Document N0GVODEJyjoMvj1X17R5mZvg

yju 7rvU. AP00008738 JTS 2J?a3 ANSI 2129.1*1982 American National Standard for hazardous industrial chemicals -- precautionary labeling ANSI Z129.1-1982 ansi american national standards institute, inc. 1430 broadway, new york, new york 10018 AP66b08739 ANSI Z129.1-1982 Revision of ANSI Z129.M976 American National Standard for Hazardous Industrial Chemicals -- Precautionary Labeling Sponsor Chemical Manufacturers Association Approved September 21,1982 American National Standards Institute, Inc AP00008740 American National Standard An American National Standard implies a consensus of those substantially concerned with its scope and provisions. An American National Standard is intended as a guide to aid the manu facturer, the consumer, and the general public. The existence of an American National Standard does not in any respect preclude anyone, whether he has approved the standard or not. from manufacturing, marketing, purchasing, or using products, processes, or procedures not conforming to the standard. American National Standards are subject to periodic review and users are cautioned to obtain the latest editions. The American National Standards Institute does not develop standards and will In no circum stances give an interpretation of any American National Standard. Moreover, no person shall have the right or authority to issue an interpretation of an American National Standard in the name of the American National Standards Institute. CAUTION NOTICE: This American National Standard may be revised or withdrawn at any time. The procedures of the American National Standards Institute require that action be taken to reaffirm, revise, or withdraw this standard no later than five years from the date of approval. Purchasers of American National Standards may receive current information on all standards by calling or writing the American National Standards Institute. Published by American National Standards Institute 1430 Broadway, New York, New York 10018 Copyright 1983 by American National Standards Institute, Inc All rights reserved. No part of this publication may be reproduced in any form, in an electronic retrieval system or otherwise, without the pxioi written permission of the pubEsher. Printed in the United States of America ASM 183/8 m AP00008741 Foreword (This Foreword is not a part of American National Standard Z129 1*1982.) This revision of the American National Standard for the Precautionary Labeling of Hazardous Industrial Chemicals, ANSI Z129.1-1976, has been developed by a technical committee of the Chemical Manufacturers Association and was submitted under the canvass procedures of the American National Standards Institute. The Labels and Precautionary Information (LAPI) Committee of the Manufacturing Chemists Association (MCA) was established in 1944. This committee produced the first published guide to precautionary labeling for hazardous chemicals (Manual L-l) in 1946, and there have been six revisions. This manual served until the development of ANSI Z129.1-1976. The need for an official standard for the precautionary labeling of hazardous chemicals used in industrial occupations had been recognized and was filled by ANSI ZI29.1-1976. The revision updates labeling information based on recent scientific developments in the areas of acute and chronic hazards. Suggestions for improvement of this standard will be welcome. They should be sent to the Chemical Manufacturers Association, 2501 M Street, NW, Washington, DC 20037. The following organizations recognized as having an interest in the standardization of precau tionary labeling of hazardous Industrial chemicals were contacted prior to the approval of this standard. Inclusion in this list does not necessarily imply that the organization concurred with the submittal of the proposed standard to ANSI. Adhesives Manufacturers Association Aerospace Industries Alliance of American Insurers American Chemical Society American Conference of Chemical Labeling American Industrial Hygiene Association American Institute of Chemical Engineers American Insurance Association American Iron and Steel Institute American Occupational Medical Association American Petroleum Institute American Society of Safety Engineers Associated General Contractors of America Can Manufacturers Institute Chemical Specialities Manufacturers Association Compressed Gas Association Consumer Product Safety Commission Cosmetics Toiletry Fragrance Association Factory Mutual Association Foundry Supply Manufacturing Group General Services Administration -- Federal Property Resources Services Industrial Risk Insurers International Chemical Workers Union Kalamazoo Label Company Motor Vehicle Manufacturers Association National Agricultural