Document NEB9R9ZbL91X10nYVxGr81d4b

TNO report Transcriptome analysis of effects of Fenofibrate or PFOS in intestine of ApoE3L.CETP mice TNO Metabolic Health Research Zernikedreef 9 P.O. Box 2215 2301 CE Leiden The Netherlands www.tno.nl T +31 888 666 028 F +31 888 660 603 info-pharma@tno.nl Date 30 October 2012 Author(s) Thomas Kelder, Lars Verschuren, Elsbet Pieterman, Hans Princen Version Previous version(s) Number of pages Number of appendices Customer Project name TNO project number 3M project number Final report Draft report 19-September 2012 59 3 3M Medical department Expression pattern of intestinal transporters in male ApoE3L.CETP mice treated with fenofibrate or PFOS 3M#07 - 051.01978 ToxDocs 11-459 Signature and date: E.J. Pieterman, B.Sc. Principal investigator Dr. H.M.G. Princen Study director Mr. C.M. Ort Head of the department Metabolic Health Research All rights reserved. No part of this publication may be reproduced and/or published by print, photoprint, microfilm or any other means without the previous written consent of TNO. In case this report was drafted on instructions, the rights and obligations of contracting parties are subject to either the General Terms and Conditions for commissions to TNO, or the relevant agreement concluded between the contracting parties. Submitting the report for inspection to parties who have a direct interest is permitted. 2012 TNO TNO report - Final 3M#07 TNO Project number: 051.01978 2 / 59 Contents Sponsor of the study ............................................................................................................... 3 Testing facility .......................................................................................................................... 3 Framework of collaboration .................................................................................................... 3 Responsible personnel............................................................................................................ 3 1 Introduction .............................................................................................................. 5 1.1 Aim............................................................................................................................. 5 2 Methods .................................................................................................................... 6 2.1 Study design .............................................................................................................. 6 2.2 Mice ........................................................................................................................... 6 2.3 Animal welfare ........................................................................................................... 6 2.4 Diets........................................................................................................................... 6 2.5 Treatment .................................................................................................................. 7 2.6 Groups ....................................................................................................................... 7 2.7 Small intestines; storage and homogenization .......................................................... 7 2.8 RNA isolation and microarray hybridization .............................................................. 7 2.9 Gene expression data analysis ................................................................................. 7 3 Results ...................................................................................................................... 9 3.1 Differentially expressed genes .................................................................................. 9 3.2 Pathway analysis ....................................................................................................... 9 3.3 Transcription factors ................................................................................................ 10 3.4 Lipid metabolism genes ........................................................................................... 12 3.5 Transporters based on GO ...................................................................................... 12 3.6 Comparison with liver gene expression................................................................... 14 4 Conclusion ............................................................................................................. 17 5 Appendices ............................................................................................................ 18 5.1 Quality control & pre-processing evaluation report ................................................. 18 5.2 Full list of genes related to transport processes that are significantly regulated by FF or PFOS ................................................................................................................... 49 5.3 Overview of affected transport processes (enrichment analysis on the transport GO terms)....................................................................................................................... 52 TNO report - Final 3M#07 TNO Project number: 051.01978 3 / 59 Sponsor of the study Sponsor Study contact 3M Medical department 3M Center, Building 0220-06-W-08 St.Paul, Minnesota 55144-1000 USA John L. Butenhoff, Ph.D., CIH, DABT Corporate Scientist 3M, Medical Department 3M Center, Building 0220-06-W-08 St.Paul, Minnesota 55144-1000, USA Phone: +1.651.733.1962 Fax: +1.651.733.9066 E-mail: jlbutenhoff@mmm.com Testing facility TNO Metabolic Health Research Mail address: P.O.Box 2215, 2301 CE Leiden Delivery address: Zernikedreef 9, 2333 CK Leiden The Netherlands TNO Microbiology and Systems Biology Mail address: P.O.Box 360, 3700 AJ Zeist Delivery address: Utrechtseweg 48, 3704 HE Zeist The Netherlands Framework of collaboration Animal work and RNA isolation were performed at TNO Metabolic Health Research, Leiden. Microarray analysis was carried out at Service XS B.V. (Leiden, The Netherlands). Transcriptome analysis was performed at TNO Microbiology and Systems Biology, Zeist. Responsible personnel Principal Investigator Elsbet Pieterman, B.Sc. Phone: +31 888 666 028 Fax: +31 888 660 603 E-mail: elsbeth.pieterman@tno.nl Principal Investigators transcriptome analysis Dr. Thomas Kelder/Dr. Lars Verschuren Phone: +31 888 664 270/ +31 888 666 039 E-mail: thomas.kelder@tno.nl/lars.verschuren@tno.nl TNO report - Final 3M#07 TNO Project number: 051.01978 Study director(s) Technical staff Dr. Hans M.G. Princen Phone: +31 888 666 124 Fax: +31 888 660 603 E-mail: hans.princen@tno.nl Annemarie Maas B.Sc. Elsbet Pieterman B.Sc. Varshna Goelela B.Sc. Dr. Thomas Kelder Dr. Lars Verschuren 4 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 5 / 59 1 Introduction In a previous study performed for 3M, 3M#03 (project number: 031.12685), the mechanism responsible for the lipid lowering effects of three perfluoralkyl sulfonates, including transcriptome analysis of liver, was investigated in APOE*3Leiden/huCETP transgenic mice. The test compounds were the potassium salts of perfluorobutanesulfonate, perfluorohexanesulfonate, and perfluorooctanesulfonate (PFOS). Fenofibrate (FF), a known hypolipidemic drug that works via activation of xenosensor nuclear receptor NR1C1 (PPAR), was included as a positive control. In addition to collecting liver tissue, total small intestines were collected, snap frozen and stored at -80C. The study reported herein analyzed the mRNA transcription patterns associated with intestinal transport processes and lipid metabolism from the small intestines of mice fed PFOS and FF that were obtained from the 3M#03 study. The genomic transcription expression patterns in small intestine were then compared to those in obtained for liver in the 3M#03 study. The information obtained is of value in understanding the differential effects of PFOS and FF on lipid homeostasis in the APOE*3Leiden/huCETP transgenic mouse model. 1.1 Aim To investigate the expression patterns of genes involved in intestinal transport and lipid metabolism in samples of small intestines from male ApoE3L.CETP transgenic mice fed PFOS or FF using the Affymetrix technology platform and Affmetrix GeneChip mouse genome MOE430-2.0 arrays and to compare these intestinal expression pattern to those previously analyzed from liver samples obtained from the same study. TNO report - Final 3M#07 TNO Project number: 051.01978 6 / 59 2 Methods 2.1 Study design Microarray and transcriptome analysis was performed on isolated RNA from intestines collected from group 1, 2 and 5 of experiment 3 of the 3M-03 study (n=5 per group). See also figure 1 for the study design. Weeks of treatment: -4 -3 -2 -1 0 1 2 3 4 Group 1: diet WTD x x Group 2: WTD + 0.03 % fenofibrate x x Group 5: WTD + 0.003 % PFOS x x mRNA isolation intestine, microarray intestine x Figure 1. Study design for transcriptome analysis on intestines 2.2 Mice Male heterozygous APOE*3Leiden.CETP mice, 7-10 weeks of age, from the SPF breeding stock at TNO-Biosciences (Leiden) were used. Mice were housed during the experiment in macrolon cages (maximum 4 mice per cage), in cleanconventional animal rooms at TNO-Leiden (relative humidity 50-60%, temperature ~21C, light cycle 7 am to 7 pm). Individual animals were marked by ear punch- holes. Mice were supplied with food and acidified tap water ad libitum. 2.3 Animal welfare Experiments performed conformed to the rules and regulations set forward by the Netherlands Law on Animal Experiments. Experiments were approved by the Animal Experiment Committee of TNO under registration number 2483. The study director was entitled to terminate experiments in case of serious, unexpected animal discomfort. 2.4 Diets Mice received Western type diet (WTD; semi synthetic diet containing 14% beef tallow, 1% corn oil and 0.25% of cholesterol), purchased from ABdiets (Woerden, The Netherlands). This diet resulted in baseline total cholesterol (TC) plasma levels of about 8 mmol/L and triglyceride levels of about 2 mmol/L. Diets were renewed once per week. TNO report - Final 3M#07 TNO Project number: 051.01978 7 / 59 2.5 Treatment FF or PFOS were incorporated into the Western type diet as a food admix at the following concentrations: 0.003% w/w PFOS in the diet (nominally 3.0 mg/kg bw/day); 0.03% w/w FF (nominally 30 mg/kg bw/day). 2.6 Groups 1) Control group: diet WTD 2) WTD + 0.03% FF (30 mg/kg bw/day) 5) WTD + 0.003% PFOS (3.0 mg/kg bw/day) (n=5) (n=5) (n=5) 2.7 Small intestines; storage and homogenization After sacrifice of the animals, total small intestines were collected, snap frozen in liquid nitrogen and stored at -80 C (storage since 25 September 2008) until RNA isolation. The intestines were homogenized under liquid nitrogen using a RNAseway pre-treated mortar and pestle, which were placed on dry ice during the whole procedure. Not all the intestinal tissue was used for RNA isolation. Intestinal tissue not used for transcriptional analysis was stored after homogenization at -80C for protein expression levels of intestinal and/or liver transporters (mRNA expression levels do not always parallel protein expression levels). 2.8 RNA isolation and microarray hybridization RNA was isolated from homogenized small intestines using RNABee (Tel-Test, Inc) and NucleoSpin RNA II kit (Machery Nagel). After quality control of the RNA, microarray analysis was carried out at Service XS B.V. (Leiden, The Netherlands) using the Affymetrix technology platform and Affymetrix GeneChip mouse genome MOE430-2.0 arrays. Data were sent to TNO. 2.9 Gene expression data analysis Preprocessing and quality control of the microarray data was performed using the ArrayAnalysis.org pipeline, which combines BioConductor packages for Affymetrix analysis (simpleaffy, affyPLM, affyQCReport). All samples passed the QC (see also appendix 5.1 for the QC and pre-processing evaluation report). Raw signal intensities were normalized using the GCRMA algorithm applied across all arrays in the dataset. Probe-level signals were summarized to gene-level intensities using the custom MNBI CDF-file (Entrez Gene annotation, version 15.0.0). This resulted in expression values for 17370 genes, represented by unique Entrez Gene identifiers. Normalized intensities were log transformed (base2). Statistical analysis was performed using the moderated t-test (empirical Bayes method) as implemented in the Bioconductor package limma (http://bioinf.wehi.edu.au/limma/). Resulting p-values were corrected for multiple testing using the Benjamini-Hochberg procedure. The cut-off for statistically significant changes was set at multiple testing adjusted p-value <0.05. TNO report - Final 3M#07 TNO Project number: 051.01978 8 / 59 To provide an overview of affected processes, a T-profiler analysis (http://www.tprofiler.org) was performed using expression values corrected for mean expression in the control group. This analysis resulted in scores (t-scores) and significance values for pathways and biological processes. A positive score means that the majority of the genes in the pathway are up-regulated; a negative score means that the majority of the genes in the pathway are down-regulated. Pathways and biological processes with significant scores (absolute score > 4) in at least 3 animals were selected. A hierarchical clustering (complete linkage, pearson-based distance) of these biological processes was generated in R (http://www.rproject.org) and visualized as heatmap using the heatmap package. To identify affected transcription factors, upstream regulator analysis was performed using the Ingenuity Pathway Analysis (IPA) software. This analysis determines activation state of transcription factors based on the observed differential gene expression. This results in an overlap p-value and activation zscore for each transcription factor in the IPA knowledgebase. The overlap p-value indicates the significance of the overlap between the target genes of the transcription factor and the differentially expressed genes. The activation z-score indicates the significance of the activation (positive z-score) or inhibition (negative z-score) of the transcription factor, based on how well the expected response of the target gene expression matches the measured differential gene expression. To further investigate processes specifically related to intestinal transport, gene ontology (GO) analysis was performed on GO terms categorized under the term "Transport" (GO:0006810) in the Biological Process ontology. This resulted in 1303 terms related to different types of transport. This list of terms contained several transport processes not directly relevant for intestinal transport: vesicle-mediated transport (GO:0016192), intracellular transport (GO:0046907), and nucleobasecontaining compound transport (GO:0015931). These terms and their offspring were excluded. Note that although vesicle-mediated transport was excluded, genes relevant to cholesterol vesicle-mediated transport process are still included in the analysis because they are present in the more generic cholesterol transport term. Overrepresentation analysis was performed on the filtered list of GO terms using the TopGO Bioconductor package. This resulted in a p-value per term that indicates enrichment of the genes in each term with significant genes, based on how many significant genes were expected to occur by chance alone. TNO report - Final 3M#07 TNO Project number: 051.01978 9 / 59 3 Results 3.1 Differentially expressed genes In the statistical analysis the PFOS and FF groups were compared to the control group. FF resulted in 247 differentially expressed genes, PFOS resulted in 2531 differentially expressed genes (figure 2). significant genes 3000 2500 2000 # genes 1500 1000 500 0 FF PFOS Figure 2. Number of differentially expressed genes for FF and PFOS compared to control. The overlap in differentially expressed genes between FF and PFOS is shown in figure 3. Of the 247 significant genes for FF, 113 (45.7%) are also regulated by PFOS. Figure 3. Venn diagram of the overlap between differentially expressed genes for FF and PFOS. 3.2 Pathway analysis Figure 4 gives an overview of functional gene sets (based on gene ontology annotation) regulated by FF or PFOS. The clustered heatmap shows a number of groups of gene sets with a similar response profile. The first cluster contains processes related to immune response, and is down-regulated specifically by FF. TNO report - Final 3M#07 TNO Project number: 051.01978 10 / 59 The second cluster contains processes related to cell-cell interaction (e.g. chemotaxis, extracellular matrix) and is down-regulated by both FF and PFOS. The third cluster contains translation-related processes and is down-regulated specifically by PFOS. In addition, the fourth cluster, related to cell division is also down-regulated by PFOS. Both the fifth and sixth clusters, containing gene sets related to cholesterol transport and intercellular signalling respectively, are specifically up-regulated by PFOS. Finally, the seventh cluster, comprising mostly processes related to oxidative phosphorylation is up-regulated by both FF and PFOS. T-score Immune response Cell-cell interaction Translation Cell division Cholesterol transport Intercellular signaling Oxidative phosphorylation Figure 4. Clustered heatmap of scores for functional gene sets (based on Gene Ontology) that are significantly affected in at least 3 animals. Boxes are colored by scores, where red indicates a positive score (majority of genes up-regulated) and blue a negative score (majority of genes downregulated). The main overlap in regulated processes between FF and PFOS is oxidative phosphorylation, which is significantly up-regulated by both treatments. Also in cellcell interaction processes there is overlap between FF and PFOS. Immune response is significantly down-regulated by FF alone, while cholesterol transport is significantly up-regulated by PFOS alone. 3.3 Transcription factors In addition to the affected processes, we aimed to identify activated or inhibited transcription factors relevant in regulating these processes, focusing on transcription factors involved in lipid metabolism in particular. Table 1 shows the top five activated or inhibited transcription factors for FF and PFOS, based on Ingenuity upstream regulator analysis. For each transcription factor, the table lists its differential expression (as log2 ratio), and an activation state prediction based on the expression of its known target genes. This prediction is based on two scores listed in the table, the activation z-score and overlap p-value. The activation z-score TNO report - Final 3M#07 TNO Project number: 051.01978 11 / 59 indicates how well the measured up or down-regulation matches the known effects of the transcription factor on its targets. The overlap p-value indicates how well the set of known targets overlaps with the measured differentially expressed genes. Transcription Factor TRIM24 STAT1 NKX2-3 NR1I2 IRF1 Log Ratio 0.056 -0.589 -0.029 -0.242 -0.133 Transcription Factor HNF4A PPARA E2F4 RORA MYC Log Ratio -0.052 0.443 0.048 -0.213 -0.191 Fenofibrate Predicted Activation Activation z-score Activated Inhibited Activated Inhibited PFOS 5.144 -4.315 4.025 1.911 -3.569 Predicted Activation Activation z-score Activated Activated Activated Inhibited 5.382 2.253 -0.271 2.887 -5.313 Overlap p-value 2.03E-29 1.40E-14 8.68E-13 1.96E-10 2.62E-09 Overlap p-value 2.10E-21 2.57E-11 9.08E-08 3.94E-07 5.76E-07 Table 1. Top five transcription factors resulting from the Ingenuity upstream regulator analysis for Fenofibrate and PFOS. A z-score 2.0 or -2.0 is considered significantly changed. These data highlight several transcription factors that connect to the observations based on pathway analysis as described in section 2.2. For example, MYC (cMYC), a transcription factor driving proliferation, is predicted to be inhibited by PFOS specifically. This is in line with the down-regulation of proliferation-related processes "Cell division" and "Translation" upon PFOS treatment as observed in the pathway analysis (Figure 3). In addition, STAT1, which is part of a family of nuclear proteins mediating the action several cytokines and known to play a role in the immune system is inhibited by FF specifically, linking to the down-regulated "Immune response" cluster in the pathway analysis. Focusing on lipid metabolism, data for transcription factors of interest related to lipid metabolism are listed in Table 2. These data show that both FF and PFOS activate several lipid metabolism related transcription factors or complexes containing these transcription factors. In the case of FF, four transcription factors are significantly activated, and, for PFOS, six transcription factors are significantly activated. The main difference between FF and PFOS in these transcription factors is the absence of significant activation of PPAR, PPAR, and LXR after FF treatment. Although the activation z-scores for PPAR and PPAR are positive, they do not reach the required significance level. TNO report - Final 3M#07 TNO Project number: 051.01978 12 / 59 TF PPAR PPAR RXR LXR PXR CAR Protein/complex PPARA PPARG RXRA NR1H2 PXR ligand-PXR-Retinoic acid-RXR NR1I2 Ncoa-Nr1i2-Rxra NR1I3 TF PPAR PPAR RXR LXR PXR CAR Protein/complex PPARA PPARG RXRA PPAR-RXR NR1H3 PXR ligand-PXR-Retinoic acid-RXR NR1I2 NR1I3 Fenofibrate Log Ratio 0.322 0.144 0.083 -0.114 -0.242 0.328 PFOS Log Ratio 0.443 -0.430 0.161 0.550 0.229 0.179 Predicted Activation Activated Activated Activated Activated Predicted Activation Activated Activated Activated Activated Activated Activated Activation z-score 1.715 1.819 2.791 2.777 1.911 2.000 2.934 Overlap p-value 2.92E-09 2.81E-02 3.83E-05 3.25E-02 3.19E-08 1.96E-10 6.82E-05 4.05E-08 Activation z-score 2.253 5.320 1.516 2.236 2.135 2.236 -0.558 2.624 Overlap p-value 2.57E-11 3.74E-05 2.36E-02 1.42E-02 5.36E-02 1.26E-01 3.62E-04 1.86E-02 Table 2. Results from the Ingenuity upstream regulator analysis of transcription factors relevant for lipid metabolism. A z-score 2.0 or -2.0 is considered significantly changed. 3.4 Lipid metabolism genes A set of genes of interest related to lipid metabolism was defined, based on the list used in the previous study investigating gene expression changes in liver (3M#03). The expression changes as a result of FF and PFOS intervention are listed in the excel file added to this report (Suppl. table 1, see also table 4-7 for comparison between small intestine and liver expression), grouped by specific processes (e.g. lipolysis, beta oxidation, uptake). Of the 95 genes for which a mouse gene identifier could be found, 91 were found to be expressed. Intervention with FF resulted in 6 significantly regulated pre-selected genes, of which 4 were down and 2 were upregulated. The PFOS intervention resulted in 31 significantly regulated pre-selected genes, of which 26 were up and 5 were down-regulated. Of the 6 pre-selected genes regulated by FF, 5 were also regulated by PFOS (SCD1, Acsl6, Acox2, Acaa1b, CD36). 