Document NELreVq9vwrJ8XRpxax4dg1Kp

FILE NAME: US Gypsum (USG) DATE: May 1937 DOC#: USG039 DOCUMENT DESCRIPTION: 1937 Progress report from Saranac Lab with cover letter to JS Offutt. v` % v~ -' tig'* Sjiffi`'r-<-:-'- ----"":S',*_/ ' I COPY . f\ . -... j o z y s -m a m v i i l e c o r p o r a t i o n TWENTY-TY/O EAST FORTIETH STREET NE'.Y y o k e , n .y . May 1 1 , 1937 u>r cX SI1U > Assistant to Presidenl S `| a States Gypsum Coapany, 300 V/est Adams Street, Chicago, 111. Re ' -BS-- Gardner - Asbestos Dust Ext-- *-- ts Dear Mr. Offutt: . Replying further to yours of April 2 9 , 1 9 37 , I M enclosing herewith copy of Dr. Gardner's first progress report dated May 5, 1 9 3 7 . | * t Very truly yours, ' Y 3 .m BD* Enclosure /s/ Vandiver 5 rov/n Vandiver `-rovra General Attorney f O K I0,, as OF Dip. IX. CO. n ste? COPY -/ 'r - - ' - ' - First Progress Report or. Asbestosis Experiments v at t"a Saranac Laboratory. Say 5, 1937. To furnish a bert^r undepeHnrinB ,, ., . provide standards L Y S f ' / u : Jfe ais?asa' asbestosis, and to animal experiments has now been started?512051* by X " r a y fll33v a group c It is expected that anatomical chantre animals inhaling fibrous a s b e i t o V ^ h i V - 3vi Pjocuced in the lungs of film comparable to those seen in cas| .shadows on an x-ray be killed as seems advisable it Since the fi n a l s can Changes in their lungs * & % * K ^ S 'tta I S s ! * ^he anatonio, i 5 to the chemical tion in the -.vails of the ai- *nao2? d ?f the result of a mild irritaicrous. foreign body (i.e Its^nhvtvtfiUlilns fro? the action of a are in progress. If no fibrosis esu?tcS'dUOt'dre^ ^ J ^ t i o n experiments in other organs it -- ay nrohaht-- >.1 . -t- ^ron accumulations of asbestos of the tissues is n^resSonsble% a!s':Sed ^ at ^cnical stimulation uua responsiole ior tne pulmonary fibrosis. action ofherou"dser-entine"i51r-' VS` the chemical hypothesis, the Since they-bot^hv^tte L e o e d ? L ? raPred-:?-th that <* chrysotile. be instructive v;hatever the result^"1 conpos-'-10- zhe conparison should f i t r M s * s<v-ereied h - ? ere ibrous structure, a search for oth -- could be d i s M r - d ThieS'h.TM^ ther thosa classified as" isbestcs because of 0-1? " ^ ^ itruoturrl composition. H 0,," ^ S fibrous) and a"= nl o sSa i d 10?.?1 EypsU3' a " c?la i satin s o " ' testing. ne of soca tremlate -rere selected, for comparator I p i i t i ' ; S S c S ; S . 0L d ` S S ; B"? S ? S a r e ' a U ^ i O 0-: lro a * a= P ^ b= lc , o: cnrysotile. re a11 ce m g compared with that beenS^ - - ! ^ rly-to ie?ort =?e than the fact that the 6vnpT. ^ 0 . . -'ishei fioararDi ^ t" ?E M d ? l 'If ^ j ^ i s ^ i ast,furishd by7 .iuipcs! `I-!?! -arch II. " e'proper^yp^o 3 * % * TM % * --- ' ^ - y "a overcome and inhalation -.vas b b d e n thi; cars. .\!ore"o*f 1. i c . e r WSiillll 3bbee"*Dp:;rrLooncre.uai rrpepdd-?.a,c' 2t0heyravt.sO,7rnSeraabvUbUaiJl\-iabO 3 4/ CEP. EX. tlO .3 FOR 13., AS OF .? A-f. n - - '**>-.* * * -r u ..-,-'; - , -J- -. ,,> ,i.: , a*-"" i;tuS=\ooV f u n o / i ^ S ! ^ 17! " H 9 W . U , w cnanged. O-sr ?:; of rh* `=lne:* unis may later b diameter. S- cic-^-if* '"tcx;f rre -e55 tnan 5 nicrc^- - develop until iuoiurpe^; 2 nn ??nnc* 5e e"Pected to` . there can be little to report W o r ^ - 11TM * 0 f or^ from 1 to 2 years The various injection experiment* - ~ o f y P lratin of that tine, it is too early to report any re^iT1! 