develop an information package on APEs for distribution at three upcoming work shops. MISSION: The Council is to develop technically and eco nomically sound programs for the responsible use, recovery and conservation of plastics and their component raw materi als that address public interests and concerns. CMA**5*1 II---- Among the goals for the APC, the following stand out: To develop environmentally, economically, and technically proven programs based on sound integrated solid waste man agement principles including: o reusability o source reduction o mechanical & feedstock recycling o energy recovery o landfilling (when no better alternative existk) officials to broaden the current public policy debate to include effective solutions such as recycling, advanced recycling and energy recovery. The Plastics Mobilization Committee develops a core group of motivated downstream industry representatives commit ted to speak as a credible voice on critical resource manage ment public policy issues. The Committee targets key local management personnel with a concerned community view point and focuses their efforts at the local, state and federal levels. To gain public acceptance for long-term integrated solutions that serve the public and the industry. To meet these goals, 25 of the nation's leading plastics itesin producers and representatives of the broader plastics proces sor community have come together through a joint initiative with the Society of the Plastics Industry, Inc. The purpose is to encourage efficient resource conservation throughout the life-cycle of plastics products. Council members have made a substantial commitment and pledged significant resources to achieve this goal. Top executives including chief executive officers, presidlients and senior executives have joined forces in this effort because industry believes it has the responsibility not on :y to respond to public needs with its products but also to re:spond to public values through its actions. The APC has an integrated organization, directed by the APC Board of Directors, focusing efforts on Product Stewardship, Outreach, Advocacy and Industry Mobilization to pro vide industry-wide solutions to integrated resource management issues. The Product Stewardship Task Force's function is to research and encourage economically sound integrated resource management technologies and implement these solutions in a timely manner. Some of those efforts include: continuin.g to develop technology to determine the optimum level for mechanical recycling of plastics; furthering the develop ment of advanced technology recycling; conducting life cycle analyses of plastic products; and, compiling and/or dev :loping energy recovery information. The Outreach Task Force dialogues with the public, policy makers, educators and other target audiences to convey the resource management benefits that demonstrate the positive role of plastics in society and the environment. This (com munication will help build public support for industry-spon sored solutions and position plastics as an efficient use of natural resources. The Advocacy Task Force works with legislators and regula tors to ensure an appropriate government role in providing responsible integrated resource management programs. The Task Force will focus on local, state and federal government Z7 MISSION: Before coming to CMA, the manufacturers were part of an ad hoc committee which formed to respond to inclusion of the chemical category in the Second Report of the Interagency Testing Committee in 1978. When EPA an nounced its intention to initiate rulemaking underTSCA Sec tion 4, the members disbanded the Committee and reformed as a CHEMSTAR Panel. ACCOMPLISHMENTS: In March 1993, EPA provided the Panel with a draft enforceable consent agreement for the aryl phosphate TSCA Section 4 test program. In many signifi cant areas, the Agency's draft agreement coincided with the Panel's September 1992 proposed testing program, which was submitted under EPA's open season initiative. PLANS: The Panel will initiate the consent order negotia tions with EPA soon, ^ttrer Panel activities include sponsor ing the negotiated testing program and responding to other regulatory concerns. ^ ^ fa MISSION: The Council formed to address issues concern ing the impact of chemical industry emissions on regional and global atmospheric change. Activities include: identify ing and resolving scientific uncertainties about effects of in creased concentrations of chemicals in the atmosphere; ob taining research data that will assist in developing chemical industry positions on such issues as Clean Air Act imple mentation and global climate change; and, providing a sci entific