Document NEwQjYmNGxKjD9p1918G5z1aw

>/!/ I I A TECHNICAL REPORT SUMMARY Umim .llllli* M i , TO: TECH N ICA L COMMUNICATIONS C E N T E R - 201-2CN IIm portant - I f report is p rin ted on both sides ofpepor. send two copies to TCCJ UiviNOn Dapt. Number c i.N lU A I. RESEARCH I.A B 0 K A T 0 R IE S , Analytical and Properties Research Laboratory 0502 *l I O |H l I ATipmor-t rTilli'i u o r o c h e m i c a l s in the Environment Protect Number A000007 Report Number AK N o . 7166 - FC-143 Inhalation Study - Analysis For F~ and RF 166 To w. C. McCOKMICK - 220-2E AwtHO'UI ION BEL1SLE, VICKI BUNNELLE Notebook Reference - Empioyaa Numbsriti 088240, 013817 No. of Rages Including Covenbeet SEC U R ITY ^ Open (Compeny Confidential) 9 Ooead (Spacial Authorisation) SM CH EM ICA L ^ R IO M T R Y W KEYW ORDS: (Salaci tarrra (rom 3M Thesaurus. Suggest other applicable terms.) CU RREN T O B JECTIV E: Request No. A71423 Central Research Analytical Report Requestor - Bill McCormick Project No. 91721100 2 New Chemicals Reported Yes Q No UN22 1979 Chemical Analysis R EP O R T A B STR A C T: (200-260 words) This A ttract information is distributed by t start 3M'ars to Company RA D . It is Company corddamisi material. (cations Cantar i The analysis of serum from the Bio/Dynamics rat inhalation study of FC-143 is reported in terms of organic and inorganic fluoride. ABSTRACT CLOSED Information Liaison Initials: 000036 CENTRAL ANALYTICAL* LABORATORY Report No. 7166 Date June__20j _1979 Subject: KC-143 Inhalation Study - Analysis For F" and RF Requestor :. Dept. Name _I<KtepJpgx____ Request No. _ A 7 1522 --------- Report: Dated . . F e frm U Jt*. 12Z* _ - p roj. No. _ 91721100 Serum from Bio/Dynamics study 78-7184 (3M designation T-2305 CoC) was received for analysis of organic and inorganic fluoride. The 2 submitted samples were from Group I, one being the male rats (animals 10-14) and the other female rats (animals 20-24). Therefore, only one exposure concentration was analyzed. Rat female male F~ (Inorganic) 0.01 ppm 0.02 RF (Organic) 2 ppm 42 It is most interesting to once again see the difference in RF levels between male and female. You will recall that the 28 day IBT and the 90 day IRDC feeding study (both reported on Request A67821, Report 6925) found the male serum FC-143 levels approximately lOOx greater than the female serum levels. The difference was con firmed by analysis of the IRDC livers. Therefore, 3 separate studies (IBT, IRDC, Bio/Dynamics) using 2 approaches (feeding, inhalation) indicate that the male rat accumulates more perfluorooctanolc acid/salt than the female. A similar study on monkeys (A68616, Report 6919) indicated no or very little difference between male and female. JB/VB/rs Vicki Bunnelle 000037