Chemicals Association National Bureau of Standards National Fire Protection Association National Institute of Occupational Safety and Health National Paint and Coatings Association National Safety Council Naval Research Laboratory Naval Supply Systems Command Rubber Manufacturers Association Soap and Detergent Association Society of the Plastics Industry Society of Toxicology Synthetic and Organic Chemicals Manufacturers Association Underwriters Laboratories U.S. Coast Guard U.S. Congress Health Program US. Department of Transportation AP00008742 The Occupational Safety and Health Committee (OSHC) and the Hazards Communications Special Committee of the Chemical Manufacturers Association (HCSC) had the following mem bers while this revision was being developed; W. a. Bittenbender -- HCSC (Borden, Inc) B. H. Brubaker - HCSC (Diamond Shamrock Corporation) J. Caporcasi - OSHC (American Cyanamid Company) C. D. Carley - HCSC (Hooker Chemical Company) T. W. Carmody - HCSC (Union Carbide Corporation) A. C Carey - HCSC (Stauffer Chemical Company) J. D. Dougherty -- OSHC (Celanese Corporation) H. A- Eschenbach - OSHC (W. R. Grace & Company) T. F. Evans - HCSC. OSHC (Monsanto Company) W. Ferugson - OSHC (Allied Corporation) J. H. Hanes - HCSC (The Dow Chemical Company) D. W. Hillman - OSHC (Diamond Shamrock Corporation) R. B. Hoots, Jr-OSHC (1CI Americas, Inc) W.C. Kmmrei - HCSC (The Procter A Gamble Company) P. McNulty-OSHC (Rohm &. Haas Company) M. S. Marino - HCSC (Koppers Company, (nc) J.W. Morgan - HCSC (The Procter & Gamble Company) J. T. O'Reilly - HCSC (The Procter A Gamble Company) C. Richards - OSHC (Gulf Oil Chemical Company) J. D. Robertson -- OSHC (Exxon Chemical Americas) C. Ryan - OSHC (Sun Company) A. W. Sheldon-OSHC (MAT Chemicals, Inc) C. W. Smith - HCSC (Shell Chemical Company) J. D. Spainhour - HCSC (Borg-Warner Corporation) G. A. Sunshine - HCSC (ICI Americas, Inc) J. J. Trexel - HCSC (E. I. du Pont de Nemours A Company) C. W. Umland - HCSC (Exxon Chemical Americas) R. Van Mynen - OSHC (Union Carbide Corporation) N. K. Walters-OSHC (E. I. du Pont de Nemours & Company) J.R. Wheeler-OSHC (Standard Oil Company) The Task Group of the CMA Occupational Safety and Health Committee, which was responsi ble for the development of this standard, had the following members; L. W. Burnette (GAF Corporation) A. C. Casey (Stauffer Chemical Company) R. H. Dewey (IMC Corporation) W. H. Jones (Eastman Kodak Company) R. Y. Levine (Olin Corporation) K. A. Logan-Petrilli (Pennwalt Corporation) A. W. Sheldon (MAT Chemicals Inc) H. Sherman (E. I. du Pont de Nemours A Company) G. R. Sido (Monsanto Company) A. T. Talcott (The Dow Chemical Company) J. J. Trexel (E. I. du Pont de Nemours St Company) P. Willard (Minnesota Mining and Manufacturing Company) AP00008743 Contents SECnoN FAGE Introduction....................................................................................................................................6 1. Scope.........................................................................................................................................6 2. Definitions................................................................................................................................. 6 3. General Requirements .............................................................................................................. 9 4. Selection of Precautionary Label Text..................................................................................... 9 4.1 General............................................................................................................................... 9 4.2 Fire Action.......................................................................................................................13 4.3 Spill or Leak Action......................................................................................................... 13 4.4 Instructions for Container Handling and Storage............................................................ 13 4.5 Antidote Statements.......................................................................................................... 14 4.6 Notes to Physicians............................................................................................................. 15 4.7 Other Useful Statements of Hazard.................................................................................... 15 4.8 Other Useful Precautionary Measures.......... .................................................................. 