foundation for the industry's position in the debates on a global effort to control greenhouse gases. ACCOMPLISHMENTS: The Council continued its research program to increase understanding of the impact of chemi cal emissions and volatile products on global climate change. The Council decided to become a major co-funder of a project to develop an assessment model for the chemical industry. As part of this project, a workshop was held in Cambridge, Massachusetts on three-dimensional chemical transport as sessment modeling in September. The Council also contrib uted funding for: an international workshop by NIST on chemical kinetics; a project by the International Global At mospheric Chemistiy for the development of global emis sions inventories; and, a project to update estimations of hy droxyl radical reaction rate constants. CMA 054548 The Panel has been following OSHA reform legislation with a focus on the provision which would reinstate the 1989 Air Contaminants Standard which was vacated by the court. The Panel has worked with a consortium of trade associates and convinced OSHA to support a modification to this provision which preserves settlement arguments arising from the law suit. Both the House and Senate bills currently contain the modified wording. The Panel submitted comments opposing the listing of H2S under EPCRA 313 and is currently working with American Petroleum Institute and the American Forest Products Asso ciation to convince EPA to withdraw H:S from the final rule. The Panel commented on the EPA document "Principals of Neurotoxicity Risk Assessment." The Panel also commented on the proposed Universal Treatment Standard for CS2 under RCRA land disposal restriction rules. The Panel met with EPA and provided data that show that the UTS for CS3 is not feasible for the viscose process. Most recently, the Panel provided data to ACGIH as they begin development of a Threshold Limit Value for CSr PLANS: The Panel will continue a dialogue with EPA and NTP on the testing of carbon disulfide and on the develop ment of an appropriate reference concentration. The Panel will follow OSHA reform legislation closely, and ensure that the provisions of the settlement agreement are incorporated into any new legislation. Also, the Panel will continue to moni tor EPA's activities in developing TSCA test rules on carbon disulfide. The Panel will continue its reanalysis ofthe NIOSH data to support both a TLV and reference concentration and present its findings to EPA and ACGIH. MISSION: The Council formed to address carrier assessment issues of concern to the CMA membership. A major goal of the Council is to help interested CMA members meet the car rier safety provisions (3.1 and 3.2) of the Distribution Code of Management Practices. These provisions require that CMA members: establish a process for qualifying carriers of all modes and types; evaluate carriers for safety fitness and regu latory compliance; and, provide feedback and suggestions for improvement to carriers on their safety performance. Activi ties to accomplish this goal include developing assessment protocols, promoting their use and working with the Distribu tion Committee to optimize assessment protocol value to chemical shippers and carriers. ACCOMPLISHMENTS: The Council completed develop ment of the Highway Carrier Assessment Protocol and com pleted pilot field testing of the final protocol. Assessment protocol development was initiated for rail, barge and con tainer vessel modes. Active participation of the carriers is a hallmark of all protocol development work. Work on these three protocols is 90% completed as of May 31, 1994. The Highway Protocol was referred to the CMA Distribution Com mittee Implementation Work Group, and Council members are working to ensure a smooth transition from the develop ment to the implementation phase. Final drafts ofthe remain ing protocols are being utilized by the Distribution Commit tee to facilitate use planning. PLANS: The Council will complete rail, barge and container vessel assessment protocols in July 1994. ChemicalDistributors MISSION: The Council formed to address issues of concern to chemical distributor members of CMA. Council activities include: collecting, evaluating and disseminating informa tion on issues that affect chemical distribution; and advocat ing the interests of the chemical distributor sector. The Coun cil maintains a strong interaction with the National Associa tion of Chemical Distributors through that Association's for mal membership in the Council. A CCOMPLISHMENTS: The Council worked to develop the Responsible Care Product Stewardship Code Assessment Protocol for Distributors. Although primarily developed for