3.5 Transporters based on GO In addition to the global pathway and transcription factor analysis, we zoomed in to transporter processes more specifically. Based on the Gene Ontology functional annotation, we defined a list of transport processes and genes playing a role in transport. Excel file Supplementary table 2 (see also appendix 5.2) provides a full list of 211 genes related to transport processes that were found to be significantly regulated in FF or PFOS. To provide an overview of affected transport processes, we performed enrichment analysis on the transport GO terms. Supplementary table 3 (see also appendix 5.3) lists terms that were significantly enriched with differentially expressed genes. For both FF and PFOS these include fatty acid TNO report - Final 3M#07 TNO Project number: 051.01978 13 / 59 transport, carbohydrate transport, and organic cation transport. For PFOS, but not for FF, cholesterol and steroid transport were also found to be significantly enriched with up-regulated genes. Table 3 lists the significantly regulated genes for lipid, fatty acid, and cholesterol transport. Overall, PFOS has a more extensive effect on both fatty acid and cholesterol transport. For PFOS, 43 genes related to these transport processes are significantly regulated of which 35 are up-regulated, while FF regulates only 5 genes. Only one gene (Slco3a1) is significantly regulated by FF but not by PFOS. This gene, which is down-regulated by FF, is part of the solute carrier organic anion transporter family and is involved in transport of prostaglandins. The other 4 genes regulated by FF are also regulated by PFOS in the same direction. Gene Abca1 Apoa1 Apoa2 Apoa4 Apoc1 Apoc2 Lrp6 Pon1 Soat1 Nr1h3 Stard3 Npc1l1 Apob Ace Plin2 Fabp2 Pla2g4a Pparg Slc25a17 Slco2a1 Slc27a2 Slc27a4 Acsl4 Slco3a1 Acsl6 Irs2 Acsl5 Cd36 Pla2g10 Apoh Atp8a1 Atp9a Mttp Ppara Rbp4 Ncor1 Abca7 Atp9b Osbpl1a Osbpl3 Spns1 Osbp Osbpl6 Atp11c GO Term Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Cholesterol transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport Fatty acid transport, Cholesterol transport Fatty acid transport, Cholesterol transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Lipid transport Log ratio FF 0.399656498 -0.013288054 -0.015664843 0.020732206 0.157078306 0.053058232 0.114634192 0.174067816 -0.30075352 0.403793146 0.331645073 -0.038333172 0.02962116 0.784504955 0.206782996 0.044312676 -0.299450267 0.144238673 -0.138422212 -0.003232584 0.217371068 0.079582 -0.181161325 -0.352662435 -1.089101021 0.091281184 0.063527376 0.902175972 0.156001682 0.151326465 0.010815546 -0.046226118 0.133672906 0.321692959 0.261885841 -0.087039968 -0.00093738 -0.042787572 0.513281719 0.049679582 0.032927194 -0.077245556 0.316647745 -0.042425327 Log ratio PFOS 0.443072493 0.173022994 1.930995618 0.148084 2.892596171 0.201098616 0.478049359 1.396351251 -0.368232718 0.549647293 0.416774058 0.396216094 0.22312843 0.727528929 0.521267518 0.17663018 -0.773886139 -0.429813179 -0.621176806 0.276017563 0.321086678 0.491262696 -0.361629619 0.165143781 -0.909807239 0.725427648 0.199618908 0.362311736 adj. p-value FF 0.062922264 0.966169442 0.996523819 0.940374602 0.937047146 0.832105695 0.762021683 0.865544216 0.264580815 0.130927537 0.018252518 0.939331136 0.937047146 0.00621252 0.42001136 0.852409611 0.584626097 0.75574906 0.775853991 0.99667172 0.225444714 0.881634889 0.557141061 0.019098564 0.04007155 0.895840566 0.76081509 0.000330286 adj. p-value PFOS 0.009227433 0.021628587 0.005313706 0.045425502 0.000401783 0.021869206 0.005140573 0.001486693 0.035739568 0.007424532 0.00189498 0.007570549 0.027931954 0.003035417 0.003347215 0.026935752 0.008605923 0.022559948 0.004386132 0.048332391 0.010855195 0.007497354 0.024669412 0.133439813 0.023157133 0.003301897 0.018621682 0.027625836 -0.791892031 1.007759024 0.218925917 0.408690367 0.19549194 0.44323114 1.015488235 0.20055416 0.650276019 0.386668953 0.927176281 0.539486384 0.314080719 0.403201078 0.304845396 -0.212064254 0.859851753 0.873732013 0.977072624 0.947515973 0.319022268 0.161773479 0.85662955 0.643859039 0.999068508 0.940319582 0.132895066 0.942016181 0.954223013 0.848015564 0.081215497 0.893349246 0.010252283 0.004206667 0.025805131 0.024435828 0.022372955 0.009227433 0.032792997 0.024887407 0.009291023 0.015203566 0.002158091 0.006742039 0.025464131 0.006588983 0.022992524 0.025998398 Table 3. Genes annotated to GO terms "Lipid transport", "Fatty acid transport", or "Cholesterol transport" that are significantly regulated by FF or PFOS. The log ratio column is colored according to the direction of regulation (red is up-regulated, blue is down-regulated). Significant p-values are marked with bold font type TNO report - Final 3M#07 TNO Project number: 051.01978 14 / 59 3.6 Comparison with liver gene expression In a previous analysis in this experiment (3M#03 study), liver gene expression was analysed. In comparison to liver, there are less significantly regulated genes involved in lipid metabolism, especially for FF. For the set of preselected lipid metabolism related genes more than 50% was regulated for both FF and PFOS in liver, but only 6.6% and 34% respectively in intestine (for comparison of gene expression of preselected lipid metabolism related genes between liver and intestine see table 4, 5, 6 and 7). Pathway common name TG metabolism lipolysis LXRb LXRa FXR PPARa PPARg LPL HL ApoC 3 ApoC 1 ApoC 2 ApoA5 GPIHBP1 C ontrol 4.48 6.77 9.78 11.03 5.58 8.92 10.82 14.10 13.81 12.49 13.14 7.41 Average expression (2log) Liv e r small intestine Fenofibrate PFOS C ontrol Fenofibrate PFOS 4.33 6.76 9.82 11.33 5.28 11.13 10.42 13.98 13.77 12.54 12.94 7.52 4.37 6.42 10.06 10.55 6.18 10.01 10.33 14.08 13.71 12.11 12.45 7.85 5.48 5.52 9.04 8.53 6.41 7.03 1.77 13.47 3.25 13.62 2.79 2.59 5.37 5.93 8.82 8.85 6.56 7.23 1.78 13.38 3.41 13.67 2.84 2.47 5.58 6.07 8.86 8.97 5.98 6.71 1.81 13.54 6.14 13.82 3.10 2.44 Fenofibrate vs control PFOS vs Control Liv e r small intestine Liv e r small intestine Fold change q-value Fold change q-value Fold change q-value Fold change q-value -1.11 -1.01 1.03 1.23 -1.23 4.63 -1.32 -1.08 -1.03 1.04 -1.15 1.08 0.271 0.505 0.436 0.055 0.256 0.000 0.000 0.011 0.235 0.402 0.064 0.344 -1.08 1.32 -1.16 1.25 1.11 1.15 1.01 -1.07 1.12 1.04 1.03 -1.09 0.683 0.131 0.596 0.162 0.756 0.866 0.983 0.510 0.937 0.832 0.955 0.727 -1.08 -1.27 1.21 -1.40 1.52 2.13 -1.40 -1.01 -1.07 -1.30 -1.61 1.36 0.277 0.008 0.028 0.003 0.042 0.000 0.000 0.370 0.020 0.003 0.000 0.012 1.07 1.46 -1.13 1.36 -1.35 -1.25 1.03 1.05 7.43 1.15 1.24 -1.11 0.447 0.007 0.398 0.009 0.023 0.410 0.839 0.359 0.000 0.022 0.079 0.295 FA/TG synthesis LXRa 6.77 6.76 6.42 FXR 9.78 9.82 10.06 PPARa 11.03 11.33 10.55 PPARg 5.58 5.28 6.18 SREBP1a/c 11.05 10.90 10.03 PXR 6.74 7.10 7.41 FAS 10.06 10.99 9.89 DGAT1 5.99 6.56 6.44 DGAT2 9.25 9.02 9.04 SC D1 13.15 13.47 13.10 SC D2 1.98 2.10 2.30 AC LY 11.10 11.02 9.79 s14 12.36 12.75 12.53 AC S, Acsl1 11.68 12.79 12.48 AC S, Acsl3 6.89 8.51 7.67 AC S, Acsl4 8.29 8.95 8.78 AC S, Acsl5 11.73 12.31 11.76 ACS, Acss1 2.04 2.03 2.28 ACS, Acss2 10.77 11.58 10.43 ACS, Acsm1 11.23 10.89 11.18 ACS, Acsm2 2.09 1.95 2.05 ACS, Acsm3 9.74 9.92 9.25 ACS, Acsm5 9.85 9.77 9.94 AC S, Acsl6 measured, but not expressed SC D3 measured, but not expressed SC D4 not measured (not on array) ACC, Acaca not measured (not on array) ACC, Acacb not measured (not on array) ACS, Acsm4 not measured (not on array) ACS, Acss3 not measured (not on array) S14-THRSP -SP OT14 12.36 12.75 12.53 5.52 9.04 8.53 6.41 10.10 7.96 6.23 12.28 8.51 11.39 7.40 9.15 5.33 7.22 9.00 4.34 13.29 8.91 8.59 1.97 1.60 5.07 5.38 5.80 1.98 6.57 2.89 5.93 8.82 8.85 6.56 10.37 7.72 6.85 12.32 8.68 12.10 7.66 9.23 6.32 7.36 9.33 4.16 13.35 8.93 8.77 1.91 1.63 5.03 5.43 4.71 1.93 6.82 2.97 6.07 8.86 8.97 5.98 11.09 8.19 6.58 12.58 8.73 11.99 8.03 9.04 6.37 7.29 9.33 3.98 13.49 9.04 8.40 2.04 1.59 4.26 5.36 4.89 1.94 7.24 3.29 -1.01 1.03 1.23 -1.23 -1.11 1.28 1.90 1.48 -1.17 1.24 1.09 -1.05 1.31 2.15 3.07 1.58 1.49 -1.01 1.76 -1.27 -1.10 1.13 -1.06 0.505 0.436 0.055 0.256 0.350 0.010 0.068 0.002 0.046 0.207 0.247 0.476 0.326 0.000 0.000 0.000 0.001 0.487 0.068 0.000 0.130 0.168 0.373 1.32 -1.16 1.25 1.11 1.20 -1.18 1.54 1.03 1.13 1.63 1.19 1.06 1.99 1.10 1.26 -1.13 1.05 1.01 1.13 -1.04 1.02 -1.03 1.03 -2.13 -1.03 1.19 1.06 0.131 0.596 0.162 0.756 0.305 0.161 0.095 0.904 0.410 0.008 0.592 0.832 0.268 0.513 0.107 0.557 0.761 0.973 0.507 0.927 0.897 0.954 0.968 0.040 0.858 0.660 0.858 -1.27 1.21 -1.40 1.52 -2.03 1.59 -1.13 1.37 -1.16 -1.03 1.25 -2.47 1.12 1.73 1.71 1.40 1.03 1.18 -1.26 -1.04 -1.02 -1.40 1.06 0.008 0.028 0.003 0.042 0.000 0.000 0.374 0.008 0.042 0.420 0.013 0.003 0.389 0.000 0.016 0.001 0.407 0.057 0.257 0.305 0.371 0.001 0.300 1.46 -1.13 1.36 -1.35 1.98 1.17 1.28 1.23 1.17 1.51 1.55 -1.09 2.05 1.05 1.25 -1.28 1.15 1.09 -1.14 1.05 -1.01 -1.76 -1.02 -1.88 -1.03 1.60 1.32 1.31 0.326 1.12 0.389 0.007 0.398 0.009 0.023 0.000 0.051 0.185 0.004 0.066 0.006 0.011 0.375 0.070 0.586 0.026 0.025 0.019 0.333 0.189 0.704 0.935 0.001 0.941 0.023 0.675 0.014 0.013 beta oxidation PPARa PGC 1alpha PXR C AR C PT1a C PT1b ACO, Acox1 ACO, Acox2 ACO, Acox3 bifunc tional enzym thiolase, Acaa1a thiolase, Acaa1b thiolase, Acaa2 AC S, Acsl1 AC S, Acsl3 AC S, Acsl4 AC S, Acsl5 ACS, Acss1 ACS, Acss2 ACS, Acsm1 ACS, Acsm2 ACS, Acsm3 ACS, Acsm5 AC S, Acsl6 C PT1c HNF3b-FoxA-2 HNF4a TR 11.03 6.40 6.74 7.46 10.89 2.60 13.55 10.85 2.18 12.71 10.26 14.31 12.74 11.68 6.89 8.29 11.73 2.04 10.77 11.23 2.09 9.74 9.85 measured, measured, 8.58 9.02 3.53 11.33 6.50 7.10 7.86 11.25 5.20 14.14 10.99 2.05 14.33 11.17 14.68 13.02 12.79 8.51 8.95 12.31 2.03 11.58 10.89 1.95 9.92 9.77 but not but not 8.37 8.77 3.33 10.55 5.12 7.41 8.32 10.74 3.84 14.03 11.26 2.07 14.24 11.12 14.62 12.82 12.48 7.67 8.78 11.76 2.28 10.43 11.18 2.05 9.25 9.94 expressed expressed 7.68 8.77 3.39 8.53 10.01 7.96 6.63 10.12 11.48 5.71 2.63 11.11 10.41 12.33 11.30 7.22 9.00 4.34 13.29 8.91 8.59 1.97 1.60 5.07 5.38 5.80 2.34 8.85 9.90 7.72 6.96 10.10 11.62 7.28 2.45 10.96 10.84 12.66 11.46 7.36 9.33 4.16 13.35 8.93 8.77 1.91 1.63 5.03 5.43 4.71 2.38 8.97 10.00 8.19 6.81 9.83 11.76 7.14 2.43 10.72 10.74 12.69 11.29 7.29 9.33 3.98 13.49 9.04 8.40 2.04 1.59 4.26 5.36 4.89 2.46 1.23 0.11 1.28 1.32 1.28 6.08 1.51 1.10 -1.10 3.08 1.89 1.29 1.21 2.15 3.07 1.58 1.49 -1.01 1.76 -1.27 -1.10 1.13 -1.06 -1.16 -1.19 -1.15 0.055 0.436 0.010 0.172 0.010 0.000 0.000 0.108 0.243 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.487 0.068 0.000 0.130 0.168 0.373 0.322 0.025 0.099 1.25 -1.08 -1.18 1.26 -1.01 1.10 2.97 -1.14 -1.10 1.35 1.26 1.11 1.10 1.26 -1.13 1.05 1.01 1.13 -1.04 1.02 -1.03 1.03 -2.13 1.02 0.162 0.579 0.161 0.332 0.976 0.484 0.005 0.674 0.811 0.019 0.124 0.647 0.513 0.107 0.557 0.761 0.973 0.507 0.927 0.897 0.954 0.968 0.040 0.958 -1.40 -1.27 1.59 1.82 -1.12 2.37 1.39 1.33 -1.08 2.89 1.82 1.24 1.06 1.73 1.71 1.40 1.03 1.18 -1.26 -1.04 -1.02 -1.40 1.06 -1.87 -1.19 -1.10 0.003 0.000 0.000 0.007 0.143 0.000 0.000 0.000 0.240 0.000 0.000 0.000 0.107 0.000 0.016 0.001 0.407 0.057 0.257 0.305 0.371 0.001 0.300 0.003 0.019 0.161 1.36 -1.01 1.17 1.13 -1.22 1.21 2.69 -1.15 -1.31 1.26 1.28 -1.01 1.05 1.25 -1.28 1.15 1.09 -1.14 1.05 -1.01 -1.76 -1.02 -1.88 1.09 0.009 0.933 0.051 0.406 0.014 0.016 0.003 0.328 0.063 0.018 0.019 0.937 0.586 0.026 0.025 0.019 0.333 0.189 0.704 0.935 0.001 0.941 0.023 0.440 Table 4. Gene expression data of triglyceride metabolism pathway in liver and intestine with transcription factors and genes involved. Continued on next page. TNO report - Final 3M#07 TNO Project number: 051.01978 15 / 59 Pathway common name Average expression (2log) Liv e r small intestine C ontrol Fenofibrate PFOS C ontrol Fenofibrate PFOS TG metabolism FA uptake, transport, binding SREBP2 3.32 3.50 3.09 4.63 4.46 4.90 SREBP1a/c 11.05 10.90 10.03 10.10 10.37 11.09 PPARg 5.58 5.28 6.18 6.41 6.56 5.98 PXR 6.74 7.10 7.41 7.96 7.72 8.19 FABP, Fabp1 14.47 14.61 14.55 14.19 14.26 14.14 FABP, Fabp2 11.78 12.22 10.64 14.05 14.09 14.22 FABP, Fabp4 9.16 10.29 10.31 10.70 10.78 10.62 FABP, Fabp6 2.32 2.40 2.22 14.31 14.06 14.24 FABP, Fabp7 7.51 5.71 7.07 3.21 2.71 2.86 FATP, Slc27a1 2.82 5.01 4.04 2.70 2.74 2.65 FATP, Slc27a2 13.86 14.06 13.96 11.96 12.18 12.28 FATP, Slc27a3 measured, but not expressed FATP, Slc27a4 4.48 6.20 5.53 10.57 10.65 11.06 FATP, Slc27a5 13.16 13.06 13.06 2.24 2.20 2.46 C D36 9.45 11.23 11.22 9.96 10.86 10.32 LDLR 6.51 7.11 6.21 6.36 6.32 6.25 PC SK9 5.42 6.14 4.86 5.10 4.70 5.18 Fabp9 measured, but not expressed 1.76 1.81 1.78 Fenofibrate vs control PFOS vs Control Liv e r small intestine Liv e r small intestine Fold change q-value Fold change q-value Fold change q-value Fold change q-value 1.13 -1.11 -1.23 1.28 1.10 1.36 2.19 1.05 -3.48 4.59 1.15 3.30 -1.07 3.42 1.52 1.64 0.165 0.350 0.256 0.010 0.012 0.006 0.000 0.412 0.000 0.000 0.001 0.000 0.181 0.000 0.016 0.110 -1.12 1.20 1.11 -1.18 1.05 1.03 1.06 -1.19 -1.41 1.03 1.16 1.06 -1.03 1.87 -1.03 -1.32 1.03 0.698 0.305 0.756 0.161 0.727 0.852 0.935 0.256 0.183 0.920 0.225 0.882 0.926 0.000 0.930 0.487 0.913 -1.17 -2.03 1.52 1.59 1.06 -2.20 2.21 -1.08 -1.35 2.33 1.07 2.08 -1.08 3.40 -1.23 -1.48 0.077 0.000 0.042 0.000 0.087 0.000 0.000 0.303 0.169 0.000 0.043 0.000 0.127 0.000 0.137 0.142 1.20 1.98 -1.35 1.17 -1.04 1.13 -1.06 -1.05 -1.27 -1.04 1.25 1.41 1.16 1.29 -1.08 1.06 1.02 0.155 0.000 0.023 0.051 0.604 0.027 0.787 0.670 0.167 0.706 0.011 0.007 0.069 0.028 0.397 0.841 0.888 VLDL assemblage/formation ApoB 14.19 14.15 14.04 ApoBEC 6.06 6.06 6.10 MTTP 8.67 9.18 8.96 Apobec2 measured, but not expressed Apobec3 measured, but not expressed Apobec4 measured, but not expressed 12.44 9.42 12.17 3.25 2.79 1.73 12.47 9.38 12.30 3.23 2.67 1.61 12.67 9.70 12.36 3.26 2.82 1.84 -1.02 1.00 1.42 0.374 0.515 0.000 1.02 -1.03 1.10 -1.02 -1.09 -1.09 0.937 0.951 0.319 0.976 0.822 0.790 -1.11 1.03 1.22 0.012 0.413 0.020 1.17 1.21 1.15 1.01 1.02 1.08 0.028 0.063 0.022 0.979 0.893 0.521 PL excretion MDR2 10.85 11.20 11.05 2.32 2.48 2.54 1.27 0.003 1.12 0.733 1.14 0.055 1.17 0.244 Table 4. Gene expression data of triglyceride metabolism pathway in liver and intestine with transcription factors and genes involved. The fold change column is colored according to the direction of regulation (red is up-regulated, blue is down-regulated). Significant q-values (or multiple testing adjusted p-values) are marked with bold font type. Interestingly, for PFOS a number of genes, which were significantly regulated in the liver, were also significantly regulated in the small intestine but in opposite direction (LXRa, PPARa, PPARg, ApoC1, ApoC2, SREBP1a/c, Acsl4, Fabp2, ApoB). Pathway common name Average expression (2log) Liv e r small intestine C ontrol Fenofibrate PFOS C ontrol Fenofibrate PFOS Cholesterol cholesterol synthesis, storage, uptake and metabolism SREBP2 3.32 3.50 3.09 4.63 4.46 4.90 LXRa 6.77 6.76 6.42 5.52 5.93 6.07 SREBP1a/c 11.05 10.90 10.03 10.10 10.37 11.09 Fenofibrate vs control PFOS vs Control Liv e r small intestine Liv e r small intestine Fold change q-value Fold change q-value Fold change q-value Fold change q-value 1.13 -1.01 -1.11 0.165 0.505 0.350 -1.12 1.32 1.20 0.698 0.131 0.305 -1.17 -1.27 -2.03 0.077 0.008 0.000 1.20 1.46 1.98 0.155 0.007 0.000 s y nthe s is AC LY HM G Co A reductase HM G Co A synthase squaleen synthase HMGC S 11.10 11.02 9.79 7.69 8.48 7.33 12.45 12.83 12.53 8.64 9.50 8.53 not measured (not on array) 9.15 8.73 8.34 8.40 9.23 8.73 7.68 8.23 9.04 8.51 7.84 8.41 -1.05 1.73 1.29 1.83 0.476 0.039 0.000 0.003 1.06 1.00 -1.58 -1.13 0.832 0.998 0.500 0.859 -2.47 -1.28 1.05 -1.08 0.003 0.204 0.244 0.360 -1.09 -1.17 -1.42 1.01 0.375 0.192 0.355 0.983 storage AC AT1 AC AT2 11.40 9.41 11.88 10.33 11.54 9.37 11.03 8.48 10.94 7.88 10.88 8.28 1.39 1.89 0.000 0.004 -1.06 -1.52 0.738 0.006 1.10 -1.03 0.034 0.429 -1.11 -1.14 0.158 0.212 uptake SREBP2 SREBP1a/c LXRa LXRb LDLR PC SK9 NPC 1-like1 3.32 3.50 3.09 11.05 10.90 10.03 6.77 6.76 6.42 4.48 4.33 4.37 6.51 7.11 6.21 5.42 6.14 4.86 not measured (not on array) 4.63 10.10 5.52 5.48 6.36 5.10 4.46 10.37 5.93 5.37 6.32 4.70 4.90 11.09 6.07 5.58 6.25 5.18 1.13 -1.11 -1.01 -1.11 1.52 1.64 0.165 0.350 0.505 0.271 0.016 0.110 -1.12 1.20 1.32 -1.08 -1.03 -1.32 0.698 0.305 0.131 0.683 0.930 0.487 -1.17 -2.03 -1.27 -1.08 -1.23 -1.48 0.077 0.000 0.008 0.277 0.137 0.142 1.20 1.98 1.46 1.07 -1.08 1.06 0.155 0.000 0.007 0.447 0.397 0.841 metabolism FXR LXRa LXRb C AR PXR C YP7A IBAT bsep ntcp 9.78 6.77 4.48 7.46 6.74 7.82 5.01 11.12 12.19 9.82 6.76 4.33 7.86 7.10 7.77 4.15 10.67 12.02 10.06 6.42 4.37 8.32 7.41 5.90 3.52 10.32 11.77 9.04 5.52 5.48 6.63 7.96 1.76 10.05 1.56 1.49 8.82 5.93 5.37 6.96 7.72 1.70 10.36 1.52 1.46 8.86 6.07 5.58 6.81 8.19 1.72 9.88 1.69 1.58 1.03 -1.01 -1.11 1.32 1.28 -1.04 -1.81 -1.37 -1.13 0.436 0.505 0.271 0.172 0.010 0.506 0.062 0.004 0.242 -1.16 1.32 -1.08 1.26 -1.18 -1.04 1.24 -1.03 -1.02 0.596 0.131 0.683 0.332 0.161 0.833 0.879 0.937 0.951 1.21 -1.27 -1.08 1.82 1.59 -3.78 -2.80 -1.74 -1.34 0.028 0.008 0.277 0.007 0.000 0.021 0.002 0.000 0.014 -1.13 1.46 1.07 1.13 1.17 -1.02 -1.12 1.09 1.06 0.398 0.007 0.447 0.406 0.051 0.747 0.833 0.355 0.527 excretion LXRa LXRb ABC G5 ABC G8 6.77 4.48 11.00 7.20 6.76 4.33 10.65 7.05 6.42 4.37 10.13 5.95 5.52 5.48 11.99 7.45 5.93 5.37 11.80 7.40 6.07 5.58 12.09 7.72 -1.01 -1.11 -1.28 -1.11 0.505 0.271 0.049 0.369 1.32 -1.08 -1.14 -1.03 0.131 0.683 0.203 0.954 -1.27 -1.08 -1.83 -2.38 0.008 0.277 0.000 0.000 1.46 1.07 1.08 1.20 0.007 0.447 0.293 0.188 Table 5. Gene expression data of cholesterol metabolism pathway in liver and intestine with transcription factors and genes involved. The fold change column is colored according to the direction of regulation (red is up-regulated, blue is down-regulated). Significant q-values (or multiple testing adjusted p-values) are marked with bold font type. TNO report - Final 3M#07 TNO Project number: 051.01978 16 / 59 Pathway common name HDL metabolism HDL formation LXRa LXRb PPARa PXR ApoA1 APOA2 C ontrol Average expression (2log) Liv e r small intestine Fenofibrate PFOS C ontrol Fenofibrate PFOS 6.77 4.48 11.03 6.74 14.38 14.52 6.76 4.33 11.33 7.10 14.34 14.55 6.42 4.37 10.55 7.41 13.85 14.50 5.52 5.48 8.53 7.96 4.64 5.93 5.37 8.85 7.72 4.63 6.07 5.58 8.97 8.19 6.58 Fenofibrate vs control PFOS vs Control Liv e r small intestine Liv e r small intestine Fold change q-value Fold change q-value Fold change q-value Fold change q-value -1.01 -1.11 1.23 1.28 -1.03 1.03 0.505 0.271 0.055 0.010 0.365 0.310 1.32 -1.08 1.25 -1.18 -1.01 0.131 0.683 0.162 0.161 0.997 -1.27 -1.08 -1.40 1.59 -1.45 -1.01 0.008 0.277 0.003 0.000 0.000 0.373 1.46 1.07 1.36 1.17 3.81 0.007 0.447 0.009 0.051 0.005 HDL maturation LXRa LXRb PPARa ABC A1 LC AT 6.77 4.48 11.03 5.14 10.98 6.76 4.33 11.33 5.06 10.82 6.42 4.37 10.55 5.01 10.55 5.52 5.48 8.53 4.60 2.23 5.93 5.37 8.85 5.00 2.14 6.07 5.58 8.97 5.04 2.15 -1.01 -1.11 1.23 -1.06 -1.12 0.505 0.271 0.055 0.244 0.080 1.32 -1.08 1.25 1.32 -1.06 0.131 0.683 0.162 0.063 0.700 -1.27 -1.08 -1.40 -1.09 -1.35 0.008 0.277 0.003 0.092 0.000 1.46 1.07 1.36 1.36 -1.06 0.007 0.447 0.009 0.009 0.456 HDL modelling/destabilisation LXRa 6.77 6.76 6.42 LXRb 4.48 4.33 4.37 PLTP 7.65 9.38 8.05 endothelial lipase 2.90 3.41 2.65 HL 10.82 10.42 10.33 GPIHBP1 7.41 7.52 7.85 C ETP not measured (not on array) 5.52 5.48 3.72 2.51 1.77 2.59 5.93 5.37 3.62 2.55 1.78 2.47 6.07 5.58 3.59 2.42 1.81 2.44 -1.01 -1.11 3.32 1.42 -1.32 1.08 0.505 0.271 0.000 0.045 0.000 0.344 1.32 -1.08 -1.07 1.03 1.01 -1.09 0.131 0.683 0.841 0.916 0.983 0.727 -1.27 -1.08 1.31 -1.19 -1.40 1.36 0.008 0.277 0.171 0.185 0.000 0.012 1.46 1.07 -1.09 -1.06 1.03 -1.11 0.007 0.447 0.465 0.483 0.839 0.295 HDL uptake LXRa LXRb PPARa FXR PXR SRB1 ATPsynth 6.77 4.48 11.03 9.78 6.74 9.50 13.07 6.76 4.33 11.33 9.82 7.10 8.99 13.20 6.42 4.37 10.55 10.06 7.41 8.68 13.05 5.52 5.48 8.53 9.04 7.96 4.70 5.93 5.37 8.85 8.82 7.72 4.42 6.07 5.58 8.97 8.86 8.19 4.46 -1.01 -1.11 1.23 1.03 1.28 -1.42 1.10 0.505 0.271 0.055 0.436 0.010 0.001 0.064 1.32 -1.08 1.25 -1.16 -1.18 -1.21 0.131 0.683 0.162 0.596 0.161 0.790 -1.27 -1.08 -1.40 1.21 1.59 -1.76 -1.01 0.008 0.277 0.003 0.028 0.000 0.000 0.424 1.46 1.07 1.36 -1.13 1.17 -1.18 0.007 0.447 0.009 0.398 0.051 0.571 Table 6. Gene expression data of HDL metabolism pathway in liver and intestine with transcription factors and genes involved. The fold change column is colored according to the direction of regulation (red is up-regulated, blue is down-regulated). Significant q-values (or multiple testing adjusted p-values) are marked with bold font type. In the small intestine, PFOS treatment resulted in up-regulation of a number of genes involved in HDL formation and maturation (APOA2, ABCA1, LXRa, PPARa). Pathway common name C ontrol Safety and transcription factors safety ALAT 9.58 Average expression (2log) Liv e r small intestine Fenofibrate PFOS C ontrol Fenofibrate PFOS 9.64 9.80 9.95 10.09 10.52 Fenofibrate vs control PFOS vs Control Liv e r small intestine Liv e r small intestine Fold change q-value Fold change q-value Fold change q-value Fold change q-value 1.04 0.368 1.11 0.688 1.17 0.039 1.49 0.003 transcription factors LXRa 6.77 6.76 6.42 LXRb 4.48 4.33 4.37 PPARa PPARg C AR FXR PXR PGC 1alpha PGC 1beta PPARd C YP3A11 11.03 5.58 7.46 9.78 6.74 6.40 7.00 measured, 13.53 11.33 5.28 7.86 9.82 7.10 6.50 6.84 but not 13.39 10.55 6.18 8.32 10.06 7.41 5.12 6.55 expressed 13.73 5.52 5.48 8.53 6.41 6.63 9.04 7.96 10.01 9.04 3.17 12.87 5.93 5.37 8.85 6.56 6.96 8.82 7.72 9.90 8.87 2.98 12.90 6.07 5.58 8.97 5.98 6.81 8.86 8.19 10.00 9.04 3.08 13.10 -1.01 -1.11 1.23 -1.23 1.32 1.03 1.28 0.11 -0.16 -1.10 0.505 0.271 0.055 0.256 0.172 0.436 0.010 0.436 0.405 0.100 1.32 -1.08 1.25 1.11 1.26 -1.16 -1.18 -1.08 -1.12 -1.14 1.02 0.131 0.683 0.162 0.756 0.332 0.596 0.161 0.579 0.271 0.172 0.947 -1.27 -1.08 -1.40 1.52 1.82 1.21 1.59 -1.27 -0.44 1.15 0.008 0.277 0.003 0.042 0.007 0.028 0.000 0.000 0.139 0.013 1.46 1.07 1.36 -1.35 1.13 -1.13 1.17 -1.01 -1.00 -1.06 1.17 0.007 0.447 0.009 0.023 0.406 0.398 0.051 0.933 0.999 0.381 0.018 Table 7. Gene expression data of transcription factors and safety parameters in liver and intestine. The fold change column is colored according to the direction of regulation (red is up-regulated, blue is down-regulated). Significant q-values (or multiple testing adjusted p-values) are marked with bold font type. At the level of pathways and processes, energy metabolism was observed to be activated by FF and PFOS in liver, and this was also observed in intestine ("Oxidative phosphorylation" cluster in section 2.2). In addition, a down-regulation of inflammation by FF was observed in liver and a similar response was seen in intestine, by inactivation of STAT1 and down-regulation of immune response related processes. At the level of transcription factors relevant for lipid metabolism, the observed LXR activation by both PFOS and FF in liver could also be observed in intestine by PFOS. The main difference with the observations in liver was the apparent lack of strong activation of PPAR and PPAR by FF in intestine. TNO report - Final 3M#07 TNO Project number: 051.01978 17 / 59 4 Conclusion - PFOS has a more extensive effect than FF on the intestinal transcriptome in ApoE3L.CETP mice. - Oxidative phosphorylation is up-regulated by both FF and PFOS. - Fatty acid transport is up-regulated by both FF and PFOS, while cholesterol transport is up-regulated by PFOS, but not by FF. - For the set of preselected lipid metabolism related genes, there are less significantly regulated genes in the intestine as compared to the liver, especially for FF. For PFOS, a number of genes, which were significantly regulated in the liver, were also significantly regulated in the small intestine, but in opposite direction. In the intestine PFOS treatment resulted in up-regulation of a number of genes involved in HDL formation and maturation (APOA2, ABCA1, LXRa, PPARa). - Several lipid metabolism related transcription factors are activated by both FF and PFOS. PPAR, PPAR and LXR are only activated by PFOS. TNO report - Final 3M#07 TNO Project number: 051.01978 5 Appendices 5.1 Quality control & pre-processing evaluation report 18 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 19 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 20 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 21 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 22 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 23 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 24 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 25 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 26 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 27 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 28 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 29 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 30 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 31 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 32 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 33 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 34 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 35 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 36 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 37 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 38 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 39 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 40 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 41 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 42 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 43 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 44 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 45 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 46 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 47 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 48 / 59 TNO report - Final 3M#07 TNO Project number: 051.01978 5.2 Full list of genes related to transport processes that are significantly regulated by FF or PFOS 49 / 59 S PFO alue_ - C intestine - Con stine adj.p.v _FFinte ontrol .value tine - C testine adj.p Sintes ntrolin log FC_PFO ne - Co sPFOS logF C_FF intesti igTerm linte ontro NrS e testin trolin NrSig stine intestine Term NrTe e Nam gene entrezId bol sym sFF rms Abca1 Abca7 Abcb1a Abcb6 Abcc3 Abcc6 Abcc9 Abp1 Accn2 Ace Acsl4 Acsl5 Acsl6 Acvr1c Acvr2b Adipor2 Ahcyl1 AI317395 Ano6 Apoa1 Apoa2 Apoa4 Apob Apoc1 Apoc2 Apoh Aqp11 Aqp3 Aqp8 Arg1 Arl2 Arrb1 Atp11c Atp13a1 Atp1a1 Atp2a2 Atp6ap1 Atp6v0a1 Atp6v0b Atp8a1 Atp9a Atp9b Casp1 Cd209d Cd36 Cdk1 Chd7 Clcc1 Clcn2 Clic6 Cln8 Cox6b2 Cox8a Cpt1a Crym Dab2ip Dgat1 Ect2 Edn1 Ednra Eif2ak3 Ensa F2 F2rl1 Fabp2 Fgf15 Flna Fxyd1 G6pc Gc Gcg Glud1 Grid1 Hiat1 Hnf1b Hyal2 Inpp5k Ins2 Irs2 Itln1 