Document N2aNKG92429rxdK6xnb18zmE8

CHEMICALS 3 3.3 ^4 i INDUSTRIES INTEROFFICE / LAKE CHARLES TO FROM 4Distribution R* p* I*ync DATE SU3JECT April 22, 1974 VCM Tank Car Safety Meeting A review of the rulings and company reactions to these rulings was made in Philadelphia at the VCM tank car safety meeting. X was most impressed with the change in attitudes of most of the VC Poly peopleThey are doing most of the things that were impossible ' " in-February (by their words). ^fiThe mos^important item was the mouse failure- A table of" results shows this: .---4 rU3L" ---i. -C'v/ Control Group - 50'ppm VC*" l^zoa ppm vc^^.., Mortality (M/F) Rates 4/4 10/8 6/9 5/7 - " Hamsters 13/22 20/20 22/29 ^ 27/27 1 v_ JT *The VC was administered for 7 hours/day for 5 days/week. The rodents JT were not fed-anything and 100 of each sex were used. ' r -zszz - : -Cl-' ` -i ^ 50 e?^ 200-ppm t> 2500^ppm -,.T7ff -. c -- j.;--_ . - Results of Autopsies Tumors- Lung Anglo - ... - - 4 22 6 34 19 17 17 Skin "3" 2 2 .3 As. may be. readily seen these results will lead to some severe restrictions on- VC- The existing temporary standard will probably not stand. It is hoped that 10 ppm will be triad. The mice test is equivalent to approximately 20 to 25 years for a human when the first angios were found. Moltoni is also finding tumors at low levels but his work is not released yet. (Most of the mortalities are from eating one another because of hunger.) BFG new has approximately ten cases. Only two or three died of ahgio but the others are reasonably real. Most of them had slides of biopsies that were checked for angio. Some of the deaths are back to 1969. SL 027160 16396 PROPOSED RULES <c) Tile Deputy Administrator, Vet have been occura.tionally related. As a the level from a ceiling of 5CO ppm to 50 erinary Services, upon request to him. result of this novacation and after con ppm ceiling: It was expressly recognized may approve other Identification systems sultation with the National Institute for tlmt this standard limiting exposures to in specific cases and under such condi Occupational Safety and Health a 50 ppm level was intended to be a ten tions as he may prescribe if he deter (NIOSH), and a joint inspection of the tative. Interim standard, to he in effect mines that such systems provide the plant b7 OSHA. NIOSH, and the Ken no longer than six months, during widen necessary inlormatlon to allow for trace- tucky Department of Labor, a fact-lind- time the whole question of possible safe bach ol the swine to their herd of onsin. lng hearing on possible hazards Involved exposure to VC would be reconsidered Any person who wishes to submit writ with the manufacture and use of VCT more fully and In the light ol more In ten data, views or arguments concernin': was announced on January 30, 107+ <39 formation, especially results of experi the proposed amendment may do so by FH 3374) and held on February 15, 1974. ments winch were known to be under filing them with Deputy Administrator, 2. Carcinogenicity of VC. Information way at that time. Veterinary Services, Animal and Plant produced at tills hearing demonstrated 4. Additional tntormation. OrrApril 1 Health Inspection Service, U.S. Depart that exposure of laboratory animals I9T+. information aud data were-pro-, ment of Agriculture. Hyattsviiie, Mary t mostly Sprague-Dawley ratal to VC by land 20732 before August 12. 1374. inhalation a: and below the then current All written submissions mads pursuant OSHA standard of 500 ppm Induced sented representatives-- at- OSHA,. NIOSH and tire BPa by the Industrial' Bio--Test. Laboratories,. Northbrook. Illi to this notice will be made available for tumors, including angiosarcomas of the nois,- concerning results .aairoahex-= public inspection at the Federal Build- liver. Professor Cesare Maltonl, of the - posure-studies with VC, sponscred-by then in?, 6505 Belcrest Road. Room 870, Institute dl Oncologia, Bologna. Italy, Manufacturing. Chemists Assoeiatkm, Hyattsville, Maryland 20782, durine reg reported on a series of experiments on (MCAin-AIthough, only preliminary )_ ular hours of business (3 am. to 4:30 toe effect of exposure of rats, mice, and natureLthuse results revealed that Z oufc^. pan., Monday to Friday, except holidays) hamsters to VC at- concentrations of ot 200-mice exposed to VC concentrations \- in a manner convenient to the public 