use by distributors, the protocol can be been useful in assess ing manufacturers' in-house distribution operations. PLANS: The Council plans to focus on wider dissemination and use of the Chemical Distributors Self-assessment Proto col developed in 1992 and the new implementation aid for the Product Stewardship Code. MISSION: The Panel formed to promote safety practices worldwide in the processing, packaging, warehousing, trans portation, and use ofchlorinated pool chemicals. Panel mem bers include producers of calcium hypochlorite and chlori nated isocyanurates worldwide. ACCOMPLISHMENTS: The Panel submitted its research report on chloroform releases from swimming pools to the California Air Resources Board. The Transportation Task Group's bulletin on the transportation of calcium hypochlo rite and chlorinated isocyanurates was finalized and prepared for publication. The Panel continued to research the "selfreactive" classification recommended by the U.N. Expert Committee on the Transport of Dangerous Goods and dis cussed the issue with the U.S. Department of Transportation. PLANS: The Panel will continue to work with DOT on the classification of specific pool chemicals. The transportation bulletin soon will be available for distribution to shippers of pool chemicals and personnel responsible for in-transit stor age. In addition, the Panel will continue distribution of its training videotapes for fire and emergency response person nel and guidelines for safe handling and storage ofpool chemi cals. The group will proceed with monitoring various fire and building code regulations and other requirements affect ing chlorinated pool chemicals. >i -- CMA 054549 to the various regulatory agencies. Panel member companies are awaiting the outcome of EPA's evaluation of the data. During the past year, the TSCA Interagency Testing Commit* tee designated 2,4-DNT for dermal absorption testing. The Panel submitted technical comments to ITC advocating that dermal absorption testing of 2,4-DNT is unnecessary. The Panel is waiting for ITC's response. PLANS: The Panel intends to interact with German and U.S. agencies as results of its voluntary testing are assessed. The Panel also plans to monitor ITC dermal absorption testing re quirements. Future plans include publishing research results. MISSION: Manufacturers of EBS formed the Panel to vol untarily collect, generate, and evaluate information required to complete a Screening Information Data Set (SIDS) dossier for evaluating environmental and health toxicity potentials of this chemical. ACCOMPLISHMENTS: One ofthe sixty-two chemicals as signed to Phase 3 of the OECD High Production Volume Ex isting Chemicals Voluntary Testing Program is N,N'-1,2ethanediylbisoctadecanamide, also known as N,N'-ethylenebis(stearamide) (EBS). The Panel has developed a SIDS dos sier for EBS and has worked with EPA to ensure that all avail able data and data gaps are identified for consideration in the OECD process. PLANS: Following notification of the recommendations agreed upon during the September 1993 Phase 3 OECD SIDS Review Meeting in Paris, the Panel will consider the recom mendations concerning EBS and then take appropriate action. MISSION: The Panel formed to address federal and state agencies in all safety and health issues arising from the pro duction, distribution, and use of ethylene dichloride. ACCOMPLISHMENTS: During its time as a CHEMSTAR group, p C~th<rpanel evaluated scientific literature, identified data gaps, and, in an effort to improve the research data base, com pleted a voluntaiy testing program which included chronic inhalation, metabolism, and teratogenicity studies. The Panel also responded to regulatory issues affecting EDC from vari ous federal and state agencies, such as ATSDR, EPA, OSHA, and California EPA. WHO, IF ANYONE, IS ADDRESSING OTHER ISSUES: No other group has been identified which will address EDC issues. Ethylene Glycol MISSION: The Panel formed in 1986 to augment the ethyl ene glycol toxicological data base The Panel then completed a voluntary testing program, focusing on developmental tox icity and pharmacokinetics research in mice and rats. ACCOMPLISHMENTS: As a result of the Ethylene Glycol Panel's advocacy efforts, EPA issued a proposed rulemaking in November 1993 to adjust the reportable quantity (RQ) for ethylene glycol from the statutory CERCLA default of one pound to 5,000 pounds, based on a review of EG toxicity and environmental data. In addition, the Panel was successful in correcting the classification of ethylene glycol in the pro posed Section 112(g) rulemaking before that NPRM was pub lished. The Panel also submitted extensive comments to the Agency for Toxic Substances