Document N2QZnL6KgybNQLVYKyvmZebvD
CM.
EC n
sia tio MRA 474069
ke osor 0373 TRAE" 095%
7
July 24,2000
:
RECEIVED
DEC 1 8 2000
M.A. 128k
BEHP-%0- Document Processing Center (7407)
Attn: Section 8(e) Coordinator Office of Pollution Prevention and Toxics
US EPA
4`W0a1shMinSgttroene,t,DSCW.20460
37 2
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CERTIFIED MAIL id
PTeSrCflAuo8r(oEo)ctSaUnBesSuTlfAoNnaTmIiAdoLERtIhaSnKolNOTICE ON: N-Methyl
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Dear Sir:
3
t3oMxiciistryeipsorctoinnsgisitnefnotrwmiatthiotnhatthaotfrsehloawtesdpNe-rMfeltuhoyrlooPcetrafnlyulorsouolfcotnaanteessuplrfeovniaomuisdloy submitted to EPA [see 8() dockets #373 and 374]. Enclosedis the final report from Covance Laboratory on a 13-Week Dietary Study ofN-Methyl Perfluorooctanesulfonamido Ethanol QLMerode) inRats. As expected,`higher
dfiovseer lcehvaenlgse(s30inacnldud1ed00ipncprmeaNs-eMdelFivOe!r wEeiignhifso,odh)eppartoodcuycteedhliyvpeerretfofpechtys,.anTdhe `efhfoefpenacdttoscinenoltlrhuelcahhroilvgeahsctudeoorloaslt(/iro1in0g.l0yL0ceoprw)iedaernccdhhoailnegdsetdseorwsoeleraeSn0fdpotuprnridg)liynacnetirhmieadellsso.lwedNveeolisstehw(ee3rrpelpiavmel)rso animals. S`ribegednguiicfneindcianbngotaldtyywrweeeediukgch4etdsanbodocdocyuornwrteeiidnguihintnstghwueentmriieldptrhdeeosseeenndtaonifinmttahhleeshsbitegugdhiydn.onisSneiggaannitifwimceaalenstkly7 and
continued until the endofthe study. Weekly body weights ofthe lowdose
aNcnoonintmreaoollfsst.dhuHeroiwlneogvwtehdreo,ssetehcweoenoedvkeh lryalabloobfldotydhfyweewisetgiuhgdthystwwgeearrieen ssdiougmrnieinfwgihcatahtnetllseytsdusidftyfhea(rnweencetonkftsrroo|lms. through 14)ofthe low dose animals was significantly less than the controls.
iin & epa-oTS
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Contain NO CF
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* Document Processing Center (7407)
Page Two July 24, 2000
`The Covance report
adverse-effect level
concludes
(NOAEL)
that the 3ppm dose was the no-observable --
as the minor body weight effect found at 3ppm
`itwawsansontoctorcroenlsaitdeedrewdittho
abneybciloilnoigciaclaclhleymaidsvterryseo.r.
anatomic
.
pathological
changes;
`The study report is attached.
Please contact Dr. William Weppner, 651-733-6374, for further information.
Clu Sincerely,
C0
Vice President,
`Specialty Materials
Markets
-
|
`Enclosures:
1. 4Pe-rWfeleuokrRoaoncgtean-eFsiunldfionngamDiideotaErtyhTaonxoilci(tNy-SMteuFdyOwSiEt)hiNn RoatMsa(T!-6314)
2. 13-Week Dietary Study with'N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE) in Rats (T-6314)
z 4/3