Jak2 Kcne3 Kcnj13 Kcnk1 Kcnk2 Kcnmb4 Kcns3 Kctd12 Kctd14 11303 ATP-binding cassette, sub-family A (ABC1), member 1 27403 ATP-binding cassette, sub-family A (ABC1), member 7 18671 ATP-binding cassette, sub-family B (MDR/TAP), member 1A 74104 ATP-binding cassette, sub-family B (MDR/TAP), member 6 76408 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 27421 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 20928 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 76507 amiloride binding protein 1 (amine oxidase, copper-containing) 11419 amiloride-sensitive cation channel 2, neuronal 11421 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 50790 acyl-CoA synthetase long-chain family member 4 433256 acyl-CoA synthetase long-chain family member 5 216739 acyl-CoA synthetase long-chain family member 6 269275 activin A receptor, type IC 11481 activin receptor IIB 68465 adiponectin receptor 2 229709 S-adenosylhomocysteine hydrolase-like 1 215929 expressed sequence AI317395 105722 anoctamin 6 11806 apolipoprotein A-I 11807 apolipoprotein A-II 11808 apolipoprotein A-IV 238055 apolipoprotein B 11812 apolipoprotein C-I 11813 apolipoprotein C-II 11818 apolipoprotein H 66333 aquaporin 11 11828 aquaporin 3 11833 aquaporin 8 11846 arginase, liver 56327 ADP-ribosylation factor-like 2 109689 arrestin, beta 1 320940 ATPase, class VI, type 11C 170759 ATPase type 13A1 11928 ATPase, Na+/K+ transporting, alpha 1 polypeptide 11938 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 54411 ATPase, H+ transporting, lysosomal accessory protein 1 11975 ATPase, H+ transporting, lysosomal V0 subunit A1 114143 ATPase, H+ transporting, lysosomal V0 subunit B 11980 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 11981 ATPase, class II, type 9A 50771 ATPase, class II, type 9B 12362 caspase 1 170779 CD209d antigen 12491 CD36 antigen 12534 cyclin-dependent kinase 1 320790 chromodomain helicase DNA binding protein 7 229725 chloride channel CLIC-like 1 12724 chloride channel 2 209195 chloride intracellular channel 6 26889 ceroid-lipofuscinosis, neuronal 8 333182 cytochrome c oxidase subunit VIb polypeptide 2 12868 cytochrome c oxidase, subunit VIIIa 12894 carnitine palmitoyltransferase 1a, liver 12971 crystallin, mu 69601 disabled homolog 2 (Drosophila) interacting protein 13350 diacylglycerol O-acyltransferase 1 13605 ect2 oncogene 13614 endothelin 1 13617 endothelin receptor type A 13666 eukaryotic translation initiation factor 2 alpha kinase 3 56205 endosulfine alpha 14061 coagulation factor II 14063 coagulation factor II (thrombin) receptor-like 1 14079 fatty acid binding protein 2, intestinal 14170 fibroblast growth factor 15 192176 filamin, alpha 56188 FXYD domain-containing ion transport regulator 1 14377 glucose-6-phosphatase, catalytic 14473 group specific component 14526 glucagon 14661 glutamate dehydrogenase 1 14803 glutamate receptor, ionotropic, delta 1 15247 hippocampus abundant gene transcript 1 21410 HNF1 homeobox B 15587 hyaluronoglucosaminidase 2 19062 inositol polyphosphate 5-phosphatase K 16334 insulin II 384783 insulin receptor substrate 2 16429 intelectin 1 (galactofuranose binding) 16452 Janus kinase 2 57442 potassium voltage-gated channel, Isk-related subfamily, gene 3 1E+08 potassium inwardly-rectifying channel, subfamily J, member 13 16525 potassium channel, subfamily K, member 1 16526 potassium channel, subfamily K, member 2 58802 potassium large conductance calcium-activated channel, subfamily M, beta member 4 238076 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 239217 potassium channel tetramerisation domain containing 12 233529 potassium channel tetramerisation domain containing 14 32 1 4 1 3 2 11 0 10 6 1 0 10 0 8 3 24 1 12 6 6 5 21 8 21 8 21 0 8 0 12 2 21 1 8 3 6 0 40 1 50 2 14 1 5 1 15 1 16 1 4 1 12 10 13 10 9 6 18 5 5 3 24 0 7 1 4 0 17 2 9 0 9 0 9 0 9 0 7 1 7 1 7 1 23 0 14 0 20 7 7 0 15 0 6 0 11 0 11 0 19 5 7 0 7 0 15 0 9 5 8 0 8 0 8 0 32 5 30 4 10 0 15 0 20 0 35 0 7 6 12 2 11 0 6 0 7 4 2 0 45 0 21 0 3 0 3 2 8 0 8 0 28 4 32 2 50 8 12 2 26 0 15 0 13 0 13 0 13 0 9 0 13 0 13 0 3 0 2 0.399656 0.443072 0.062922 0.009227 0 -0.00094 0.650276 0.999069 0.009291 2 0.647908 0.325517 0.022998 0.121306 1 0.183483 0.531006 0.749729 0.024208 3 0.190597 0.429963 0.497141 0.009291 1 0.302609 0.759864 0.366495 0.002501 1 0.044795 0.415312 0.937047 0.010117 1 0.161802 0.479711 0.727145 0.016058 2 0.152625 0.409895 0.592576 0.007644 1 0.784505 0.727529 0.006213 0.003035 1 -0.18116 -0.36163 0.557141 0.024669 4 0.063527 0.199619 0.760815 0.018622 4 -1.0891 -0.90981 0.040072 0.023157 1 0.063323 -0.47373 0.833871 0.000929 1 0.153941 0.698501 0.799134 0.005582 1 -0.06442 0.230315 0.770504 0.011298 3 -0.37372 -0.42173 0.190859 0.030787 2 0.111607 0.211313 0.550928 0.030787 1 0.175448 0.611481 0.783741 0.015336 1 -0.01329 0.173023 0.966169 0.021629 1 -0.01566 1.930996 0.996524 0.005314 0 0.020732 0.148084 0.940375 0.045426 0 0.029621 0.223128 0.937047 0.027932 0 0.157078 2.892596 0.937047 0.000402 0 0.053058 0.201099 0.832106 0.021869 0 0.151326 1.007759 0.873732 0.004207 4 0.318079 0.102976 0.007666 0.233873 4 0.995629 0.098848 0.004761 0.727164 2 -0.67865 -0.66762 0.073379 0.018359 2 0.048994 0.559133 0.959328 0.017292 1 0.050604 0.352622 0.931033 0.025478 1 -0.49137 -0.14646 0.005644 0.234627 1 -0.04243 -0.21206 0.893349 0.025998 1 -0.06755 0.464935 0.896673 0.006346 4 -0.02663 0.227368 0.937499 0.016509 1 -0.15996 0.293949 0.30994 0.007105 2 -0.02095 0.267693 0.965148 0.021688 2 -0.04705 0.258139 0.89016 0.015642 2 0.169058 0.402685 0.51217 0.008013 1 0.010816 0.218926 0.977073 0.025805 1 -0.04623 0.40869 0.947516 0.024436 1 -0.04279 0.386669 0.94032 0.015204 1 -0.10122 -0.4163 0.738429 0.004229 1 0.153148 -0.2469 0.486298 0.04105 3 0.902176 0.362312 0.00033 0.027626 1 0.017304 -0.49792 0.981254 0.009501 1 0.009645 0.385672 0.989581 0.012078 1 -0.00513 -0.4766 0.994731 0.003985 1 0.266597 0.485785 0.497141 0.025734 1 -0.20646 -0.5004 0.712674 0.037156 1 0.325705 0.555563 0.283398 0.00833 2 0.753322 0.390843 0.018151 0.092848 2 -0.07609 0.308031 0.87596 0.045084 1 -0.01444 -0.28829 0.975637 0.013998 1 -0.79748 -0.6698 0.042898 0.023736 1 -0.00689 0.447806 0.994515 0.013981 1 0.037053 0.304442 0.904421 0.003941 1 0.141677 -0.70672 0.749423 0.002025 3 0.176555 0.765875 0.715584 0.00265 3 -0.0406 -0.25499 0.934754 0.047703 1 0.045459 0.20845 0.857987 0.015369 1 0.208171 0.366669 0.271678 0.006687 1 -0.06089 0.529375 0.937419 0.014676 1 0.297781 0.381454 0.311549 0.039481 1 0.044313 0.17663 0.85241 0.026936 1 -2.93426 -1.20891 0.044856 0.267921 1 -0.1137 0.530728 0.866314 0.017623 1 0.036859 0.232738 0.933788 0.044598 3 -1.14837 -0.37791 0.007171 0.21849 1 -0.45751 3.119747 0.841228 0.001793 3 -0.09799 -0.75361 0.930566 0.014711 1 0.425597 0.272193 0.007666 0.022478 1 -0.18859 -0.30674 0.429515 0.027416 1 -0.01918 -0.28194 0.966169 0.012361 1 0.087007 0.290049 0.735501 0.010307 1 0.023106 0.482602 0.979805 0.035606 2 0.079199 0.35521 0.861179 0.018917 3 -0.21908 0.783639 0.777905 0.012778 5 0.091281 0.725428 0.895841 0.003302 1 -0.35147 -1.15251 0.797986 0.025478 2 0.192332 0.248992 0.317905 0.039033 2 -0.01238 -0.54301 0.987636 0.005582 1 0.532385 1.229739 0.695929 0.039302 1 -0.39943 -0.47967 0.295787 0.046719 1 -0.13396 -0.37865 0.669314 0.011706 1 -0.13078 -0.33273 0.753024 0.045317 1 -0.16044 -0.4995 0.735686 0.014497 1 -0.16122 -0.36113 0.509127 0.010645 1 -0.89441 -0.77891 0.014797 0.008225 TNO report - Final 3M#07 TNO Project number: 051.01978 50 / 59 sym bol Kctd2 Kctd3 Kctd5 Lrp6 Ly6e Maob Mcoln1 Mfsd2a Mfsd4 Mfsd7b Mfsd7c Micu1 Mttp Ncor1 Nisch Npc1l1 Nr1h3 Osbp Osbpl1a Osbpl3 Osbpl6 Oxct1 Panx1 Pde2a Pdx1 Pdzk1 Pex6 Pla2g10 Pla2g4a Plin2 Pon1 Ppara Pparg Ppp3ca Prdx1 Prkcz Psmd10 Ptger4 Pycard Rbp4 Rhbg Scamp5 Sfxn1 Sfxn5 Slc12a2 Slc12a6 Slc12a7 Slc13a2 Slc16a1 Slc16a10 Slc16a11 Slc18a1 Slc22a1 Slc22a13 Slc22a23 Slc22a3 Slc22a4 Slc23a1 Slc24a3 Slc25a10 Slc25a16 Slc25a17 Slc25a22 Slc25a26 Slc25a42 Slc27a2 Slc27a4 Slc2a1 Slc2a3 Slc30a10 Slc35a4 Slc36a1 Slc36a2 Slc37a2 Slc37a4 Slc39a1 Slc39a4 Slc39a5 Slc39a9 Slc3a1 Slc46a3 Slc47a1 Slc4a2 Slc4a3 Slc5a11 Slc5a12 Slc5a3 Slc5a4a Slc5a4b Slc5a9 Slc6a14 Slc6a3 Slc6a4 Slc6a8 Slc7a15 entrezId gene Nam e 70382 potassium channel tetramerisation domain containing 2 226823 potassium channel tetramerisation domain containing 3 69259 potassium channel tetramerisation domain containing 5 16974 low density lipoprotein receptor-related protein 6 17069 lymphocyte antigen 6 complex, locus E 109731 monoamine oxidase B 94178 mucolipin 1 76574 major facilitator superfamily domain containing 2A 213006 major facilitator superfamily domain containing 4 226844 major facilitator superfamily domain containing 7B 217721 major facilitator superfamily domain containing 7C 216001 mitochondrial calcium uptake 1 17777 microsomal triglyceride transfer protein 20185 nuclear receptor co-repressor 1 64652 nischarin 237636 NPC1-like 1 22259 nuclear receptor subfamily 1, group H, member 3 76303 oxysterol binding protein 64291 oxysterol binding protein-like 1A 71720 oxysterol binding protein-like 3 99031 oxysterol binding protein-like 6 67041 3-oxoacid CoA transferase 1 55991 pannexin 1 207728 phosphodiesterase 2A, cGMP-stimulated 18609 pancreatic and duodenal homeobox 1 59020 PDZ domain containing 1 224824 peroxisomal biogenesis factor 6 26565 phospholipase A2, group X 18783 phospholipase A2, group IVA (cytosolic, calcium-dependent) 11520 perilipin 2 18979 paraoxonase 1 19013 peroxisome proliferator activated receptor alpha 19016 peroxisome proliferator activated receptor gamma 19055 protein phosphatase 3, catalytic subunit, alpha isoform 18477 peroxiredoxin 1 18762 protein kinase C, zeta 53380 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 19219 prostaglandin E receptor 4 (subtype EP4) 66824 PYD and CARD domain containing 19662 retinol binding protein 4, plasma 58176 Rhesus blood group-associated B glycoprotein 56807 secretory carrier membrane protein 5 14057 sideroflexin 1 94282 sideroflexin 5 20496 solute carrier family 12, member 2 107723 solute carrier family 12, member 6 20499 solute carrier family 12, member 7 20500 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 20501 solute carrier family 16 (monocarboxylic acid transporters), member 1 72472 solute carrier family 16 (monocarboxylic acid transporters), member 10 216867 solute carrier family 16 (monocarboxylic acid transporters), member 11 110877 solute carrier family 18 (vesicular monoamine), member 1 20517 solute carrier family 22 (organic cation transporter), member 1 102570 solute carrier family 22 (organic cation transporter), member 13 73102 solute carrier family 22, member 23 20519 solute carrier family 22 (organic cation transporter), member 3 30805 solute carrier family 22 (organic cation transporter), member 4 20522 solute carrier family 23 (nucleobase transporters), member 1 94249 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 27376 solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 73132 solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 20524 solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 68267 solute carrier family 25 (mitochondrial carrier, glutamate), member 22 67582 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 73095 solute carrier family 25, member 42 26458 solute carrier family 27 (fatty acid transporter), member 2 26569 solute carrier family 27 (fatty acid transporter), member 4 20525 solute carrier family 2 (facilitated glucose transporter), member 1 20527 solute carrier family 2 (facilitated glucose transporter), member 3 226781 solute carrier family 30, member 10 67843 solute carrier family 35, member A4 215335 solute carrier family 36 (proton/amino acid symporter), member 1 246049 solute carrier family 36 (proton/amino acid symporter), member 2 56857 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 14385 solute carrier family 37 (glucose-6-phosphate transporter), member 4 30791 solute carrier family 39 (zinc transporter), member 1 72027 solute carrier family 39 (zinc transporter), member 4 72002 solute carrier family 39 (metal ion transporter), member 5 328133 solute carrier family 39 (zinc transporter), member 9 20532 solute carrier family 3, member 1 71706 solute carrier family 46, member 3 67473 solute carrier family 47, member 1 20535 solute carrier family 4 (anion exchanger), member 2 20536 solute carrier family 4 (anion exchanger), member 3 233836 solute carrier family 5 (sodium/glucose cotransporter), member 11 241612 solute carrier family 5 (sodium/glucose cotransporter), member 12 53881 solute carrier family 5 (inositol transporters), member 3 64452 solute carrier family 5, member 4a 64454 solute carrier family 5 (neutral amino acid transporters, system A), member 4b 230612 solute carrier family 5 (sodium/glucose cotransporter), member 9 56774 solute carrier family 6 (neurotransmitter transporter), member 14 13162 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 15567 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 102857 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 328059 solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 NrTe rms lo adj. adj.p.v logFC _FFin gFC_P p.value alue_P FOSin _FFin FOSin testin testin testin testin NrS e - Con e - Con e - Con e - Con NrSigTe igTerm trolinte trolinte trolinte trolinte rmsFF sPFOS stine stine stine stine 3 0 1 0.047733 0.298621 0.925083 0.028887 13 0 1 0.069391 -0.40473 0.788429 0.001624 13 0 1 0.19762 0.429141 0.691295 0.048482 4 1 0 0.114634 0.478049 0.762022 0.005141 12 6 2 -1.28866 -0.37615 0.046399 0.454807 16 5 3 0.440557 0.317027 0.008297 0.013554 8 0 1 -0.02106 0.497028 0.974988 0.00504 1 0 1 0.125095 0.596174 0.60803 0.000608 1 0 1 -0.79317 -0.79339 0.005225 0.001793 3 1 1 0.3956 0.310223 0.006213 0.006527 3 0 1 -0.08691 0.573341 0.936613 0.045945 10 0 1 -0.01441 0.377713 0.982402 0.018464 3 1 0 0.133673 0.195492 0.319022 0.022373 6 1 0 -0.08704 0.200554 0.643859 0.024887 11 6 2 -0.02737 0.324073 0.960015 0.016271 5 1 0 -0.03833 0.396216 0.939331 0.007571 33 1 0 0.403793 0.549647 0.130928 0.007425 2 1 0 -0.07725 0.403201 0.848016 0.006589 2 1 0 0.513282 0.927176 0.132895 0.002158 2 1 0 0.04968 0.539486 0.942016 0.006742 2 1 0 0.316648 0.304845 0.081215 0.022993 21 0 1 -0.25651 -0.59546 0.311599 0.002626 32 0 2 -0.00984 0.495011 0.993677 0.033467 7 0 1 -0.09359 0.433702 0.902368 0.048423 21 0 1 -0.33146 -0.42615 0.3534 0.048006 22 6 3 0.056647 0.413572 0.856959 0.001793 3 0 1 -0.02275 0.27801 0.958978 0.012196 43 6 1 0.156002 -0.79189 0.859852 0.010252 14 6 1 -0.29945 -0.77389 0.584626 0.008606 7 6 1 0.206783 0.521268 0.420011 0.003347 17 1 0 0.174068 1.396351 0.865544 0.001487 6 1 0 0.321693 0.443231 0.161773 0.009227 8 6 1 0.144239 -0.42981 0.755749 0.02256 28 0 1 0.06944 0.273893 0.87504 0.048738 5 0 1 0.095605 -0.44139 0.81134 0.005837 33 2 2 0.112041 0.334825 0.759278 0.023398 9 0 1 0.000135 -0.21582 0.999681 0.027748 19 0 1 -0.42468 -0.25817 0.008533 0.03101 20 0 1 -0.08654 -0.26571 0.67821 0.008606 36 1 1 0.261886 1.015488 0.85663 0.032793 9 1 2 -0.03312 0.498486 0.973937 0.035606 15 0 1 -0.29237 -0.06228 0.043992 0.59737 7 0 1 0.096887 0.206911 0.520767 0.01421 11 3 1 -0.2318 -0.24992 0.102012 0.016639 16 2 3 -0.14407 -0.31648 0.437249 0.00691 10 0 1 0.158669 0.472627 0.635663 0.006901 10 0 1 -0.08958 0.457203 0.86703 0.011783 6 1 2 0.662521 0.904854 0.148608 0.008425 8 4 2 -0.09417 -0.2736 0.580741 0.004918 1 0 1 0.379794 0.502903 0.045538 0.003147 1 0 1 -0.29782 -0.29748 0.155371 0.039955 36 8 4 0.514958 0.515259 0.139547 0.034486 21 9 5 -0.01417 0.302727 0.977017 0.016451 1 0 1 -0.30979 -0.29999 0.088739 0.024436 2 0 1 0.052406 0.826259 0.975637 0.042495 17 8 4 0.665486 0.729751 0.030273 0.005198 18 7 4 0.253032 0.404957 0.371938 0.019995 17 7 3 1.139962 0.927103 0.000125 0.000608 10 1 2 -0.02189 0.472493 0.977017 0.01291 19 3 1 0.023601 0.375093 0.972916 0.018359 1 0 1 0.109637 -0.34273 0.616876 0.004781 9 6 2 -0.13842 -0.62118 0.775854 0.004386 14 5 2 -0.15293 0.737301 0.76407 0.002852 13 5 2 -0.1203 -0.28226 0.660718 0.026022 1 0 1 -0.04183 0.276754 0.925738 0.023938 6 5 1 0.217371 0.321087 0.225445 0.010855 8 6 1 0.079582 0.491263 0.881635 0.007497 11 2 2 0.012268 -0.5242 0.983279 0.002758 11 2 2 0.021012 0.262763 0.956601 0.008225 9 0 1 -0.69182 -0.67669 0.050554 0.013554 10 2 2 0.079278 0.384182 0.879309 0.022068 20 5 3 0.741176 0.663291 0.018705 0.008913 20 5 3 0.18978 0.266081 0.120984 0.005832 7 5 3 -0.36103 -0.61588 0.55464 0.049481 10 4 4 -0.23316 0.282136 0.213191 0.025845 10 0 1 0.071215 0.27199 0.85162 0.03222 9 0 1 -0.16834 0.497856 0.683397 0.010855 9 0 1 0.36306 1.092576 0.479434 0.002215 9 0 1 -0.12697 0.507317 0.649849 0.002101 6 5 1 0.241014 0.488538 0.467846 0.012144 1 0 1 0.581066 0.709336 0.083594 0.007713 10 3 4 0.355041 0.554435 0.04899 0.00159 6 0 1 -0.11995 0.569789 0.901871 0.04273 4 0 1 0.190836 0.245286 0.261251 0.027903 8 3 2 0.543223 0.773285 0.024227 0.001366 6 1 2 0.738422 0.652507 0.000265 0.000608 10 4 3 -0.06889 0.44887 0.914221 0.014825 5 1 1 0.158238 0.475505 0.782661 0.030614 5 1 1 0.850079 0.79096 0.000828 0.000812 6 1 2 0.349414 0.578876 0.134107 0.003161 16 7 4 1.394426 0.405794 0.007666 0.29182 20 8 5 0.731049 0.732603 0.005839 0.001989 17 6 5 0.241102 0.414416 0.295787 0.008781 24 9 5 0.098875 0.437797 0.81134 0.007259 6 5 1 0.421986 0.872956 0.525714 0.016885 TNO report - Final 3M#07 TNO Project number: 051.01978 51 / 59 Slc7a8 Slc9a3r1 Slco1b2 Slco2a1 Slco3a1 Smpd3 Soat1 Spns1 Src Srebf1 Stard3 Stk39 Stxbp3a Tap1 Tap2 Thra Tlr3 Tmem38b Tnfrsf1a Tomm22 Trf Trpm4 Ttyh1 Ttyh2 Vdac1 Vdr Wfs1 50934 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 26941 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 28253 solute carrier organic anion transporter family, member 1b2 24059 solute carrier organic anion transporter family, member 2a1 108116 solute carrier organic anion transporter family, member 3a1 58994 sphingomyelin phosphodiesterase 3, neutral 20652 sterol O-acyltransferase 1 73658 spinster homolog 1 (Drosophila) 20779 Rous sarcoma oncogene 20787 sterol regulatory element binding transcription factor 1 59045 START domain containing 3 53416 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 20912 syntaxin binding protein 3A 21354 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 21355 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 21833 thyroid hormone receptor alpha 142980 toll-like receptor 3 52076 transmembrane protein 38B 21937 tumor necrosis factor receptor superfamily, member 1a 223696 translocase of outer mitochondrial membrane 22 homolog (yeast) 22041 transferrin 68667 transient receptor potential cation channel, subfamily M, member 4 57776 tweety homolog 1 (Drosophila) 117160 tweety homolog 2 (Drosophila) 22333 voltage-dependent anion channel 1 22337 vitamin D receptor 22393 Wolfram syndrome 1 homolog (human) 13 6 3 0.531801 0.350535 0.017941 0.036414 45 7 6 0.115663 0.337808 0.70098 0.013748 11 7 4 0.067659 0.391533 0.858281 0.005413 8 5 1 -0.00323 0.276018 0.996672 0.048332 13 6 2 -0.35266 0.165144 0.019099 0.13344 7 0 1 0.148041 0.315599 0.636098 0.033745 5 1 0 -0.30075 -0.36823 0.264581 0.03574 3 1 1 0.032927 0.314081 0.954223 0.025464 14 0 1 0.007178 0.329356 0.990685 0.011707 21 0 1 0.265679 0.986098 0.305233 0.000181 4 1 0 0.331645 0.416774 0.018253 0.001895 12 0 1 -0.19001 -0.51966 0.719267 0.022274 17 2 2 0.005758 -0.33149 0.991461 0.007058 4 2 3 -0.36692 0.08503 0.044402 0.559903 5 3 4 -0.51802 0.086131 0.040609 0.68688 9 0 1 0.007307 0.651091 0.996253 0.013998 8 0 1 -0.27877 -0.33529 0.070098 0.0069 9 0 1 -0.09279 -0.32961 0.705536 0.005708 7 0 1 0.076318 0.427609 0.910479 0.02595 2 0 1 -0.10449 -0.60714 0.894998 0.013377 10 0 1 0.29867 1.080709 0.760798 0.009525 8 0 1 0.034791 0.447356 0.96923 0.032203 6 0 1 -0.10579 -0.29194 0.623932 0.008663 6 0 1 -0.02759 0.305529 0.953114 0.011541 14 0 1 -0.03196 0.246724 0.947344 0.044179 27 0 2 0.01063 0.282215 0.977017 0.006346 13 0 1 -0.3523 -0.36017 0.032424 0.007469 TNO report - Final 3M#07 TNO Project number: 051.01978 52 / 59 5.3 Overview of affected transport processes (enrichment analysis on the transport GO terms) GO.ID Term GO:0071702 organic substance transport GO:0071705 nitrogen compound transport GO:0046942 GO:0015849 GO:0035672 GO:0006857 GO:0015850 GO:0015793 GO:0015840 GO:0015695 GO:0015908 GO:0015837 GO:0015791 GO:0015911 GO:0042886 GO:0015909 GO:0015844 GO:0046968 GO:0051615 GO:0097037 GO:0015718 GO:0008643 GO:0006833 GO:0006855 carboxylic acid transport organic acid transport oligopeptide transmembrane transport oligopeptide transport organic alcohol transport glycerol transport urea transport organic cation transport fatty acid transport amine transport polyol transport plasma membrane long-chain fatty acid tr... amide transport long-chain fatty acid transport monoamine transport peptide antigen transport histamine uptake heme export monocarboxylic acid transport carbohydrate transport water transport drug transmembrane transport GO:0006814 sodium ion transport GO:0010747 GO:0070904 GO:0015882 GO:0071436 GO:0051937 GO:0042044 GO:0015893 GO:0014063 GO:0015760 GO:0015712 positive regulation of plasma membrane l... transepithelial L-ascorbic acid transpor... L-ascorbic acid transport sodium ion export catecholamine transport fluid transport drug transport negative regulation of serotonin secreti... glucose-6-phosphate transport hexose phosphate transport GO:0055085 transmembrane transport GO:0015872 GO:0071715 GO:0070295 GO:0070837 GO:0015886 GO:0046717 GO:0006865 GO:0015808 GO:0015816 GO:0015824 GO:0060455 GO:0070327 GO:0014062 GO:0060453 GO:0015833 dopamine transport icosanoid transport renal water absorption dehydroascorbic acid transport heme transport acid secretion amino acid transport L-alanine transport glycine transport proline transport negative regulation of gastric acid secr... thyroid hormone transport regulation of serotonin secretion regulation of gastric acid secretion peptide transport GO:0015672 monovalent inorganic cation transport GO:0003097 GO:0010746 GO:0032328 GO:0006869 GO:0015807 GO:0035725 GO:0015992 GO:0006818 GO:0035774 GO:0048242 GO:0032024 GO:0001696 GO:0048241 GO:0050715 GO:0015732 GO:0001820 GO:0051181 GO:0051608 GO:2000193 GO:0090277 GO:0070633 GO:0003333 GO:0002793 GO:0051051 GO:0015697 GO:0030301 GO:0015918 GO:0042953 renal water transport regulation of plasma membrane long-chain... alanine transport lipid transport L-amino acid transport sodium ion transmembrane transport proton transport hydrogen transport positive regulation of insulin secretion... epinephrine secretion positive regulation of insulin secretion gastric acid secretion epinephrine transport positive regulation of cytokine secretio... prostaglandin transport serotonin secretion cofactor transport histamine transport positive regulation of fatty acid transp... positive regulation of peptide hormone s... transepithelial transport amino acid transmembrane transport positive regulation of peptide secretion negative regulation of transport quaternary ammonium group transport cholesterol transport sterol transport lipoprotein transport FF affected transporter terms Annotated Significant Expected Rank in classic classic weight avgFC.sig avgFC sigGenesUp 444 19 6.69 26 4.40E-05 1 0.100483257 0.010990863 Ace; Aqp3; Cd36; Slc6a3; Slc22a3; Slc23a1; Slc7a8; Slc6a14; Stard3; Aqp11; Maob; Slc36a1; Slc5a11 200 10 3.01 45 0.00092 1 0.373205729 0.033806831 Aqp3; Slc6a3; Slc22a3; Slc7a8; Slc6a14; Aqp11; Maob; Slc36a1 172 9 2.59 48 0.0012 1 0.36164469 0.032399751 Ace; Cd36; Slc23a1; Slc7a8; Slc6a14; Slc36a1 174 9 2.62 49 0.0013 1 0.36164469 0.032261902 Ace; Cd36; Slc23a1; Slc7a8; Slc6a14; Slc36a1 4 2 0.06 51 0.00133 0.00133 -0.442469599 -0.220967149 15 3 0.23 59 0.00134 0.15259 -0.412533878 -0.060796858 60 5 0.9 68 0.00207 1 0.284315526 0.051034293 Aqp3; Slc6a3; Slc22a3; Aqp11 6 2 0.09 76 0.00325 0.00325 0.656853976 0.228404527 Aqp3; Aqp11 6 2 0.09 77 0.00325 0.00325 0.656853976 0.258955314 Aqp3; Aqp11 21 3 0.32 81 0.00367 0.00592 0.517442443 0.12366709 Slc22a3; Slc7a8; Slc47a1 45 4 0.68 94 0.0046 1 0.061229368 0.00860675 Ace; Cd36 176 8 2.65 98 0.00524 1 0.302293667 0.03031946 Slc6a3; Slc22a3; Slc7a8; Slc6a14; Maob; Slc36a1 8 2 0.12 104 0.00596 1 0.656853976 0.170390262 Aqp3; Aqp11 9 2 0.14 118 0.00758 0.04433 -0.093462524 -0.054484156 Cd36 9 2 0.14 119 0.00758 1 0.656853976 0.176985002 Aqp3; Aqp11 30 3 0.45 126 0.01014 1 0.199193302 0.02061467 Ace; Cd36 59 4 0.89 134 0.01195 1 0.137106723 0.015309 Slc6a3; Slc22a3; Maob 1 1 0.02 162 0.01506 0.01506 -0.518023528 -0.518023528 1 1 0.02 164 0.01506 0.01506 0.665485622 0.665485622 Slc22a3 1 1 0.02 173 0.01506 0.01506 0.395600194 0.395600194 Mfsd7b 66 4 0.99 202 0.01745 1 0.061229368 0.009615049 Ace; Cd36 101 5 1.52 210 0.01829 0.28109 -0.44513846 -0.016144287 Aqp3; Aqp11; Slc5a11 16 2 0.24 218 0.02358 0.14031 0.656853976 0.093939831 Aqp3; Aqp11 17 2 0.26 228 0.02646 0.02646 0.501474803 0.129370458 Abcb1a; Slc47a1 sigGenesDown Crym; Fgf15; G6pc; Ly6e; Slco3a1; Acsl6 