and Disease Registry (ATSDR) on its technical report on ethylene and propylene glycol. The Toxicology Research Task Group completed two research projects, an in-vitro skin penetration study and a plasma metabolite identification study, and is in the midst of having several research projects published, including a perspective of ethylene glycol developmental toxicity, PLANS: The Ethylene Glycol Toxicology Research Task Group will continue its investigation into the mechanism of EG developmental toxicity by conducting a whole embryo culture assay on EG and a study to determine the relationship between developmental toxicity effects and the onset of meta bolic acidosis. The Panel will monitor the status of the RQ rulemaking within EPA and the final technical report from ATSDR. In addition, the Panel will provide input into ACGIH during its review process of ethylene glycol's TLV values. The Ethylene Glycol Panel will develop an appropriate strat egy for disseminating available EG data to interested patties. MISSION: The Panel formed to develop an adequate toxic ity data base on ethylene-based glycol ethers, provide infor mation to users and government agencies on the safety of the chemicals, and promote scientifically sound regulatory action. ACCOMPLISHMENTS: Results ofa number ofyear's worth of voluntary and required toxicology testing were highlighted this past year, with papers presented at an international sym posium and a number of publications published or pending. A primary focus ofthe last year, the International Symposium on Health Hazards of Glycol Ethers, was cosponsored by the U.S., Netherlands, and France and held in Nancy, France in April, 1994. Four members ofthe Toxicology Research Task Group gave oral and written presentations on ethylene glycol butyl ther, diethylene glycol butyl ether and triethylene gly col ethers. The Panel also prepared informational packages describing their research and advocacy programs for mem bers of the international audience. A number of papers given at the symposium will also be published in the peer-reviewed literature. Completed research over the past year included further re finements to a physiologically-based pharmacokinetic model of EGBE and a unique human exposure protocol to assess the K CMA 054550 nature of dermal uptake from vapors. The latter study re sponded to earlier reports that the skin could potentially be a Ethylene Oxide much greater route of exposure than even general biological MISSION: The Panel formed to evaluate the results of an considerations would predict. animal study that may affect OSHA and EPA regulatory pro ceedings on ethylene oxide. The EOIC addresses many regu The Panel sponsored active involvement in an ECETOC Tech latory and scientific activities in an effort to provide agencies nical Committee developing an Indicative Limit Value for a with enough information to make reasonable and scientifi European Union occupational standard on EGBE. A repre cally sound decisions on regulatory controls. sentative of the Panel's TRTG participated in meetings throughout the year and all of the Panel's sponsored research ACCOMPLISHMENTS: The Ethylene Oxide Industry Coun on EGBE was compiled for the effort. An ECETOC Special cil and Chemical Industry Institute of Toxicology continued Report has been published and transmitted to the Scientific cofunding a pharmacokinetics physiological modeling study Expert Committee of the European Union. being conducted at CUT. The study results will be very help ful in looking at ethylene oxide risk assessment, specifically The Panel worked with the U.S. Department of Transporta mutagenicity risk assessment. The EOIC continued working tion to submit a paper to the United Nations Committee on with the EPA on ethylene oxide risk assessment. The EOIC the Transport of Dangerous Goods. The paper proposes to worked with IARC as they revisited ethylene oxide. The epi change the current United Nations and DOT classification of demiology studies of ethylene oxide do not agree with the ethylene glycol butyl ether from its current Packing Group results ofthe animal studies and recent EOIC sponsored meta III Poisonous Substance class to non-regulated. This prece analysis further illustrates this point. This point was carried dent-setting paper utilizes acute toxicity data generated by to IARC during their ethylene oxide review. The final Haz the Panel in an alternative species, the guinea pig, as more ardous Organic NESHAPS was issued this past winter and the relevant to human assessment. The UN Committee will meet EOIC assessed how ethylene oxide may be effected. The EOIC in July, 1994 to take action on the proposal. is sponsoring an ethylene oxide flame