Document NE2dZ0GjBZnOYbkQjYrdak1jV

ll/?l /<-/?//-(/?) ^\/ VINYL CHLORIDE "Because vinyl chloride is a gas, the only significant route of toxic exposure is inhalation. If it Is confined on the skin in a liquid, some might be expected to be absorbed, but the relative amount is small. The likelihood of acute effects is not nearly as significant as are liver injury, angiosarcoma [liver cancer] and probably acroosteolysis [softening of the tips of the bones] which may occur following excessive repeated exposures".1 The acute effects possible from exposure to high concentrations of vinyl chloride include depression of the central nervous system. Light headedness, some nausea and dulling of visual and auditory responses may develop in acute exposures.1 Teratology studies in several animal species indicated that vinyl 2 chloride does not cause any significant effect on the fetus. Vinyl chloride is regarded as a human carcinogen, and a causal agent of angiosarcoma of the liver In humans. The OSHA permissible exposure limit for vinyl chloride is 1.0 ppm. (8-hr TWA). The odor of vinyl chloride is only noticeable at levels in great excess of the TLV. REFERENCES 1Patty`s Industrial Hygiene and Toxicology, p. 3538, 3rd Revised Edition, Vol. 2B, John Wiley & Sons, 1981. ^John, J. A., et al., Tox. & Appl. Pharmacol., 39 (3), 497-513 (1977). R&S 130193