Document N2k3p7wJ4wjkQO89ObzDnbvaQ

-. V ASERVICIO NACIONAL DE SALUD IRECCION GENERAL / E. Mac-l ver 541 Casi l l a 3979 SA N Tl A G O / TT- Dr, Mornan Oyenguren M, . Occupational' Health "action N a t io n a l H e a lt h - Se r r ic e ' Pcx 3979, 7e.nti.a50, Chile October,lth, 1959 professor lobart A, -ahoe Director of the Institute of Industrial HSalth University of Cincinnati Cincinnati 21, Ohio, U.S.A. . t t Dear Professor Hehoe; ' ^ I had. opportunity to meet 7011 during my trip of the hlH.O. ' 3 fe llowship or. I'-rreh last year In our interview I pro.missed you to send the details about a group of children intoxicated by lead, whose families lived in a soil that contains > 1C;I cf metallic lead. Unfortunately this work is managed by podiatritians-and npideni legists who will present pretty scon the results to our mod;'col societies. Only in t moment I will be able to have sent to _ou the _ua_uor 1 o w n : v:e onlw advise '.am on li assays, '. - The purpose of this letter is to ash your advice in ' follojdWg subject. During a curve;/ in a mine end foundry of the Couth of Chile wo found an enerv opus pollution with load or-cidas on the air and the soil of the plant and also in the roil of the environs of the plant. The children of the mineral camp use to play in hills close to the plant that are eov-'rod with lead dust and where ssdst- some wild . * fruits that they -are fond of sating, The intake of lead is more .likely to occur thru the oral way in the children, while the inhalation way is most important in the worker The concentrations of the lead oxides in the work place -were in the range from 38 to 1500 mg / ii-3 air ( almost pure clouds of dust in dust chambers). In the camp '/here thf population Lives vne impossible to detect t'*-e concentration because the wind '-.lows the housing oung to the plant, that it is situated in one end of the place, During /our stay, besides thus frequent acute cases on lead in; xicatasB*? among the v/orkers, we observed a case in a child, male, 5 yeras old, who -sented a cirrmlsive picture in unconsciousness. The lumbar puncture gave a clear at hig' ^ The child died/ after jo hours of the onset of the convulsive ;that chang'd from one limb to another and involved too the cranial nervs. Copropoif.ki~v rins were to the qualitative test, he suspected a lead encephalitis and we perffor- ; ,med the autopsy ( the family did not approved to open the skull). The results thicone test made in our Industrial Hygiene laboratory were in mgrs % (weight Blood 0.214 ngrs % Flat bone (rib) 0.21/3 mgrs % livor 5.1 mgrs % Firinev 1.02 mgrs % he had read the rasper of Korlog and Id/llor of three cases!if scu- lead poisoning in women dead after ingestion of .lead monoxid' in attemps to produce a- ' bortionr. (Acta pharmacol,ot toxil. 15:3,1953) -The results by polarographic detsVi.unatior are similar are similar to our observation: high, concentration of lead in the liver and. kidney and low in the bone. They state "This accords with the results of animal"vcpsri- ments, which show that the concentration in liver and kidneys is the highest dcing. tho firt few weeks after the ingestion of lead. After a oonger interval the cancertr?.felon of lead in the bones is much the highest" -< Kir 0015981 ;/ r ./ . SRVICI.O- N A T IO N A L DE SALUD ^ DIRECCION GENERAL E. Mac-! ver 541 Casi l l a 3979 SAN T I A GO - 2- vi" I have tried to find, in the literature'these references, in order i,& void an ajqesrimegtai trial that vO have planed, tie intend to see in white irdc.e the lead content in bones incrsssog on the lung run "and 'decreases in the.'liver kidney,?' after a total amount of lead acetate injected by intrape&itoneal via 4 shots,. v?e have succeeded to keep survivor niece of 150 *rs '-nth a total dps 400 Ogrs Kg/weighi The work of H. Esmy and H. Buckup in white nice (Zentralb, fttr Ar" ned. and -schuts, 7:233,, 1957) gives irtforaiution only on the bna content that ses with the tine, I don't know any other publication on the subject. In these cirennstances, I will appreciate very much if you can answ on the problem, specially if there is information of the ssperisental trials in sals .made by you or other authors,in order to avoid an useless work, kith my best regards to your staff, very truly'yours. . KE~ 0015982