propagation study in two and twelve inch lines. The EOIC Safety task group has The Panel brought a second and final effort forward to see had several information exchanges on ethylene oxide stew the defeat of a bill proposed by Senator Tom Hayden in Cali ardship. fornia on glycol ethers. In it's evolution, the bill's provi sions ranged from criminilazing the use of certain members PLANS: The CUT pharmacokinetics physiological model of the class to directing Cal-OSHA to carry out redundant ing study will continue, into its fourth year. The Toxicology and needless reviews. task group will review several ethylene oxide reproductive studies and evaluate ethylene oxide carcinogenicity risk as The Panel continues efforts to clarify and correct the inap sessment. The group will host with CIIT ajoint planning meet propriate use of the term "glycol ethers" in articles and state ing on mutagenicity risk assessment, this August with EPA ments characterizing toxicology, use and exposure informa representatives, industry toxicologists and academicians. A tion on the more than 30 different commercial products in scientific paper on the CIIT research will be published this cluded in the chemical category. These efforts includes let year. An international symposium cosponsored with CIIT and ters to the editor and other responses to popular press, trade EPA on mutagenicity risk assessment is planned for 1995. The and scientific journals, and the mass media. ethylene oxide flame propagation study will continue through 1994, with a final report due in January, 1995. "Information The Panel continues to seek avenues for relief from inappro Exchange" workshops focusing on safety and handling ofeth priate regulatory actions as a result of being listed as a cat ylene oxide and on toxicology issues are planned for 1995. egory of chemicals. Such regulations include those The Environmental task group will summarize the final HON implementating provisions of the Clean Air Act and Report- Standards as it effects ethylene oxide manufacturing and use. able Quantities requirements under CERCLA. A petition to They will also evaluate ethylene oxide exposure for ultimate EPA on RQs is still pending Agency action. use in risk assessment. The Industrial Hygiene task group will publish an article on ethylene oxide protective PLANS: The Panel will continue a focus on international ac clothing.trial Hygiene task group will publish an article on tivities and pursue a coordianted industry program with the the results of our ethylene oxide protective clothing research. Ethylene Glycol Ethers Sector Group of CEFIC. They hope to have a third opportunity to meet with representatives ofthe nuereattenes Group this year and will also work to include members of an MISSION: The manufacturers of fluoroalkene monomers ad hoc Japanese consortium in the discussions. Voluntary re originally formed an ad hoc coalition to address the Inter search on EGBE will continue to be supported in the area of agency Testing Committee's 1980 designation of fluoroalkenes human risk assessment and species specific mechanisms of for priority consideration under TSCA Section 4. The coali hemolysis. tion reorganized as a CHEMSTAR panel when EPA issued the final test rule. <7 ------- CMA 054551 ACCOMPLISHMENTS: In July 1992, the Panel completed the requirements for its TSCA Section 4 test rule, which in cluded mutagenicity, subchronic toxicity, and oncogenicity on four fluoroalkene monomers--vinyl fluoride, vinylidene fluo ride, hexafluoropropene, and tetrafluoroethene. PLANS: The Panel will respond to any issues regarding the results of its TSCA testing program, as well as monitor other regulatory issues on fluoroalkenes. HexamethyleneDiisocyanate MISSION: The Panel formed to address the inclusion of HDI on the Interagency Testing Committee priority list of chemicals for testing under TSCA Section 4. ACCOMPLISHMENTS: The Panel continues to wait for EPA to issue the final TSCA Section 4 test rule on HDI. In the meantime, the group commented on EPA's proposed rule making to adjust the reportable quantity for HDI from a statu tory one-pound limit to 100 pounds. In addition, the Panel responded to the inclusion of HDI on EPA's proposed Toxics Release Inventory expansion list. PLANS: The Panel will proceed with the required testing program when EPA issues the final rule. In addition, the Panel intends to contact DOT regarding HDI classification under Hazardous Material Transportation Rule 181. The group will continue to track other regulatory issues affecting HDI. MISSION: The Panel formed to support hydrazine-related product stewardship activities. Panel members have reviewed and evaluated published and unpublished