Document NE0wKbLzqqQRGGOXYxp2xn5mD
FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1949 June 3
DOC#: API056
DOCUMENT DESCRIPTION: Minutes of the API Subcommittee on Carcinogenicity Meeting with Attachments
AMERICAS PETROLEUM INSTITUTE
SUBCOMMITTEE OS PARCISOGENI CITY MISUTES OF ISTERIM MEETIBO / June *3. 1949
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51 An Interla meeting of the Subcommittee on Carcinogenicity was held
on Triday, June 3rd, 1949, at 15 Vest *t Street, Sew Tork City.
MEMBERS PRESIST
ASSOCIATES PRESENT
Marshall Clinton T.M. Frank A.E. Hoag J.P. Holt T.J. Kelly M.S. Sewquist Mclver Voody
QUESTS
L.C. H.P. K.Q. H.M. H.E.
Beard, Jr. Lankelma Mackenzie Shepardson Zuidema
(representing H.Q.M.
Fischer)
H.V. Faulk - Shell Oil Company A. Wesley Horton - University of Cincinnati
AD7ISOR
D.V. Stroop - API
TOTAL IS ATTEHHAICE - 15
MEMBERS ABSEST
ASSOCIATES ABSEST
L.E. Curtis V.R. Levis C.A. Swan
S.S. Bonsib AJE. Dooley H.Q.K. Fischer
Minutes of the meeting of March 11th were approved as issued.
Mr. Stroop stated that the API prefers not to be included in the American Cancer Society's list of grants-in-aid for cancer research.
Dr. Horton submitted a progress report. attached as Appendix A).
(Copy of the report is
Dr. Voody said the Federal Security Administration has awarded over $450,000. in federal grants for cancer control and teaching activities. The
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largest amount, $35*000. vent to the Pennsylvania Department of Health, vhere Dr. Shllen, Director of the Division of Industrial Hygiene, has set up an occupational cancer control program vith a physician and a nurse. At a later date, tvo engineers and a statistician vill he assigned to the project. The attached forms (Appendix B) are being prepared i n quantity for use in their surveys and are essentially identical vith the form submitted to them by Dr. Hueper to insure uniform data from the various states participating in the industrial cancer program. The oil industries located I n the Philadelphia area are high on their agenda.
Dr. Hoag and Dr. Kevqulst spoke briefly concerning articles on cancer they have vritten for the Secony-Vaettnm Hevs and Texaco Topics re spectively. It vas agreed that other companies could veil afford to follov their example.
T.M. IBAHK Secretary
McITEH WODY Chairman
I
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ipprauii x
API.PROJECT ON CARCINOGENICITY AT THE UNIVERSITY OF CINCINNATI
The program at the Kettering Laboratory is roughly divided into, three major phases. Of perhaps most immediate importance is the effort to pin point throughout the industry .materials and operations which represent potential hazards from the cancer standpoint. The second phase, which will be prosecuted simultaneously with the first phase, will involve the concentration >and isolation of the compounds re sponsible for the carcinogenic action of certain catalytically cracked oils which have already been tested biologically. From the physical and chemical properties of such concentrates, an effort will be made to develop an analytical tool which may then be applied to any refinery stream to determine its carcinogenicity without resorting to animal testing. The third major phase will be an epidemiological study of cancer in the petroleum industry.
In carrying out the first phase in the program, as
described above, a series of typical refinery samples will
be tested on suitable laboratory animals to determine their
relative carcinogenic potencies. It is expected that,
in the course of the coming year ending June 1, 1950, testing
of approximately 150 to 200 such samples will be started at
the Kettering Laboratory. Thus an average of about 12 samples
from each of the following processes will be studied:
,
1. Non-catalytic gas oil cracking
2. Viscosity breaking of residues and extracts
3. Naphtha reforming
4. Polyforming
5. Coking operations
~ 6. Houdry catalytic cracking
7. Fluid catalytic cracking
,
~
S. Thermofor catalytic cracking
9. Cycloversion
'
10. Houdryflow cracking
11. Hydroforming
12. Slack waxes and aromatic extracts therefrom
13. Solvent extracts from lube oils and heavy gas oils.
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The potencies of the samples will be compared with those f coal tar and shale oil fractions on which clinical data is available from England.
