Document NE8J2nNqzpNe5YmnM8pVedqRR

2 -4 5 C *. 7* nrr c: . t. t:r E . 1. d u P o n t d e N e m o u r s & C o m p a n y W i l m i n g t o n . D e l a w a r e 19898 POLVMCR PRODUCTS DEPARTMENT EXPERIWCN1A1. El P I lON PERSONAL AND CONFIDENTIAL cc: A. J. Dahl B. K. Karrh L. J. Papa Pral File l.C. - 353 - N11400 - 269 -4>ez.2-/SS7 July 16, 1981 DR. D. 0. INSLEE SPRUANCE TEXTILE FIBERS RICHMOND, VA. ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 811-601; PRAL Nos. 81-2244-2278; Notebook Nos. E22514,E26238) As requested in your letter of 5/8/81 to L. J. Papa, the 35 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table. As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of n, 0.004 ppm which can be distinguished from the reagent background but not well quantitated. Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be . directed to J. W. Raines or L. F. Percival. Attachment jah Key Word s : Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis GC S. S. Stafford The-re's a world of things we re doing something about OOOlOl EXP000037 EID713851 TABLE I CONC.ENTRATIOK OF PEKFLUOROOCTANOATE IK BLOOD (a) Sample PRAL N o . Date Sampled 81-2244 5/6/81 81-2245 4/27/81 81-2246 4/27/81 81-2247 5/6/81 81-2248 4/28/81 81-2249 5/11/81 81-2250 4/28/81 81-2251 5/5/81 81-2252 4/28/81 81-2253 4/27/81 81-2254 4/28/81 81-2255 5/7/81 81-2256 4/27/81 81-2257 5/6/81 81-2258 5/7/81 81-2259 5/7/81 81-2260 5/14/81 81-2261 5/14/81 81-2262 5/15/81 81-2263 5/7/81 81-2264 5/18/81 81-2265 5/15/81 81-2266 5/15/81 81-2267 81-2268 5/14/81 5/6/81 81-2269 81-2270 5/14/81 5/7/81 81-2271 5/7/81 81-2272 5/7/81 81-2273 5/14/81 81-2274 5/7/81 P.R.No. Name 898 1084 992 357 983 923 1605 1544 1212 946 1538 3060 2093 2457 1908 2542 2151 2205 651 3184 1190 sal. 1949 1856 2771 sal 1466 sal sal pensione sal GC Analysis____________________ (b ) Date Analyzed [Cft], ng F/g blood 6/11/81 6/11/81 6/11/81 6/12/81 6/12/81 6/12/81 6/12/81 6/15/81 6/15/81 6/15/81 6/15/81 6/15/81 6/15/81 6/15/81 6/15/81 6/15/81 6/16/81 6/16/81 6/16/81 6/18/81 6/17/81 6/11/81 6/11/81 6/11/81 6/12/81 6/12/81 6/12/81 6/12/81 6/15/81 6/15/81 6/15/81 0.036 0.022 0.022 0.030 0.027 0.033 0.041 0.012 0.045 0.086 0.056 n.d. 0.018 <.007 0.009 n.d. 0.016 0.011 n.d. n.d. 0.082 n.d. n.d. n.d . n.d. n.d. n.d. n.d . n .d . n.d. n .d . *REDACTED* 000102 EXP000038 EID713852 TABLE 1 CONCENTRATION OF PEKFLUOROOCTASOATE IK BLOOD (a) Samle P R A L No. Date Sampled 81-2275 81-2276 5/7/81 5/7/81 P.R.No. Name pensioned sal 81-2277 5/7/81 2898 81-2278 5/8/81 pensioned GC Analysis (b) Date Analyzed [Cp], UR F/g blood 6/15/81 6/16/81 4 6/18/81 6/16/81 & 6/18/81 6/17/81 n.d . 0.027 0.010 n.d. (a) Analysis as described in Lab Method ES-567 (''Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard. (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10Z relative standard deviation. The lower limit for quantitation is 0.007 UgF/g. The detection limit is n. 0.004 pgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [Cg] 0.004 ppm, which cannot be distinguished from reagent background. REDACTED* EXP000039 EID713853 000103