16 Tables Table I Selection of Precautionary Label Text........................................................................10 Table 2 Fire Action Statements.................................................................................................13 Table 3 Spill or Leak Action Statements..................................................................................13 Appendixes Appendix A Illustrative Use of Precautionary Label Texts................................................... 18 Al. General............................................................................................................................18 A2. Labels for Chemicals with Single Hazards.................................................................. 18 A3. Labels for Chemicals with Multiple Hazards.............................................................. 24 Appendix B Labeling Serious Chronic Hazards....................................................................... 37 Bl. General........................................................................................................................... 37 B2. Labeling Carcinogens..................................................................................................... 37 B3. Labeling Reproductive Toxicants................................................................................. 37 B4. Labeling Other Serious Chronic Effects....................................................................... 37 BS. Labeling Mixtures........................................................................ 37 B6. Signal Words Applicable to Serious Chronic Effects ^............................................... 37 B7. Precautionary Measures Applicable to Serious Chronic Effects..................................38 B8. Placement of Statements of Hazard for Serious Chronic Effects..............................38 AP00008744 American National Standard for Hazardous Industrial Chemicals -- Precautionary Labeling Introduction The development of new chemicals1 3and the introduc tion of chemical processes into ever-widening fields have accentuated a need to furnish information for the guidance of persons who, in their occupations, use, handle, or store ha2ardous industrial chemicals. The dissemination of this information includes ap propriate precautionary statements expressed as simply and briefly as possible on labels affixed to containers of hazardous chemicals and in other written material provided for the guidance of industrial users. The wording on precautionary labels cannot be expected to cover the complete information on the properties of a material or the complete details of its proper handling under all conditions. Greater detail can be found in other appropriate material such as the producers' ma terial safety data sheets, technical bulletins, or other literature. Precautionary labeling shall be used only when., and to the extent, necessary. The language shall be practical -- not based alone upon the inherent properties of a product, but directed toward the avoidance of hazards resulting from the occupational use, handling, and stor age that may be reasonably foreseeable. Many products present no hazard in normal handling and storage. For these products, no precautionary statements may be necessary on the label. 1. Scope This standard applies to the preparation of precau tionary labeling of hazardous chemicals, as defined 1 The term, chemical, as used in this standard, includes a single chemical and chemical mixtures. 6 herein, used under industrial occupational conditions. It recommends only the warning language, not when or where a label should be attached to a container. 2. Definitions The following terms are used throughout this standard. The definitions given apply specifically to the use of these terms in arriving at appropriate precautionary statements for the labels for hazardous industrial chem icals. In this respect, these terms serve only as a guide for the application of the principles of labeling set forth in this standard. adequate ventilation. A condition falling within either or both of the following categoiies: (1) Ventilation to reduce levels of air contaminant below that which may cause personal injury or illness1 (2) Ventilation sufficient to prevent accumulation of concentrations of contaminant vapor in air over 20% of the lower flammable limit antidote. A specific therapeutic measure that may or may not require the services of a physician. chronic effect. An adverse effect from exposure to a hazardous chemical resulting in either of the following: (1) A persistent illness or injury that develops over time from a single exposure (2) A persistent illness or injury that develops from prolonged or repeated exposure under conditions that would produce the effect from a single exposure 3 Values have been established by many sources for specific chemicals, c.g., permissable exposure levels (PELs), threshold limit values (TLVs), and short-term