In considering the selection of samples from each of
the processes listed, attention is at present being re
stricted to those intermediates or products with a distilla
tion end point above 650F. On the basis of confidential
information supplied to the Kettering Laboratory by each
of the API member companies on such materials and the unit
operations producing them, a sampling program is being
organized which will cover the current range of variations
in each process. Careful consideration is being given
not only to the characteristics of the particular products
which will be tested for carcinogenicity but to the feed
stocks and the unit operating conditions as well. In this
manner it will be possible to correlate the effect of the
trends in available charge stocks and refining practices
with the relative carcinogenic potencies of products formed.
ThuSj the results of the testing program now planned should
permit prediction of potential hazards as unit operations
change in the years to come.
-
As yet, a list of the specific samples to be tested during the coming year has not been prepared since the necessary data from the individual companies is not complete. However, sufficient information is available to permit the selection of a small number of samples from thermal cracking of high boiling materials, both virgin gas oils and those previously subjected to catalytic cracking. In additionit is planned to request samples of high boiling oils from TCC units since to date no physiological testing of the heaviest products from these operations has been carried out.
In reporting results of tests on future oil samples, a direct comparison with a solution of a known concentration of a standard carcinogenic hydrocarbon in a standard solvent will be made. Preliminary tests are being'run with solu tions of mthylcholanthrene in benzene, at concentrations from 0.01% t#, 0.6%. Previous results have indicated that the tumor incidence curves for typical heavy catalytically
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V .
T
- 3 -
cr
cracked oils may be compared nicely with the curves for
i -
such standard solutions,
*
In further work the effect of the benzene solvent on
the tumor incidence and the induction period in mice will
be determined. Various non-volatile solvents, such as
methylnaphthalene, are being considered for this purpose.
However, it must be kept in mind that benzene solutions
li
of methylcholanthrene have been employed as standards for
many years in studies by English scientists. Their use
in
may therefore facilitate the interpretation of our laboratory
L
results in terms of practical hazards to exposed workers.
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June- 3, 1949.
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A, Wesley Horton
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AffEWIS 2.
BIH-C-3 1 . Nane o f Conpany:
PLANT CANCER RECORD
Date:
2. Location:
S . In Operation since:
4 . Products Manufactured:
8 . Nimber o f Workers: T o ta l
Resales
Males White Colored
Office:
Production:
Q e
ff fin ii wAUJOlViail
8. Insurance Carrier:
9. Carcinogenic Haiarde:
10. Operations Involved
a
b e
d e f
8
h 1 i k 1 n
n
Nunber of Workers
T o ta l, White Colored Male Ecnale
Exposure
Constant Interm ittent Occasional
11. Type o f Exposure Inhalation Skin Ingestion Other
a
b
e d
e
f
8 h 1
J k
1 n
n
Duration o f Exposure Average Longest
12. Bate o f Labor Turnover:
Cancers Observed S it e Nuaber Period
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(Interim Sub-Corn. Med.Adv.API Meeting held in New York,
Friday, June 3, 9:30 A.M. MOTES FOE THE MEETIHQ R0m 673 > f f S 5ia^Cs^ *
Sample8 from processes listed in February 1 meeting.
A t t e s t to show offset of varying food stocks and operating conditions with minimum number of samples*
Reserve 150 of the 200 samples for refinery samples* Rest on samples for analytical tool from laboratory*
Specifle Samples
1* Clarified slurries from FCCB already indicted - some variation shown* 3632 nearly most potent*
2* Effect of thermal cracking on heavy cat* cycle stock.
3* Effect of selected feeds in Houdry and TCC.
4* Highly aromatic samples from 2 and 3 - pass Houdry operation* Does recycling increase carcinogen concentration or destroy carcinogens previously formed!
5* Effect of sulfur and nitrogen HCOOH extraction of H bases.