literature on the health effects of hydrazine in order to maintain a current, ac curate point of reference for discussion of the safe use of hy drazine products. ACCOMPLISHMENTS: The Panel submitted comments to ACGIH on the proposal to lower the Threshold Limit Value for hydrazine from 0.1 ppm to 0.01 ppm. In response, ACGIH has postponed the decision for another year so that the TLV Committee may further consider research results. The Panel cooperated with the EPA in its Risk Management Review of hydrazine through meetings and submission of other perti nent information. The Panel also and submitted a petition to the EPA for reconsideration of the weighting factor for hydra zine under the Early Reduction Rule. The Panel submitted analytical methods for analyzing hydrazine in water and soil to the EPA for consideration in the drafting ofa proposed haz ardous waste identification rule under RCRA, and supported a petition for a new classification of hydrazine by DOT for "less than 37% hydrazine". PLANS: The Panel will continue its product stewardship ac tivities, and will work with regulatory agencies and other con cerned organizations ion matters relating to health and safety aspects of hydrazine. MISSION: The Panel formed to provide a forum for U.S. and Mexican producers and shippers to share information on safety in the manufacture, handling and transportation of, and emergency response procedures for anhydrous hydrogen fluo ride and hydrofluoric acid. ACCOMPLISHMENTS: The Panel expanded to include us ers and suppliers of raw materials as members and broadened its focus to include advocacy activities. The Management Group and Advocacy/Communications Task Group led the Panel's participation in EPA's Congressionally-mandated pro gram to prepare a study of the industry. The Panel also sub mitted to EPA an independent study of transportation inci dents involving anhydrous HF. The Panel commented exten sively on ATSDR's Draft Toxicology Profile on HF. Mem bers of the Medical & Toxicology Task Group also worked with the CMA Health and Safety Committee to develop com ments on ATSDR's draft protocols for emergency medical treatment of HF exposure victims. PLANS: The Panel will track a lawsuit filed against the Cali fornia South Coast Air Quality Management District that banned specific uses of HF. The technical task groups will work toward completion oftheir recommended guidelines for industry safety practices. The Panel will continue to host the Annual Meeting and Safety Seminar. Hytironuinone MISSION: The Panel formed in response to a TSCA Section 4 test rule published by EPA in 1984. The current focus ofthe Panel is voluntary research. ACCOMPLISHMENTS: In 1990, the Panel completed a TSCA Section 4 testing program for hydroquinone. All re quired data and reports have been submitted to EPA, and the Panel has prepared a Research Summary Report outlining the findings and conclusions of the various studies. Completed TSCA Section 4 studies include evaluations of developmen tal toxicity, reproductive toxicity, subchronic neurotoxicity, and pharmacokinetics. During the past year, the Panel initiated a voluntary research program to further evaluate the health effects of hydro quinone. Voluntary research currently in progress includes PBPK modeling and studies on epidemiology, protein bind ing dosimetry, oxidative stress in the kidney, comparative enzymology, and in vitro metabolism. To disseminate results of its research program, the Panel has published a number of abstracts and scientific articles, and has given poster presentations at various scientific confer ences. The Panel also has provided various trade groups, including the Nonprescription Drug Manufacturers Associa tion, the Cosmetic Ingredient Review, and the Cosmetic, Toiletry, and Fragrance Association, with summaries and fi nal reports of its studies. -- n-- CMA 054552 the concerns raised by the Panel were not only important for the vinyl chloride epidemiology study but also for occupa tional epidemiologic studies in general. In May, The Panel invited Dr. Richard Reitz, a consultant, to present a seminar on predicting cancer risk from vinyl chlo ride exposure with a physiologically-based pharmacokinetic (PB-PK) model. The risk assessment based on the PB-PK model predicted considerably fewer risks than would be cal culated by non-pharmacokinetic procedures. The Panel plans to meet with EPA to discuss the risk assessment of vinyl chlo ride using PB-PK and multistage modeling before the Agency develops a risk number for vinyl chloride in the Integrated Risk Information System database. VinylChloride Transportation MISSION: The Panel was formed in 1971 by vinyl chloride manufacturers to develop