Document N75oyYo8k4DqyrkrnJv5JOJb

/ facLfJ, ~D**''V'*K', ..*4"W>&d '^-- AN' ACNJvFOim DJ-RMATKKCOSJS JACK W. JONT.S, M.D, ^ IlltRDKRT S. ALDKX, M.IX AVtAtCrA, RA. . It I# only within comparatively recent time* tlint the dcrmatologiM has interested himself in dermatoses associated with 01 caused hy the daily work. With the advent of a more clearly (termed approval of the words eczema and dermatitis and the more general use of the patch test, dcr- . matologijts have necessarily inquired more and more deeply into the hmumerahlc chemical contacts that occur in the day hy day lives ni their jKilieiKs.' As well as bum" conversant with dermatology, the der* ' matologUt must have ;\ working knowledge of the manufacture and content of the many new and old cotH|x>uiuU that are kindled and *l>|v|ic<l hy large iiunikr* of persons. Hence, more ami more derma tologists arc Iwcnitiing industrially minded, and it h dawning on them tlint tlte solution of some of their industrial difficulties may aid them in a clearer conception of (tic dermatoses that are cucmmtercd in their every-day practice. Derinatergoscs of the neneform ly|>e occurring in jH rsons working with chemicals have ken repeatedly reported in FurnjK* ami discussed a* industrial "chlor-ncnc." 4 This term "chlur-acne" was first used by Ifcrxluimer? in 1 8W to dcscrik* an eruption com|*>*cd of comedones and small sebaceous pustules that occurred on the arms and faces of workers manufacturing chlorine gas electrolyticallv. using carlmu electrodes. It was natural to assume that the chlorine was the causative agent, lietiinnn ~ had observed in March 1897 two patients whose skins were dilTuscfy pigmented, dark, rough and dry. in whom were observed small tenacious comedones associated with mumrrnus small follicidiir abscesses. Sultsecpieully Ik* rejwuted twenty-une addiliimal cases with similar symptoms in workmen wlw were engaged in cleaning out an acid tower used in the manufacture of hydrochloric acid. At no time did tk'se men couk' in contact with free chlorine. Iml numerous liaise Read at the FiftyKSghth Aimanl Mcvdne of the American Dtfrmatidojjieal Assuefolitm. tM*_ Wliile Sulphur Sprii*n*. W. Vn.. Mar - 1WJ. 1. While, Pmowr: Tlic l^rmitUrptnc*. |. 4. N\*vr Yiek. Paul IV IWm. Iue.,1934. . 2. Ilerxltcimcr: Mniiclwn. mcd. Wchwrhr. 4C:27P, lltV9. J. Ikttman: Deutclie tiled. Wclmschr. 27; -437* IWI. . HONS 09 7398 JOXfiS-.iUtiiX-- h:\ /'/ (n\\u IfliKM. I ' Of the twenty-four men working in (he manufacture of chlorinated tli-phcnyl witliin the period fiom the laic summer of 19J2 In October, \9a.t, twenty-three were reported to leivv had an nenefonn erti|itinn on the lace and IhhIv. Of the I went}-(luce, sixteen were examined. These men presented eruptions of ncucfnnn charaeiev similar in tyjic and di>* trilnui.m 10 that in (he case referred tn hut varying in severity (lahle). )n many patients numerous small sebaceous ahscesses dcvciojtcd. par ticularly mound the collora line, which exuded heavy, tenacious pus. nnrl the remaining ulcers were indolent, leaving in their wake much scarring. In two of the cases particularly, many large alrsevsscs tlevvl*n>etl on the ncckaud liack. '' Until very recent times di-plwnyl and chlorinated di-phenyl were only lalmratorv curiosities, and llieir commercial manufacture was unknown. In the cx)X*riuu'mal stage of manufacture the apparatus was necessarily crtnle, ami cxjienmcntcrs ami workers were cxjsised Mr long (Wtod* to fumes and dusts containing much chlorine. l*oth free and conihiiwd. Jn llie early cxiKrimcuts. ns well as in (lie early numitfaciurc in targe '."^vnp.v jrr/r." MQNS 097399 r