Document NG1Dnb7axmO3nxMkaKp5bQk0p

/ c fh\ }\ NOV ^ 5 6Ho . October 50, 1974 Hear Iaul: i'V following arc ry initial comments and questions on the material you scut ne on the Turner Brothers' data: Hov much information is av;dlable on those workers who fit the criteria Cor i; elusion in the study except for being alive in 1906? Table / (comparisons between Doll 195 5 and Table 1(a) ) seems to be the only reference to earlier deaths in the material I lave. 1lv othi r cor.i<a risons arc all between the experience in the cohort since 19eo and the general population. As I know vou are aware, this tvpe of staid-, can be misleading; for example, nary of the very suscep tible r.v have dj -.d before 19oo, leaving n stud. ,grout) that looks ood . i: i 1 - r.<']' detailed an.l'sis and information will get at this. A com parison with i lie :cner.il population is always sore what informative, lmt it ran, at Irasr i.n theory, !>r. misleading in either direction. That is, it is possible to . iss roblems or make them appear to exist when tlie.- don't. It is mv strong opinion that fore specialized popu lation-specific copparisons should be made whenever possible. f'-c corn rents above rone rally r*fer to d .tn that ray or r,w not be available or obtainable. -However, it should he possible to look at the cohort free a core are, lmeth of exposure, tire of exposure point of view t'an it arp-arr to have been 'o far. George in certainly petting at this duestion bv inquirinr. .bout the exixisure prior to 195r, hut 1 am thinking of an even i ore detailed analysis. Iwri not clear on the relation between TABLE 3 and the rest of the information, -.bat do the totals (o59 and 1105) refer to? The ^91 and 391 mentioned cls'-wlie re for the original aid utrdate.il cohort, respectively, do .lit ai-rcs with these figures. Undoubtedly I am missing something, either hvc.u-.-e 1 don't 1 nvc the information, or I am mis interpreting ti-r i formation J o have. 1 would also like to see e.xactlv how the "expected" values were co::put< <-!-. 1'r. :. t r.-.Tlv inter, ti oiling tlvn, but it is possible to apnrori.r>ate the** rev. r.-.l vv. v s . For oxer i le , r ing the. age at the r id-poi; t ot the. i fried md rr revi.>* can 11. ct. t o estimates, cj,.etuiin ..n Ur le 'i th n the p.-rin.;, t he ch.nr.iio rates, am the ape distri bution r-i tec cohort.. If tb-ve is lot ci l i 11 r> atirn for the period 1 rior to l'h.o, -. '"rjdn't > 1 i! e -1 a i' 1 - t: | o of lc'ok ,-11: l.h- i.-'tn t'C another useful way l;o i. .v -: i i- at-- i1' to tail rioturr? |n general, J feel that that approach is not ":--d .r i ncV as it rd'-cnld be. an envirelv Pi i. r->nt approach, how r urh i nio p-st ior i: av-i 1 a hi c in the -nr ra 1 h.v.-.l tl- status d tirin' the past.? Tire off work, d i sabi 1 i t. i" s, etc.f As w'- l-.-i-.-p ;] ready d i. -.cussed, the chronic effects l.a e far nor-, i -.- I or:->tive .-id ir.rort--.nt than just the death:;. a. i'ri -urr.-t ri.-.r iy rnoral iripronsions oT t. ho i n !o rr.ati' >: 1 H-> vo , I o.n.'t i''. np.ro* '.-ith nuv oL' tho tatn'nts - hut in some cases 1 foci thnt rnro ccul- 't. ilmo -'ncl in otho.r .-irons it won Id >* holpCul to havo. rorr. 'ict.iilc'l inioiTiat ion. rr-