and assess health and safety data on vinyl chloride monomer. The Panel expanded its scope of activities in 1991 to address safety issues in the transpor tation of vinyl chloride monomer. In 1992, the Panel formed the Vinyl Chloride Transportation Network to provide tech nical expertise and assistance by the industry and contrac tors to emergency responders at vinyl chloride railroad trans portation incidents. Shippers of vinyl chloride are able to activate the network through CHEMTREC, CMA's hazard ous materials hotline. VCNet is the first mutual-aid network to be formed under CHEMSTAR, ACCOMPLISHMENTS: In September, VCNet updated an Emergency Response Operation Manual to facilitate the op eration of the mutual aid network among CHEMTREC, vinyl chloride manufacturers and users, "for-hire" contractors, and railPractices. Also in December, CHEMTREC conducted a VCNet emer gency response drill to test the operation of VCNet. The drill demonstrated that VCNet can be successfully activated in case of an emergency involving vinyl chloride. Panel members, on a periodic basis, shared non-proprietary safe-handling and distribution incident information on vinyl chloride to promote safety and to protect environmental qual ity during manufacturing and distribution. PLANS: VCNet will identify additional "for-hire" contrac tors to provide emergency response services when the ship per cannot be contacted by CHEMTREC or when the shipper cannot reach the incident site quickly. VCNet will continue to conduct periodic mock emergency response exercises to ensure that CHEMTREC, "for-hire" contractor response teams, and company response teams are aligned and can act quickly in case of an emergency. The Panel will work with CMA's Interindustry Rail Group to recommend to the American Rail road Association that future vinyl chloride railcars be con structed in a manner that would make them adaptable to a capping kit. The Panel will continue its technical support for the Vinyl Chloride Safety Awareness Training Workshops to be held throughout the U.S. The Panel will prepare a media communication brochure for VCNet and a video on the safe handling of vinyl chloride. VlnylidoneChloride MISSION: The Panel formed to sponsor research on the po tential toxicologic effects and pharmacokinetics ofVDC. The objective was to develop data for ensuring the safety of work ers involved in the manufacture, handling, and use of the chemical, as well as the safety of communities surrounding production facilities. ACCOMPLISHMENTS: The Panel tracked the California Air Resources Board Compound Review for VDC, contained in CARB's Assessment of Indoor Concentrations, Indoor Sources, and Source Emissions of Selected Volatile Organic Compounds. CARB did not include VDC in its recommen dation for further research. PLANS: The Panel will continue to respond to potential regulations affecting vinylidene chloride. WaterAdditives MISSION: The Panel formed to address regulations of di rect and indirect potable water additives. The objectives are to monitor regulatory policies, improve communication, re view toxicology data, develop advocacy positions, ensure that any water additives program is designed and administered in a cost-effective manner, and ensure that water additives are used in a manner that does not compromise public health, safety, or the environment. ACCOMPLISHMENTS: The Panel continued to work with the National Sanitation Foundation (NSF) in an effort to have NSF accept the water additives certification packages for the following chemicals: polydiallyldimethylammonium chlo ride (PDADMAC), copolymers of epichlorohydrin and dimethylamine (EPI/DMA), and polyacrylamide (PAM). The Spring of 1994, after several meetings with NSF and address ing many issues, the certification packages were finally ac cepted. Two companies have now used these certification packages along with their own company application to re ceive NSF certification for one water additive. Other Panel member companies are also seeking this certification. Even tually all Panel members will have their own water additives certified by NSF and the accepted certification packages will be used to benefit each Panel member. The data in the certi fication packages is confidential and is to be used only for the certifications of Panel members. The data is compensable and can be purchased by non-Panel members. PLANS: The Panel and Panel members will continue to work with NSF to receive water additives certification for all three chemistries. At their Spring 1994 Planning Meeting, the Panel identified a value in continuing the Panel after NSF certifica tion. The Panel will continue to monitor water additive regu- --- a --- CMA 054553