Document N2zLN1850Loekpgpkavzn3rMD

IN REPLYING ADDRESS Division of Research Grants and Fellowships FEDERAL SECURITY AGENCY PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH Be t h e s d a 14, Ma r y l a n d April 4, 1949 In reply refer to our RG--1970 OOKFIDMTIAL Dr. Robert A. Kehoe Director, Kettering laboratory of Applied Physiology University of Cincinnati College of Medicine Cincinnati, Ohio Dear Doctor Kehoe: The research project outlined in the accompanying application submitted by Dr. Frank Princi, University of Colorado Medical Center, is being prepared for review by the Hematology Study Section of the Rational Institutes of Health. Your opinion of the scientific merits of the proposed research and the qualifications of the investigator would be of considerable assistance to the Study Section members in their formulation of a recommendation concerning the desirability of supporting Doctor Princi1s project. All applications for research grants are treated as strictly confidential and, except in special circumstances, are not circulated beyond the membership of the study sections and councils that review the applications. Any information or opinion that you would be will ing to furnish also will be held in strict confidence. ior your information, the membership of the Hematology Study Section .is given below: Dr. Chas. A. Doan (Chairman) Dr. K. K. Brinkhous Dr. Edwin J. Cohn Lt. Comdr. 3. P. Cronkite Dr. Louis IC. Diamond Dr. Kenneth M. Endicott Dr. Roy R. Hracke Dr. Carl 7. Moore Lt. Col. Howard A. Tan Auken Dr. Maxwell 14. Vint robe A self-addressed envelope which requires no postage is enclosed for your convenience in replying. Sincerely yours, Enclosures 2 TP"1 \-- t J. Franklin Yeager. ,.v i executive Secretary- Hematology Study Section / I APPLICATION FOR GRANT FOR RESEARCH PROJECT Rccoivcd l/l7/49 Page 1 RG 1970 Hematology I. APPLICANT: Univorsity of Colorado Medical Center Denver 7, Colorado II. DIRECTOR CF PROJECT: Frank Princi, M.D., Director, Division of Industrial Medicine; Assistant Professor of Medicine HI* SUBJECT: "The Value of Different Diagnostic Methods in Lead Absorption and Lead Intoxication*" IV. FUNDS REQUESTED: (July 1, 1949 - June 30, 1950) Personnel: Chemist 2 Laboratory technicians Consumable Sup-plies: Stains, glassnare, reagents Travel: At *08 per mile Subtotal Overhead: To u a- , ~~ / V. FUNDS FROM OTHER SOURCES: None, 3,600. 4j .9P.Qi. 3.000* 1,000* $ 8,400. , .3 000 l-.OOO* $12,400. --2221 $13,392. VI. OTHER SUPPORT FOR THIS OR RELATED RESEARCH: Ifonc VII. EXPLANATION OF RESEARCH PROJECT: A. Results to date: - -i 1 ~m j t 1-- fi-- 1* Investigator: ^ Stipple coll counts are done routinely in this laboratory in all cases of occupational disease. Many toxic substances do produce stippling of the red cells. However, there is-no information on the de gree of stippling in the vast majority of diseases. 2. Others: Johnstone, R. T., "Occupational Medicine and Industrial Hygiene", C, V. Mosley Company, St, Louis, 1948, pp, 237-242: "Stipple cells are not pathognomonic of lead intoxication". Despite this statement, no studies have been systematically carried out to prove this point and the medical literature continues to recommend stipple coll counts as diagnostic. 00 6; r N 24725.01 Page 2 RG 1970 Hematology B, Proposed research plan; Stipple cell counts would be done on all possible hospital and outpatient patients. This work would be done in the thirteen hospitals of the Medical Centor. At the same time, blood and urine samples would be collected and analyzed for lead content. Particular attention would be paid to attempt to study patients who present a large variety of dis eases and the various stages of disease, A number of men who are actually exposed to lead would be studied in the same manner, and similar studies would be made on a group of healthy unexposed indi viduals, . After the data is accumulated, the following infor mation should be derived: 1, The incidence of stipple cells in exposed and non-exposed individuals would be compared, 2. The incidence of stipple cells in the various diseases and in their different stages would be established, 3, JThc amount of stippling in the different stages of lead absorption would bo found, 4. The specificity of stipplo cells in the diagno sis of lead intoxication would be determined. C, Bibliography submitted with application: None D, Reprints submitted with application: None E, Anticipated duration of study: D061 7