exposure levels (STELs). AP00008745 A chronic effect such as reduced life expectancy, disfigurement or deformity, or a major reduction in functional capacity is a serious chronic effect. combustible liquid. Any liquid having a flash point at or above 100F (37.8C) but less than 200*F (93.3*C), except any liquid mixture having one or more com ponents with a flash point at or above the upper limit that make up 99% or more of the total volume of the mixture. (For test method, see flash point.) NOTE: For the purposes of this standard, an aqueous solution containing 24% or less alcohol by volume shall be considered to have a flash point no less than 100 F (37.8 C), If the re mainder of the solution is not flammable. corrosive chemical. A chemical that causes visible de struction of or irreversible alterations in living tissue by chemical action at the site of contact. For example, a chemical is considered corrosive if, when tested on the intact skin of albino rabbits by the method de scribed by the U.S. Department of Transportation in Appendix A to 49 CFRPart 173, it destroys or changes irreversibly the structure of the tissue at the site of contact following an exposure period of 4 hours. This term shall not refer to action on inanimate surfaces, dangerously reactive chemical. A chemical that is able to undergo a violent self-accelerating exothermic chemical reaction with common materials, or by itself. dust. Solid particles generated by handling, crushing, grinding, rapid impact, detonation, or decrepitation of organic or inorganic materials such as rock, ore, metal, coal, wood, grain, etc. Dusts can be dispersed readily in air and settle slowly under the influence of gravity. Dusts are normally characterized by an average particle size smaller than 74 micrometers (200 mesh). extremely flammable liquid. See flammable chemical first aid. Immediate measures that can be taken in case of contact or exposure by the victim or other persons, using materials generally available to reduce or eliminate adverse health effects. First aid is aimed principally at terminating the exposure. flammable chemical. A substance falling within any of the following categories: flammable liquid. Any liquid having a flash point below 100F (37.8C), except any liquid mixture having one or more components with a flash point at or above the upper limit which make up 99% or more of the total volume of the mixture. (For test method, set flash point.) AMERICAN NATIONAL STANDARD Z129.1-19B2 extremely flammable liquid3 flammable gas. A gas with either of the following properties: (1) At atmospheric temperature and pressure, forms a flammable mixture with air when present at a concentration of 13% or less (by volume), or forms a range of flammable mixtures with air wider than 12% regardless of the lower limit (2) Projects a flame or more than 18 inches beyond the ignition source with the valve opened fully, or the flame flashes back and burns at the valve with any de gree of valve opening, when tested in the Association of American Railroads' Bureau of Explosives' flame projection apparatus. flammable solid. A solid, other than an explosive, that is liable to cause fire through friction, absorption of moisture, spontaneous chemical change, or retained heat from manufacturing or processing, or that can be ignited readily and, when ignited, burns so vigorously and persistently as to create a hazard. flash point. The minimum temperature at which a liquid gives off a vapor in sufficient concentration to ignite when tested by one of the following: (1) Tagliabue closed tester (in accordance with American National Standard Method of Test for Flash Point by Tag Closed Tester, ANSI/ASTM D56-79) for liquids with a viscosity of less than 45 Saybolt Universal Seconds (SUS) at 100*F (37.8C), that do not contain suspended solids and do not have a tendency to form a surface film under test. (2) Pensky-Martens closed tester (in accordance with American National Standard Method of Test for Flash Point by Pensky-Martens Closed Tester, ANSI/ ASTM D93-80) for liquids with a viscosity of 45 SUS or over at 100F (37.8C), or that contain suspended solids, or that have a tendency to form a surface film under test. (3) Setaflash closed tester (in accordance with American Society for Testing and Materials Method of Test for Flash Point by Setaflash Closed Tester, ASTM D3278-784). (4) For mixtures, if the result of the test by any of these methods is above I0OF (37.8C), evaporate a fresh sample to 90% of the original volume and retest. The lower of the two values shall be taken as the flash point. *Some states and other regulatory agencies require that prod ucts with flash points below 20 F {-6.7Q be labeled as "EX TREMELY FLAMMABLE." 