Crym; Ly6e Crym; Slco3a1; Acsl6 Crym; Slco3a1; Acsl6 Tap1; Tap2 Tap1; Tap2; Slco3a1 Ly6e Slco3a1; Acsl6 Crym; Ly6e Acsl6 Acsl6 Ly6e Tap2 Slco3a1; Acsl6 Fgf15; G6pc 154 6 2.32 238 0.02918 0.11129 0.899526936 0.054131504 Slc6a3; Slc23a1; Slc6a14; Slc5a4b; Slc5a11; Slc5a12 2 1 0.03 2 1 0.03 2 1 0.03 47 3 0.71 47 3 0.71 20 2 0.3 21 2 0.32 3 1 0.05 3 1 0.05 3 1 0.05 895 20 13.48 25 2 0.38 25 2 0.38 4 1 0.06 4 1 0.06 4 1 0.06 27 2 0.41 101 4 1.52 5 1 0.08 5 1 0.08 5 1 0.08 5 1 0.08 5 1 0.08 5 1 0.08 5 1 0.08 151 5 2.27 346 9 5.21 6 1 0.09 6 1 0.09 6 1 0.09 159 5 2.39 37 2 0.56 76 3 1.14 77 3 1.16 78 3 1.17 8 1 0.12 8 1 0.12 41 2 0.62 9 1 0.14 9 1 0.14 45 2 0.68 11 1 0.17 11 1 0.17 11 1 0.17 11 1 0.17 11 1 0.17 48 2 0.72 12 1 0.18 50 2 0.75 50 2 0.75 251 6 3.78 13 1 0.2 52 2 0.78 52 2 0.78 14 1 0.21 258 0.02989 0.02989 -1.089101021 -0.512786822 Acsl6 272 0.02989 0.02989 1.139962295 0.519896547 Slc23a1 279 0.02989 1 1.139962295 0.519896547 Slc23a1 296 0.03364 0.03364 1.088479139 0.103437408 Slc6a3; Slc23a1; Slc6a14 298 0.03364 1 0.035956559 0.031210524 Slc6a3; Slc22a3 Ly6e 306 0.0359 1 0.656853976 0.091515534 Aqp3; Aqp11 312 0.03929 1 0.501474803 0.107768997 Abcb1a; Slc47a1 329 0.0445 0.0445 0.440557216 0.14071944 Maob 330 0.0445 0.0445 -1.148366805 -0.476239121 G6pc 348 0.0445 1 -1.148366805 -0.476239121 G6pc Aqp3; Cd36; Slc6a3; Abcb1a; Slc22a3; Slc23a1; 372 0.05044 0.02839 0.358793992 0.000358302 Slc7a8; Slc6a14; Aqp11; Slc47a1; Slc16a10; Slc36a1; Tap1; Tap2; Mfsd4; Acsl6; Kctd14 Slc5a11; Slc5a12; Cox6b2 373 0.05398 0.05398 0.698267297 0.076938554 Slc6a3; Slc22a3 375 0.05398 1 0.21592126 0.004818963 Ace Slco3a1 399 0.05889 0.05889 0.99562939 0.388835353 Aqp3 400 0.05889 0.05889 1.139962295 0.247530904 Slc23a1 404 0.05889 1 0.395600194 0.016995759 Mfsd7b 424 0.06195 1 2.794049798 0.198799151 Ace; Tff2 434 0.06624 0.36355 0.467480611 0.046291452 Slc7a8; Slc6a14; Slc36a1 Crym 449 0.07307 0.07307 0.74117569 0.229237028 Slc36a1 450 0.07307 0.07307 0.74117569 0.243092893 Slc36a1 451 0.07307 0.07307 0.74117569 0.229662435 Slc36a1 461 0.07307 0.07307 4.80359464 0.919581863 Tff2 462 0.07307 0.07307 -0.797479908 -0.11737469 Crym 468 0.07307 1 0.440557216 0.076147292 Maob 483 0.07307 1 4.80359464 0.919581863 Tff2 492 0.07826 1 -0.260675528 -0.02014092 Glud1 Tap1; Tap2; Slco3a1; Arrb1 493 0.07885 1 0.805188912 0.02866912 Slc6a3; Slc23a1; Slc6a14; Slc5a4b; Slc47a1; Slc36a1; Slc5a11; Slc5a12; Cox6b2 526 0.08703 1 0.99562939 0.262518806 Aqp3 528 0.08703 1 -1.089101021 -0.220994103 Acsl6 530 0.08703 1 0.74117569 0.184499402 Slc36a1 547 0.0926 1 0.115312509 0.001954209 Ace; Cd36; Stard3 Slco3a1; Acsl6 607 0.10674 0.38375 0.6364881 0.047071432 Slc7a8; Slc36a1 611 0.10689 1 1.088479139 0.076731617 Slc6a3; Slc23a1; Slc6a14 614 0.11005 0.11005 0.616512864 0.032801066 Slc47a1; Slc36a1; Cox6b2 620 0.11325 1 0.616512864 0.032839164 Slc47a1; Slc36a1; Cox6b2 624 0.11433 0.11433 -0.491372673 -0.049291186 Arrb1 630 0.11433 0.11433 -1.288664917 -0.18183245 Ly6e 663 0.1265 0.39307 -0.032888004 -0.022740597 Glud1 Arrb1 681 0.12767 1 4.80359464 0.5162938 Tff2 686 0.12767 1 -1.288664917 -0.163202766 Ly6e 723 0.14704 0.14704 -0.358521808 -0.006204047 Ptger4; Scamp5 731 0.15376 0.15376 -0.352662435 -0.021803379 Slco3a1 739 0.15376 1 0.440557216 -0.089367921 Maob 749 0.15376 1 0.395600194 -0.030699299 Mfsd7b 750 0.15376 1 0.665485622 0.056130993 Slc22a3 755 0.15376 1 -1.089101021 -0.108156531 Acsl6 765 0.16286 1 -0.032888004 -0.017811486 Glud1 Arrb1 783 0.16651 1 1.139962295 0.10538884 Slc23a1 788 0.17356 0.17356 0.6364881 0.048611882 Slc7a8; Slc36a1 791 0.17356 1 -0.032888004 -0.016376406 Glud1 Arrb1 795 0.1786 1 0.817731767 0.021707034 Cd36; Tff2; Maob Cnn2; Ptger4; Scamp5 807 0.17907 0.17907 0.665485622 0.12714319 Slc22a3 825 0.18438 0.18438 0.616910523 0.011290148 Cd36; Stard3 828 0.18438 1 0.616910523 0.011290148 Cd36; Stard3 843 0.19144 0.19144 0.902175972 0.071181783 Cd36 TNO report - Final 3M#07 TNO Project number: 051.01978 53 / 59 GO.ID Term GO:0001504 neurotransmitter uptake GO:0072337 modified amino acid transport GO:000560846892 lairpaicdhtirdaonnsipcoarctid secretion GO:0006812 cation transport GO:0035307010 pnheogasptihvoelripeigduelaftfilounx of cytokine secretio... GO:001056980387 fsaetrtoytaocniidnttrraannssppoorrtt GO:00135268952 oprogsaitniivcecraetigounlattriaonnspoof rotrganic acid tran... GO:2000191 regulation of fatty acid transport GO:0015914 phospholipid transport GO:0006811 ion transport GO:0051180 GO:0050707 GO:007016780326 GO:0051953 GO:0015804 GO:0035773 GO:0061178 GO:005416198013 GO:001551900498 GGOO::00001352731089 GO:0050714 GGOO::00003125376588 GO:0050663 GGOO::00003302330710 GO:0008645 GGOO::00001456981887 GO:0015749 GO:007009893174 GO:00145683826 GO:003521327214 GO:003521307540 GO:005007750925 GO:00332384940 GO:0015074079 GO:0010828 GGOO::00004561904427 GO:0050796 GO:0046324 GO:0050432 GGOO::00001456834293 GO:0050708 GO:0090276 GO:0050027091 GO:001950901817 GO:00304279693 GO:001551629079 GO:003120386297 GO:004521905436 GO:0030300 GGOO::00000324327240 GO:00032733698 GO:00130704763 GO:003521397552 GO:003125377121 GO:005007751879 GO:007009633046 GGOO::00007320600782 GO:0050705 GGOO::00007320306071 GGOO::00004334679614 GO:0051222 GGOO::00001177003388 GO:0060402 GGOO::00000072578990 GGOO::00001551899238 GGOO::00005600740061 GGOO::00000466885853 GGOO::00005312198400 GGOO::00000571529253 GO:0002740 GGOO::00004521900489 GGOO::00001453628720 GGOO::00005416681709 GGOO::00005501790234 GGOO::00005006780196 GGOO::00005700780348 GGOO::00003722357101 GGOO::00001056689230 GGOO::00003150492589 GGOO::00000314570642 GGOO::00007423323679 GO:0003096 GO:0015709 GO:0015759 GO:0015794 GO:0015798 GO:0015881 GO:0015898 GO:0032782 GO:0034197 GO:0034633 GO:0035926 vitamin transport regulation of cytokine secretion onreguarnoitcrasunbsmstiatntecer ttrraannssppoorrtt negative regulation of amine transport neutral amino acid transport insulin secretion involved in cellular r... regulation of insulin secretion involved... csoefcarecttoiorntransport lnoengga-tcihvaeinrefgauttlaytaiocindotfrasnescpreotriton micoosnaoncoairdbosexcyrleictiaocnid transport positive regulation of protein secretion rgelugcuolasteiotrnaonfspliopritd transport cytokine secretion cphooslietisvteerroelgturlaantisopnorotf lipid transport hexose transport sptoesriotilvterarnesgpuolarttion of hormone secretion monosaccharide transport dheohrmydornoeastcraonrbspicoarctid transport hpeomsiteivterarnesgpuolarttion of glucose import rneeggualtaitvieonreogfusltaetironl toraf npsrpootertin transport rpeogsuitliavteiornegouf lcahtoiolensotef rtoralntrsapnosrptort ilnactetartleiounkin-1 beta secretion crehgoulelastieornoloeffoflrugxanic acid transport pnoesgiattiviveerreegguulalattioionnooffpplarosmteainmsemcrebtriaonne l... positive regulation of glucose transport cpaorsbiotixvyelirceagcuildattiroannsopfosretcretion regulation of insulin secretion regulation of glucose import catecholamine secretion oglrugcaonsiceaimcidpotrratnsport regulation of protein secretion regulation of peptide hormone secretion irnetgeurlaetuioknino-1f pseecprteidtieonsecretion prelagsumlaatimonemofbpreanpetidloentgr-acnhsapionrftatty acid tr... innetgeastivnealrcehgoulleastitoenroolfatbrsaonrspmtieomn brane tra... qreulaetaesrenaorfysaemqumeostneiuremd gcraolcuipumtraionnspionrtto ... nreeggualtaivtieonreogfuglaluticoonseoftrlaipnisdptorratnsport lriepgouplraotitoeninotfrasencsrpeotriton regulation of intestinal cholesterol abs... cioyntotkriannesmseecmrebtiroanneintvraonlvsepdoritn immune re... regulation of cliyptiodktirnaensepcorrettion involve... rinesguliantisoencroeftpiolansma membrane long-chain... nreeggualtaivtieonreogfualamtiionne otrfacnhsoploerstterol trans... noerggaantivceanreiognultartainosnpoofrtsterol transport pbosdiytifvleuirdegseuclaretitoionnof interleukin-1 alp... tprraontseeinpistehcerleiatlioanmmonium transport ipnetpetrildeeukhionr-m10osneecrseetciroention regulation of interleukin-1 alpha secret... rmeegutalal tioionntorafnlisppiodrttransport by regulat... rpeovseitrisveecrheogluelsatteioronlotrfatnrasnpsomrtembrane tra... positive regulation of protein transport pprrootteeiinn iimmppoorrtt calcium ion transport into cytosol bpoedpytidfleuisdescerectrieotnion dprousgittivraenrsepgourltation of calcium ion trans... rceygtouslaotliiocncaolcfiiunmteirolenutkriann-s1pboertta secreti... drerugugltartainosnmoef mhobrrmanoenetrasencsrpeotriton vseitcarmetiinotnrabnyscpeolrlt lraecgtualtaiotinon of protein transport negative regulation of cytokine secretio... xreegnuolbaitoiotinc otrfatnraspnosprtort fpeorsriitcivireonretgruanlastpioonrtof ion transport sheorromtoonniensuepctraekteion irnetgeurllaetuioknino-1f caalplchiuamseicornettiroannsport ncaelgcaiutimveiorengturalantsipoonrotf protein secretion rdeivgaulleantitomn eotfailnitoenrlteruaknisnp-o1rstecretion pdoivsaitleivnet riengourglaatnioicncoatfiloipnitdratrnasnpsoprot rt manaigonnetsriaunmspioornt transport hreegxuolsaetitornanosfmmeemtablriaonnettrraannssppoorrtt nreeguurloattriaonnsomfittrtaenrsumpteamkebrane transport mreogduilfaiteiodnamofinioonatcriadntsrpaonrstport renal sodium ion transport thiosulfate transport beta-glucoside transport glycerol-3-phosphate transport myo-inositol transport creatine transport amiloride transport bile acid secretion triglyceride transport retinol transport chemokine (C-C motif) ligand 2 secretion Annotated 14 14 15195 667 116 4156 2116 16 33 858 17 60 41414 19 20 20 20 51815 13202 6262 70 4771 71 5223 72 5722 73 1848 245 277 42372 1257 3238 228 30 127027 91 36 38 17349 101 101 11074 1094 493 1436 1486 31748 6 5769 467 1164 1502 1504 537 1330 1331 3 5531 1519 133 220066 61 15376 2612 1622 11378 51173 22277 4 9143 847 1749 1246 22285 21539 22632 1693 1694 31149 31240 1 1 1 1 1 1 1 1 1 1 1 Significant 1 1 431 13 71 151 91 1 12 16 1 2 893 1 1 1 1 161 113 191 2 142 2 151 2 152 2 34 31 92 98 61 101 21 1 364 2 1 1 361 2 2 62 42 41 51 61 56 3 39 31 32 41 41 21 2 22 2 28 41 2 393 1 132 61 41 52 57 73 2 122 21 22 21 72 42 62 31 31 42 41 1 1 1 1 1 1 1 1 1 1 1 Expected 0.21 0.21 230.9263 10.04 10.6264 60.7284 30.1264 0.24 4.97 12.92 0.26 0.9 661.9712 0.29 0.3 0.3 0.3 18.6861 41.5824 90..9353 1.05 71..0087 1.07 70..8345 1.08 71..8048 1.1 20.8.63 00.3.68 41.0176 46.0571 20.2461 40.9472 00.4.32 0.45 253..9122 1.37 0.54 0.57 260..2529 1.52 1.52 21.567 1.3567 10.3665 10.9669 20.7619 25.1619 0.9 80.7.92 00.7.91 10.7.92 10.5718 10.581 0.4856 01.4956 01..4957 0.45 0.84.53 10..6869 2 31.30.51 0.92 82..5095 30..1963 10..8913 22..5068 27..5762 43..0472 0.6 130.7.65 10.3.61 02..67 01..69 43..2329 1.39.69 33..4975 12..3465 12..3467 2.41.18 24..1812 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Rank in classic 845 860 85820 897 96141 99127 99178 924 98 927 952 958 190920 1006 1019 1022 1027 1100376 1101610 1101755 1083 1105807 1088 1105959 1106 1115069 1113 1210427 1210530 1212603 1212717 1213847 124016 126141 1241 1229609 1312 1349 1389 1342073 1409 1410 13443 1345425 1345636 1355092 1357063 1359123 400 1451115 1451220 1451239 1462050 1462179 1467427 1467546 1468631 497 1560603 1562658 1675 1566817 1694 1566949 1578020 1671044 1672144 1672677 1673901 684 1689883 1781927 1791335 2703874 2704896 2716492 2717466 2813610 2813633 2827098 2829556 918 953 954 955 956 958 959 987 996 1002 1015 classic 0.19144 1.91E-01 60.5.200E3-0653 0.20705 0.020105363 0.0201157653 0.0201250673 0.21563 0.00215 0.22274 0.22746 0.22844 0.00.02244683 0.25057 0.26187 0.26187 0.26187 0.0206277817 0.00.02370838 00..0208331976 0.2843 00..0208796848 0.28988 00.2.09048716 0.29546 00.2.09058416 0.30104 0.031241431 0.031251837 0.0312431264 0.0312461367 0.0313761345 0.0314969376 00.3.04262376 0.36593 00..0327394381 0.39921 0.42122 0.43856 00..0424776013 0.45099 0.45099 0.0436264074 0.0436464034 0.0437494638 0.0530427839 0.054026869 00.5.0457954 0.04789 00..0540798298 0.00.45718094 0.0541748397 0.0554066278 0.055096878 0.0567192584 0.056815248 00..0568192686 0.06128 00..0569122088 00..0579023195 0.59793 00..0670520623 0.60439 0.00.76816091 00..0681401347 00..0691304327 00..1601081085 00..1605071381 00..1606073758 0.11042 00..1712074321 00..1713034824 0.01.17054426 00..1815034321 00..1815752861 00..1910945412 00..1920077898 00..1941263726 00..1941283023 00..1945853013 00..1949823519 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 weight 1 1.00E+00 0.5210132683 1 0.020105363 0.026751 0.022631 1 0.28116 0.28138 1 1 0.444213 1 1 1 1 0.1068567516 0.005951 0.72791 1 11 1 0.141561 1 11 1 0.012131 0.0361152837 1 1 0.0363161375 0.032371 0.02271 1 11 1 1 1 11 1 1 1 0.387141 0.387141 00.5.0621829 0.479321 0.04751 0.04789 0.766617 1 1 0.110331 0.559818 0.061281 0.061281 0.150661 1 11 0.070391 1 11 1 0.683111 0.610317 11 0.100181 0.833861 0.100351 0.11042 0.110421 0.150671 0.150671 11 0.509991 11 11 0.142321 0.142321 11 11 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 avgFC.sig 0.665485622 -0.797479908 0.37682475303499575 0.591090921 -0.94129486775948773 -0.040450850537524146 -10.0.3879510816021 -1.089101021 0.537456239 0.42219945 1.139962295 -0.358521808 0.390330635260822498 0.440557216 0.74117569 -0.491372673 -0.491372673 0.138492711078363459 01.062076144992911218 -00..071804858034395555 -0.358521808 -02..504431030101087038 -0.358521808 -01..506839411041809211 -2.041311808 -00..506332481848809014 -2.041311808 -0.25231789890125058 -02.497314522536082161 0.07.721348471580235 0-.07.7513424013872338 0.173510942819072 -01.605879417041306291 -0.345254069745146763 -2.934256811 -00..116965173074996096 -0.032888004 -2.934256811 -1.288664917 -02..196364123576986191 -0.358521808 -0.032888004 -0.1035208982810024 -0.0934238878706034 0.696020179569762 -0.45077560068039 -02.9137492758688161 0.171403454535530792 0.750700871 00..862081499803993194 -01.802889419001903291 -0.00352087898707024 10.045480159597529136 -10.03582169692549335 0.0739130548194732 -0.039518050201981058 -00..305382183898801094 0.039358143 00.5.3729168699266557 -01..607839719031707261 -0.358521808 -00..021323334184208764 -0.407506809 -00..107302689838304094 -00..434552620947656564 --00..040037459036582019 -00.0.4332887888304014 -00..926808158201584478 00..106611075190072835 1.052009306 -0.004.70101673952248 -00..735522821937251564 -00..406342883878203044 -00..033592325987154534 -00..436769894032210891 --00..030739499032512811 -00..134779893012717891 --00..339572766612642335 -00..030562829997856594 -00..505933744662956224 -0-0.3.0542421917450584 0.337808006 0.375093168 1.930995618 -0.61587845 0.448870105 0.43779731 0.479710944 0.337808006 1.007759024 1.015488235 0.381454205 avgFC 0.164748516 0.000508433 0.0936484620080641 0.00189613 -0.600782543905313553 0.0076077352905197 -0.20167094617919393 -0.102474889 0.197316775 -0.001040409 -0.000183721 -0.031973477 0.06833169627465 0.069396732 0.077459524 -0.07443549 -0.07443549 -0.10085569748311395 0.01495075113107831 0.00.2041413993132829 -0.009232102 -00..108564679901701467 -0.030923031 -00..104017520497451292 -0.05349307 -00..104012530890431691 -0.050273839 -0.100260820493026087 -0.31025846410499312 0.30048934671701687 -0.3002409748774138 0.0410738127919935 -0.20525952691065 -0.305151069149136568 -0.092512402 0.00.5050112259613542 -0.023529061 -0.074746981 -0.002091313 -00..005752038412764934 -0.017494262 -0.021955426 0-.00.403227296975689 0-.01.101297194947369 -0.0908064671706587 -0.20249817393791644 -0.3067510917503861 0.1071104851452162 0.396660363 0.04.0080817176350467 -0.40018387747130961 0-.00.602178535826082 00.0.48770304688364 -00.0.4080793448608564 -0.003247121250564 -0.092128178982838 -00..301049889972150253 -0.003411506 -00..300034280636642123 -00..201463200937160281 -0.011013216 -00..000086497083914663 -0.045915008 0-.00.2071759685561881 -00..106671999075524874 --00..001505169930629061 -00..106099646545783032 -00..301103135698189358 -00..003056154697949825 0.526373286 -00..004161633043742247 -00.0.3670795663229881 -00..207059627401516033 -00..000423050422221413 -00..101410354915590176 -0-0.0.0306008905594341 -00..005384976088632835 --00..006069102933539631 -00..000319090670279587 -00..108139665379624924 -00..004284046763195967 0.337808006 0.375093168 1.930995618 -0.61587845 0.448870105 0.43779731 0.479710944 0.337808006 1.007759024 1.015488235 0.381454205 sigGenesUp ASlbcc2a21a;3Ace; Plin2; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Apoh; Atp8a1; Atp9a; Cd36; Fabp2; Lrp6; MActetp; Pon1; Ppara; Rbp4; Ncor1; Nr1h3; Slco2a1; Slc267aa32; ;SSlcl2c27aa34; ;SAlcb2c3aa71;;ASltcp79ab8;;SStlacr6da31;4O; Sslbcp5la14ab;; OSlscb4p7al31;;SSplcn3s61a;1O;sSblcp5;aO1s1b; pSlc65; aN1p2c;1Cl1o;xA6bp2ob; Irs2; Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; AMcaeo;bPlin2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Slc22a1; Slc22a3; Slc22a4; Slc7a8; Rhbg; Pdzk1; Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; ASltcp68aa31;;SAlct2p29aa3;;ASblcc2a37a; 1A;tSpl9cb7a8; Slc6a14; Slc5a4b; AAbqcpa111;;ASclce4;7Pal1in; 2S;lcA3p6oa1a;1S; lAcp5ao1a12;; SAlpc5oaa142;;ACpooxc61b;2 Apoc2; Apoh; Arg1; Atp8a1; Atp9a; Cd36; Slc6a3; ESdlcn213;aF1abp2; Slc37a4; Slc6a4; Ins2; Lrp6; Mttp; Prkcz; Pon1; Ppara; Inpp5k; Rbp4; Ncor1; Slc22a1; Slc262aa33; ;SSlcl2c23aa31; ;SSlcl6c2aa134; Slc3a1; Nr1h3; Slco2a1; SMlca2o7ba2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Abca7; Slco361ab12; Slc22a4; Atp9b; Slc7a8; Slc5a3; Arl2; Pdzk1; Stard3; Osbpl1a; Nisch; Slc35a4; Slc25a22; Adipor2; Osbpl3; Spns1; Osbp; Abcc3; Osbpl6; Abcecb; S6l;cS6lac36;aG8;luMdf1s;dT7fcf;2M; Mfsado7bb ATfcfe2;;PMliano2b; Cd36; Fabp2; Slc27a4; Irs2; Acsl5 Ace; Plin2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Slco1b2; Abcc3; Irs2; Acsl5 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Ppara; Ncor1; Nr1h3; Irs2; Acsl5 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Cd36; Lrp6; Pon1; Nr1h3; Stard3; Npc1l1; Apob AGblucda1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Cd36; Lrp6; Pon1; Nr1h3; Stard3; Npc1l1; Apob SGllcu2d31a1; Slc2a3 Abcb6; Mfsd7c; Mfsd7b ACdb3ca61; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; ACdb3ca61; ;GAlupdo1a1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; ASlbcc6aa13; Apoa1; F2rl1; Panx1 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Acsl5 Ace; Plin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; SGllcuod21a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; SGllcuod11b2; Slc22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; Slc6a8; Slc36a1; Slc36a2; Slc7a15; Irs2; Acsl5 Ace; Plin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; Slco2a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Slco1b2; Slc22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; SGllcu6da18; Slc36a1; Slc36a2; Slc7a15; Irs2; Acsl5 AGblucda1; Apoa1; F2rl1; Panx1 CGdlu3d61; Irs2; Acsl5 ACdp3o6a1; Apoa2; Apoa4; Npc1l1 Slc22a1; Slc22a3; Slc22a4; Pdzk1; Slc6a8 Apoa2; Apoc1; Apoc2; Nr1h3; Irs2 AGpluodc12; TCfdf23;6M; Maottbp; Apob ASlpco6a31; SAlpc2o2aa23; ;ASplco2a34a1; Slc7a8; Slc6a14; Slc47a1; ASlpco36aa11; ;ACpooxa62b; 2F2rl1 Apoa1; Apoa2; F2rl1 IGrslu2d; A1csl5 AMpaooab2; Apoc1; Apoc2 Apoa2; Apoc1; Apoc2 PSlacn6xa13 Rhbg FG2lurld11; Prkcz Panx1 PSlpca6raa3;;NSclco2r31a1; Slc6a14; Slc5a4b; Slc5a11; Slc5a12 Abca1; Apoa1; Apoa2; Apoa4 Bcl6; Cd36; Cry2; Dag1; Hyal2; Jak2; Jun; Ppp3ca; SCtda3t63; Thra; Tnfrsf1a; Ing1; Mapk1; Pex14; Tomm34; Dab2ip; Flna; Pde2a; Pex6; Ipo13 AGplurdt;1Copa; Slc6a3; Edn1; Eif2ak3; Guca2b; Nr1h3; Slc22a1; Slco1b2; Slc47a1; Abcc3; Abp1; Slc18a1 Apoa1; Panx1 SGllcu2d21a1; Slco1b2; Slc47a1; Abcc3; Slc18a1 GGclu; dR1b;pM4;aSolbc23a1; Slc2a3 ACdp3rt6; Slc6a3; Eif2ak3; Vdr; Vegfa Apoa1; Apoa2 ACdb3cc63; Glud1; Tff2; Maob Trf; Lmtk2 SGllcu6da14; Slc18a1 Panx1 Apoa1; Apoa2; F2rl1; Ins2; Nr1h3 Apoa1; Panx1 Abca1; Pon1; Nr1h3; Acsl5 Slc37a4; Slc2a3 SCldc366a4; Slc22a3; Cln8; Slc18a1 Slc9a3r1; Slc6a8 Slc9a3r1 Slc25a10 Apoa2 Slc5a3 Slc6a8 Abp1 Slc9a3r1 Apoh Rbp4 F2rl1 sigGenesDown Crym Pla2g4a; Pparg; Slc25a17; Soat1; Pla2g10; Acsl4; Acsl6; Atp11c Lck; Wfs1 Ptger4 Pla2g4a; Pparg; Slc25a17; Pla2g10; Acsl4; Acsl6 SAlcs1l26a2 Acsl6 Pla2g10; Atp11c Lck; Wfs1; Slco3a1; Kctd14 APtqgpe8r;4C; rSycmam; Epd5nra; Hiat1; Itln1; Pla2g4a; Pparg; Slc16a1; Slc25a17; Slc2a1; Soat1; Stxbp3a; Pla2g10; Acsl4; Slc37a2; Slc25a26; Sfxn5; Acsl6; Atp11c Arrb1 Arrb1 PHpckt1;;LSyl6ce2;5Pat2g6er4; Scamp5; Arrb1; Car9 Pltag2egr4a; Pparg; Pla2g10; Acsl6 Aqp8; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pla2g10; APtcgsel4r;4A; Scscla6mp5 PFglaf21g51; 0G;6Apccsl6 Ptger4; Scamp5 SAocaslt61; Pla2g10 Fgf15; G6pc SAorrabt11; Pla2g10 Fgf15; G6pc SClrcy2ma1; Ly6e; Arrb1 Fgf15 Pltag2egr140 PFglaf21g51; 0Ptger4; Wfs1; Scamp5; Arrb1; Acsl6 Casp1; Pycard SAocaslt61; Pla2g10 APtcgsel6r4 Fgf15 APtqgpe8r;4C; rSycmam; Ppl5a;2Agr4rab;1Pparg; Slc16a1; Slc25a17; PAlrar2bg110; Acsl4; Slc25a26; Sfxn5; Acsl6 Fgf15 Ly6e AFgqfp185; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pltag2egr140; ;SAcacmsl4p;5Slc25a26; Sfxn5; Acsl6 Arrb1 CAarrsbp1; Pycard Acrrsbl61 Lck PFglaf21g510 Pptgaergr4; Scamp5; Arrb1 Kctd14 Acsl6 Acrrsbl61 Pla2g10 PSlcao23ga110 Casp1 SPltcg1e2ra42; Scamp5 Arrb1 Casp1 Lck; Wfs1 Acsl6 APtrgnetlr;4C;dSkca1m; Epc5t2; Hspa4; Kpnb1; Kpna3; Prdx1; RAarnnt;lT;iPmikm3r91; Mtx2; Psmd10; Nop58; Pex3; Snupn; ILpcok5; Ipo4; Pex12; Tlr3; Tomm22 UAsrrfb2;1Agr2; Sytl2; Socs2 Wfs1 CLcaksp1; Pycard Arrb1 SHlcck2;aL1y6e; Ptger4; Scamp5; Arrb1 UPtsgf2e;r4S;oSccsa2mp5 Cnn2; Fgf15; Hck; Ptger4; Wfs1; Scamp5; Arrb1; SAlccs2la61 Wfs1 Arrb1 CWafssp11 PLctkg;eWr4f;sD1ph3 CLcaks;pW1;fPs1ycard PLclak2; gW1f0s;1Acsl6 TSulcsoc33a; 1Nipa2; Nipa1 SWlcf2sa11 Acsl6 CWryfsm1; Slc25a26 Slc37a2 TNO report - Final 3M#07 TNO Project number: 051.01978 54 / 59 GO.ID Term GO:0006869 lipid transport GO:0033700 phospholipid efflux GO:0015908 fatty acid transport GO:0015695 organic cation transport GO:0015914 phospholipid transport GO:0071702 organic substance transport GO:0051181 cofactor transport GO:0015909 long-chain fatty acid transport GO:0015718 monocarboxylic acid transport GO:0032368 regulation of lipid transport GO:0030301 cholesterol transport GO:0015918 sterol transport GO:0070837 dehydroascorbic acid transport GO:0015886 heme transport GO:0032371 regulation of sterol transport GO:0032374 regulation of cholesterol transport GO:0050702 interleukin-1 beta secretion GO:0033344 cholesterol efflux GO:0010747 positive regulation of plasma membrane l... GO:0046942 carboxylic acid transport GO:0015849 organic acid transport GO:0050701 GO:0015911 GO:0030299 GO:0015697 GO:0032369 GO:0042953 GO:0030300 GO:0002374 GO:0002739 GO:0010746 GO:0032375 GO:0032372 GO:0050717 GO:0070634 GO:0072608 GO:0050705 GO:0072367 GO:0043691 interleukin-1 secretion plasma membrane long-chain fatty acid tr... intestinal cholesterol absorption quaternary ammonium group transport negative regulation of lipid transport lipoprotein transport regulation of intestinal cholesterol abs... cytokine secretion involved in immune re... regulation of cytokine secretion involve... regulation of plasma membrane long-chain... negative regulation of cholesterol trans... negative regulation of sterol transport positive regulation of interleukin-1 alp... transepithelial ammonium transport interleukin-10 secretion regulation of interleukin-1 alpha secret... regulation of lipid transport by regulat... reverse cholesterol transport GO:0017038 protein import GO:0007589 GO:0015893 GO:0050706 GO:0006855 GO:0051180 GO:0007595 GO:0002740 GO:0042908 GO:0015682 GO:0051610 GO:0050703 GO:0050709 GO:0050704 GO:0032370 GO:0015693 GO:0035428 GO:0001504 GO:0072337 GO:0003096 GO:0015709 GO:0015759 GO:0015794 GO:0015798 GO:0015881 GO:0015898 GO:0032782 GO:0034197 GO:0034633 GO:0035926 body fluid secretion drug transport regulation of interleukin-1 beta secreti... drug transmembrane transport vitamin transport lactation negative regulation of cytokine secretio... xenobiotic transport ferric iron transport serotonin uptake interleukin-1 alpha secretion negative regulation of protein secretion regulation of interleukin-1 secretion positive regulation of lipid transport magnesium ion transport hexose transmembrane transport neurotransmitter uptake modified amino acid transport renal sodium ion transport thiosulfate transport beta-glucoside transport glycerol-3-phosphate transport myo-inositol transport creatine transport amiloride transport bile acid secretion triglyceride transport retinol transport chemokine (C-C motif) ligand 2 secretion PFOS affected transporter terms Annotated 159 11 45 21 33 444 11 30 66 47 52 52 4 4 27 27 15 33 2 172 174 17 9 9 13 18 14 6 6 6 6 10 10 3 3 3 3 3 11 206 57 21 12 17 17 27 4 4 4 4 4 28 13 23 9 9 14 14 1 1 1 1 1 1 1 1 1 1 1 Significant 43 7 15 9 12 89 6 11 19 14 15 15 3 3 9 9 6 10 2 36 36 6 4 4 5 6 5 3 3 3 3 4 4 2 2 2 2 2 4 39 13 6 4 5 5 7 2 2 2 2 2 7 4 6 3 3 4 4 1 1 1 1 1 1 1 1 1 1 1 Expected 23.96 1.66 6.78 3.16 4.97 66.91 1.66 4.52 9.95 7.08 7.84 7.84 0.6 0.6 4.07 4.07 2.26 4.97 0.3 25.92 26.22 2.56 1.36 1.36 1.96 2.71 2.11 0.9 0.9 0.9 0.9 1.51 1.51 0.45 0.45 0.45 0.45 0.45 1.66 31.05 8.59 3.16 1.81 2.56 2.56 4.07 0.6 0.6 0.6 0.6 0.6 4.22 1.96 3.47 1.36 1.36 2.11 2.11 