Document N2DK2nBe2J55RagGgj16pnmaE

bcc: Hr. H, ... Newman - Newport Mr. J. P. Churchill -LOndon Mr. P. H. Langeirfeld-St. Louie December 18, 1962 Dr. Richard B. Body The Stool Oaapany of Males, ltd. fort Talbot, Glamorgan Dear U:1. Body; RAM ,_ 1i-\\ k I heve boon asked to ion/ord toxicity lniovriitio.i on OU2 fluid \Fydraul 150. Tl>o toxicity r-epoit on Pydrrul 150 indicates tint it ic praotioally innocuous whon fed orally to rats since the animals ourvived single doses of 28.5 nano per kilogram with loou of appetite and severe diarrhea ac ti only toxic effeote, Tho fluid apparently ie not absorbed through the unbroken akin of rabbits since this epecioo survived doeos up to 9.5 grass per kilogram of body weight. In rabbit skin and eye irritation etudiea, Pydraul 150 wac no more irritating than a 10 per oent aoap solution totted similarly. In cooes where workmen have accidentally splashed or rubbed Pydraul 150 Into the eyes, there has been severe pain out of proportion to the degree of irritation. Thin iu similar to the situation with most synthetic fluids as well as with any light petroleum alia, Physicians hove used a 1 per cent pontoclalne eolutlon and ophthalmic cortisone acetate solution to relieve irritation. Zn acute vapor inhalation studies, rats survived a six-hour exposure to an atmosphere saturated with Pydraul 150 vapors at row toaperaturc. Baaed on the anlaal toxicity data and handling experience, our label lnoludes the following precautionary lnferastleni CAUTION! CONTAINS CSLOBZNATED HfUBOCARBOC Avoid prolonged breathing of vapors or mists. Avoid oontact with eyes or prolonged contact with skin. If skin contact occurs, ranove by washing with seas and water, following aye oootaot, flush If oXo&hfig*heoones soolMiif with fluid, launder before wearing again. DSW 018575 STLCOPCB4005119 Dr, Riohard B. Body -2* Deoeniber 13, 1962 Wt have not carried out inhalation tests on this saterlal at higher than aablant taaperatunes. however, X an certain that, based on this type or work ulth aoaewhat eonpounds, no hasard would exist frota such expoeurec as would be neoeseary to turn off Machines, stop aojor leaks, etc. X feel that at Quite elevated teoper&turec, the char acter of the vapors would be Irritating sufficiently that either respiratory protection would be used or the individual would not renain in the ataosphore. We do not, however, have any MAC'S available because thic figure lo, ao you well know, for eight hour inhalations, and not for acute episodes. The flash point for fydraul 150 Is 425F., Cleveland Open Cup. Hho fire point is b65F,, Cleveland Open Cup. It is my understanding that the flash and fire points at these teopereturns arc the results of breakdown of the fluid rather than balng the flash and fire points for the vapors of tho fluid Itself. Although wo do not have oeaplete analytical data as to the opposition of breakdown products, X would oxpeet that a Major eonetitusnt would be carbon nonoride alone; with phonolios, aldehydes, CO2 and water, depending on the deem of breakdown. XX you have any further Questions, please write as directly. Vsry truly yours. sast/in DSW 018576 STLCOPCB4005120