4 Available from the American Society for Testing and Ma terials, 1916 Race Street, Philadelphia, PA 19103. 7 AP00008746 AMERICAN NATIONAL STANDARD Z129.1-I982 fume. Soiid particles generated by condensation from the gaseous state, generally after volatilization from molten metals, etc., and often accompanied by a chem ical reaction such as oxidation. Fumes may flocculate and sometimes coalesce. gas. A normally formless fluid that occupies the space of enclosure and that can be changed to the liquid or solid state by the effect of increased pressure or de creased temperature, or both. A gas diffuses. hazardous chemical. A chemical (or mixture of chemi cals) that is either toxic or highly toxic; an irritant; corrosive; a strong oxidizer; a strong sensitizer; com bustible; either flammable or extremely flammable; dangerously reactive; pyrophoric or pressure-generat ing; or that otherwise may cause substantial acute or chronic personal injury or illness during or as a direct result of any customary or reasonably foreseeable handling or use. If available data on human experience indicate results different from those obtained on animals, the human data shall take precedence. highly toxic chemical (poison). A chemical falling within any of the following categories: (1) A chemical that has a median lethal dose (LD50) of 50 milligrams or less per kilogram of body weight when administered orally to albino rats weighing be tween 200 and 300 grams each ' (2) A chemical that has a median lethal dose (LDS0) of 200 milligrams or less per kilogram of body weight when administered by continuous contact for 24 hours (or less, if death occurs within 24 hours) with the bare skin of albino rabbits weighing between 2 and 3 kilo grams each (3) A chemical that has a median lethal concentra tion (LC50) in air of 200 parts per million by volume or less of gas or vapor, or 2 milligrams per liter or less of mist, fume, or dust, when administered by contin uous inhalation for 1 hour (or less, If death occurs within 1 hour) to albino rats weighing between 200 and 300 grams each, provided such concentration and/or condition are likely to be encountered by man when the chemical is used in any reasonably foresee able manner irritant. A chemical, not a corrosive, that causes a reversible inflammatory effect on living tissues by chemical action at the site of contact. For example, a chemical is a skin irritant if, when tested on the intact skin of albino rabbits in accordance with the methods of 16 CFR 1500.41 by exposure for 4 hours or by other appropriate techniques, it results in an empirical score of 5 or more. For example, a chemical is an eye irritant if so determined under the procedure 8 listed in 16 CFR 1500.42 or other appropriate tech niques. median lethal dose or concentration. The dose (LDS0) or concentration (LC5 0) of a chemical administered in a single dose or as a concentrated air-mixture over a short specified period of time that is calculated to kill one-half of a group of animals under the specified time and conditions of the test. mist. Liquid droplets suspended in air generated by condensation from the gaseous to the Liquid state or by breaking up a liqud into a dispersed state such as by splashing, foaming, or atomizing. mixture. A combination of two or more chemicals not involving a chemical reaction. poison. See highly toxic chemical pressure-generating chemical. A chemical falling with in any of the following categories: (1) A chemical that generates pressure unless pro tected from spontaneous polymerization by the addi tion of an inhibitor, or by refrigeration or other thermal control (2) A chemical that may decompose to release gas in its container (3) A chemical that comprises the contents of a self-pressurized container pyrophoric chemical. A chemical that will ignite spon taneously in dry or moist air at a temperature of 130F (S4.4C) or below. strong oxidizer. A chemical that promotes oxidation readily and, on contact with combustible material, may cause fire. strong sensitizer. A chemical that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated ex posure to the chemical. toxic chemical. A chemical falling within any of the following categories: (1) A chemical that has a median lethal dose (LD$o) of more than 50 milligrams per kilogram but not more than 500 milligrams per kilogram of body weight when administered orally to albino rats weighing between 200 and 300 grams each. (2) A chemical that has a median lethal dose (LD50) of more than 200 milligrams per kilogram but not more than 1000 milligrams per kilogram of body weight when administered by continuous contact for 24 hours (or less, if death occurs within 24 hours) with the bare skin of albino rabbits weighing between 2 and 3 kilo grams each. m AP00008747 (3) A chemical that has a median lethal concentra tion (LC50) in air of more than 200 parts per million, but not more than 2000 parts per million by volume of gas or vapor, or more than 2 milligrams per liter, but not more than 20 milligrams per liter of mist, fume, or dust, when administered by continuous inhalation for 1 hour (or less, if death occurs within 1 hour) to albino rats weighing between 200 and 300 grams each, pro vided such concentration and/or condition are likely to be encountered by man when the chemical is used in any reasonably foreseeable manner. vapor. The gaseous form of a chemical that may diffuse and that is normally in the solid or liquid state. 