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Rank in classic 52 64 92 97 98 102 107 111 115 150 155 156 202 203 220 221 234 241 264 290 327 343 352 353 359 376 392 400 411 412 413 425 427 472 474 483 497 500 525 561 564 582 614 624 627 630 684 698 712 713 737 749 769 776 831 833 879 895 918 953 954 955 956 958 959 987 996 1002 1015 classic 6.50E-05 0.00033 0.00175 0.00207 0.00215 0.00248 0.00271 0.00303 0.00317 0.00764 0.0081 0.0081 0.01213 0.01213 0.01416 0.01416 0.01714 0.01997 0.0227 0.02348 0.02761 0.03247 0.03443 0.03443 0.03473 0.04266 0.0475 0.04789 0.04789 0.04789 0.04789 0.05067 0.05067 0.06128 0.06128 0.06128 0.06128 0.06128 0.07039 0.07502 0.07869 0.08414 0.09342 0.10018 0.10018 0.10035 0.11042 0.11042 0.11042 0.11042 0.11042 0.11726 0.11951 0.12079 0.14232 0.14232 0.14831 0.14831 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 weight 0.51128 0.00033 0.02675 0.02263 0.28116 1 0.16571 0.00595 0.7279 1 0.14156 1 0.01213 0.06123 1 1 0.06117 0.03237 0.0227 1 1 1 0.38714 0.38714 0.0612 0.47932 0.0475 0.04789 1 1 1 0.11033 1 0.06128 0.06128 0.15066 1 1 0.07039 1 0.68311 1 1 0.10018 0.83386 0.10035 0.11042 0.11042 0.15067 0.15067 1 0.50999 1 1 0.14232 0.14232 1 1 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 0.15071 avgFC.sig 0.362733997 0.919877987 -0.005803544 0.37508621 0.537456239 0.303656829 0.189717335 0.027149911 -0.010883355 0.543000073 0.563414891 0.563414891 0.221889155 0.471523026 0.771441823 0.771441823 0.135092102 0.657474369 -0.355094166 0.166137969 0.166137969 0.135092102 0.094387763 0.662079676 0.457760803 0.917978886 0.110443509 0.750700871 0.828490939 0.828490939 0.005079772 1.058199593 1.058199593 0.039358143 0.091000915 0.358139819 0.039358143 0.32189265 0.673793776 0.012348286 0.170693349 0.445604666 -0.003493521 0.43878341 0.960180547 0.161059023 1.052009306 -0.047117924 0.752813216 0.464837234 0.039358143 0.466843209 -0.003493521 0.147831779 -0.397761623 0.006899869 0.553746962 -0.04411408 0.337808006 0.375093168 1.930995618 -0.61587845 0.448870105 0.43779731 0.479710944 0.337808006 1.007759024 1.015488235 0.381454205 avgFC 0.096860004 0.608530335 0.007075959 0.217967999 0.197316775 0.068369276 0.108594319 0.019051173 0.024439122 0.186690716 0.141509419 0.141509419 0.106809068 0.302861491 0.304947718 0.304947718 0.040317193 0.255529165 -0.355094166 0.055125634 0.055081743 0.043226758 0.111914439 0.098661768 0.229133964 0.367191536 0.171081516 0.396660363 0.408877306 0.408877306 0.062755268 0.48734686 0.48734686 -0.003411506 0.091818923 0.314897105 -0.003411506 0.303203622 0.216203108 0.008478946 0.027798518 0.167997547 -0.010193696 0.169664733 0.310159195 0.035149992 0.526373286 0.046634724 0.37756298 0.275670563 0.002002211 0.111341507 -0.00080544 0.058968623 -0.066123593 0.001007298 0.183657642 0.048066156 0.337808006 0.375093168 1.930995618 -0.61587845 0.448870105 0.43779731 0.479710944 0.337808006 1.007759024 1.015488235 0.381454205 sigGenesUp Abca1; Ace; Plin2; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Apoh; Atp8a1; Atp9a; Cd36; Fabp2; Lrp6; Mttp; Pon1; Ppara; Rbp4; Ncor1; Nr1h3; Slco2a1; Slc27a2; Slc27a4; Abca7; Atp9b; Stard3; Osbpl1a; Osbpl3; Spns1; Osbp; Osbpl6; Npc1l1; Apob; Irs2; Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Ace; Plin2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Slc22a1; Slc22a3; Slc22a4; Slc7a8; Rhbg; Pdzk1; Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Atp8a1; Atp9a; Abca7; Atp9b Abca1; Ace; Plin2; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Apoh; Arg1; Atp8a1; Atp9a; Cd36; Slc6a3; Edn1; Fabp2; Slc37a4; Slc6a4; Ins2; Lrp6; Mttp; Prkcz; Pon1; Ppara; Inpp5k; Rbp4; Ncor1; Slc22a1; Slc22a3; Slc23a1; Slc2a3; Slc3a1; Nr1h3; Slco2a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Abca7; Slco1b2; Slc22a4; Atp9b; Slc7a8; Slc5a3; Arl2; Pdzk1; Stard3; Osbpl1a; Nisch; Slc35a4; Slc25a22; Adipor2; Osbpl3; Spns1; Osbp; Abcc3; Osbpl6; Abcb6; Slc6a8; Mfsd7c; Mfsd7b Ace; Plin2; Cd36; Fabp2; Slc27a4; Irs2; Acsl5 Ace; Plin2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Slco1b2; Abcc3; Irs2; Acsl5 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Ppara; Ncor1; Nr1h3; Irs2; Acsl5 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Cd36; Lrp6; Pon1; Nr1h3; Stard3; Npc1l1; Apob Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Cd36; Lrp6; Pon1; Nr1h3; Stard3; Npc1l1; Apob Slc23a1; Slc2a3 Abcb6; Mfsd7c; Mfsd7b Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Abca1; Apoa1; F2rl1; Panx1 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Acsl5 Ace; Plin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; Slco2a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Slco1b2; Slc22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; Slc6a8; Slc36a1; Slc36a2; Slc7a15; Irs2; Acsl5 Ace; Plin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; Slco2a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Slco1b2; Slc22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; Slc6a8; Slc36a1; Slc36a2; Slc7a15; Irs2; Acsl5 Abca1; Apoa1; F2rl1; Panx1 Cd36; Irs2; Acsl5 Apoa1; Apoa2; Apoa4; Npc1l1 Slc22a1; Slc22a3; Slc22a4; Pdzk1; Slc6a8 Apoa2; Apoc1; Apoc2; Nr1h3; Irs2 Apoc2; Cd36; Mttp; Apob Apoa1; Apoa2; Apoa4 Apoa1; Apoa2; F2rl1 Apoa1; Apoa2; F2rl1 Irs2; Acsl5 Apoa2; Apoc1; Apoc2 Apoa2; Apoc1; Apoc2 Panx1 Rhbg F2rl1; Prkcz Panx1 Ppara; Ncor1 Abca1; Apoa1; Apoa2; Apoa4 Bcl6; Cd36; Cry2; Dag1; Hyal2; Jak2; Jun; Ppp3ca; Stat3; Thra; Tnfrsf1a; Ing1; Mapk1; Pex14; Tomm34; Dab2ip; Flna; Pde2a; Pex6; Ipo13 Aprt; Copa; Slc6a3; Edn1; Eif2ak3; Guca2b; Nr1h3; Slc22a1; Slco1b2; Slc47a1; Abcc3; Abp1; Slc18a1 Apoa1; Panx1 Slc22a1; Slco1b2; Slc47a1; Abcc3; Slc18a1 Gc; Rbp4; Slc23a1; Slc2a3 Aprt; Slc6a3; Eif2ak3; Vdr; Vegfa Apoa1; Apoa2 Abcc3 Trf; Lmtk2 Slc6a4; Slc18a1 Panx1 Apoa1; Apoa2; F2rl1; Ins2; Nr1h3 Apoa1; Panx1 Abca1; Pon1; Nr1h3; Acsl5 Slc37a4; Slc2a3 Slc6a4; Slc22a3; Cln8; Slc18a1 Slc9a3r1; Slc6a8 Slc9a3r1 Slc25a10 Apoa2 Slc5a3 Slc6a8 Abp1 Slc9a3r1 Apoh Rbp4 F2rl1 sigGenesDown Pla2g4a; Pparg; Slc25a17; Soat1; Pla2g10; Acsl4; Acsl6; Atp11c Pla2g4a; Pparg; Slc25a17; Pla2g10; Acsl4; Acsl6 Slc12a2 Pla2g10; Atp11c Aqp8; Crym; Ednra; Hiat1; Itln1; Pla2g4a; Pparg; Slc16a1; Slc25a17; Slc2a1; Soat1; Stxbp3a; Pla2g10; Acsl4; Slc37a2; Slc25a26; Sfxn5; Acsl6; Atp11c Ppt1; Slc25a26 Pla2g4a; Pparg; Pla2g10; Acsl6 Aqp8; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pla2g10; Acsl4; Acsl6 Pla2g10; Acsl6 Soat1; Pla2g10 Soat1; Pla2g10 Slc2a1 Pla2g10 Pla2g10 Casp1; Pycard Soat1; Pla2g10 Acsl6 Aqp8; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 Aqp8; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 Casp1; Pycard Acsl6 Pla2g10 Pparg Acsl6 Pla2g10 Pla2g10 Casp1 Slc12a2 Casp1 Arntl; Cdk1; Ect2; Hspa4; Kpnb1; Kpna3; Prdx1; Ran; Timm9; Mtx2; Psmd10; Nop58; Pex3; Snupn; Ipo5; Ipo4; Pex12; Tlr3; Tomm22 Usf2; Agr2; Sytl2; Socs2 Casp1; Pycard Slc2a1 Usf2; Socs2 Slc2a1 Casp1 Ptger4; Dph3 Casp1; Pycard Pla2g10; Acsl6 Tusc3; Nipa2; Nipa1 Slc2a1 Crym; Slc25a26 Slc37a2 TNO report - Final 3M#07 TNO Project number: 051.01978 55 / 59 GO.ID Term GO:0050713 negative regulation of interleukin-1 bet... GO:0051615 histamine uptake GGOO::00000561896797 lliypsiodpthraonsspphoorltipid transport GO:0060695 negative regulation of cholesterol trans... GO:0071423 malate transmembrane transport GGOO::00003732730609 prehgouslpahtioolnipoidf leipffilduxtransport by positiv... GGOO::00001752950182 ftaritvtyalaecnidt itnroanrgsapnoirctcation transport GGOO::00001950619958 onreggaantiicvecarteiognultartainosnpoofrtchemokine secreti... GO:0090341 negative regulation of secretion of lyso... GGOO::00001957901347 phheomsepheoxlpipoirdt transport GO:2001153 positive regulation of renal water trans... GO:2001181 positive regulation of interleukin-10 se... GO:0015743 malate transport GO:0034196 acylglycerol transport GGOO::00007416780624 oisrogpanreicnsouidbsttrancsepotratnsport GO:0046865 terpenoid transport GO:0060694 regulation of cholesterol transporter ac... GO:0071938 vitamin A transport GO:2001151 regulation of renal water transport GGOO::00005016188219 czoinfaccitoonr transport GGOO::00001150910097 lpoontga-scshiuaimn fioatntyimacpiodrtransport GGOO::00001155771282 mcaonnaoliccaurlbaor xbyilleicaacciiddttrraannssppoorrtt GO:0015808 L-alanine transport GGOO::00003125386186 rgelygcuilnaetiotrnanosfpliopritd transport GO:0015879 carnitine transport GGOO::00003105380214 cphroolleinsetetrroalntsrpaonrstport GO:0015838 betaine transport GGOO::00001050901481 sttreanroslittiroannsmpeotratl ion transport GO:0070837 dehydroascorbic acid transport GGOO::00001551828264 hneemgaetitvreanrespgourlat tion of protein transport GGOO::00003520377110 rneeggualtaitvieonreogfusltaetrionl torafncsyptokrtine secretio... GGOO::00003120387744 rreegguullaattiioonnooff cchhoolleesstteerrooll terfafnluspxort GGOO::02005000710921 irnetgeurlaetuiokinno-1f bfaetttaysaeccidrettriaonnsport GGOO::00003130384745 cphooslietisvte rroelgeuflfaltuioxn of cholesterol efflu... GGOO::00001500774178 ppoossiittiivvee rreegguullaattiioonnooff pinlatesmrleaumkienm-1bbraent.e..l... GO:0050716 positive regulation of interleukin-1 sec... GGOO::00004561964028 chairsbtaomxyinliec atrcaidnstpraonrstport GO:2000193 positive regulation of fatty acid transp... GO:0070508 cholesterol import GO:0015696 ammonium transport GGOO::00001352834298 oarlagnaniniceatcraidnstrpaonrstport GO:0035376 sterol import GO:0035382 sterol transmembrane transport GGOO::00005006780216 iinrotenriloenuktirna-n1spseocrrtetion GGOO::00001550971115 pploasimtivaemremgublaratinoenlofncgy-ctohkainefastetcyraectido.t.r.... GGOO::00003500279194 ipnotesisttiivnearlecghuolaetsitoenroolfapbrsooterpintiosencretion GO:0015697 quaternary ammonium group transport GGOO::00003028366493 ncaergbaotihvyedrreagteultartainosnpoofrtlipid transport GO:0042953 lipoprotein transport GGOO::00003500370008 rreegguullaattiioonnooff ipnrtoetsetiinnaslecchreotleiosnterol abs... GGOO::00000322327744 cgyotnoakdinoetrsoepcirnestieocnreintivoonlved in immune re... GGOO::00000322733793 rpeogsuitlaivteiorneoguf lcayttiookninoef steecrroelttiorannisnpvoorltve... GGOO::00001302734766 rpeogsuitlaivteiorneoguf lpaltaisomnaofmcehmolbersatneerollotnragn-csh..a.in... GGOO::00003720367353 ntreagnasteivpeitrheegluiallatrioansopfocrhtolesterol trans... GGOO::00003021357729 nmeegdaituivme-rcehgauinlaftaiottnyoafcisdtetroanl tsrpaonrstport GGOO::00005002771471 ppoossiittiivvee rreegguullaattiioonnooff icnytteorkleinuekisne-c1reatlpio.... GGOO::00007100693643 trreagnusleaptiiothneolifaLl-aamrgminoinneiuimmptroarntsport GGOO::00007320610885 innitterircleouxkidine-1tr0asnescproerttion GGOO::00005302740156 rneeggualtaitvieonreogfuilnatteiorlneuokf isno-d1iaulmph:haysdercorgeet.n..a... GGOO::00007426386871 rpeogsuitlaivteiorneoguf llaiptiiodntroafnfsoplolirctleb-ystriemguullaatt...... GGOO::00004531699315 rgeluvetarmseactheoulpetsatekeroilntvroanlvsepdorint synaptic tr... GO:0060621 negative regulation of cholesterol impor... GGOO::00001770093084 ptrraonteseinpiitmhpeoliratl L-ascorbic acid transpor... GO:0072368 GGOO::00000772568493 GGOO::00001950829338 GGOO::02005000760664 GGOO::02000060865657 GGOO::00005110198508 GGOO::00000175589852 GGOO::00000322724708 GGOO::00004422990486 GGOO::00001550678121 GGOO::00005511611802 GGOO::00005501790333 GGOO::00005701780096 GGOO::00005702760043 GGOO::00003722367101 GGOO::00001950619832 GGOO::02003050462580 GGOO::02000010560642 GGOO::02007020363675 GGOO::02000030099160 GGOO::02001051710799 GGOO::00001056785291 GGOO::00001354729149 GGOO::00001750729584 GGOO::00001550878017 GGOO::00001155879281 GGOO::00003426738226 GGOO::00003344179677 GGOO::00003446683834 GGOO::00003350912567 regulation of lipid transport by negativ... binotdeyrffeluroidn-sgeacmremtioansecretion dprousgittirvaenrsepgourltation of arachidonic acid ... rpeogsuitlaivteiorneoguf lianttieornleoufkiinnt-e1rbleeutkaisne-5crseetci...... dprousgittirvaenrsemgeumlatbiroannoeftirnatnesrpleourtkin-13 se... vreitgaumlaintiotrnanosfpaomrtino acid import lLa-catsactoiorbnic acid transport npeogsaittiivvee rreegguullaattiioonn ooff gcoyntoakdionterospeicnresteiocr...... xgeluncoobsiiodteictrtarannssppoortrt fneergriactiirvoenretrgaunlsaptioornt of interleukin-1 sec... sceoreontzoynmineutpratankseport ianmteinrloeuakciidn-u1patlapkheaisnevcorlevteiodnin synaptic t... nperogtaetiivnetrraengsumlaetimonbroafnpertortaenisnpsoerctretion riengteurllaetuioknino-f5isnetcerreletiuoknin-1 secretion pinotseitrilveeukreing-u1l3atsieocnreotfiolinpid transport mreaggunlaetsiiounmoifosnetcrraentisopnorotf lysosomal enz... hneexgoastievetrarengsumlaetmiobnraonfesotrdainusmpoiortn transm... nreeguurolattriaonnsmofitinteter rulpetuakkien-5 secretion mreogduilfaiteidonamofininoteacrliedutkrainn-s1p3osret cretion rneengaaltsivoediruemguiloantiotrnanosfpsotertrol import trheigouslualtfiaotneotrfainnsteprolretukin-10 secretion bcheltoar-igdluectorasindsepotrratnsport gclayrcbeorhoyl-d3r-aptheotsrpanhsamteetmrabnrsapnoerttransport mmyuoc-uisnosesictroelttiorannsport crreegautlianteiotnraonfscpyotrotkine secretion abmileiloarciiddeatnrdanbsipleosrtalt transport bpiolesiaticvied rseegcurelatitoionn of glucose import tproigsliytciveerirdeegturlaantisopnorotf ion transmembrane... rfeotlilnicolel -tsratinmspuolartting hormone secretion cphaenmcroekaitnicej(uCic-Ce mseoctrieft)iloignand 2 secretion GO:0015791 polyol transport Annotated Significant Expected Rank in classic classic weight avgFC.sig avgFC sigGenesUp sigGenesDown 1 1 0.15 1044 0.15071 0.15071 0.173022994 0.173022994 AAbpcoaa11; Ace; Plin2; Apoa1; Apoa2; Apoa4; Apoc1; 1 1 0.15 1591 431 230..9165 1 1 0.15 1049 0.15071 0.15071 0.729750694 0.729750694 ASlpco2c22a;3Apoh; Atp8a1; Atp9a; Cd36; Fabp2; Lrp6; 105522 60.5.105E0-0751 00..5115102781 -00..376921783932909371 -00..079961886902000341 Mttp; Pon1; Ppara; Rbp4; Ncor1; Nr1h3; Slco2a1; 1060 0.15071 0.15071 1.930995618 1.930995618 SAlpc2o7aa22; Slc27a4; Abca7; Atp9b; Stard3; Osbpl1a; PPllaa22gg41a0; Pparg; Slc25a17; Soat1; Pla2g10; Acsl4; Acsl6; Atp11c 1 1 0.15 1079 0.15071 0.15071 0.375093168 0.375093168 OSlscb2p5la31;0Spns1; Osbp; Osbpl6; Npc1l1; Apob; Irs2; 111 71 10..6165 106848 00..0105003731 00..0105003731 0.09.1494837273918174 0.06.0484533203313154 APbpcaara1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; 451 151 60..7185 109920 00..0105107751 00..0125607751 -01..000850870039524848 01..000870077059925898 ATrcfe; Plin2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Pla2g4a; Pparg; Slc25a17; Pla2g10; Acsl4; Acsl6 211 91 30..1165 109972 00..0105200771 00..0125206731 00.3.3871540584622015 00..231871946574929095 SFl2cr2l21a1; Slc22a3; Slc22a4; Slc7a8; Rhbg; Pdzk1; Slc12a2 1 1 0.15 331 121 40..9175 1096 0.15071 0.15071 0.549647293 0.549647293 ANbr1cah13; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; 109987 00..0105201751 00..2185101761 00..533170425262253094 00..139170321262757054 AMtfps8da71b; Atp9a; Abca7; Atp9b Pla2g10; Atp11c 1 1 0.15 1119 0.15071 0.15071 0.355209957 0.355209957 AInbpcpa51k; Ace; Plin2; Apoa1; Apoa2; Apoa4; Apoc1; 1 1 0.15 1120 0.15071 0.15071 0.334825433 0.334825433 APprkoccz2; Apoh; Arg1; Atp8a1; Atp9a; Cd36; Slc6a3; 1 1 0.15 1152 0.15071 1 0.375093168 0.375093168 ESdlcn215;aF1a0bp2; Slc37a4; Slc6a4; Ins2; Lrp6; Mttp; 1 1 0.15 1173 0.15071 1 1.007759024 1.007759024 PArpkoczh; Pon1; Ppara; Inpp5k; Rbp4; Ncor1; Slc22a1; Aqp8; Crym; Ednra; Hiat1; Itln1; Pla2g4a; Pparg; 4441 891 660..9115 1110929 00..0105204781 11 01..300135645868822395 01..006185346898227365 SRlbc2p24a3; Slc23a1; Slc2a3; Slc3a1; Nr1h3; Slco2a1; Slc16a1; Slc25a17; Slc2a1; Soat1; Stxbp3a; Pla2g10; 1 1 0.15 1200 0.15071 1 1.015488235 1.015488235 SRlbc2p74a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Abca7; Acsl4; Slc37a2; Slc25a26; Sfxn5; Acsl6; Atp11c 1 1 0.15 1217 0.15071 1 1.930995618 1.930995618 SAlpcoo1ab22; Slc22a4; Atp9b; Slc7a8; Slc5a3; Arl2; 1 1 0.15 1224 0.15071 1 1.015488235 1.015488235 PRdbzpk41; Stard3; Osbpl1a; Nisch; Slc35a4; Slc25a22; 1 1 0.15 1252 0.15071 1 0.355209957 0.355209957 AIndpipo5kr2; Osbpl3; Spns1; Osbp; Abcc3; Osbpl6; 1215 66 13..6767 1120679 00..0106237917 00..1066527713 00..138396721279343254 00..100780559046341593 AAbpc3bd61;;SSllcc63a98a;1M; Sflscd379ca;5M; Sfslcd379ba4; Slc39a9 PSplct310; aS1lc025a26 305 112 40..5725 1121819 00..0106360037 00..0106569057 00..032271134399991815 00..011492045616177037 AActep;1Pa1li;nA2b; Cccd936; Fabp2; Slc27a4; Irs2; Acsl5 Pla2g4a; Pparg; Pla2g10; Acsl6 665 192 90..9755 5 2 0.75 1121953 00..0106361077 00.1.76267097 --00..011108888330375852 -00..002048403596152326 AAcbec;cP3lin2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; AAqqpp88; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pla2g10; 1294 0.16607 0.16607 0.464685718 0.156034409 SSllcco316ba12; SAlbc3cc63a;2Irs2; Acsl5 Acsl4; Acsl6 475 142 70..0785 5 2 0.75 1125905 00..0106766047 0.166017 00..544634060805077138 00..118863699705721862 ASlbcc3a61a;1A; pSloca316;aA2poa2; Apoa4; Apoc1; Apoc2; Pon1; Pla2g10; Acsl6 1296 0.16607 0.16607 0.409264589 0.266599321 PSplca2r2aa;4N;cPodrz1k;1Nr1h3; Irs2; Acsl5 525 152 70..8745 5 2 0.75 1135152 00.1.06068017 00..1247185665 00..546634461845879118 00..124417590590491498 ASlbcc3a61a;1A; pSloca316;aA2poa2; Apoa4; Apoc1; Apoc2; Cd36; Soat1; Pla2g10 1321 0.16607 1 0.409264589 0.266599321 LSrlpc262; aP4o;nP1d; zNkr11h3; Stard3; Npc1l1; Apob 5625 1153 7.98.48 1135362 00.1.07028111 11 00..536335481047829315 00..104515550798461397 AAbpc3ad11;;ASpfxona1; TArpf;oSal2c;3A9ap1o;aS4l;c2A5pao3c71;;SAlcp3o9ca25;;Cd36; SLotfa;tS1c;oP1l;aS2lgc1300a10 LSrlpc369; aP4o;nA1b; cNbr61;hL3m; Stkta2r;dS3lc; 3N9pac91l1; Apob 4 3 0.6 747 135 101..66 202 0.01213 0.01213 0.221889155 0.106809068 SAlpc2o3aa11;;ASplco2aa23; Cd36; F2rl1; Ins2; Inpp5k; Thra; 1230336 00..0117251836 00..0368172034 00..447019562534032167 00..300929806418409613 ANbr1cbh63; MNdfsfdip71c; DMafbs2di7pb; Flna; Pde2a Slc2a1 Ptger4; Psmd10; Dph3 2176 94 42..0471 1242309 00..0211421561 0.804515 00..757516484214842737 00..310243964075741888 AAbpcoaa11;;AAppooaa12;;AFp2orla12; Apoa4; Apoc1; Apoc2; Pon1; PPltag2egr140 2176 94 42..0471 1242414 00..0211421561 11 00..737919424914872531 00..310746904870701782 AAbbccaa11;;APpoona11; ;NAr1pho3a2; Apoa4; Apoc1; Apoc2; Pon1; PPllaa22gg1100 1156 64 22..2461 1243446 00..0211721541 0.061171 -00..113954019623110729 -00..004501331670179331 AIrbs2ca; 1A;cAslp5oa1; F2rl1; Panx1 CPalas2pg11; 0P;yAcacsrdl6 3131 103 41..9676 1244715 00..0212939279 00..0232233279 00..675976437547306192 00..235150562694186059 AAbbccaa11;;APpoona11; ;NAr1pho3a2; Apoa4; Apoc1; Apoc2; Pon1; Soat1; Pla2g10 121 23 10.6.36 1246749 00.2.02232279 00.2.02232279 -0-.03.5056029343126366 --00..305256089449176569 APcasnlx51 ACcasslp61; Pycard 11 3 1.66 1496 0.22329 1 -0.06233236 -0.026849759 APcaen;xP1lin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; Casp1; Pycard 17121 363 251..9626 11 3 1.66 1249908 00..0222334289 1500 0.22329 11 0.01.6461133574946198 00..015257132053693646 SEldcno12;aS1l;cS2l2ca237a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; AEdqnpr8a; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; 1 -0.500693454 -0.179730209 SAlcsol15b2; Slc22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; PPllaa22gg1100;;AAccssll46; Slc25a26; Sfxn5; Acsl6 6 2 0.9 1528 0.22516 0.38735 1.052009306 0.303282605 SAlpc6oaa81;;SAlcp3o6aa21; Slc36a2; Slc7a15; Irs2; Acsl5 6 2 0.9 1540 0.22516 1 0.091000915 0.115602732 ARcheb;gPlin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; Slc12a2 1746 362 26.02.29 6 2 0.9 1352471 00..0222756116 1544 0.22516 11 00..146664163875976198 00..015557018817704431 SSllcco326a1; Slc2376a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Aqp8; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; 1 1.052009306 0.303282605 SAlpcoo1ab12; ;ASploc2a22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 6 2 0.9 1545 0.22516 1 1.052009306 0.303282605 SAlpc6oaa81;;SAlcp3o6aa21; Slc36a2; Slc7a15; Irs2; Acsl5 1272 65 23..5362 1354634 00..0232294073 0.645715 00..143450099828190526 00..004533212467715889 ASfbxcna1; TArpf;oSal1c;2F52ar3l71; LPmantkx21 CLtafsp1; Pycard 495 49 16..3768 1355627 0.00.32424934 0.03.86751445 00..019246338575796138 00..101318941540463194 CFd2r3l61;;IIrnss22;;APcrsklc5z; Src; Panx1 ACcasslp61; Ptger4; Pycard; Cd209d 790 143 110..3565 1365037 00..0234494737 00..3586711541 00..626027047193647461 00..009383616213756889 AF2prol1a;1I;nAsp2o; Pa2rk; cAzp; oRab4p;4N; Sprcc1;lP1anx1; Zfp384; Exph5 Casp1; Ptger4; Pycard; Dnm1l; Cd209d 13 5 1.96 11081 168 125..7212 359 0.03473 0.0612 0.457760803 0.229133964 SAlpc2o2aa21;;ESdlnc212;aS3lc;3S7lca242;aIn4s; 2P;dPzrkk1c;zS;lIcn6pap85k; Slc2a3; 1367168 00..0245266361 00..4276963223 00..921175947987838265 00..306575139011553161 ASlpco3a52a;4A; Apdoicp1o; rA2p;oAcI23;1N73r915h;3S; lIcr5s2a11; Irs2 PEldan2rga1;0Hiat1; Itln1; Slc2a1; Stxbp3a; Slc37a2 14 5 2.11 1061 138 150.2.92 392 0.0475 0.0475 0.110443509 0.171081516 AAppooca21;;CAdp3o6a;2M; Ftt2pr;l1A;pInosb2; Prkcz; Rbp4; Src; Nr1h3; Pparg 1460109 00..0245768391 00..0545778797 00..725904780205827117 00..309469696803386132 APpanoxa1; Arpfoipa12; ZAfppo3a84; Exph5 Casp1; Ptger4; Pycard; Dnm1l; Dph3; Cd209d 162 33 10.8.91 1461316 00..0246768598 0.150619 00..822480449307903396 00..400184887273360569 AApcvora21a;;AMpeoga32; TFb2xrl31 162 33 10.8.91 1461520 00..0246768598 11 00..872986439507903192 00..420787877775380865 AApboca1; PAopno1a;2N; Fr12hrl31 162 33 10.8.91 1461531 00..0246768598 11 00..070956037597707122 00..026727775755286885 IArsb2c;aA1c;sPlo5n1; Nr1h3 Acsl6 1102 43 11..5811 1462552 00..0256066578 0.110331 10..035689179091579334 00.1.4087753844678667 ASlpco2a32a;1A; Rphobc1g; Apoc2 PSlac122ga120 102 41 1.05.13 1462772 00..0257086771 0.278711 10..045981129692569936 00.2.4189763343618769 ASlpco2a72a;4Apoc1; Apoc2 Pla2g10 32 21 0.04.53 1467823 00..0267182781 00..0267182781 00..033891345584124035 -00..010733481815530468 PFa2nrlx11 Casp1 32 21 0.04.53 32 21 0.04.53 32 21 0.04.53 32 21 0.04.53 112 41 1.06.63 2 1 0.3 2062 391 31.00.53 2 1 0.3 572 131 8.05.93 212 61 3.01.63 122 41 1.08.13 172 51 2.05.63 172 51 2.05.63 272 71 4.00.73 42 21 00..63 42 21 00..63 42 21 00..63 42 21 00..63 42 21 00..63 282 71 4.02.23 132 41 1.09.63 232 61 3.04.73 92 31 1.03.63 92 31 1.03.63 142 41 2.01.13 142 41 2.01.13 12 11 0.01.53 12 11 0.01.53 718 114 101..1756 118 14 02..1751 17 12 01..1055 610 111 09..1054 113 13 01..1956 215 15 03..1757 18 12 01..1251 18 12 01..1251 18 12 01..1251 1477142 1478332 1479470 1570807 1572958 1809 1586211 1833 1586345 1588329 1681448 1682449 1682679 1683702 1688746 1689981 1791025 1791038 1793171 1794495 1796499 1797560 1893512 1893537 1897598 1899559 1991680 1995631 1995644 1995754 1995860 2905587 2905991 2918372 2919568 12010621 12011856 00..0267182781 00..0267182781 00..0267182781 00..0267182781 00..0277083791 0.27871 00..0277580721 0.27871 00..0277886791 00..0287481741 00..0297384721 00..1207081781 00..1207081781 00..1207083751 00..1217084721 00..1217084721 00..1217084721 00..1217084721 00..1217084721 00..1217782761 00..1217985711 00..1227087791 00..1247283721 00..1247283721 00..1247883711 00..1247883711 00..1257087711 00..1257087711 0.01.52087114 00..1258027712 00..1258057319 00..1258087812 00..1351007711 00..1352017513 00..1354057017 00..1354057017 00..1354057017 00..0267182781 00..1257086761 0.278711 0.278711 00..0277083791 0.27871 0.278711 0.27871 00..6287381711 0.278711 0.278711 00..1207081781 0.833861 0.100351 0.110421 0.110421 0.150671 0.150671 11 0.509991 11 11 0.142321 0.142321 11 11 0.150711 0.150711 0.01.53007115 00..1756097915 0.01.51057017 0.150711 0.01.57027912 00..1352017513 00..1155007711 0.01.52077817 00..1457097711 00..059519010302981659 00..375685183794891599 00..033397385088104036 00.2.3028138694236656 00..657535759632767864 1.930995618 00..091227314083238763 0.20055416 00..137801649534324095 -00..474951680942606361 -00..030334489235542313 00.3.4334887285344313 00..956509118302584679 00..196217015093032733 10..025028030694330666 -01..094370191975962148 00..715723801232291964 -00..426842823578203547 00..053595355682164834 00..426768804130220493 -00..030334489235542313 00..134374883215747393 -00..359479766417622933 00..030367889098806096 00..535334784265946323 0-0.3.0344481215440383 01..393370890985060168 00..337354089235146383 10..913007909055671584 0-0.1.6011528270844558 -00..444381857006190159 00.2.4934767596753314 00..407591721900954946 00..313874830389060068 1-.00.0177705091082441 10..021157428684213052 00..348710405342200951 0.00.9211841589982133 00..351244849078110251 -00..010938421412580862 00..300830210334652722 00..221564280836120481 1.001284885 00..050089497680924561 0.233189862 00..012873779587551389 -00..156370959676554474 -00..011600149433619563 00..116690646443713533 0.03.1201145599189153 00..053059194690929521 00..502860317334258762 00..094568653947762748 00.1.3472745368239181 00..227152617302526236 00..020524080826221411 00..121117394819580978 0-0.1.0600048403514543 00..015680946483612533 -00..036264132137569138 00..010918020472289882 00..118630645473614523 00..014680046463115563 