Document N2YyJj0exqvKrMoozGpEJ03KQ

March 5,2007 Via Electronic and U.S. Mail Richard Irons, PhD, DABT Principal Investigator, Shanghai Health Study University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Ralph J Altiere, PhD Dean, School of Pharmacy University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Re: The Shanghai Health Study Dear Drs. Irons and Altiere: We are writing on behalf of the the scientific and clinical research being We appreciate Dr. Shanghai and his conditionally We look forward to (API) in support of '-HH"HE:,uU~ Health Study. unique project in which have been Research Consortium. worthy effort. payment. for Extension the University of represents funding money to continue the study ~~H'UH"~U~ commitments from the five members of Additional conditions of the study being independent Quality metrics and milestones for progress and Draft request, Shanghai Health Study Proposed Budget dated November 10, 2006, submitted by Dr. Irons of U.''-'HHJHU~ funding up to $6,559,864 has been agreed to. This (as described in the referenced request): Plan A Study Completion Total (Tables I and 2) $5,759,864 Plan B Laboratory Transition Personnel Proposed Budget (From Table 3) $400,000 Post Study Costs for continued publication of study findings $400,000 TOTAL $6.559.864 Formal authorization and disbursement of these additional monies is contingent upon successful execution of an agreement between API and the research entity that will be continuing the study. SHELL-MCCLURG-06S141 Given the urgency to execute a grant/contract to continue the study, API looks forward to receiving a proposal in the near future to extend the existing grant or to establish a new contract with the University of Colorado, CynPathogen, Inc. or another entity. API Exhibits A-I to A-III, Proposal Guide For Prospective Contractors are attached; the information requested therein is necessary for the establishment of the new commitment. Sincerely, Red Cavaney Cc: C. Klaus D. Ross D. Wilkerson SHELL-MCCLURG-06S142