3. General Requirements 3.1 The precautionary label for any hazardous chem ical shall be based upon the hazards It possesses. 3.2 The following subject matter shall be considered for inclusion on precautionary labels: (1) Identity of product or hazardous components), (2) signal word, (3) statement of hazards, (4) precautionary measures, (5) instructions in case of contact or exposure, (6) anti dotes, (7) notes to physicians, (8) instructions in case of fire and spill or leak, and (9) Instructions for con tainer handling and storage. 3.3 Identification of the product or its hazardous chemical component(s) shall be adequate to permit selection of proper action in case of exposure (see Ap pendix A). Identification shall not be limited to nondescriptive code designation or trade name. If the prod uct is a mixture, those chemicals (compounds) that contribute substantially to the hazard(s) shall be iden tified. 3.4 The Signal Word shall indicate the relative degree of severity of a hazard in the diminishing order of DANGER!, WARNING!,and CAUTION! When a product has more than one hazard, only the signal word corresponding to the class of greatest hazard shall be used (for serious chronic effects, see Appendix B, Sec tion B6). 3.5 Inclusion of the word POISON and the skull and crossbones shall be limited to highly toxic chemicals. When used, this legend shall not replace the signal word. 3.6 The Statement of Hazards shall give notice of the hazard or hazards (such as EXTREMELY FLAM MABLE and HARMFUL IF ABSORBED THROUGH SKIN) that are present in connection with the custom AMERICAN NATIONAL STANDARD Z129.1-1982 ary or reasonably foreseeable handling or use of the product. With products possessing more than one such hazard, an appropriate statement for each significant hazard shall be included. In general, the most serious hazard shall be placed first (for serious chronic effects, see Appendix B, Section B8). 3.7 The Precautionary Measures (such as "Keep away from heat, sparks, and flame" and "Avoid breathing dust") shall supplement the statement of hazards by providing briefly measures to be taken to avoid injury from the hazard or hazards. 3.8 Instructions in Case of Contact or Exposure shall be included where the results of contact or exposure warrant immediate treatment (first aid), and where simple remedial measures may be taken safely before medical assistance is available. They shall be limited to procedures based on methods and materials com monly available. Simple remedial measures (such as washing or removal of clothing) shall be included where they will serve to lessen or avoid serious injury following contact or exposure. 3.9 Instructions in Case of Fire and Spill or Leak shall be included when applicable to provide persons who handle containers during shipment and storage with appropriate instructions for confining and extinguish ing fires and for cleaning up spills or leaks. They shall be as simple and brief as possible and advise the use of suitable material for control. 3.10 Instructions for Container Handling and Storage shall be included to provide additional information for those chemicals requiring special or unusual handling and storage procedures. 3.11 Antidotes that may be administered by a lay person shall be included on the label when applicable under the designation, Antidote. Antidotes that must be administered by a physician as well as other useful therapeutic measures, other than purely supportive treatment, shall be included on the label under the designation. Note to Physicians. 