01..303071820884080865 00..327851069138156585 10..903002999054631286 -00..6010548279874051 -00..404587807708180057 00.0.4635717196783418 00..407298711406984142 00..303674820081030764 1-.00.0073755399082948 -10..001152478587233059 -00..308412415240280755 RAhrgb1g FE2drnl11; Prkcz PSalcn9xa13r1 PApcavrra2;aNcor1 ACblnc8a1; Apoa1; Apoa2; Apoa4 BAcpl6o;aC2d36; Cry2; Dag1; Hyal2; Jak2; Jun; Ppp3ca; SStlac2t33;aT1hra; Tnfrsf1a; Ing1; Mapk1; Pex14; TNocmorm134; Dab2ip; Flna; Pde2a; Pex6; Ipo13 AF2prrlt1; Copa; Slc6a3; Edn1; Eif2ak3; Guca2b; Nr1h3; Slc22a1; Slco1b2; Slc47a1; Abcc3; Abp1; Slc18a1 APprkocaz1; Panx1 SPlrck2c2za1; Slco1b2; Slc47a1; Abcc3; Slc18a1 GAcr;gR1bp4; Slc23a1; Slc2a3 ASlpcr2t3; aS1lc6a3; Eif2ak3; Vdr; Vegfa AApcvora21a; Apoa2 AAbpcoca32 TArpf;oLam1tk2 Slc6a4; Slc18a1 PCalnn8x1 APpeox6a1; Apoa2; F2rl1; Ins2; Nr1h3 APprkocaz1; Panx1 APbrkccaz1; Pon1; Nr1h3; Acsl5 Nr1h3 SSllcc397aa34r1; Slc2a3 SPlrck6caz4; Slc22a3; Cln8; Slc18a1 SPlrck9caz3r1; Slc6a8 SAlpc9oaa32r1 SPlrck2c5za10 ACplcona22; Slc12a7; Slc4a2; Fxyd1; Clca6; Ano6; Slc12a6; Slc37a4; Slc2a3; Slc35a4 Slc5a3 SAlpc6oaa81; Apoa2; F2rl1; Ins2; Prkcz; Src; Panx1 ASlbcpo11b2; Abcc3 SInlcs92a;3Prr1kcz; Adipor2; Irs2 APpdozkh1 RAbcpvr42a; Tbx3 FC2orpl1a; Nr1h3 Slc12a2 Casp1 Arntl; Cdk1; Ect2; Hspa4; Kpnb1; Kpna3; Prdx1; Ran; Timm9; Mtx2; Psmd10; Nop58; Pex3; Snupn; Ipo5; Ipo4; Pex12; Tlr3; Tomm22 Usf2; Agr2; Sytl2; Socs2 Pla2g10 Casp1; Pycard Slc2a1 Usf2; Socs2 Slc2a1 Slc25a26 Casp1 Ptger4; Dph3 Casp1; Pycard Pla2g10; Acsl6 Tusc3; Nipa2; Nipa1 Slc2a1 Crym; Slc25a26 Clns1a; Slc12a2; Clca3; Ttyh1; Clic6; Clcc1 SSllcc327aa12 Agr2; Sytl2 Casp1; Ptger4; Pycard; Cd209d Aqp8 Itln1 Gcg 8 2 1.21 2198 0.34507 1 -0.083504172 0.066326841 Slc5a3 Slc37a2 TNO report - Final 3M#07 TNO Project number: 051.01978 56 / 59 GO.ID Term GO:0051589 negative regulation of neurotransmitter ... GGOO::00000561826292 lpipoisdittirvaenrsepgourltation of protein transport GO:0015758 glucose transport GO:0050663 cytokine secretion GO:00343670107 pahciodsspehcorleiptiiodnefflux GO:0015092048 feastttaybalcisidhmtreanstpoorrmt aintenance of transmem... GO:00154609653 onreggaantiicvecarteiognultartainosnpoofrtserotonin secreti... GGOO::00001155971640 pghluocsopsheo-6li-ppihdotsrapnhsapteorttransport GO:0033572 transferrin transport GO:0034635 glutathione transport GO:0035524 proline transmembrane transport GO:0051612 negative regulation of serotonin uptake GO:0071422 succinate transmembrane transport GO:00712740828 oarmgamnoicnsiumbstraanncsemtreamnsbpraonrte transport GO:0090188 negative regulation of pancreatic juice ... GO:2000484 positive regulation of interleukin-8 sec... GO:2000778 positive regulation of interleukin-6 sec... GO:0015712 hexose phosphate transport GO:005115178410 cCo4f-adcitcoarrbtroaxnyslpaoterttransport GO:0015970494 lsouncgc-inchaateintrfanttsypaocritd transport GGOO::00001452791389 mtriopneopctaidrbeotxryalnicspaocirdt transport GO:0043091 L-arginine import GGOO::00003521356881 rneeggualtaitvieonreogfulliaptiidotnraonfsnpeourrtotransmitter ... GO:0051611 regulation of serotonin uptake GGOO::00003600360210 crheogulelastteiornolotfracnhsopleosrtterol import GO:0072604 interleukin-6 secretion GGOO::00001752961086 sinteterorlleturakninsp-8osrtecretion GO:0090237 regulation of arachidonic acid secretion GO:020700843872 dreeghuyldartoioanscoofrbinictearcliedutkriann-s8psoerctretion GO:0201050898069 hreegmuelattriaonnsopfosrterol import GO:003521327210 rceygtouplaltaisomniocfssetqeuroelsterarninsgporftprotein GO:003520347842 raergauchlaidtionicofacihdoslesctrertoiolntransport GO:005008760425 ihnetexorlseeutkriann-1spboertta secretion GO:0033344 cholesterol efflux GGOO::00001009734076 pporositteivinesreecgrueltaitoinon of plasma membrane l... GO:0001821 histamine secretion GGOO::00004362984920 craergbuolaxtyiloicnaocfidortgraannsicpoacrtid transport GO:0015749 monosaccharide transport GO:0032024 positive regulation of insulin secretion GO:0006837 serotonin transport GGOO::00001352884992 oprogsaintiivcearceidgutrlaantisopnoortf organic acid tran... GO:0015870 acetylcholine transport GGOO::00005501720213 GO:0015911 GGOO::00003100279498 GGOO::00001150679676 GGOO::00003125376496 GGOO::00004324975535 GGOO::00003402300405 GGOO::00000425337342 GGOO::00000426793299 GGOO::00001700724567 GGOO::00003720357754 GGOO::00003722337221 GGOO::00005900731770 GGOO::00007006683442 GGOO::00007125660981 GGOO::00005302740155 GGOO::00007324326074 GGOO::00004930619816 GO:2000192 GGOO::00001170083288 irnetgeurllaetuiokinno-1f sperocrteetiinotnransport plasma membrane long-chain fatty acid tr... innetegasttiinvealrcehgoulleasttioenrool fapblsaosrmptaiomnembrane l... qnueagtaetrivnearryeagmulmatoionniuomf sgordoiuupmtriaonnstproarntsp... ncietgraatteivterarnesgpuolarttion of lipid transport liirpoonpiroontetrinantsramnesmpobrrtane transport reepgiuthlaetliioanl foluf iidntterasntisnpaol rctholesterol abs... cpyhtooskpinheolsiepcidrettriaonnsilnovcaotlivoend in immune re... rneeggualtaitvieonreogfuclyattoiokninoefsneecurerotitornaninsmvoitlvteer...... rpeogsuitlaivteiorneoguf lpaltaisomnaofmmeumcbursasneecrloentigo-nchain... ncaedgmatiiuvemrieognutlaratinosnmoefmchboralensetetrraonl strpaonrst... ncheagpateirvoenree-gmueladtiiaotneodfpsrtoetreoilntrtarannspspoortrt pnoesgiatitviveereregguulalatitoionnoof finchteorlleesutkeirno-l1eaflfplu...... ttrraicnasrebpoixthyleicliaalciadmtmraonnspiuomrt transport icnatdemrleiuumkinio-n10trsaencsrpeotirotn rreegguullaattiioonn ooff isnotdeirulemu:khiynd-1roaglephnaasneticpreotr.t.e.r... rleipgiudlatrtaionnsloofcalitpioidntransport by regulat... rreevgeurlsaetiochnoolef sptaenrcorletaratincsjpuoicret secretion negative regulation of fatty acid transp... pproostietiivneimrepgourltation of glucose transport GGOO::00000072578990 GGOO::00001155889037 GGOO::00005105770362 GGOO::00000463805952 GGOO::00005712158300 GO:0007595 GGOO::00000320704702 GO:0042908 GGOO::00001155688323 GGOO::00005312641100 GGOO::00005105780732 GGOO::00005404700790 GGOO::00005701770145 GGOO::00003426337203 GGOO::00001155689731 GGOO::00003350432281 GGOO::00000610540545 GGOO::00007720333277 GGOO::00000134009662 GGOO::00001650740593 GGOO::02001050765499 GO:0015794 GGOO::00001350709783 GGOO::00001453808910 GO:0015898 GGOO::00003521708428 GGOO::00003444109672 GGOO::00003442603434 GGOO::00003950922767 GO:0015793 GO:0032275 GO:0035814 GO:0003097 GO:0033299 bpoedpytifdleuisdescerecrteiotnion dL-raumg tinraonascpiodrttransport rpergousltaatgiloanndoifnintrtaenrlsepuokritn-1 beta secreti... dL-raumg tinraonascmidemimbproanrte transport vpiutarimnein-ctoranntaspinoirntg compound transmembrane... lactation npeegpattidiveehroergmuloantieonseocfrecytitoonkine secretio... xenobiotic transport fpeerpritcidireontratrnasnpsoprotrt sneergoattoinveinruepgutalakteion of transporter activ... idnotepralmeuinkeint-r1aanlspphoartsecretion nreeggualtaivtieorneogfualantiioonn torfanpsroptoeritn secretion riecogsualantoioidntorafninspteorrlteukin-1 secretion pgoluscitoisvee irmegpuolrattion of lipid transport mchaoglnineesiturmanisopnorttransport htreaxnosseeptitrhaneslimalecmhlborraidnee ttrraannssppoorrtt nneeugraotitvraenrsemguitltaetriounpotafkgeastric acid secr... mthoydroifiidedhoarmmionnoeactridantsrapnosrpt ort rreengaullastoidoinuomf isoenrottroannsinposertcretion trheigouslualtfiaotneotrfagnassptroirctacid secretion breegtau-lgaltuiocnosoidf esotdraiunmspioornt transmembrane t... glycerol-3-phosphate transport minysou-liinnosseictroel ttiroannsport carmeaintioneactirdanimsppoorrtt amiloride transport bnielegaatciivdesreecgrueltaiotinon of secretion trreiggluylcaetiroidneotfraenxscpreotriton rfelutiindotlratrnasnpsoprot rt cphoesmitiovkeinreeg(uCl-aCtimonotoiff)pleigpatnidde2hsoercmreotnioens... glycerol transport luteinizing hormone secretion negative regulation of renal sodium excr... renal water transport secretion of lysosomal enzymes Annotated Significant Expected Rank in classic classic weight avgFC.sig avgFC sigGenesUp sigGenesDown 8 2 1.21 2216 0.34507 1 0.46257697 0.100458884AAbcccan12;;ASclce1;8Pal1in2; Apoa1; Apoa2; Apoa4; Apoc1; 115393 4232 2230..9064 71 12 10.7 2232 0.35253 1 0.135763383 0.03304736AFp2orlc12;;HAypaol2h;;IAntsp28; aJa1k; 2A;tMp9dam; C2d; 3P6rk; cFza;bRpb2p;4L;rpS6rc;; PClaa2sgp41a;;CPdpka1r;gE;cStl2c;2P5tag1e7r;4S;oPaytc1a;rPdl;aT2mg1e0m; A3c0sal;4; 52 6.50E-05 0.51128 0.362733997 0.096860004 MTnttfprs; fP1oan; 1P;aPnpxa1r;aF;lnRab;pZ4f;pN3c8o4r;1E;xNprh15h3; Slco2a1; ADcnslm6;1Al;tTpl1r13c; Cd209d 2295 0.38157 0.319 0.123082989 0.035427633SElcd2n71a;2S;lSc3lc72a74a;4I;nAs2b;cPar7k;cAzt;pIn9bp;pS5tka;rSdl3c;2Oa3s;bApdl1ipa;or2; Ednra; Itln1; Slc2a1; Stxbp3a 71 12 10.7 2297 0.38157 1 0.307024531 0.054703679OAsbbcpal13; ASpnosa11;;OAspbopa;2O; Fsb2rpll16;;INnsp2c;1Pl1rk; cAzp;oSbrc;;IPrsa2n;x1 Casp1; Ptger4; Pycard; Cd209d 1217 75 14..6067 236140 00..0308053337 0.000331 00.9.81299857571998872 00.6.10387593807343552AAbccea;1T;fAf2p;oSal1c9; aA3pro1a2; Apoa4; Apoc1; Apoc2; Pla2g4a; Pla2g10 453 151 60..7485 239428 00..0308177453 00..0328677453 -00.0.30052870236584342 00.0.10971007158975391ASclec2; 2Pali1n2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Pla2g4a; Pparg; Slc25a17; Pla2g10; Acsl4; Acsl6 213 91 30..1465 239573 00..0308270473 00..0328276433 00.3.371570082662911 00.2.01676966778959095SMlca2o2ab1; Slc22a3; Slc22a4; Slc7a8; Rhbg; Pdzk1; Slc12a2 333 121 40..9475 3 1 0.45 239585 00..0308271453 00..2388171463 00.5.23872415365253197 -00.1.09374361766717257ASblc3a71a; 4Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; 2380 0.38743 0.38743 0.424917145 0.143180877ALtmp8tka21; Atp9a; Abca7; Atp9b Pla2g10; Atp11c 3 1 0.45 2383 0.38743 0.38743 0.337808006 0.107977187ASblc9aa13; rA1ce; Plin2; Apoa1; Apoa2; Apoa4; Apoc1; 3 1 0.45 2387 0.38743 0.38743 0.266080627 0.13634755ASplco3c62a;2Apoh; Arg1; Atp8a1; Atp9a; Cd36; Slc6a3; 3 1 0.45 2410 0.38743 0.38743 0.515258897 0.229422227ESdlnc18; aF1abp2; Slc37a4; Slc6a4; Ins2; Lrp6; Mttp; 3 1 0.45 2432 0.38743 0.38743 0.375093168 0.128091359PSrlkcc2z5;aP1o0n1; Ppara; Inpp5k; Rbp4; Ncor1; Slc22a1; Aqp8; Crym; Ednra; Hiat1; Itln1; Pla2g4a; Pparg; 4443 891 660..9415 2140326 00..0308274483 0.387413 00.3.40938645865892991 00.0.26480396798297268SRlch2b2ga3; Slc23a1; Slc2a3; Slc3a1; Nr1h3; Slco2a1; Slc16a1; Slc25a17; Slc2a1; Soat1; Stxbp3a; Pla2g10; 3 1 0.45 2440 0.38743 0.38743 0.549647293 0.240035744SNlcr217ha32; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Abca7; Acsl4; Slc37a2; Slc25a26; Sfxn5; Acsl6; Atp11c 3 1 0.45 2448 0.38743 0.38743 0.381454205 0.027715962SFlc2orl11b2; Slc22a4; Atp9b; Slc7a8; Slc5a3; Arl2; 3 1 0.45 2450 0.38743 0.38743 0.381454205 0.079739856PFd2zrkl1; Stard3; Osbpl1a; Nisch; Slc35a4; Slc25a22; 3 1 0.45 2491 0.38743 1 0.282135517 -0.034676127ASdlcip37oar24; Osbpl3; Spns1; Osbp; Abcc3; Osbpl6; 113 61 10..6465 2140972 00..0308277413 0.165711 00.1.38795701973313658 00.1.10288509941331599ASblc2b56a;1S0lc6a8; Mfsd7c; Mfsd7b Ppt1; Slc25a26 303 111 40..5425 2141913 00..0308370433 0.005951 00.0.32775104993911618 00.0.11298005911137539ASclec2; 5Pali1n02; Cd36; Fabp2; Slc27a4; Irs2; Acsl5 Pla2g4a; Pparg; Pla2g10; Acsl6 663 191 90..9455 3 1 0.45 2151256 00..0308371473 0.72791 -00.0.31307888038305056 00.0.12047493797112827ASclec9; aP3lirn12; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Aqp8; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pla2g10; 2527 0.38743 1 0.559132869 0.062061004SAlcrog1b2; Abcc3; Irs2; Acsl5 Acsl4; Acsl6 473 141 70..0485 3 1 0.45 2155406 00..0308776443 2547 0.38743 11 00.5.54135020508087937 00.1.28269649202721267ASblc1a81a; 1Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Pla2g10; Acsl6 1 0.515258897 0.229422227PSplca1ra8;aN1 cor1; Nr1h3; Irs2; Acsl5 523 151 70..8445 3 1 0.45 2155553 00..308078413 0.141561 01.5.96330491945869118 00.1.64617500195481291AAbpcoaa12; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Cd36; Soat1; Pla2g10 2570 0.38743 1 0.381454205 0.079739856LFrp2r6l;1Pon1; Nr1h3; Stard3; Npc1l1; Apob 523 151 70..8445 3 1 0.45 2155761 00..308078413 2574 0.38743 11 00.5.36831441544829015 00.1.04217570195491692AFb2cral11; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Cd36; Soat1; Pla2g10 1 -0.791892031 -0.330864141Lrp6; Pon1; Nr1h3; Stard3; Npc1l1; Apob Pla2g10 43 31 00..465 2250821 00..0318271433 0.012131 00.2.32811848594125055 00.1.00267870195096682SFlc22rl31a1; Slc2a3 Slc2a1 43 31 00..465 2250834 00..0318271433 0.061231 01.4.97310592935062168 00.3.60627806115489211AAbpcoba62; Mfsd7c; Mfsd7b 2175 93 42..0276 2262101 00..0319481868 0.38714 00.7.37211494918842936 00.3.00643984578791882ATbhcraa1;;FAlnpaoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; PPlas2mgd1100 2175 93 42..0276 2262117 00..0319481868 0.559214 -00..727719444116842134 -00.3.00742984974711882AAbccea1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; PPlala22gg140a; Pla2g10 1752 162 120..2865 2263345 00..0410711048 0.061171 00.1.13253009822190829 00.0.04305351373109438AEbdcna11;;SAlcp3o7aa14;;FI2nrsl21; Prakncxz1; Inpp5k; Slc2a3; Adipor2;CEadsnpr1a;;PIytlcna1r;dSlc2a1; Stxbp3a 33 10 4.97 1320 221 190..539 241 0.01997 0.03237 0.657474369 0.255529165 AAbbccaa11;;AAppooaa11;;AAppooaa22;;AFp2orla14;;IAnsp2o;cP1r;kAcpz;oRcb2;pP4o; Snr1c;; Soat1; Pla2g10 2266347 00..400212273 00..706292973 -0.305.351019547106269 -00.3.05359089143156164ANcrs1l5h3; Panx1; Mon1a; Arfip1; Traf3ip2; Zfp384; ACcassl6p1; Ptger4; Pycard; Dnm1l; Dph3; Cd209d 9 2 1.36 2640 0.40299 0.40299 0.255440923 0.079610903AEcden;1Plin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; Ednra 17228 365 254..9222 73 12 11 2269909 00..0421374286 2702 0.42064 11 -00..106463153073996699 -00.0.05055152655633541SAlcrog21a; 1Ir;sS2l;cA27csal25; Slc27a4; Cln8; Slc9a3r1; Slc25a10; APqlpa28g; 1C0ry; mAc;sPl6la2g4a; Pparg; Slc16a1; Slc25a17; 1 0.123082989 0.039973069SElcdon11b;2S;lcS3lc72a24a;4In; sS2lc;7Par8k;cPz;dIznkp1p; 5Sklc;2S5lac2a23; ;AAbdccip3o; r2;PElad2ngr1a0; ;ItAlnc1sl;4S;lSc2lca215;aS2t6x;bSpf3xan5; Acsl6 41 7 6.18 2707 0.42453 0.37862 0.069555023 0.010916789SGlcl6uad81;;SJlack326;aR1b; pSl4c;3I6rsa2; Slc7a15; Irs2; Acsl5 Gcg; Pdx1; Oxct1 16 3 2.41 2745 0.44189 1 0.415567126 0.03961791ASclec6; aP4li;nM2;aAobrg;1S;lcC1d83a61; Fabp2; Slc23a1; Slc3a1; 17146 363 262..2421 10 2 1.51 21277 365 324..5261 9 4 1.36 94 41 1.03.66 134 51 1.09.66 184 61 2.07.16 144 51 2.01.16 64 31 00..96 64 31 00..96 64 31 00..96 64 31 00..96 104 41 1.05.16 104 41 1.05.16 34 21 0.04.56 34 21 0.04.56 34 21 0.04.56 34 21 0.04.56 34 21 0.04.56 114 41 1.06.66 4 1 0.6 20360 395 314..0552 15376 1231 82.05.95 2317 66 35..1568 1121 42 11..8616 1171 52 21..5666 1171 52 21..5666 27 7 4.07 1341 220 190..764 4 2 0.6 1541 223 220..766 148 23 20..761 245 24 30..767 2285 74 43..2727 1235 44 13..9767 2339 66 35..4878 95 31 10..3765 95 31 10..3765 145 41 20..1715 145 41 20..1715 15 11 00..1755 15 11 00..1755 15 11 00..1755 1 1 0.15 1114 117 107..1158 112 12 01..1851 1 1 0.15 1212 118 108..1359 210 13 03..1051 210 13 03..1051 418 17 07..1253 2372479 2779 2384334 352 2385632 2385693 2387668 2389921 2480908 2491012 2491120 2491238 2492259 2492375 2497326 2497447 2498539 2499677 2590704 3502258 3033 3506318 3506546 3508623 3601947 3612349 3612476 630 3618540 698 3711521 3711631 3713974 3714996 3726095 3727260 3823417 3823534 3827993 3829958 3931280 3935631 3935744 955 3935769 3945182 959 3948678 3949968 13050121 13051251 00..0424716819 0.45835 00..0437204075 0.03443 00..0437494737 00..0437497737 00..0447296767 00..407497757 00..0447798797 00..0447798797 00..0447798797 00..0447798797 00..0457096777 00..0457096777 00..0467192787 00..0467192787 00..0467192787 00..0467192787 00..0467192787 00..0477093797 0.47977 00..0477590929 00..0478886599 00..0489421146 00..0591304528 00..1501001588 00..1501001588 0.10035 00..1511024428 0.11042 00..1511024926 00..1512034823 00..1513024927 00..1513722967 00..1513925917 00..1524067496 00..1545283129 00..1545283129 00..1545883119 00..1545883119 00..1555087119 00..1555087119 00..1555087119 0.15071 00..1555097218 00..1555097318 0.15071 00..1557087019 00..1559087617 00..1559087617 00..1559097415 11 0.45835 11 0.38714 00..3487791747 00..407691727 00..4477993727 00..407497757 00..0447798797 0.479717 0.479717 0.479717 00..1417093737 0.479717 00..0467192787 0.061281 0.150661 11 11 0.070391 1 11 00..6287381713 0.846818 0.387416 0.100181 0.833861 0.10035 00..1314054128 0.11042 0.150671 00..1652046776 0.106512 00..5503929997 11 0.387419 00..1545283129 00..1545283129 0.558119 0.558119 0.150711 0.150711 0.150711 0.15071 0.01.52057916 0.150711 0.15071 0.150711 00..1358077511 0.150711 0.150711 -00..156060163973946594 0.327674443 00.1.23154039424170026 0.094387763 00.6.76225047297667468 00.4.35377786008800036 -00..921479997185888765 01.1.01800474039520898 00.7.75605780704897519 00.8.42483409702943993 00.8.42089489905903493 -00..020954077399757329 10.0.55381109095579734 -10..095686129195599637 -00..073991385982104331 -00..029419090105981755 00.3.55381103095871794 00.0.33397385088104036 00..43423108792246953 00.6.57439769437727963 0.725427648 00.0.11824334389268068 00.1.27101609332384593 00.4.54251690843686269 --00.0.20537499337522314 00..54537837487374717 -00..946501178107544371 0.161059023 10.0.15929040390380761 -0.047117924 00.7.25224831932261664 0.406.846803273203342 00.0.53790305884184432 -00..406467844034200699 -0-.000.134409535572912 00.1.14977843110717792 -0.309.473776719672331 -00..030166849894816692 04.5.65438724061916428 --00..60649481013450881 0.303.371870082060961 04.3.67458029031116488 10.9.33307989058601086 -0.61587845 00.4.14488837201180355 00..54537737497773717 0.479710944 00.3.63274800383060464 1.000.579785499092648 10.0.11551418583243353 00.3.08619455545200253 -00.0.15256098515784139SAlccos2l5a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; APqlpa28g; 1C0ry; mAc;sPl6la2g4a; Pparg; Slc16a1; Slc25a17; 0.060196964SSlclco212ba21;;SAlcrl222a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 SAlcp6oaa81; ;SAlcp3o6aa21;; CSldc3366;aF22; rSll1c;7Ha1y5a;l2Ir;sI2n;sA2;cJsal5k2; 00.0.04433272863715789AMbdcam12; ;APprokac1z;; IFn2prlp15;kP;aRnbxp14; Src; Thra; Tnfrsf1a; CCaasspp11; ;PCydcakr1d; Ect2; Prdx1; Ptger4; Psmd10; Pycard; 0.111914439 CNdr316h;3Ir;sP2a;nAxc1s;l5Ndfip1; Dab2ip; Arfip1; Flna; Pde2a;ATcmsle6m30a; Dnm1l; Dph3; Tlr3; Cd209d 00.0.29781666719796884AIrpso2a1; Apoa2; Apoa4; Npc1l1 00.2.12095173637976848SSlclc292aa31r;1Slc22a3; Slc22a4; Pdzk1; Slc6a8 -00.3.06778199616593369Apoa2; Apoc1; Apoc2; Nr1h3; Irs2 PSlafx2ng510 0.1701.1018816571369ATprfoc2; Cd36; Mttp; Apob Pparg 00.3.19162636301356239AEpdona11; Apoa2; Apoa4 00.4.00986887978390867AApbocaa11; Apoa2; F2rl1 00.4.00281837671370668AApcocan12; Apoa2; F2rl1 00.0.06422705456286081Irs2; Acsl5 AScystll62 00..04189783742658069AApbocab26; Apoc1; Apoc2 Pla2g10 -00..24088733647628463Apoa2; Apoc1; Apoc2 PTlaim2gm109 --00.0.10439461217530569Panx1 CPalsap21g10 -00.0.09718891686992339Rhbg SSlcf1x2na52 00.3.01149889772150059FA2brlc1b; 6Prkcz -00.0.00930461112520266PSalnc9xa13r1 Casp1 00.3.00936280938692827PApbacraa1; Ncor1 00.2.21064270733170983ANbrc1ah13; Apoa1; Apoa2; Apoa4 0.271679984BIcrsl62; Cd36; Cry2; Dag1; Hyal2; Jak2; Jun; Ppp3ca; Arntl; Cdk1; Ect2; Hspa4; Kpnb1; Kpna3; Prdx1; 00.0.00582467780954163SItnast23;; PTrhkrcaz;;TAndfripsfo1ra2;;IInrsg21; Mapk1; Pex14; RIatlnn;1Timm9; Mtx2; Psmd10; Nop58; Pex3; Snupn; TAobmcma13;4A;cDvar2bb2;ipD;gFaltn1a;;EPddne12;aE;iPf2eaxk63;;IGpolu1d31; Jak2; Ipo5; Ipo4; Pex12; Tlr3; Tomm22 00.0.02073779181591088APpprpt;3Ccao;pRab; pSl4c;6Sar3e;bEfd1n; 1H;nEfi1f2ba; kE3n;sGa;uScma2pbd;3N;rC1hhd37; ; UCspf2t1; aA;gGr2c;gS; yPtdl2x;1S; oSctxs2bp3a; Oxct1; Acvr1c 00.1.06870959772514077SAlcr2g21a;1C;lnSl8c;oS1lbc72a; 8S;lcS4l7c2a51a; 2A2b;cScl3c;3A6ab1p;1S;lScl3c61a82a1 --00.0.01305189437669866ASplcooa21a; 1Panx1 CPalsap21g;1P0ycard 00.1.06890696143773337SAlcr2g21a;1C;lnSl8co1b2; Slc47a1; Abcc3; Slc18a1 -00.3.11100155190179454Gc; Rbp4; Slc23a1; Slc2a3 SSlclc22a51a17; Slc25a26 0.035149992 AApcrvtr;2Sblc;6Dag3a;tE1i;f2Eadkn31;;VEdifr2;aVke3g; fGalud1; Jak2; Ppp3ca; Usf2; Socs2 00.5.02161327032298365ARpbopa41;;SArepbofa12; Hnf1b; Ensa; Smpd3; Chd7; Irs2 Cpt1a; Gcg; Pdx1; Stxbp3a; Oxct1; Acvr1c 0.046634724 AAbbccca31; Acvr2b; Dgat1; Edn1; Eif2ak3; Glud1; Jak2; Slc2a1 00..03173715565289888TPrfp;pL3mcatk;2Rbp4; Srebf1; Hnf1b; Slc9a3r1; Slco1b2; Cpt1a; Gcg; Pdx1; Stxbp3a; Oxct1; Acvr1c 00.2.17850657903516139SAlcp6oaa42; ;SSlclc198aa31r1; Ndfip1 00.0.00920060922211816PSalnc6xa13; Slc22a1; Slc22a3; Slc18a1 00.1.01013334818580876ACplcona21;; VAdpaoca12; F2rl1; Ins2; Nr1h3 --00.0.002078803534841AApcoea;1S;lcPoa2nax11 00.0.05588966180642739AInbsc2a;1P; Prkocnz1; ;SNlcr21ah33;;AAdcisplo5r2; Irs2 -00.0.16365172437589632 Slc6a8 -00.0.10510030575259384Slc37a4; Slc2a3 00.1.98436605779674925STlcff62a4; Slc22a3; Cln8; Slc18a1 -00.0.14088096064155665Slc9a3r1; Slc6a8 00.3.03475870880000763SMlca9oa3br1 00.3.97456009739176985STlcff225a10 10.9.03505919355681284ASplco9aa23r1 -0.61587845 Acvr2b; Dgat1; Eif2ak3; Glud1; Jak2; Ppp3ca; Rbp4; -00.4.04082847705110554SSlcre5ab3f1; Hnf1b; Ensa; Irs2 00..04837707690703111SAlcr6ga18; Cln8 0.479710944 AAbcpc1n2; Apoa1; Apoa2; Edn1; F2rl1; Ins2; Anpep; 00.3.03972840281010267SPlcp9pa33cra1; Srebf1; Tff2; Nr1h3; Maob; Abr; Bcr 10.0.00376725392062342AEpdonh1; Anpep; Slc9a3r1 10.0.01055438387273356REbdpn41; Inpp5k 00.3.08112485342280557FG2lrul1d1; Jak2; Rbp4; Irs2 Casp1 PCtgliec6r4; ;ADhpchyl31 CPalsap21g;4Pay; cPalrad2g10 PIltaln2g110; Acsl6 Tusc3; Nipa2; Nipa1 SSlclc21a21a2 CCryrymm; Slc25a26 Slc37a2 Cpt1a; Gcg; Pdx1; Stxbp3a; Oxct1; Ptger4; Stxbp3a; Dph3; Acvr1c Aqp8 Gcg; Pdx1; Oxct1 Acvr1c 6 1 0.9 3615 0.6248 0.6248 -0.61587845 0.012836579 Slc37a2 6 1 0.9 3624 0.6248 0.6248 0.226163838 0.012699997 Tbx3 6 1 0.9 3636 0.6248 0.6248 0.691816074 0.103435884 Anpep 6 1 0.9 3676 0.6248 1 0.355209957 0.114094041 Inpp5k 6 1 0.9 3695 0.6248 1 0.549647293 0.119111335 Nr1h3 TNO report - Final 3M#07 TNO Project number: 051.01978 57 / 59 GO.ID GO:0046880 GO:0051580 GO:007006285659 GO:0072348 GO:0015991 GO:001353978080 GO:000135393038 GO:00012576935 GGOO::00003145796134 GO:0046324 Term regulation of follicle-stimulating hormo... regulation of neurotransmitter uptake rliepgiudltartaionnspoofrmt ucus secretion sulfur compound transport ATP hydrolysis coupled proton transport epnheorsgpyhcooliuppidleedffplruoxton transport, against... afamttiynoacaicdidtrtarnasnpsomrtembrane transport poorgsaitnivicecraetgiounlattriaonnsopfoprteptide secretion npehgoastpihveolriepgidultaratinosnpoofrttransmembrane tra... regulation of glucose import GO:0015698 inorganic anion transport GO:0032309 icosanoid secretion GGOO::00000761872002 aonrgioannitcrasunbspstoarntce transport GO:0006865 amino acid transport GO:0033603 GO:0051024 GO:00950121801 GO:00158909 GGOO::00005115973188 GO:0090195 GGOO::00009302139668 GO:0034764 GGOO::00005310238011 GO:0006857 GGOO::00001155895108 GO:0010827 GO:0070837 GO:000195981846 GO:0032371 GO:001352831734 GO:000560873032 GO:0032330484 GO:003150473457 GO:0035774 GGOO::00004436296482 GO:0032306 GO:0032310 positive regulation of dopamine secretio... positive regulation of immunoglobulin se... pcoofsaitcitvoer rteragnuslpatoirotn of calcium ion impor... alorgnign-icnheaitnrafnastptyoartcid transport Lm-golnuotacmarabtoexiymlicpoacrtid transport chemokine secretion rreegguullaattiioonn ooff clihpeidmtorakninseposertcretion positive regulation of transmembrane tra... pchoosilteisvteerreogl utrlaantisopnoortf release of seques... oligopeptide transport ostregraonlictraalncsophoorlttransport regulation of glucose transport dehydroascorbic acid transport hoermmeotnreantsrapnosrpt ort regulation of sterol transport Lre-ggluultaatmioanteoftrcahnoslpeostret rol transport winateterlreturaknins-p1obrteta secretion pchoosilteisvteereogl uelfafltuioxn of prostaglandin sec... phoosistpivheatregiounlatrioansomf epmlabsmraanemtermanbsrpaonret l... positive regulation of insulin secretion... pcaorsbitoixvyelirceagcuildattiroannsopfoprot tassium ion tra... regulation of prostaglandin secretion prostaglandin secretion GGOO::00001155883479 aomrgianneictraacnidsptorarnt sport GO:0050796 GO:00458037051 GO:0031589131 GO:0030299 GGOO::00004165867997 GO:004382234619 GO:000412699563 GGOO::00003320237060 GGOO::00003022330754 GGOO::00004022878369 GGOO::00009100277466 GGOO::00004362838775 GGOO::00001352837742 GO:0050717 GO:0070634 GO:0072608 GO:0050705 GO:0072367 GO:0043691 GO:0055085 regulation of insulin secretion imntmerulenuokgilno-b1usleincrseetciroention rpelagsumlaatimoneomfbrreannael sloondgiu-cmhaeixncfraetttiyonacid tr... intestinal cholesterol absorption hqouramteornnearsyeacmremtioonnium group transport enpeignaetipvherirneegutrlatnisopnoortf lipid transport gl iapsotprircoatceiidn steracnrestpiornt rreegguullaattiioonn ooff ginotneasdtiontarlocphinolseesctreertoiloanbs... pcyotsoitkiivneerseegcurleattiioonnionfvioclovseadnionidimsemcurentei..r.e... aremgiudleattiroannsopfocryttokine secretion involve... rreegguullaattiioonn ooff ppelapstmidaemheomrmboranneeselocnregt-icohnain... pnoesgiattiviveerreegguulalattioionnooffhcohromleosnteersoelctrreatnios.n.. nnoergeaptiivneeprehgruinlaettiorannospf