10.0001.6,000: 2J00; 500; 250; and 50 of-5ttppnrifor^3.hours a. day. fiverdays a,r> business (7 CFR 1.27 tb) >, ppm for varying periods of time (TR-- -weeief foroapproximatety .Tmpnths^der* Comments submitted should bear a 43-63). Some of toe experiments have vetoped:angiosarcomas oX-thaliver:^' reference to the date and page number been concluded, and others are still on The ThdustrinrBio-TcsrEaB data In of this issue in the Fs>exai. Recusiza. going. The experimental results reported dicate thatrexposure- to-.VCrak, SQs'ppai Done at Washington. P-C. this 7th day ol Mat 1974. Fixers A. Cjiatoux, Acting Deputy Administrator, Veterinary Sendees, Animal and Plant Health Inspection Service. were that tumors have been observed in .-maxwell constitutesatsertonsdaraitiPhn?^ groups of animals exposed to VC at eon-'-anfito-emplcyeea. Also, thr-qaestloixof-sf*- centrationa as low as 250 ppm. Notumors in OirptBmre- wefty)iiserfcdidDEftiwigrniqpoC~animnlT nothedetermbied atrthigttimcgamrimhyjfc' eaposed:hriVC atfaiconcgntratton?.og5(g conttnuetrasrsd.rnatter forosoentifle^df- ppmglgalauappeamdJVRteth^tbtaChhng* Eb&aUbiromany years.nv^thereforr bcr^bCtuincrs2.a^reI^'as the*numbers' conclude thatltlsnow necessary to pro pose to change the 50 ppm level estab 1FR Doc.74-10832 Filed 5-9-74;8;45 am] lished in the ETS to as low a level as can toigSttjppinf Another experiment by Pro be detected using methodologies outlined DEPARTMENT OF LABOR Occupational Safety and Health Administration fessor Maltonl was -xeportecL_undcrway, in this proposal. Involving the exposure ofia30QcanfinalaL to BC$a& cdacenixatSnS oCSfKpmbij m order*to as5ess^fiaS%drefceftriltfVB*way - [29 CFR Part 1910] (Docket OSH-331 whether that level of exposure produces tumors In animals. Data reported by tviriwWmfriySP andSKow? (American yin*l-chiorid: Industrial Hygiene Association J 22: 254--- ProposwfaSSwdwtS 361 (1981)) indicate thatafexiiSsur^t? Vent concen trations 1. Background. Vinyl chloride (chloro- cthene) Chemical Abstracts Service Registry No. 75015, Is a synthetic chemi cal made by oxychlorination of ethylene or by hydrochlorination of acetylene. It is the parent compound of a series of themoplastic resin polymers and co polymers which are widely used for con tainers, wrapping film, electrical insula tion. pipe, conduit, and a variety of other products. Vinyl chloride has been made commercially in this country since 1939 and present production is in excess of seven billion pounds per year. Vinyl chloride <VC) is a gas at ambient temperature and pressure and is a chlorinated hydrocarbon which has moderate liver toxicity. The previous standard set a ceiling value of 500 parts per million (ppm) (29 CFR 1310.93, Table "*Th?employe of the B. F. Goodrich Chemical rinwipany who died from angio sarcoma of the liver had an average ex posure of approximately 19-years to vinyl chloride, at unknown concentrations, and variable exposures to other- volatile chemicals. (TR 93). Some employees of Union Carbide, Firestone Tire and Rub-. ber. and Goodyear were also reported in post-hearing comments to have had ex posure to vinyl chloride and to have died from angiosarcoma of the liver. Finally, autopsies of four deceased employees re vealed their liver migiCEarcoina tumors wero histologically indistinguishable from the angiosarcoma tumors observed in Professor Maltoui's experimental G-l). meT^enj~y^TimvomnrfSland^ On January 22, 1974. the Occupational ard&On the basis or all Information Safety and Health Administration availal'le at that time, and the fact that, (OSHA) was informed by the National employees were being exposed at levels Institute for Occupational Safety and around the experimentally observed ef Health (NIOSH) that the B. F. Good fect level of 250 ppm, an Emergency rich Chemical Company reported that Temporary Standard (ETS) was promul deaths of several of its employees from gated on ApriI 5-jfgj?(39 FR 12342) ns a rare liver cancer (angiosarcoma) may 29 CFR lartJ.yJcrTTus standard reduced FEDERAL REC4STER, VOL. 37, NO. 92--FRIDAY, MAY TO, T974 SL 027161 April 22, 1974 Dr. Perez-Roig, PPG CARIBE, Ponce, Puerto Rico Dr. Harold Loveioy. Lake Charles, La. OSHA HEALTH COMMITTEE: 2. G. Bell R. E. Sourwine D. P. Bridge L. W. Keller J. T. Destefano R. L. Rubino L. T. Powell H. Maruca H. C. Underwood FOR YOUR INFORMATION! Lee B. Grant, M.D. Medical Director SL 027162