2lthT-?a have been analysed chemically n c ^ nr' w th... purpose all cunts then ground and fractionat^ by Th^ '-ere \ - microns in diameter yr*re mvr'""on* n ^ r Particles 1 one eked by the same methods of'^nsiycis**3^ ^ ^ 02 tion v;ar ?'-in .aoulated for your information. * The various tests are Chrvsotile fT^etfo-r^) a. intravenous Injections. Have prevd d^f^icnl + n ,,,, w s. , apparently f r o n W h i b c I l ' ^ h * . u-`*"e* attempts are in progress. b. 3I1nt,r1a9p3e7ritoneal'In1J-ec-tHicns - c 5 guinea pigs, * March One killed after one month. No gross fibrosis. iln phibole a. Intravenous Infection. L rabb'ts b n < S Tfai" S ! lT'a 11 dSeS t S f i n o s s ^ S ! 8 * b. | ^ a-Deritoneel Injection. 5 guinea pigs. ?eb> 5> 2 killed after 12 and 30 ^. Oust plaques without gross i^bre^is^1^ 1*** &* intravenous Injection. I raefe-4- . nave each received 1 1 doses tot-i V n v n ?ro?ress '-o fatalities. `otall^ng 0.55 grams. ' 1i9Q3l7peritorie2l InjJection. ?5 geuuiinnee-a pni.-gs on F_eb> < died of infection. - -<tiied after 1 month. no -ibrosis. Most the dust abso: SSSfe.*- S- '- i ' ' W 3- Crocidelite a. intravenous Injection. 4- rabbits.have each -- received full dose of one gram i n '20 injections. iione killed. . ?..b*... .-Intraperitoneal -njection. 7 guinea "pigs V 2 died of infection. i,-. -- - i killed after 1 month. . Pigmented dust plaques without fibrosis.............. . Anthorhvllite ... intravenous ^Injection. 4- rabbits have each received dose of 1 gran in 20 injections* . m after 3 1/2 to 6 months respectively. No evidence oi fibrosis in the lunas, spleen, . liver or bone marrow. " b. Intraperitoneal Injection. 5 guinea oies. - 3 _killed after 1, L and 3 months respectively. Disappearing reaction with gross evidence of fibrosis'. ' " ' Serpentine a. Intravenous Injection. L rabbits have each received full dose of 1 gram in 20 injections. All 'a-1*ve'and well. . " b. Intraperitoneal Injection. 5 guinea piss. 2 killed after 1 and L months respectively. . Soft pigmented dust plaques Without fibrosis. Fibrous C-ypsum - Satin Soar a. Intravenous Injection. L rabbits have eac~ 11 of 20 injections, or a total of 0.55 *-*.-, fatalities. . ';V - b. Intraperitoneal Injections - not mace. t -v . . . Soca ?ren.oli te - -- . -,. ._ a * Intravenous Injection. L rabbits have each re-- i-ed to.au. dose of 1 gram: in 20 injections. All alive ana well. ' - " b. Intraperitoneal Injection. 5 guinea pigs. . , ^ killed ax .<=r 1 month. Sni]_ pigmented dust t' * - '.--%-.-,s-vAi- v--iw-r ./-si-'a*-'.-- i ' - ; ; *-;' - ' ^ -- . : -% .. :V'AATk -` '' -r:r.iJ`'r-sV'^.v ' *- V rfrss.r-T4--... -- A '; V. iN ''v ~': ' , / _ _ plaques 'runout fibrosis. * 'v-- -` : - %/? -Si- `^?ne. "ff? sarly results is regarded as slsnifleant and no -e dr-rri tbe observations have been continued t?ih i,,iSS * ne re" - Xt is not <'et clear whether the d i f f i c u l t ! M njeciions of chr/sotile are merely a matter of w.,.ee aarrae *aPttt+epmrpntii^negtht!or 'd^is1cSovseubrstth:eicecauisse.essen.tially toxic.