4. Selection of Precautionary Label Text 4.1 General. Table 1 classifies chemicals on the basis of the hazardous properties that are most frequently encountered. Opposite each class of hazard are given a Signal Word. Statements of Hazard, Precautionary Mea sures, and, In most cases, Instructions in Case of Con tact or Exposure and additional markings. Applicable 9 AP00008748 AMERICAN NATIONAL STANDARD Z129.W982 o INGESTION Class or Hazard Highly Toxic Toxic Highly Toxic Toxic Signal Word DANGER! WARNING! DANGER! WARNING! Table 1 Selection of Precautionary Labe] Text Statements of Hazard MAY BE FATAL IF SWALLOWED HARMFUL IF SWALLOWED MAY BE FATAL IF ABSORBED THROUGH SKIN HARMFUL, IF ABSORBED THROUGH SKIN Precautionary Measures Wash thoroughly after handling. Wadi thoroughly after handling. Do not get in eyes, on skin, on clothing Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. Instructtom in Case of Contact or Exposure POISON Call a Physician FIRST AID:$ If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an unconscious person. FIRST AID:$ If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an unconscious person. Call a physi cian. POISON Call a Physician FIRST AID: In case of contact, immedi ately flush eyes or skin with plenty of water for at least 15 mintueg while re moving contaminated dothing and shoes. Wash clothing before reuse. (De stroy contaminated shoes.)'!' (Thorough ly dean shoes before reuse.)t FIRST AID: In case of contact, immedi ately flush eyes or skin with plenty of water for at least 15 minutes while re moving contaminated clothing and shoes. Call a physician. Wash clothing be fore reuse. (Destroy contaminated shoes.)f (Thoroughly dean shoes before reuse.tf . ABSORPTION INHALATION Highly Toxic DANGER! Toxic WARNING! Strong Sensitizer, Lungs WARNING! Physiologically inert Vapor or Gas CAUTION! Irritant, Eye Irritant, Eye and Skin WARNING! WARNING! Strong Sensitizer, Skin WARNING! MAY BE FATAL IF INHALED HARMFUL IF INHALED MAY CAUSE ALLERGIC RESPIRATORY REACTION (VAPOR) (GAS)* REDUCES OXYGEN AVAILABLE FOR BREATHING CAUSES EYE IRRITATION CAUSES IRRITATION MAY CAUSE ALLERGIC SKIN REACTION Do not breathe (dust, vapor, mist, gas).* Keep container closed. Use only with adequate ventilation. Avoid breathing (dust, vapor, mist, gas),* Keep container closed. Use with adequate ventilation. Avoid breathing (dust, vapor, mist, gas).* Keep container closed. Use with adequate ventilation. Keep container dosed. Use with adequate ventilation. Do not enter storage areas unless ade quately ventilated. Avoid contact with eyes. Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. Avoid prolonged or repeated contact with skin. Wadi thoroughly after handling. POISON <KT Call a Physician * FIRST AID: If Inhaled, remove to fresh air. If not breathing, give artificial respi ration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. Call a physician. FIRST AID: If inhaled, remove to fresh air. If not breathing, give artificial respi ration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. Call a physician. FIRST AID: If inhaled, remove to fresh air. If not breathing, give artificial respiration, preferably inouth-lo-ntouth. If breathing is difficult, give oxygen. Call a physician. FIRST AID: If inhaled, remove to fresh air. if not breathing, give artificial respi ration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. Call a physician. FIRST AID: In case of contact, immedi ately flush eyes with plenty of water for at least 15 minutes. Call a physician. FIRST AID: In case of contact, immedi ately flush eyes with plenty of water for at least 15 minutes. Call a physician. Flush skin with water. (Wash clothing before reuse.)f FIRST AID: In case of contact, immedi ately wash skin witli soap and plenty of water. CONTACT , AMERICAN NATIONAL STANDARD Z129-M982 NOTE: Additional useful statements may be found in 4.2 through 4.7 and Tables 2 and 3. 'Select applicable word or words. f Use phrase when appropriate. > $ Do not use when vomiting is not recommended. For recommended statements, see 4.5 and 4.6. ooo 00 t/1 O' AMERICAN NATIONAL STANDARD Z129.1-I982 tsJ CORROSIVE FLAMMABILITY I Class of Hazard Corrosive, Eye Corrosive, Eye and Skin Signal Word DANGER! DANGER! Table I -- Continued Statements of Hazard CAUSES (SEVERE)* EYE BURNS CAUSES (SEVERE)* BURNS Precautionary Measures Do not get in eyes. Avuid breathing (dust, vapor, mist, gas).* Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. Do not get in eyes, on skin, on clothing. Avoid breathing (dust, vapor, mist, gas).* Keep container dosed. Use with adequate ventilation. Wash thoroughly after handling. Extremely Flammable Liquid or Flammable Gas Flammable Liquid DANGER! WARNING! l-lammuble Solid Combustible Liquid Pyroforic Chemical WARNING! CAUTION! DANGER! EXTREMELY FLAMMABLE FLAMMABLE FLAMMABLE COMBUSTIBLE EXTREMELY FLAMMABLE CATCHES FIRE !F EXPOSED TO AIR Keep away from heat, sparks, and flame. Keep container closed. Use with adequate ventilation. Keep away from heal, sparks, and flame. Keep container closed. Use with adequate ventilation. Keep away from heut, sparks, and flame. Keep away from heat and flame. Keep away from heat, sparks, and flame. Keep container closed. Strong Oxidizer DANGER! STRONG OXIDIZER CONTACT WITH OTHER MA TERIAL MAY CAUSE FIRE Keep from contact with clothing and other combustible materials. Do not store near combustible materials. Store in tightly closed container. NOTE: Additional useful statements may be found in 4.2 through 4.7 and Tables 1 and 3. `Select applicable word or words. -fUse phrase when appropriate. Instructions in Case of Coniact or Exposure FIRST AID: In case of contact, immedi ately flush eyes with plenty of water for al least 1S minutes. Call a physician. FIRST AID: In case of contact, immedi ately flush eyes and skin with plenty of water for at least 15 minutes while re moving contaminated clothing and shoes. Call a physician. Wash clothing before reuse. (Destroy contaminated shoes.)