ostretrol transport positive regulation of interleukin-1 alp... transepithelial ammonium transport interleukin-10 secretion regulation of interleukin-1 alpha secret... regulation of lipid transport by regulat... reverse cholesterol transport transmembrane transport GO:0017038 protein import GO:0007589 GO:0015893 GO:0050706 GGOO::00001056880505 GGOO::00005511915830 GGOO::00003057851955 GGOO::00005012972490 GGOO::00006402192038 GGOO::00007115567872 GGOO::00001501165150 GGOO::00001550870023 GGOO::00003520370039 GGOO::00003520879014 GGOO::00001352834740 GGOO::00000125769913 GGOO::00009305048278 GO:0001504 GO:0072337 GGOO::00005013005906 GO:0015709 GO:0015759 GGOO::00007115770954 GO:0015798 GGOO::00007105580891 GGOO::00001155880948 GO:0032782 GGOO::00005314015917 GO:0034633 GGOO::00000385297226 GO:0001820 GO:0032413 GO:0060986 body fluid secretion drug transport regulation of interleukin-1 beta secreti... adcriudgictraamnsinmoeamcibdratrnaenstrpaonrstport nvietgaamtiivnetrraengsuplaotriton of amine transport plaocstiattiivoenregulation of renal sodium excr... pnoesgiattiviveerreegguulalattioionnooffccaylctoiukmineiosnetcrraentsio...... rxeegnuolbatioiotnicotrfagnrsopwotrht hormone secretion zfeinrcriicoinrotnratnrasmnsepmorbtrane transport rseegroutlaotnioinnuopftparkoeton transport binatseicrlaemukinino-1acaildphtraansespcroerttion rneeggualtaitvieonreogfuilcaotsioannooifdpsreoctreeitniosnecretion nreeggualtaivtieonreogfuilnatteiornleoufkoinr-g1anseiccraectidiotnran... mpoosnitoivaemriengeutlraatniospnoorftlipid transport rmeaggunlaetsioiunmofiopnetprtaindsepsoerctretion rheegxuolsaetiotrnanosfmpeepmtbidreanteratnrsapnosprtort neurotransmitter uptake modified amino acid transport preonsaitlivsoedrieugmuliaotniotnraonfstpraonrtsport thiosulfate transport beta-glucoside transport ngliytrcoegreonl-3c-opmhpoospuhnadtetratrnasnpsoprotrt myo-inositol transport ccarelcaituimneiotrnanimsppoorrtt nameuiltorarildaemtirnaonsapcoidrttransport bile acid secretion ntreigglaytcieveridreegturalantsiopnorotf transport retinol transport scuhlefmatoektirnaens(pCo-Crtmotif) ligand 2 secretion serotonin secretion negative regulation of ion transmembrane... endocrine hormone secretion GO:0015992 proton transport GO:0046903 secretion Annotated Significant Expected Rank in classic classic weight avgFC.sig avgFC sigGenesUp sigGenesDown 6 1 0.9 3711 0.6248 1 0.208364366 -0.047411983 Acbvcra21a; Ace; Plin2; Apoa1; Apoa2; Apoa4; Apoc1; 6 1 0.9 1569 413 230.9.96 6 1 0.9 3714 0.6248 373582 6.500.6E2-4085 3741 0.6248 1 0.515258897 0.174885286 SAlpc1o8ca21; Apoh; Atp8a1; Atp9a; Cd36; Fabp2; Lrp6; 0.511218 -0.2396427393593997 0.0298618260404024 Mttp; Pon1; Ppara; Rbp4; Ncor1; Nr1h3; Slco2a1; 1 -0.282258057 -0.097499803 Slc27a2; Slc27a4; Abca7; Atp9b; Stard3; Osbpl1a; SPylat2l2g4a; Pparg; Slc25a17; Soat1; Pla2g10; Acsl4; SAlccs2l56a; 2A6tp11c 21 3 3.16 3763 0.63306 0.63306 0.309505712 0.097801402 AOtspb6pvl03a; 1Sp; Anstp1;6Oaps1b;pA; tOps6bvp0lb6; Npc1l1; Apob; Irs2; 211 37 31.166 37684 0.6030300363 0.000313 0.39019580757791827 0.069078850310430325 Atbpc6av10; aA1p;oAat1p;6Aapo1a; 2A;tAp6pvo0ab4; Apoc1; Apoc2; 5405 175 76.5748 378932 0.6040412715 0.7032162725 -0.30608528403356464 0.07067304775296559 SAlcce2;2Pa4li;nS2l;cC7da83;6S; lFca2b5pa2;2S; lScloc62a81; Slc3267a12; Slc3267a24; SPlca225ga42a6; Pparg; Slc25a17; Pla2g10; Acsl4; Acsl6 5201 79 73.5146 378947 0.6040422017 0.022613 0.00.63975505806231 0.02167192697893919 GSllcu2d21a;1J;aSkl2c;2R2ab3p;4S;lIcr2s2a4; Slc7a8; Rhbg; Pdzk1; GSlccg1;2Pad2x1; Oxct1 4333 162 64..4987 36 5 5.43 381998 00..6040622135 0.281116 00..655307340516421359 00.1.1907636156772775 Apbocaa12;;ACpdo36a;1T; hArpao;aD2a;bA2pipo;aI4r;s2Apoc1; Apoc2; 3828 0.64966 1 0.184339608 0.055329255 IAntsp28;aP1r;kAczt;pA9ad;ipAobrc2a;7I;rsA2tp9b PPslam2dg1100; Atp11c Itln1 107 15 16.13 3845 0.6609 CAlbccna21;;SAlcc1e2;aP7l;inS2lc;4Aap2o; aS1lc;2A5pao10a;2F; xAypdo1a;4C;lAcap6o;c1; 1 0.124878249 0.010009267 Anpo6c2; ;SAlcp1o2ah6; ;ATrtgy1h;2Atp8a1; Atp9a; Cd36; Slc6a3; Clns1a; Slc12a2; Clca3; Ttyh1; Clic6; Clcc1 22 3 3.32 3857 0.66534 1 -0.279416414 -0.059051073 AEdcen1; Fabp2; Slc37a4; Slc6a4; Ins2; Lrp6; Mttp; Pla2g4a; Pla2g10 146434 2839 2646..5971 APrbkccaz1;;PColncn12; ;PSplacr1a2;aI7n;pSpl5c4ka; 2R;bSpl4c4; aN3c;oVr1d;aScl1c;2C2lan18;; CAlqnps81;aC; Srylcm12; aE2d;nSralc;1H6iaa1t;1C; Iltclan31;;TPtlyah21g;4Saf;xPnp5a; rCgl;ic6; 3816012 00..6060729418 0.285841 00..133073261516982219 00..001638233629323756 Slc252a130; ;SFlcx2y3da11;;SSllcc225aa32;2S;lcC3lcaa16; ;NArn1ho36; Slco12a61; ASlhcc1y6la11;;CSllccc215a17; Slc2a1; Soat1; Stxbp3a; Pla2g10; 101 14 15.22 ASlrcg217;aS2l;c3Salc12;7Cal4n;8C;lSnl8c9; aS3lcr91a;3Srl1c2; 2Salc42;5Sal1c70a; 8A;bPcdaz7k; 1; Acsl4; Slc37a2; Slc25a26; Sfxn5; Acsl6; Atp11c 3871 0.67538 0.68447 0.366819283 0.078306356 Slc2o51ab222;;SSlclc262aa84;;SAlctp396ba1; ;SSlcl7c3a68a; 2S;lcS5lac73a; 1A5rl2; Crym; Slc25a26 7 1 1.05 3908 0.68136 0.68136 0.515258897 0.059985866 SPldcz1k81a;1Stard3; Osbpl1a; Nisch; Slc35a4; Slc25a22; 7 1 1.05 3919 0.68136 0.68136 1.015488235 0.171740998 RAbdpip4or2; Osbpl3; Spns1; Osbp; Abcc3; Osbpl6; 171 16 1.0656 3913017 0.6080123761 0.6186153761 -0.715839670197130385 -0.01909853974733129 Abcb6; Slc6a8; Mfsd7c; Mfsd7b GPpcgt1; Slc25a26 370 11 14.0552 3914191 0.6080133063 0.005915 0.50529713429896191 0.0310920551911743 Arcge1; Plin2; Cd36; Fabp2; Slc27a4; Irs2; Acsl5 Pla2g4a; Pparg; Pla2g10; Acsl6 676 119 19..0955 7 1 1.05 3917115 00..6080133167 3989 0.68136 0.72719 -00..505150586823638545 00..008264941389412212 CAlcne8; Plin2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Aqp8; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pla2g10; 1 0.381454205 0.041860271 FS2lcrol11b2; Abcc3; Irs2; Acsl5 Acsl4; Acsl6 477 114 17..0058 59 8 8.89 3919500 00..6080173664 4009 0.68241 11 00..358413405040200753 00..014816866900277116 FA2brcl1a1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Pla2g10; Acsl6 1 -0.134863426 -0.003635108 HPpyalr2a; PNdczokr1; FNlnr1ah;3A;cIsrls52; Acsl5 Ect2; Gcg; Tlr3; Acsl6 1552 125 27..2864 15 2 2.26 4011545 0.06.80402841 00..6184412546 00..153673149114082951 00..010411754069648169 FA2bca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Cd36; ESdonatr1a; Pla2g10 4018 0.68424 0.85921 0.364670679 0.098781308 SLrlcp96a;3Pro1n; 1S;lcNor11bh23; Stard3; Npc1l1; Apob 6502 185 97..0844 46 6 6.93 4016516 0.07.00100811 4074 0.7116 11 00..355693440104280951 00..016451050049041139 SAlbc6ca13; ASlpco2a21a;1A; Sploc2a2a; 3A;pSolca54a;3A;pNoics1c;hA; Splocc62a;8C; d36; SSloca3t71a;2Pla2g10 1 0.212818 0.047870739 ILnrps26; Proknc1z; INnrp1ph53k;;SAtadridp3o;rN2;pIcrs12l1; Apob Itln1 4 3 0.6 1884 263 28.03.36 27 9 4.07 202 0.01213 4028003 0.701420153 220 0.01416 0.01213 0.061213 1 0.221889155 0.14478195727390276 0.771441823 0.106809068 ASlccv2r32aa1;;ASclvc2r2ab3; Dgat1; Edn1; Eif2ak3; Glud1; Jak2; Slc2a1 0.03102984661740931 MAbecgb36;;PMppfs3dc7ac;;RMbpfs4d;7Sblc22a1; Srebf1; Tbx3; Hnf1b; Cpt1a; Crym; Gcg; Pdx1; Scg5; Stxbp3a; Oxct1; 0.304947718 EAnbscaa;1S;mApoda31; ;CAhpdo7;aI2r;sA2poa4; Apoc1; Apoc2; Pon1; APlcav2rg11c0 1267 29 24.4017 4028291 0.70184816 0.770221 0.6747614341787223 0.037084098417079198 CAlbnc8a;1S;lAc2p5oaa212; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Pla2g10 165 26 2.4216 4029304 0.701878164 0.8006418157 0-0.1.135602902713032 0.00440836107811963 IAnbpcpa51k; Apoa1; F2rl1; Panx1 ACaqspp81; Pycard 383 110 14.2917 4123471 0.702194917 0.7023924317 -0.769517849724033619 -0.12254575020931635 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; PSolaa2tg11; 0Pla2g10 82 12 1.02.13 4124654 0.07.20924217 0.07.20924217 -0.375509341686 -0.13156560399414646 SAlccs2l5a10 Acsl6 8 1 1.21 4146 0.72941 0.72941 -0.753609108 -0.074789283 Ace; Plin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; Gcg 1782 316 215..2912 8 1 1.21 4124990 00..7022934418 0.729411 -00..511696616347994699 -00..005565419225960394 Slco2a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; SAtqkp389; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; 4184 0.72941 1 -0.791892031 -0.124700363 Slco1b2; Slc22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 8 1 1.21 4185 0.72941 1 -0.791892031 -0.124700363 Slc6a8; Slc36a1; Slc36a2; Slc7a15; Irs2; Acsl5 Pla2g10 Arcge1;;PSllicn62a;3A;rEgd1n; 1C;dS3l6c;6Faa4b; pSl2c;2S2lac12;3Sal1c;2S2lac3;aS1l;c3a1; 117764 2346 2266..5222 4232217 00..7032474651 11 00..318686915317290699 00..006555203851276463 CSlcno82;aS1lc;9Salc32r17;aS2l;cS2l2ca247;aS4l;cC7lan88;;ASrllc29;aP3dr1z;kS1l;cN25isac1h0;; CArqypm8; CEdrynmra;;PSllac2g54aa2;6Pparg; Slc16a1; Slc25a17; Slc2o51ab222;;SSlclc262aa84;;MSlac7oab8;;SPlcd1z8ka11;;SSlclc2356aa212;;SAlcb3c6ca32; ; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 91 12 13.71 4222 0.73583 0.71916 0.11262697 -0.008116635 GSllcu6da18;;JSalkc23;6Pa1p;pS3lca3;6Rab2;pS4l;cS7rae1b5f;1I;rsE2n;sAac;sIrl5s2 Cpt1a; Gcg; Pdx1; Oxct1; Acvr1c 17 26 2.56 423453 0.7053022427 0.558321 0.61375502992913092 0.08443021276377578 RAbpca41; ;TArapfo3iap12; F2rl1; Panx1 Casp1; Pycard 179 24 21.536 4236532 0.7053042423 0.387114 0.702984834857571673 0.012191396134646319 ECdn316; AIrns2p;eApcsl5 Acsl6 9 4 1.36 17193 245 261..9986 353 0.03443 0.38714 0.662079676 0.098661768 Acpvora21a;;AApcvora22b;;ADpgoaat41; NEdpnc1l;1Eif2ak3; Glud1; Jak2; 4239529 0.003.746743 0.06112 00..147567678670681083 00..021289713373590674 MSlce2g23a;1P;pSplc32c2aa;3R;bSplc42;2Sare4;bPf1d;zTkb1x; 3S;lcH6naf81b; Ensa; Cpt1a; Gcg; Pdx1; Scg5; Stxbp3a; Oxct1; Acvr1c 198 16 12.3761 431796 0.7074022616 0.747092312 0.39012779276883826 0.030627910961852346 SAlpc2o2aa21; Apoc1; Apoc2; Nr1h3; Irs2 Pla2g10 194 15 12.3161 432992 0.07.70042715 0.04715 40.614180240413154089 0.419712008159186 TAfpf2oc2; Cd36; Mttp; Apob Pparg 96 13 1.03.69 96 13 1.03.69 96 13 1.03.69 1016 133 15.02.29 7120 94 101..8551 1180 24 21..7511 3 2 0.45 3 2 0.45 3 2 0.45 3 2 0.45 3 2 0.45 11 4 1.66 895 127 134.88 206 39 31.05 57 13 8.59 21 6 3.16 12 4 1.81 1197 25 22..8566 1197 25 22..8566 1207 17 14..5017 104 12 1.05.16 104 12 1.05.16 104 12 1.05.16 104 12 1.05.16 104 12 1.05.16 1208 17 14..5212 1103 14 11..5916 5293 76 83..8497 1049 133 151..6376 1049 133 151..6376 14 4 2.11 14 4 2.11 4321 591 650..1115 1 1 0.15 1 1 0.15 2001 261 300..1145 1 1 0.15 201 21 30..0115 201 21 30..0115 1 1 0.15 2511 331 370..8135 1 1 0.15 111 11 10..6165 4344020 00..7074072819 0.047819 00..270580376040386761 -00..033926366680034673 AAcpvora21a; Apoa2; Apoa4 4344131 00..7074072819 11 -00..789218849920093319 0-0.4.1048087767034046 Apoa1; Apoa2; F2rl1 Pla2g10 4345122 00..7074072819 11 00..487298741900994349 00..143058784757336086 AAbppo1a1; Apoa2; F2rl1 4347123 00..7074270839 11 00..103035603709477722 -00..000642175585221658 GIrlsu2d; 1A;cJsal5k2; Ppp3ca; Rbp4; Srebf1; Ensa; Chd7; Irs2 CApcstl16a; Gcg; Pdx1; Oxct1; Acvr1c 4349245 00.0.75706667 00..9171205363 01..106528314979156953 0.00.3478973354269896 AAcpvora22a;;AEdpno1c1; ;GAlupdo1c;2Jak2; Rbp4; Irs2 GPlcag2;gP1d0x1; Oxct1 4349297 00..7075805627 0.38761 01..301538410909057913 0.00.3458070374669816 SAlpc2o2aa21; ;ANpioscc1h; Apoc2 Pla2g10 472 0.06128 0.06128 0.039358143 -0.003411506 APabncax11; Accn2; Apoa1; Apoa2; Atp1a1; Atp2a2; Casp1 474 0.06128 0.06128 0.091000915 0.091818923 ARhtpb6gv0a1; Atp8a1; Atp9a; Cd36; Clcn2; Cox8a; Slc12a2 483 0.06128 0.15066 0.358139819 0.314897105 SFl2cr6l1a;3P; Srkfxczn1; Slc37a4; Gc; Slc6a4; Hyal2; Ins2; Jak2; 497 0.06128 1 0.039358143 -0.003411506 SPlacn1x21a7; Slc13a2; Slc22a1; Slc22a3; Slc23a1; Slc2a3; ACaqspp81; Cdk1; Ect2; Gcg; Grid1; Hiat1; Kcnk1; Kcnk2; 500 0.06128 1 0.32189265 0.303203622 SPlpca4raa2;;NSlcco4ra13; Abcc9; Thra; Tnfrsf1a; Trf; Vdac1; Prdx1; Slc12a2; Slc16a1; Slc25a17; Slc2a1; 525 0.07039 0.07039 0.673793776 0.216203108 VAdbrc;aS1l;cA9ap3ora11;;SAlcp2o5aa21;0A; pAobac4c6; Slco1b2; Slc39a1; 4426 0.78905 0.16434 0.233361798 0.03557095 SBlccl262; aC4d;3A6t;pC9rby;2S; lDca7ga18;; HSlyca5la23;;JAaktp2;6Jaupn1;;PPpapn3xc1a;; Tmem38b; Psmd10; Slc37a2; Kcne3; Ttyh1; KAcrnnmtl;bC4d;kS1lc;2E5cat22;6H; Sslpca245;aK1p6n; Sbf1x;nK5p;nSalc32;2Par1d3x;1T;lr3; 561 0.07502 1 0.012348286 0.008478946 FSxtaytd31;;TRhhrab;gT;nPfdrzskf11a;;SIlnc4g71a; 1M;aSplck315;aP4e;xS1lc42;5a22; CRlainc6; ;TMimfsmd94;;MActsxl26;;PSslcm1d6a1101; ;NToopm58m; 2P2e;xS3l;cS3n0au1p0n;; TTropmmm4;3K4;ctDda5b;2Dipab; F2linpa; ;KPctdde22;aS;lPc4e6xa63;;IpSolc1339a5; KIpcotd53; ;IpAoh4c;yPl1e;xC1l2c;cT1l;rK3;ctTdo1m4;mK2c2ns3; Kctd12; Atp11c 564 0.07869 0.68311 0.170693349 0.027798518 SAlpc3rt9;aC4o;pSalc;1S6lca61a03; ;SElcd2n51a;4E2i;f2Salck232;aG2u3c; aS2pbn;sN1;r1h3; Usf2; Agr2; Sytl2; Socs2 582 0.08414 1 0.445604666 0.167997547 ASlbcc2b26a;1A; Sblccco31;bA2b; pS1lc;4M7afs1d; 2Aab;cMc3c;oAlnb1p;1S;lScl2c41a83a;1 614 0.09342 1 -0.003493521 -0.010193696 SAlpc6oaa81;; APnanox61; Slc12a6; Slc18a1; Atp6v0b; Ttyh2; Casp1; Pycard 4467254 00..8100309178 0.100118 0.06.4463483718737421 00..017609068674375343 CSllcn282;aS1lc; 2S5lcao212b2; Slc47a1; Abcc3; Slc18a1 4467297 00..8100309178 0.833816 00..491660114820950437 00..034160619589312965 MGca;oRbb;pS4lc; 1S8lca213a1; Slc2a3 Slc2a1 4469370 00..8100408365 00..8100408365 00..716651807549905293 -00..000325019499395992 EAdpnrt1; Slc6a3; Eif2ak3; Vdr; Vegfa Usf2; Socs2 4560824 00..8101408462 00..8101408462 01..208522201059433066 0-0.5.1206938753621896 VAdproa1; Apoa2 4560938 00..8101408462 00..8101408462 -00..308457617127499264 00..004496066374474274 CAhbdcc73 Slc2a1 4570142 00..8101408462 00..8105408667 00..277512988193929166 0.00.3347070576728968 STlrcf3; 9Lma1tk2 4571183 00..8101408462 0.150617 00..343674880387020364 -00..021745361780151643 SSllcc96aa34r;1Slc18a1 4572347 00..8101408462 11 00..505399133528816493 00..001042001002926191 APargn1x1 Casp1 4572499 00..8101478266 0.509919 -00..749616889423023019 0-0.1.1111938431053037 Apoa1; Apoa2; F2rl1; Ins2; Nr1h3 PPltag2egr41;0Dph3 4573619 00..8101498561 11 -00..702053442973654281 -00..1020600850556414 IArsp2oa1; Panx1 Casp1; Pycard 4575716 00..8102507769 11 00..417467585301773779 00.0.0548596668363283 SAlbc6caa13;; PSlocn61a;4N; Sr1lch232;aA1c; sSll5c22a3; Nisch; Maob; Pla2g10; Acsl6 4585341 00..8104626352 0.142312 -00..133937673601467223 --00..000616317283958963 Glud1; Jak2; Ppp3ca; Rbp4; Srebf1; Ensa; Chd7; Irs2 CTupstc13a;; NGicpga; 2P;dNx1ip;aO1xct1; Acvr1c 4585353 00..8104626352 0.142312 00..103036683909487629 -00..000011307087928968 GSllcu3d71a;4J;aSkl2c;2Pa3pp3ca; Rbp4; Srebf1; Ensa; Chd7; Irs2 CSlpct21aa1; Gcg; Pdx1; Oxct1; Acvr1c 879 0.14831 1 0.553746962 0.183657642 ASlbcc6aa14;; ASlccv2r22aa3;;CC3l;nC8d; 3S6lc;1E8dan11; F2; F2rl1; Glud1; Casp1; Cdk1; Ect2; Ednra; Ptk2; Gcg; Itln1; Pdx1; 895 0.14831 1 -0.04411408 0.048066156 HSlyca9la23;rI1n;sS2l;cC6da847; Jak2; Mbl2; Mdm2; Prkcz; Pon1; PClray2mg;4Sal;cP2p5ta12;6Ptger4; Wfs1; Pla2g10; Stk39; 4596168 00..8115504751 0.150711 00..130357789038500076 00..031327987088302026 ISnlcp9pa53kr;1Rbp4; Src; Tnfrsf1a; Nr1h3; Vdr; Vtn; Pycard; Oxct1; Tmem30a; Dnm1l; Rab27b; Sytl2; 953 0.15071 0.15071 0.375093168 0.375093168 PSlacn2x51a;1P0dzk1; Actn4; Adipor2; Abr; Bcr; Slc18a1; Tlr3; Cd209d; Acsl6; Ahcyl1 954 0.15071 0.15071 1.930995618 1.930995618 AArpgo1a;2Slc6a3; Edn1; Slc6a4; Slc22a1; Slc22a3; Slc3a1; 4598555 00..8125103711 0.150711 -00..3651355897088495 0-.00.5681553877889465 Cln8; Slc9a3r1; Slc22a4; Slc7a8; Arl2; Pdzk1; Nisch; CSlrcy3m7a; 2Ednra; Slc25a17; Slc25a26 956 0.15071 0.15071 0.448870105 0.448870105 SSllcc255aa322; Abp1; Slc6a8; Maob; Slc18a1; Slc36a1; 4599598 00..8125607781 00..6185105721 -0.01.8473974789271351 -0.00.3453279749079311 MSlcic6ua18 Gcg 4691519 00..8125607781 0.150711 00..446749678150791484 00..045729870160292414 SAlbc3p61a1; Slc36a2 987 0.15071 0.15071 0.337808006 0.337808006 ASlccc9na23;rA1poa1; Apoa2; Apoc1; Apoc2; Cd36; Edn1; 4691956 00.1.85207791 0.150711 01..503097173539807244 01..008087378589609244 FA2prol1h; Ins2; Anpep; Ppp3ca; Inpp5k; Srebf1; Tff2; Pten; Ptger4; Stxbp3a; Pla2g10; Psmd10; Dph3; 1002 0.15071 0.15071 1.015488235 1.015488235 TRhbrpa4; Nr1h3; Slc9a3r1; Ndfip1; Dab2ip; Maob; Abr; Acvr1c 41603135 00..8135402791 00..8135402791 00..337851049534126085 00..034831547514621075 SFl2cr2l15a10 11 1 1.66 4655 0.83429 1 0.31702691 -0.045341182 Maob 11 1 1.66 4670 0.83429 1 0.337808006 0.031617009 Slc9a3r1 29 3 4.37 4695 0.83436 1 0.240437036 -0.001304325 Acvr2a; Meg3; Tbx3 77 9 11.6 4702 0.83951 0.84332 0.382482794 0.041612376 Atp6v0a1; Cox8a; Slc9a3r1; Atp6ap1; Slc47a1; Slc35a4; Atp6v0b; Slc36a1; Slc36a2 Abca1; Accn2; Ace; Acvr2a; Acvr2b; Apoa1; Apoa2; Aprt; Copa; Slc6a3; Dgat1; Dvl1; Edn1; Eif2ak3; Casp1; Cpt1a; Ednra; Gcg; Pdx1; Pla2g4a; Ppt1; 585 80 88.16 4719 0.84643 0.55963 0.199184664 0.012787417 F2rl1; Glud1; Guca2b; Ins2; Jak2; Anpep; Llgl1; Meg3; Pdpk1; Prkcz; Ppp3ca; Rbp4; Src; Srebf1; Ptger4; Scg5; Stxbp3a; Usf2; Agr2; Pla2g10; Rala; Pycard; Oxct1; Dnm1l; Steap2; Cklf; Scfd1; Rab27b; Stx4a; Stxbp2; Tbx3; Hnf1b; Tff2; Nr1h3; Vdr; Sytl2; Dph3; Cd209d; Socs2; Car9; Acvr1c Vegfa; Slc9a3r1; Panx1; Ensa; Smpd3; Ralb; Nisch; TNO report - Final 3M#07 TNO Project number: 051.01978 58 / 59 GO.ID Term GO:0006818 hydrogen transport GO:00406687669 GO:0071436 GO:0051937 GO:0033700 GO:000165891048 GO:0015695 GGOO::00001105892194 GO:0030252 GO:0051023 GO:0043266 GO:0006817 GO:0033605 GO:00571975052 GO:0090279 GO:0002028 GO:0010524 nliepgidattirvaensrepgourtlation of insulin secretion sodium ion export catecholamine transport phospholipid efflux sfaotdtiyuamciidotnratrnasnpsoprot rt organic cation transport npehgoastpihveolriepgidultaratinosnpoofrtglucose transport growth hormone secretion regulation of immunoglobulin secretion regulation of potassium ion transport phosphate ion transport positive regulation of catecholamine sec... roerguanlaitciosunbosftanmcientorancisdpotrratnsport regulation of calcium ion import regulation of sodium ion transport positive regulation of calcium ion trans... GO:0051181 cofactor transport GGOO::00005115094069 rloengug-lachtiaoinnofaftsteycarceitdiotnransport GO:0015718 monocarboxylic acid transport GO:0090278 negative regulation of peptide hormone s... GGOO::00001302736658 preogsuitliavteiornegoufllaiptiiodntroafnssopdoirutm ion transp... GO:0006835 dicarboxylic acid transport GO:004360838031 rcehgoulelasttieornolotfrhanosrmpoornte secretion GGOO::00000125799128 nsteegraotlivtreanresgpuolrattion of peptide secretion GGOO::00005710084377 pdoeshiytidvreoarescgourlbaticioanciodftsreacnrseptoiortn GO:003125481816 phoesmiteivterarnesgpuolartion of transporter activ... GO:00531223791 regulation of rseteleroasl etroanf speoqrutestered cal... GO:000362832754 creogpupleartion otrfacnhsoploerstterol transport GO:004580274032 ninotreerpleinuekpinh-r1inbeetsaecsreectrieotnion GO:001353731414 ochrgoalensictearnoiloenftfrluanxsport GO:003120470497 rpeogsuitliavteiornegouf ltartainosnpofrtpelrasamctaivmityembrane l... GO:0014046 dopamine secretion GGOO::00001446095492 rceagrbuolaxtyiolinc aocfiddotrpaanmspinoertsecretion GO:0006836 neurotransmitter transport GO:0006813 potassium ion transport GO:0015849 organic acid transport GO:0050701 GO:0015911 GGOO::00000360821929 GO:0015697 GO:0032369 GO:0042953 GO:00731083050 GGOO::00007012830744 GGOO::00005012972369 GGOO::00004130277406 GGOO::00003352737735 GGOO::00006312137782 GGOO::00004560878187 GO:0070634 GO:0072608 GGOO::00001550677025 GO:0072367 GO:0043691 interleukin-1 secretion plasma membrane long-chain fatty acid tr... cinatteiosntintraalncshpoolretsterol absorption quaternary ammonium group transport negative regulation of lipid transport lipoprotein transport preogtuaslastiuiomn ioofnintrtaenstsimnaelmchboralensetetrraonl sapbosr..t. cceytllouklianrepsoetacrsesituiomniionnvotrlvaendspionritmmune re... nreeggualtaivtieonreogfuclayttiookninoef scealccrieutmionioinnvtroalnvse...... preogsuitliavteiornegouflpaltaiosmn oafmioenmtbrarannspeolortng-chain... innesgualitnivseerceregutiloantioinnvooflvcehdolienscteelrloullatrrarn..s.... rneeggualtaitvieonreogfuilnastuiolinnosfesctreertoiol ntriannvsoplovretd... npeogsiattiivveerreegguullaattiioonnooffihnotermrleounkeins-e1craelpti.o..n transepithelial ammonium transport interleukin-10 secretion mreognuolavtaiolennotfininotregralneiuckciant-i1oanlptrhaansspeocrret t... regulation of lipid transport by regulat... reverse cholesterol transport GO:0051928 positive regulation of calcium ion trans... GGOO::00003127401348 pporostiteiivneirmepguolrattion of ion transmembrane... GO:0007589 GO:0015893 GO:0050706 GO:0006855 GGOO::00000561811810 GO:0007595 GO:0002740 GO:0042908 GO:0015682 GO:0051610 GO:0050703 GGOO::00003520974009 GO:0050704 GO:0032370 GO:0015693 GO:0035428 GO:0001504 GGOO::00003742232307 GO:0003096 GO:0015709 GO:0015759 GGOO::00005115975944 GO:0015798 GGOO::00007125581811 GO:0015898 GGOO::00001302572822 GO:0034197 GO:0034633 GO:0035926 GO:0030001 body fluid secretion drug transport regulation of interleukin-1 beta secreti... drug transmembrane transport ivoitnatmrainnstpraonrtsport lactation negative regulation of cytokine secretio... xenobiotic transport ferric iron transport serotonin uptake interleukin-1 alpha secretion sneecgraettiivoenrbeygucelaltlion of protein secretion regulation of interleukin-1 secretion positive regulation of lipid transport magnesium ion transport hexose transmembrane transport neurotransmitter uptake imonodtrifainesdmaemminboraanceidtrtarannssppoortrt renal sodium ion transport thiosulfate transport beta-glucoside transport pgloyscietirvoel-r3e-gpuhloastpiohnatoef tarmaninspeotrrtansport myo-inositol transport dcrievaalteinnet itnraonrgspanoirct cation transport amiloride transport rbeilgeualactiidosneocfrectailocnium ion transport into... triglyceride transport retinol transport chemokine (C-C motif) ligand 2 secretion metal ion transport GO:0035725 sodium ion transmembrane transport GO:0070838 divalent metal ion transport Annotated Significant Expected Rank in classic classic weight avgFC.sig avgFC sigGenesUp sigGenesDown 78 9 11.76 13509 43 243.5926 47 5 7.08 4730 0.85026 47352 60.5.805E1-205 4745 0.85643 1 0.85511258 0.85643 0.382482794 0.043249771 Atbpc6av10;aA1c;eC;oPxli8na2;;SAlcp9oaa31r1; ;AAptopa62a;pA1p;oSalc44;7Aap1o; c1; SAlpc3o5ca24; ;AAptoph6;vA0tbp;8Salc13;6Aat1p;9Sal;cC36da326; Fabp2; Lrp6; 00.3.2662270383793927 -0.02916081650704034 PMptptp3;caP;oSnr1e;bPfp1ara; Rbp4; Ncor1; Nr1h3; Slco2a1; 0.547857463 0.092593653 ASltcp217aa12;;SSllcc62a73a;4S;lAc6bac4a;7S;lAc2tp39ab1; Sltca6rad83; Osbpl1a; Pla2g4a; Pparg; Slc25a17; Soat1; Pla2g10; Acsl4; AAccvslr61;cAtp11c 47 5 7.08 4747 0.85643 1 0.520882536 0.05725291 SOlscb6ap3l3; ;SSlcp2n2sa11;;OSslcb2p2;aO3;sbNpisl6ch; N; Splc1l81a;1Apob; Irs2; 11 7 1.66 64 0.00033 0.00033 0.919877987 0.608530335 Acbccna21;;AAtppo1aa11;;ASplco6a23; ASlpco6a4; ASlpco13c1a;2A; Sploc2c23;a1; 15445 195 236.2718 474992 0.8050718785 0.10246675 -0.40405388093453454 00.0.0709715296589 SAlce9;aP3rli1n;2S;lcC2d23a64;;FSalbc5pa23;;SSlclco52aa41a;;SSllcc257aa42b;;SSlclc2274aa43;; SPllca122ga42a;;APhpcayrlg1; Slc25a17; Pla2g10; Acsl4; Acsl6 21 9 3.16 97 0.00207 0.02263 0.37508621 0.217967999 Slc62a28a;1A; SI3lc12723a935;;SSllcc252aa94;;SSlclc57aa181;;RShlcb5ga;1P2dzk1; Slc12a2 1323 112 14..8917 12 1 1.81 475958 00..8050922185 00..8258912186 00..355357240596925379 00..015927831116374795 IAnbpcpa51k; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; 4778 0.85928 1 0.385672496 0.046666589 CAhtpd87a1; Atp9a; Abca7; Atp9b Pla2g10; Atp11c 12 1 1.81 4786 0.85928 1 1.015488235 0.08982852 RAbbpca41; Ace; Plin2; Apoa1; Apoa2; Apoa4; Apoc1; 22 2 3.32 4811 0.86535 0.89855 -0.531337464 -0.043801524 Apoc2; Apoh; Arg1; Atp8a1; Atp9a; Cd36; Slc6a3; Stk39; Kcne3 13 1 1.96 4878 0.8805 1 0.375093168 0.0513248 SEldcn215;aF1a0bp2; Slc37a4; Slc6a4; Ins2; Lrp6; Mttp; 13 1 1.96 4881 0.8805 1 0.515258897 0.075794411 SPlrck1c8za;1Pon1; Ppara; Inpp5k; Rbp4; Ncor1; Slc22a1; Aqp8; Crym; Ednra; Hiat1; Itln1; Pla2g4a; Pparg; 41434 819 616.961 4818052 00.0.80820458 1 0.5350931635268629 0.0464838639922776 ASlrcg212a3; Slc23a1; Slc2a3; Slc3a1; Nr1h3; Slco2a1; Slc16a1; Slc25a17; Slc2a1; Soat1; Stxbp3a; Pla2g10; 13 1 1.96 4893 0.8805 1 -0.753609108 -0.083232558 Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Abca7; GAcgsl4; Slc37a2; Slc25a26; Sfxn5; Acsl6; Atp11c 32 3 4.82 4896 0.88056 0.80505 0.047816325 0.004748011 ASltcpo11ab12;;SSlclc92a23ar41; Atp9b; Slc7a8; Slc5a3; Arl2; Ahcyl1 23 2 3.47 4912 0.88153 1 0.137191025 0.013172605 FP2dzk1; Stard3; Osbpl1a; Nisch; Slc35a4; Slc25a22; Ednra 11 6 1.66 37380 4191 564..9572 66 19 9.95 33 3 4.97 Acdcinp2o;r2A;cOvrs2bap;lA3;pSopan1s; 1A;pOosab2p;;EAdbnc1c;3F;2Orls1b;pGll6u;d1; 107 0.00271 0.16571 0.189717335 0.108594319 IAnbsc2b; 6Ja;kS2lc;6Aan8p; eMpf;sPdd7cp;kM1;fPsdrk7cbz; Ppp3ca; Rbp4; Src; CPapstp1;1S; lCcp2t51aa2;6Gcg; Pdx1; Ptger4; Scg5; Stxbp3a; 4913191 00..8090238033 0.005915 00..205277419409398161 00..003119302531112743 SArceeb;fP1l;inSt2x;bCpd23;6T;fFfa2b; Np2r1; hSl3c;2S7lac49;aI3rrs12;;PAacnsxl51; Ensa; PPllaa22gg140a;; RPaplaar;gP;yPclaar2dg;1O0;xActc1s;l6Dnm1l; Rab27b; RAacleb;;PAlirnfi2p;1C;dM3a6o; Fba; bApb2r; SBlccro; 