Hydrogenation by Union '
6* Slack w a x (or slop on outside of presses)* of those causing scrotal cancers* Rhodessa, K* Texas Ok*
Crude sources
Started 6 concentrations of Me-chol. in ben sene from O.OljC to 0*6 3 times a week.
Also 3631 and 3632,
Ask Im.yis about meeting at Chester, Thursday, June 23*
Kay 31, 1949
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ESS
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to- ' M
BIH-C-la
OCCUPATIONAL CANCER RSCORD
1 . Hama Residence
3. State:
_
2 . Place of Death: C ity :
Citar:
H o sp ita l: Street:
4 . Soolal SeourityN o. 7* Date o f B ir th :
5. Sex Age
8. Tears:
Mo 3 .
Days:
6 . Color or Rao: 9 . Date of Death:
10. Oeeupation:
1 2 . Cause of Death:
11. Indus try or Businass:
Method of Diagnosis
13. C lin ic a l:
Biopsy;
Autopsy:
Other:
jl 4 . . Name o f P h y sicia n :
15. S tre e t:
16. C ity :
17. C lin ic a l Diagnosis:
18. ` Pathologic Diagnosis:
19. Primary S i t e :
20. Date o f F ir s t Symptoms:
21. Date of F ir s t V is it to Physician:
2. Date o f F ir s t Diagnosis:
4. ls to r y of Other Illn e s se s of S it e A ffected :
23. Stage of Disease at F ir s t Diagnosis : 5. , H istory of In ju r y to S i t e A ffe c te d :
6. Exposure: HAMS OF SUBSTANCE
Have you ever handled or worked near any o f th e follo w in g? I f yea, g iv e d e t a i ls .
^AME a? 'employer
DATS
LENGTH CF EXPOSURE 1 DESCRIBE TYPE OF EXPOSURE AND ESTIMATE IERC3NT OF l ' JOHEKG TIME EXPOSED: '
i
i
'
APPENDIX B
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A m M Ii
( v t 'r*m
BU-C-lb Occupational Canoer Reoord - Page 2
27. Oooupatlonal H istory: L i s t Occupations in Chronological Order beginning with la s t or present one.
Dates. !HM TO
NAME 07 IKPLOYER
ADDRESS 07 SMPL0YER
TYPE OP BUSINESS 1 OR FRODCT MADE
1
title of jcb
TYPE 07 V X > m PSRIDiaflED
.......
i
1i
1
_______________________________________________ 1_________________________________________
APPENDIX B
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28. Are there any other Important m aterials to which you have been exposed?
(Hobbles; H abits; Medicines; Cosm etics; D ie ts; Environment)
29. Additional Information Obtainable a t:
\
Name:
(L is t Ph ysician; Laboratory; H osp ital; Insurance Co; P lan t Medical Department C lln io ; Tumor R e gistry , e tc .)
Address:
Earner
Address:
Nema:
Address:
30. Any other information pertaining to Tumor ( M u ltip lic ity , s it e s , e t c .) :
<
APPENDIX B
911230 B i n E u l M 0 1 5 8 1
ess
)
Issa era ' s s C 3
BIH-C-2
PLANT CANCER BBOCBD
i naiuo ui
S . In operation slnoe:
4 . Products Manufactured:
5 . Number o f worker* employed:
K a le : Female:
White: Colored:
In plant:
In office:
Name of plant o f f i c i a l
t
8 . Insurance Carrier:
7. Name o f P la n t Ph ysician 9 . Carcinogenic hazards:
10. Operations Involved:
I S . Sex o f exposed worksrs: M d e :
Female:
1
11. Number c f workers exposed:
a . Constant exposure b . In te rm itte n t exposure . o. Occasional exposure
13. Race:
VThite:
Oolored:
14. Duration o f exposure: . '
Humber: Number:
Number:
15. Rate o f turnover In expos ed group (s)
' S . Cancers Observed in exposed group (s) 17. Cancers by site a t
Years: Years: Years: .
Total number:
Period:
i.