2Salc11;8Salc12; 7Zafp2;3S8l4c;27a4; SAyqtpl28;;DPplah23g;4Cad;2P0p9adr;gA; Sclvcr116ca1; Slc25a17; Pla2g10; 115 0.00317 4944 0.89319 0.7279 1 -0.010883355 0.26208732 0.024439122 -0.019012456 PSlpcpo31cba2;;SArebbccf31; Irs2; Acsl5 Acvslr41;cAcsl6 1447 114 27..1018 14 1 2.11 4917590 00..8090875634 0.898531 -00..452413702070104743 -00..015826062990973116 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; APlhac2ygl110; Acsl6 4995 0.89853 1 0.375093168 -0.055628848 SPlpca2r5aa;1N0cor1; Nr1h3; Irs2; Acsl5 13582 165 270.8.84 5011565 0.09.00831 0.2174913516 0.15460314215468191 0.011441058059846169 Acbvcra21a;;AEpdona11; ;GAlupdo1a;2J;aAkp2o; Pa4p;pA3pcao;cR1b; Ap4p;oScr2e;bCfd13; 6; CSopat1t1a; PGlcag2;gP1d0x1; Scg5; Oxct1; Acvr1c ELrnps6a; PCohnd17; NIrrs12h3; Stard3; Npc1l1; Apob 3542 135 57..1824 2074 253 310..26 5012586 0.09.00406811 11 00.5.2663240184783921 -00..011451952029346119 PApbpca31ca; ;ASproeab1f;1Apoa2; Apoa4; Apoc1; Apoc2; Cd36; ASocvart11c; Pla2g10 ALrcpv6r;2Pa;oEnd1n; 1N;rF12hr3l1; ;SGtalrudd31;;NInpsc21;l1Ja;kA2p;oPbrkcz; Rbp4; Casp1; Gcg; Pdx1; Ptger4; Pla2g10; Pycard; Oxct1; 5024032 00..9001729153 0.012113 00..027251987879911535 00..011026883039901698 Srlc2; 3Pa1n;xS1l;cS2lac318a1; Zfp384; Exph5; Irs2 DSlncm2a11l; Rab27b; Sytl2; Cd209d 254 23 3.07.76 5024043 0.9001826113 00.0.46810213 0.84379125823304236 -0.031062181671247961 PAobncb1;6V; Mdrfsd7c; Mfsd7b 257 29 34.707 5025240 0.9001846116 1 0.1737711494108253 00.3.00499487972118 FA2bca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; EPdlan2rga10 1257 19 24.2067 5027251 0.901348136 0.913831 -0.37877184343108423 -0.033054493487970168 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; SPclao21g10 15 16 2.26 5027364 0.901378134 0.9016318137 00.1.325400972313012 0.02410030167712913 NAbisccah1; Apoa1; F2rl1; Panx1 Casp1; Pycard 5343 150 84.1947 512401 0.9021593997 0.9093524367 0.262587848774639629 0.02153555269414615 CAlbnc8a;1S;lAc2p5oaa110;;ASplco2a52a;2A2poa4; Apoc1; Apoc2; Pon1; Sloca1t61a;1P;lSaf2xgn150 712 72 10.73 5124664 0.09.20527227 0.02217 -0.636505106974019656 -0.03505201934311676 Apcsola52; Ins2; Pon1; Vdr; Slc9a3r1; Ndfip1 Ahcscly6l1 17 1 2.56 5220 9.38E-01 1.00E+00 0.515258897 0.022861105 SAlce1;8Pa1lin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; 11772 316 225..5962 114 12 17.18 5222910 00..9032738478 5231 0.93806 11 0.90907 00..511656215387899679 0.365846137 00..002525816215160354 Slc1o82aa11; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Aqp8; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; ASlcccon12b;2S;lcS6lca232;aD4v;lS1l;cS7lac86;aP4d; Szklc12;2Sal1c2; 5Salc2222;aA3b; cSct3x;4a; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 0.058658321 CSlcn68a;8A;rSl2lc;3S6lac61a; 8S;lcS3l6c1a82a; 1Slc7a15; Irs2; Acsl5 Ppt1 154 17 23.21 174 36 26.22 5253 0.94054 327 0.02761 0.24898 -0.027135703 1 0.166137969 Atcpe1;aP1li;nS2lc;1A2rag71;;ACbdc3c69;;FKacbtpd25; Slc234a13; Slc31a21a;6; Kcnk1; Kcnk2; Slc12a2; Tmem38b; Stk39; Kcne3; 0.006481497 KSlccnoj21a31; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; KAcqnpm8;bC4r;yKmct;dP3l;aK2gcn4as3; ;PKpcatrdg1;2Slc16a1; Slc25a17; 0.055081743 ASlcccon12b;2A;pS3lcd212;aA4t;pS1lca71a; 8A;tPpd2zak21; ;AStlpc62v50aa212; Atbpc8ca31; ; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 ASltcp69aa8;;CSolcx386aa;1S;lSc6lca336;aS2f;xSnl1c;7Fa21;5S; lIcrs62a;4A; Pcskld51; 17 6 2.56 343 0.03247 1 0.135092102 0.043226758 PApbpca31ca; ;AIpnopap15;kF;2Prsl1e;nP2a; nSxlc112a7; Slc13a2; Slc22a1; ECdanspra1;;GPcygc;aKrdcnk1; Kcnk2; Ltf; Slc12a2; Wfs1; Clca3; 9 4 1.36 6679 874 1001..5326 352 0.03443 0.38714 0.094387763 0.111914439 SCldc3262;aI3r;sS2l;cA2c3sal15; Abcc9; Trf; Vdac1; Vdr; Slc9a3r1; TAmcsel6m38b; Sco1; Stk39; Kcne3; Kcnmb4; Armc1; 5235573 00..9043146463 00..5338471124 00..262692509769265736 00..003918561641775638 SAlpc3o9aa11;;ASplco2a22a;4A;pAotap49;bN; Splcc17la18; Slc5a3; Atp6ap1; Tusc3; Nipa2; Sfxn5; Sri; Slc30a10; Kctd3; Ahcyl1; 13 5 1.96 359 0.03473 0.0612 0.457760803 0.229133964 PSlacn2x21a;1R; hSlbcg2;2Pad3;zkS1lc;2S2lac54a; 4Pad;zSkl1c;5Sal4cb6;aS8lc47a1; Nipa1; Kcns3; Kctd12; Atp11c 18 6 2.71 376 0.04266 0.47932 0.917978886 0.367191536 SAlpc2o5aa23;7A;pSolcc315;aA4p;oTcr2p;mN4r;1Khc3t;dI5rs;2Slc39a5; Slc39a4; Pla2g10 14 5 2.11 392 0.0475 0.0475 0.110443509 0.171081516 Abpcobc62; ACdb3p61; Mtctopl;nA1p; Solbc24a3; Slc6a8; Slc12a6; Pparg 1186 123 17.07.89 5343060 0.905437869 0.9084272819 -0.078550672030481791 -0.03091646061093653 Atppo1aa11;;AApbocac29; AKcptoda54; Kcnj13 Kcnk1; Kcnk2; Tmem38b; Kcne3; Kcnmb4; Kctd3; 1186 123 17.07.89 196 13 2.08.69 876 83 13.01.19 2100 14 31..0511 2100 14 31..0511 523 42 70..8445 3 2 0.45 3 2 0.45 3463 412 520..1455 3 2 0.45 11 4 1.66 62 5 9.34 22016 319 331..1065 57 13 8.59 21 6 3.16 12 4 1.81 17 5 2.56 85187 1115 1292..3516 27 7 4.07 4 2 0.6 4 2 0.6 4 2 0.6 4 2 0.6 4 2 0.6 51238 637 774..3212 13 4 1.96 23 6 3.47 9 3 1.36 9 3 1.36 14 4 2.11 57194 724 872..2161 1 1 0.15 1 1 0.15 1 1 0.15 221 11 30..3125 1 1 0.15 2621 291 390..4195 1 1 0.15 361 21 50..4135 1 1 0.15 1 1 0.15 1 1 0.15 551 67 83.04 5343171 00..9054378869 11 -00..088258642930491399 -00..040018480717936056 AAtppo1aa11;;AApbocac29;; FK2crtld15; Kcnj13 Kcnk1; Kcnk2; Tmem38b; Kcne3; Kcnmb4; Kctd3; 5345142 00.0.94575829 0.95521 00..385258240990995379 00..041038783727231026 IAnppopa51k; Apoa2; F2rl1 5440133 00..9064176849 11 -00..103055602759272792 -00..005612079515822678 FIr2s;2V; Adrc;sPl5dzk1 EAdcnslr6a; Gcg; Wfs1; Stk39; Ahcyl1 5441295 00..9065109667 0.110313 -01..705538610999150983 -00..0458379334666856 Apoa2; Apoc1; Apoc2 GPlcag2g10 5442247 00..9065109667 11 -01..705538610999150983 -00..0458379334666856 Apoa2; Apoc1; Apoc2 GPlcag2g10 5443762 00..9066413218 00..9056513238 00..308389033548212493 -00..004033847171850026 EPdann1x;1Ppp3ca; Srebf1 ACacvspr11c 474 0.06128 0.06128 0.091000915 0.091818923 ARhccbng2; Atp1a1; Atp6v0a1; Cox8a; Slc6a3; Slc6a4; Slc12a2 483 0.06128 0.15066 0.358139819 0.314897105 SFl2cr1l12;aP7;rkSclcz13a2; Slc23a1; Abcc9; Slc9a3r1; Slc22a4; 5443977 00..9066418298 11 00..206319531588315463 -00..004033443161457036 SPlacn5xa13; Atp6ap1; Slc5a4a; Slc5a4b; Slc47a1; KCcanspk11; Kcnk2; Slc12a2; Tmem38b; Stk39; Kcne3; 500 0.06128 1 0.32189265 0.303203622 SPlpca3r5aa;4N; Kcoctrd15; Slc24a3; Slc6a8; Slc12a6; Atp6v0b; Kcnmb4; Kctd3; Ahcyl1; Kcns3; Kctd12 525 0.07039 0.07039 0.673793776 0.216203108 SAlbc3ca61a;1A; ApIo3a117;3A9p5;oSal2c;5Aa9p;oSal4c5a11; Slc5a12; 5444 0.96685 0.97267 -0.111436406 -0.054635396 FB2c;l6V;dCrd36; Cry2; Dag1; Hyal2; Jak2; Jun; Ppp3ca; EAdrnntrla;;CGdckg1;;WEcfts21; Hspa4; Kpnb1; Kpna3; Prdx1; 5455661 00.0.97657072 11 00..208122231458423866 -00..008058641788491476 VStdart3; Thra; Tnfrsf1a; Ing1; Mapk1; Pex14; Ran; Timm9; Mtx2; Psmd10; Nop58; Pex3; Snupn; ATobmcam1;3A4c;cDna2b;2Aipp;3Fdl1n;aA;tPpd1ea21a; ;APtepx26a;2I;pAot1p36v0a1; Ipo5; Ipo4; Pex12; Tlr3; Tomm22 564 0.07869 0.68311 0.170693349 0.027798518 AAtppr8t;aC1o; Apatp; 9Salc;6Cal3c;nE2d; nC1o;xE8iaf;2Salkc36;aG3u; Scafx2nb1;;NFr21;h3; Usf2; Agr2; Sytl2; Socs2 582 0.08414 1 0.445604666 0.167997547 SSllcc62a24a;1P; Skldc1o;1Pbp2p; 3Sclca4;7Ina1p;pA5bk;ccP3s;eAnb2p; S1l;cS1l2ca178;a1 Clns1a; Ednra; Gcg; Grid1; Kcnk1; Kcnk2; Ltf; 614 0.09342 1 -0.003493521 -0.010193696 SAlpc1o3aa12;;PSalnc2x21a1; Slc22a3; Slc23a1; Slc4a2; Slc4a3; SClacs1p21a;2P; ySclca1r6da1; Wfs1; Clca3; Tmem38b; Sco1; 624 0.10018 0.10018 0.43878341 0.169664733 ASlbcc2c29a;1T;rSfl;cVod1abc21;;SVlcd4r7;aC1l;nA8;bSclcc39;aS3lrc11;8Sal1c25a10; 5467297 00..9160904128 00..2833437826 00..291610011800353427 00..032160111509311945 SGlcc;oR1bbp24; ;SSlcl3c293aa11; ;SSlcl2c22aa34; Atp9b; Slc7a8; Slc5a3; Stk39; Kcne3; Ttyh1; Kcnmb4; Steap2; Armc1; TSulcs2ca31; Nipa2; Sfxn5; Sri; Clic6; Slc30a10; Kctd3; 630 0.10035 0.10035 0.161059023 0.035149992 AAtppr6t;aSpl1c;6Pa3a;nExi1f;2Faxky3d; V1;dRr;hVbeg;gPfadzk1; Slc5a4a; AUhsfc2y;l1S;oCcslc2c1; Nipa1; Kctd14; Kcns3; Kctd12; 684 0.11042 0.11042 1.052009306 0.526373286 SAlpc5oaa41b; ;ASploc4a72a1; Slc25a37; Slc35a4; Slc25a22; Zdhhc13; Atp11c 698 0.11042 0.11042 -0.047117924 0.046634724 TArbpcmc34; Kctd5; Kctd2; Slc39a5; Slc39a4; Slc22a23; Slc2a1 712 0.11042 0.15067 0.752813216 0.37756298 ATrbfc;bLm6;tAkb2p1; Mcoln1; Cnnm4; Slc24a3; Clca6; 713 0.11042 0.15067 0.464837234 0.275670563 ASlbcc6aa14;;ASlccc1n82a;1Acvr2a; Acvr2b; Apoa1; Apoa2; 737 0.11042 1 0.039358143 0.002002211 DPagnatx11; Dvl1; Edn1; Eif2ak3; F2rl1; Glud1; Ins2; Jak2; CCaasspp11; Cpt1a; Gcg; Pdx1; Ppt1; Ptger4; Scg5; 5479449 00..9171170226 00.5.90797929 00..146696989433625069 00..011111335461954027 LAlpglo1a;1M; Aegp3o;aP2d; pF2kr1l;1P; rInkcsz2;;PNprp1h3c3a; Rbp4; Src; SPttxgbepr43;aD; Rpahl3a; Pycard; Oxct1; Dnm1l; Steap2; Cklf; 769 0.11951 1 -0.003493521 -0.00080544 SArpeobaf11;; PStaxn4xa1; Stxbp2; Tbx3; Hnf1b; Nr1h3; Panx1; SCcafsdp11;;RPaybc2a7rdb; Sytl2; Dph3; Cd209d; Acvr1c 776 0.12079 1 0.147831779 0.058968623 EAnbscaa;1S;mPopnd13;; NRar1lbh;3N; Aisccshl5; Mon1a; Arfip1; Traf3ip2; Pla2g10; Acsl6 831 0.14232 0.14232 -0.397761623 -0.066123593 Abca1; Accn2; Atp1a1; Atp2a2; Atp6v0a1; Atp8a1; Tusc3; Nipa2; Nipa1 833 0.14232 0.14232 0.006899869 0.001007298 ASltcp397aa;4C;lSclnc22;aC3ox8a; Slc6a3; Sfxn1; Slc6a4; Slc12a7; Slc2a1 879 0.14831 1 0.553746962 0.183657642 SSllcc262aa41; ;SSlcl2c222aa33; ;CSlnlc82;3Sal1c1; 8Salc14a2; Slc4a3; Abcc9; Gcg; Grid1; Kcnk1; Kcnk2; Slc12a2; Tmem38b; 5489955 00..9174183311 0.387561 0-.02.2034149151347078 00..002488404646919516 TSrlcf;9Va3dra1c;1S;lVc6dar8; Slc9a3r1; Slc25a10; Slc39a1; KCcrynme3;;STlcty2h5a12; 6Kcnmb4; Sfxn5; Clic6; Slc30a10; 918 0.15071 0.15071 0.337808006 0.337808006 SSllcc292aa34r1; Atp9b; Slc7a8; Atp6ap1; Panx1; Fxyd1; Kctd3; Ahcyl1; Clcc1; Kctd14; Kcns3; Kctd12; Atp11c 953 0.15071 0.15071 0.375093168 0.375093168 RSlhcb2g5;aP10dzk1; Slc47a1; Slc35a4; Trpm4; Kctd5; 954 0.15071 5591515 00..9175205781 956 0.15071 5594528 00..9175508721 959 0.15071 5599807 00..9175904771 996 0.15071 1002 0.15071 1015 0.15071 5595 0.97978 0.15071 0.150711 0.15071 0.150711 0.15071 0.150711 0.15071 0.15071 0.15071 0.28058 1.930995618 0-.05.1651255887889475 0.448870105 0.01.6483978779975321 0.479710944 00..133377189018002056 1.007759024 1.015488235 0.381454205 0.195198729 1.930995618 0-.00.3671757837181425 0.448870105 0.00.0433677789171311 0.479710944 00..031367284018308086 1.007759024 1.015488235 0.381454205 0.022687745 KAcptoda22; Slc39a5; Slc39a4; Abcb6; Abp1; Mcoln1; Slc18a1 ASlccc5na23; Ap3d1; Atp2a2; F2; Pkd1; Ppp3ca; Inpp5k; PSlsce6na28; Vdac1; Vdr; Slc39a1; Panx1; Trpm4; Slc39a5; SAlbc3p91a4; Abcb6; Mcoln1; Slc24a3; Micu1; Slc39a9 FS2lc9a3r1 AAcpconh2; Ap3d1; Atp1a1; Atp2a2; Slc6a3; Sfxn1; F2; SRlbcp6a44; Pkd1; Ppp3ca; Inpp5k; Psen2; Slc12a7; SFl2cr1l13a2; Slc23a1; Abcc9; Trf; Vdac1; Vdr; Slc9a3r1; Slc39a1; Slc22a4; Slc5a3; Panx1; Slc5a4a; Slc5a4b; Slc37a2 Ednra; Gcg; Wfs1; Clca3; Tusc3; Nipa2; Sri; Slc30a10; Nipa1 Ednra Ednra; Gcg; Kcnk1; Kcnk2; Ltf; Slc12a2; Wfs1; Clca3; Tmem38b; Sco1; Stk39; Kcne3; Kcnmb4; Armc1; Tusc3; Nipa2; Sri; Slc30a10; Kctd3; Ahcyl1; Nipa1; Slc25a37; Trpm4; Kctd5; Slc39a5; Slc39a4; Abcb6; Kcns3; Kctd12 Mcoln1; Slc24a3; Slc6a8; Slc12a6; AI317395; Micu1; 76 6 11.45 5599 0.97985 0.99132 0.524863726 0.055148957 Accn2; Atp1a1; Slc6a3; Slc6a4; Slc23a1; Slc6a8 259 28 39.03 5618 0.98177 Accn2; Ap3d1; Atp2a2; F2; Pkd1; Ppp3ca; Inpp5k; Ednra; Gcg; Wfs1; Clca3; Tusc3; Nipa2; Sri; 1 0.156058744 0.000999238 Psen2; Vdac1; Vdr; Slc39a1; Panx1; Trpm4; Slc39a5; Slc30a10; Nipa1 Slc39a4; Mcoln1; Slc24a3; Micu1; Slc39a9 TNO report - Final 3M#07 TNO Project number: 051.01978 59 / 59 GO.ID GO:0043271 GO:0050432 GO:00026286998 GO:0051952 GO:0051588 GO:0033700 GO:0015908 GO:0015695 Term negative regulation of ion transport catecholamine secretion lriepgidultartainosnpoofrtransmembrane transporter ... regulation of amine transport regulation of neurotransmitter transport phospholipid efflux fatty acid transport organic cation transport GO:001551901449 prehgouslpahtioolnipoidf ttrraannssppoorrtt GO:0073147062 orergaunlaictisounbosftatnracnestmraenmspborartne transport GO:0032412 GO:0051209 GO:0070588 GO:00510148313 GO:00105792069 GGOO::00001456791288 GO:0051925 regulation of ion transmembrane transpor... release of sequestered calcium ion into ... calcium ion transmembrane transport creogfaucltaotirotnraonfscpaotretcholamine secretion lnoenugr-octhrainnsfmatittyearcsiedctrreatniospnort mreognuolactaiorbnooxfynliecuarcoidtrtarnasnmspitotretr secretion regulation of calcium ion transport via ... GO:003026386186 rceaglcuiulamtioionnotfrlainpsidpotratnsport GGOO::00003600340012 GO:0060401 GGOO::00001354971685 GO:0010959 GO:007501893274 GO:0015886 GGOO::00003423327619 GO:0032374 GO:0050702 GO:0033344 GO:0010747 cchaloclieusmteiroonl ttrraannssppoorrtt into cytosol cytosolic calcium ion transport sretegruollattrioannsopfoirotn transmembrane transpor... regulation of metal ion transport dreeghuyldartoioanscoofrcbaiclcaiucimd tioranntsrpaonrstport heme transport rreegguullaattiioonn ooff siotenrtorlatnrsapnosprtort regulation of cholesterol transport interleukin-1 beta secretion cholesterol efflux positive regulation of plasma membrane l... GO:0046942 carboxylic acid transport GO:0015849 organic acid transport GO:0050701 GO:0015911 GO:0030299 GO:0015697 GO:0032369 GO:0042953 GO:0030300 GO:0002374 GO:0002739 GO:0010746 GO:0032375 GO:0032372 GO:0050717 GO:0070634 GO:0072608 GO:0050705 GO:0072367 GO:0043691 interleukin-1 secretion plasma membrane long-chain fatty acid tr... intestinal cholesterol absorption quaternary ammonium group transport negative regulation of lipid transport lipoprotein transport regulation of intestinal cholesterol abs... cytokine secretion involved in immune re... regulation of cytokine secretion involve... regulation of plasma membrane long-chain... negative regulation of cholesterol trans... negative regulation of sterol transport positive regulation of interleukin-1 alp... transepithelial ammonium transport interleukin-10 secretion regulation of interleukin-1 alpha secret... regulation of lipid transport by regulat... reverse cholesterol transport GO:0017038 protein import GO:0007589 GO:0015893 GO:0050706 GO:0006855 GO:0051180 GO:0007595 GO:0002740 GO:0042908 GO:0015682 GO:0051610 GO:0050703 GO:0050709 GO:0050704 GO:0032370 GO:0015693 GO:0035428 GO:0001504 GO:0072337 GO:0003096 GO:0015709 GO:0015759 GO:0015794 GO:0015798 GO:0015881 GO:0015898 GO:0032782 GO:0034197 GO:0034633 GO:0035926 body fluid secretion drug transport regulation of interleukin-1 beta secreti... drug transmembrane transport vitamin transport lactation negative regulation of cytokine secretio... xenobiotic transport ferric iron transport serotonin uptake interleukin-1 alpha secretion negative regulation of protein secretion regulation of interleukin-1 secretion positive regulation of lipid transport magnesium ion transport hexose transmembrane transport neurotransmitter uptake modified amino acid transport renal sodium ion transport thiosulfate transport beta-glucoside transport glycerol-3-phosphate transport myo-inositol transport creatine transport amiloride transport bile acid secretion triglyceride transport retinol transport chemokine (C-C motif) ligand 2 secretion Annotated Significant Expected Rank in classic classic weight avgFC.sig avgFC sigGenesUp sigGenesDown 37 2 5.58 5626 0.98215 1 0.346508982 0.011633046 AInbpcpa51k;;ASclec9; aP3lirn12; Apoa1; Apoa2; Apoa4; Apoc1; 38 2 5.73 15692 434 239.9364 52 3 7.84 5642 0.98449 565923 60.5.908E8-0851 5701 0.98945 1 0.515192182 1 0.419666103 0.022085704 ANpisocch2;;SAlcp1o8ha;1Atp8a1; Atp9a; Cd36; Fabp2; Lrp6; 0.32642574383989675 -0.09162876801070343 MIntst2p;;VPdorn; 1S;lcP9paa3ra1; Rbp4; Ncor1; Nr1h3; Slco2a1; 0.463806225 0.039399158 SAlrcg217;aM2;aSolbc2; 7Salc41;8Aab1ca7; Atp9b; Stard3; Osbpl1a; PAlhac2ygl41a; Pparg; Slc25a17; Soat1; Pla2g10; Acsl4; Acsl6; Atp11c 41 2 6.18 5714 0.98986 1 0.46257697 0.037266261 OAcscbnp2l3; ;SSlcp1n8sa11; Osbp; Osbpl6; Npc1l1; Apob; Irs2; 11 7 1.66 45 15 6.78 21 9 3.16 9313 1124 143.79.76 64 0.00033 0.00033 0.919877987 0.608530335 Abca1; Apccona21;;AAcpvor2aa2; Apoa14; Apoac12; Apoca24; Casp1; Cd2ap; Cdk1; Cpt1a; Ect2; Ednra; Ptk2; Gcg; 92 0.00175 0.02675 -0.005803544 0.007075959 Acpeo;cP1l;iAn2p;oCcd2;3A6;rgF1a;bApt2p;1Salc1o; 2Ca31;;CSdlc3267; aC2lc;nS2lc;2E7dan41;; PItllan21g;4Kac;nPkp1a; rKgc;nSklc22; 5Par1d7x;1P; lPad2xg11;0P; lAac2sgl44a; ;APcpslt61; 97 0.00207 0.02263 0.37508621 0.217967999 SFl2c;2F22ar1l1; ;SGlca2s21a;3G; lSulcd212;aH4y;aSll2c;7Ian8s;2R; hCbdg4;7P; dJazkk21;; SPltce1n2;aP2tger4; Scg5; Stxbp3a; Wfs1; Pla2g10; 579280 0.0909201453 0.281161 0.51387445964253992 0.109274391560737557 Abncpae1p;;AMpbola21;;MAdpmoa22;;PApppo1ar41;2Aa;pPodcp1;kA1;pPorck2c;z; Plsam2gd10; AStkp3191;cRala; Kcne3; Pycard; Oxct1; APotpn81a;1P;pAatrpa9; aP;pApb3ca7; ;InAptp95bk; Rbp4; Ncor1; Src; Tmem30a; Dnm1l; Scfd1; Rab27b; Sytl2; Dph3; ASrbecbaf11;;ASctexb; Ppl2i;nT2f;fA2;pTohar1a;;ATpnofras2f;1Aa;pNora14h;3A;pVodca1c;1; Prkaa1; Tlr3; Cd209d; Clic6; Acsl6; Kctd3; Ahcyl1; AVpdor;cV2;tnA;pSoyhn;j2Abrgp1; ;SAlct9pa83ar1; APtapn9xa1;;CEdn3s6a; SPldcz6ka13;; Kcns3; Kctd12; Acvr1c EAdcntn14;;FRaablpb2;;NSdlcf3ip71a;4A; Sdlicp6oar42;;IKncst2d;5L;rpD6a;bM2itpt;p; PArpkocaz;2P; Codn316; ;PCplacrna2;;InHpypal52k;;IRnbs2p;4J;aNk2co; Tr1h;rSal;c22a1; ACdqkp18;;ECcrty2m; G; Ecgd;nKracn; Hk1ia; tK1c;nItkl2n;1P;rPdlxa12;gP4asm; Pdp1a0r;g; 434149 8394 6468.9018 5170327 0.090921468 1 0.300934615260892396 0.06181346894297163 STlncf2r2saf13a;;SVlcd2a3ca11;;VSdlcr2;aS3lc;9Salc33ra11; ;PNdzr1kh1;3K; Sctlcdo52; a1; SKlccn1e63a;1T; lSrl3c;2C5lai1c67; ASlccs2la61; ;KScotda3t1; ;AShtcxyblp1;3Ka;cnPsla32; g10; SDlacb272aip2;;FSllnc2a7; aP4d;eC2lan;8I;rsS2lc;9Aac3srl15; SKlccn2j51a310; Abca7; AKctsdl41;2Slc37a2; Slc25a26; Sfxn5; Acsl6; Atp11c 57 3 8.59 5777 0.99451 0.62576 0.066098766 -0.026110371 SVldcor;1Sbl2c9; aS3lcr212a4; Atp9b; Slc7a8; Slc5a3; Arl2; Ahcyl1 46 2 6.93 5797 0.99505 1 0.137191025 -0.011698853 PF2dzk1; Stard3; Osbpl1a; Nisch; Slc35a4; Slc25a22; Ednra 81 5 12.21 5811 0.99604 0.99679 0.164591748 0.015885684 Adccipno2;r2A;tOp2sba2p;l3P;aSnpxn1s;1M; Oicsub1p; Abcc3; Osbpl6; Gcg 1314 61 15.6162 5180175 0.0909267115 0.16571 0.158195721578383957 0.10028559442371493 ASlbcc1b86a;1Slc6a8; Mfsd7c; Mfsd7b Ppt1; Slc25a26 3702 114 140.5825 5181218 0.0909360732 0.0707599854 0.0287134594911613 0.0190085815137832 Acecn; 2P;liDnv2l;1C; dS3tx64;aFabp2; Slc27a4; Irs2; Acsl5 Plpat21g4a; Pparg; Pla2g10; Acsl6 6365 191 95..9257 38 1 5.73 5181259 00..0909361773 5853 0.998 0.72791 -00..041009888935305453 00..002143493492162924 Acecn; 2Plin2; Cd36; Fabp2; Slco2a1; Slc27a2; Slc27a4; Aqp8; Pla2g4a; Pparg; Slc16a1; Slc25a17; Pla2g10; 1 0.282215436 -0.012995545 SVldcor 1b2; Abcc3; Irs2; Acsl5 Acsl4; Acsl6 24275 149 373.0981 5185802 0.0909796042 0.324518 0.5148360600807631 -0.108063639205701264 Abcccna21; Atppo2aa12;;AFp2o; Pa2k;dA1;pPopap4;3Acap;oInc1p;pA5pko; Pc2s;ePno2n; 1; PEdlan2rga1;0G;cAgc;sWl6fs1; Clca3; Sri PVpdarca1;;NVcdorr;1P;aNnrx11h;3T;rIprms24;;AMcsclo5ln1; Slc24a3; Micu1 5621 152 79..8149 62 2 9.34 5195151 00.9.09098415 0.141561 00..516337411941809215 00..104012540397411198 AF2bca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Cd36; SEodantr1a; Pla2g10 5916 0.99953 1 0.137191025 0.001346232 LFr2p6; Pon1; Nr1h3; Stard3; Npc1l1; Apob Ednra 25027 1156 73.18.42 164 11 24.72 5195168 00.9.09098515 0.996411 -00..506537431440879012 -00..104019580494441996 AClbccna21;;VAdpaoca11; ;VAdpr;oSal2c;9Aa3pro1a;4P;dAzpko1;c1K;cAtdp5o;cK2c;nCjd136; SGocagt;1K;cPnlka12;gK1c0nk2; Kcne3; Clic6; Kctd3; Ahcyl1; 5930 0.9997 1 -0.101927093 -0.023236013 LArtpp61;aP1o; nF12; NInrp1ph53k;;SVtadrrd;3S;lcN9pac31rl11; Apob Ednra; Gcg; Wfs1; Stk39; Kcne3; Ahcyl1 1246 36 180.9.69 529052 0.0919291934 0.012131 -0.202313868692105152 -0.100262860996056887 SFl2c;2I3nap1p;5Sklc; 2Vad3r SEldcn2raa1; Gcg; Wfs1 4 3 0.6 32270 292 448..0273 203 0.01213 0.06123 0.471523026 0.302861491 Abtpc1ba61;;MCflscdn72c; ;FM2;fIsndp7pb5k; Vdac1; Vdr; Slc9a3r1; Ednra; Gcg; Kcnk1; Kcnk2; Wfs1; Stk39; Kcne3; 5292605 0.014161 11 -00..707412474412812132 -00..300141994477771885 APdbzcka1; KAcptoda51; ;KAcnpjo1a32; Apoa4; Apoc1; Apoc2; Pon1; PClaic26g;1K0ctd3; Ahcyl1; Kcns3; Kctd12 27 9 4.07 221 0.01416 1 0.771441823 0.304947718 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Pla2g10 15 6 2.26 234 0.01714 0.06117 0.135092102 0.040317193 Abca1; Apoa1; F2rl1; Panx1 Casp1; Pycard 33 10 4.97 241 0.01997 0.03237 0.657474369 0.255529165 Abca1; Apoa1; Apoa2; Apoa4; Apoc1; Apoc2; Pon1; Soat1; Pla2g10 2 2 0.3 264 0.0227 0.0227 -0.355094166 -0.355094166 Acsl5 Acsl6 Ace; Plin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; 172 36 25.92 290 0.02348 1 0.166137969 0.055125634 Slco2a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Aqp8; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; Slco1b2; Slc22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 Slc6a8; Slc36a1; Slc36a2; Slc7a15; Irs2; Acsl5 Ace; Plin2; Arg1; Cd36; Fabp2; Slc23a1; Slc3a1; 174 36 26.22 327 0.02761 1 0.166137969 0.055081743 Slco2a1; Slc27a2; Slc27a4; Cln8; Slc9a3r1; Slc25a10; Aqp8; Crym; Pla2g4a; Pparg; Slc16a1; Slc25a17; Slco1b2; Slc22a4; Slc7a8; Pdzk1; Slc25a22; Abcc3; Pla2g10; Acsl4; Slc25a26; Sfxn5; Acsl6 Slc6a8; Slc36a1; Slc36a2; Slc7a15; Irs2; Acsl5 17 6 2.56 343 0.03247 1 0.135092102 0.043226758 Abca1; Apoa1; F2rl1; Panx1 Casp1; Pycard 9 4 1.36 352 0.03443 0.38714 0.094387763 0.111914439 Cd36; Irs2; Acsl5 Acsl6 9 4 1.36 353 0.03443 0.38714 0.662079676 0.098661768 Apoa1; Apoa2; Apoa4; Npc1l1 13 5 1.96 359 0.03473 0.0612 0.457760803 0.229133964 Slc22a1; Slc22a3; Slc22a4; Pdzk1; Slc6a8 18 6 2.71 376 0.04266 0.47932 0.917978886 0.367191536 Apoa2; Apoc1; Apoc2; Nr1h3; Irs2 Pla2g10 14 5 2.11 392 0.0475 0.0475 0.110443509 0.171081516 Apoc2; Cd36; Mttp; Apob Pparg 6 3 0.9 400 0.04789 0.04789 0.750700871 0.396660363 Apoa1; Apoa2; Apoa4 6 3 0.9 411 0.04789 1 0.828490939 0.408877306 Apoa1; Apoa2; F2rl1 6 3 0.9 412 0.04789 1 0.828490939 0.408877306 Apoa1; Apoa2; F2rl1 6 3 0.9 413 0.04789 1 0.005079772 0.062755268 Irs2; Acsl5 Acsl6 10 4 1.51 425 0.05067 0.11033 1.058199593 0.48734686 Apoa2; Apoc1; Apoc2 Pla2g10 10 4 1.51 427 0.05067 1 1.058199593 0.48734686 Apoa2; Apoc1; Apoc2 Pla2g10 3 2 0.45 472 0.06128 0.06128 0.039358143 -0.003411506 Panx1 Casp1 3 2 0.45 474 0.06128 0.06128 0.091000915 0.091818923 Rhbg Slc12a2 3 2 0.45 483 0.06128 0.15066 0.358139819 0.314897105 F2rl1; Prkcz 3 2 0.45 497 0.06128 1 0.039358143 -0.003411506 Panx1 Casp1 3 2 0.45 500 0.06128 1 0.32189265 0.303203622 Ppara; Ncor1 11 4 1.66 525 0.07039 0.07039 0.673793776 0.216203108 Abca1; Apoa1; Apoa2; Apoa4 Bcl6; Cd36; Cry2; Dag1; Hyal2; Jak2; Jun; Ppp3ca; Arntl; Cdk1; Ect2; Hspa4; Kpnb1; Kpna3; Prdx1; 206 39 31.05 561 0.07502 1 0.012348286 0.008478946 Stat3; Thra; Tnfrsf1a; Ing1; Mapk1; Pex14; Ran; Timm9; Mtx2; Psmd10; Nop58; Pex3; Snupn; Tomm34; Dab2ip; Flna; Pde2a; Pex6; Ipo13 Ipo5; Ipo4; Pex12; Tlr3; Tomm22 57 13 8.59 564 0.07869 0.68311 0.170693349 0.027798518 Aprt; Copa; Slc6a3; Edn1; Eif2ak3; Guca2b; Nr1h3; Usf2; Agr2; Sytl2; Socs2 21 6 3.16 582 0.08414 1 0.445604666 0.167997547 Slc22a1; Slco1b2; Slc47a1; Abcc3; Abp1; Slc18a1 12 4 1.81 614 0.09342 1 -0.003493521 -0.010193696 Apoa1; Panx1 Casp1; Pycard 17 5 2.56 624 0.10018 0.10018 0.43878341 0.169664733 Slc22a1; Slco1b2; Slc47a1; Abcc3; Slc18a1 17 5 2.56 627 0.10018 0.83386 0.960180547 0.310159195 Gc; Rbp4; Slc23a1; Slc2a3 Slc2a1 27 7 4.07 630 0.10035 0.10035 0.161059023 0.035149992 Aprt; Slc6a3; Eif2ak3; Vdr; Vegfa Usf2; Socs2 4 2 0.6 684 0.11042 0.11042 1.052009306 0.526373286 Apoa1; Apoa2 4 2 0.6 698 0.11042 0.11042 -0.047117924 0.046634724 Abcc3 Slc2a1 4 2 0.6 712 0.11042 0.15067 0.752813216 0.37756298 Trf; Lmtk2 4 2 0.6 713 0.11042 0.15067 0.464837234 0.275670563 Slc6a4; Slc18a1 4 2 0.6 737 0.11042 1 0.039358143 0.002002211 Panx1 Casp1 28 7 4.22 749 0.11726 0.50999 0.466843209 0.111341507 Apoa1; Apoa2; F2rl1; Ins2; Nr1h3 Ptger4; Dph3 13 4 1.96 769 0.11951 1 -0.003493521 -0.00080544 Apoa1; Panx1 Casp1; Pycard 23 6 3.47 776 0.12079 1 0.147831779 0.058968623 Abca1; Pon1; Nr1h3; Acsl5 Pla2g10; Acsl6 9 3 1.36 831 0.14232 0.14232 -0.397761623 -0.066123593 Tusc3; Nipa2; Nipa1 9 3 1.36 833 0.14232 0.14232 0.006899869 0.001007298 Slc37a4; Slc2a3 Slc2a1 14 4 2.11 879 0.14831 1 0.553746962 0.183657642 Slc6a4; Slc22a3; Cln8; Slc18a1 14 4 2.11 895 0.14831 1 -0.04411408 0.048066156 Slc9a3r1; Slc6a8 Crym; Slc25a26 1 1 0.15 918 0.15071 0.15071 0.337808006 0.337808006 Slc9a3r1 1 1 0.15 953 0.15071 0.15071 0.375093168 0.375093168 Slc25a10 1 1 0.15 954 0.15071 0.15071 1.930995618 1.930995618 Apoa2 1 1 0.15 955 0.15071 0.15071 -0.61587845 -0.61587845 Slc37a2 1 1 0.15 956 0.15071 0.15071 0.448870105 0.448870105 Slc5a3 1 1 0.15 958 0.15071 0.15071 0.43779731 0.43779731 Slc6a8 1 1 0.15 959 0.15071 0.15071 0.479710944 0.479710944 Abp1 1 1 0.15 987 0.15071 0.15071 0.337808006 0.337808006 Slc9a3r1 1 1 0.15 996 0.15071 0.15071 1.007759024 1.007759024 Apoh 1 1 0.15 1002 0.15071 0.15071 1.015488235 1.015488235 Rbp4 1 1 0.15 1015 0.15071 0.15071 0.381454205 0.381454205 F2rl1