! (Thoroughly dean shoes be fore reuse.)! (Sec Tabic 2 for selection ofappropri ate flre-extinguishing statement.) Remove and wash contaminated clothing promptly. O oOo 00 SI in precautionary statements should be selected from 4.2 to 4.8 and Tables 1,2, and 3. When the texts for different classes of hazard are combined, it may be necessary to eliminate some re* dundancies that occur in the Precautionary Measures or First Aid statements. Some Statements of Hazard and Precautionary Measures in Table 1 contain words in parentheses. These words represent choices that are to be made according to the facts in a particular situa tion. Precautionary labeling detailed in Table 1 is directed primarily to the avoidance of acute effects from single, accidental exposures to a chemical. Some chemicals, however, produce delayed, cumulative, or chronic (long-term) effects. When generally accepted and wellestablished evidence of such effects exists, a statement of the hazard(s) together with suitable instructions for the avoidance of such effect(s) shall be included with the other label information from Table l. However, labeling for some known chronic effects, such as al lergic skin reaction and delayed lung injury is described in 4.7 and Table 1 (see Appendix B for labeling serious chronic hazards). There are hazards other than those dealt with In Table 1 such as those presented by compounds that may be explosive, carcinogenic, teratogenic, muta genic, or that present other recognized hazards to safe ty and health. It is beyond the scope of Table 1 to cover all possible label needs. However, the general format provided allows for the preparation of ap propriate label statements. Each hazardous chemical must be considered individually in the light of its own characteristics and customary or reasonably foresee able handling or use. In such cases, suitable statements should be developed to fit the situation. Additional useful statements may be found in 4.2 through 4.8 and Tables 2 and 3. Until consensus definitions and test protocols for chronic effects are established, precau tionary label texts should be used only when generally accepted, well-established evidence of such chronic effects exist or when required by law. Label texts rela tive to chronic hazards shall be in accordance with Ap pendix B, Labeling Serious Chronic Hazards. 4.2 Fire Action. For additional statements to be used in case of a fire hazard, see 3.9,4.1, and Table 2. 4.3 Spill or Leak Action. For additional statements to be used in case of a hazard from spilling or leaking, see 3.9,4.1, and Table 3. 4.4 Instructions for Container Handling and Storage. Applicable instructions (see 3.10) may be selected from 4.4.1 through 4.4.8. AMERICAN NATIONAL STANDARD ZI29.1-1982 Table 2 Fire Action Statements Type of Product For water-soluble or dilut able liquids For water-immiscible liquid For solids such as oxidizing agents where water is ap propriate and not dan gerous For solids where water is not appropriate For flammable gases Fire Extinguishing Statements* In case of fixe, use water (flood with water), dry chemical, CO^, or "alco hol" foam. In case of fire, use water spray, foam, dry chemical, or C02. [n case of fire, soak (flood) with water. In case of fire, smother with dry sand, dry ground lime stone, or dry powder-type agents specially designed for metal powder fires. Do not use carbon tetrachloride, COj, extinguishers, or water. In case of fire, allow gas to bum if flow cannot be shut off Immediately. Apply water from a safe distance to cool container and pro tect surrounding atea. Substitute oi add appropriate words in parentheses. Table 3 Spill or Leak Action Statements Type of Chemical Spill or Leak Statements* For most liquids For liquids where water may cause dangerous re action or otherwise create further hazard (such as in sewer) For materials that generate vapor or fumes with water For most solids (when ap propriate, add Instruc tions for disposal of swept-up material) Flush spill (area) with water (spray). In case of spill, do not use water. Soak up with sand or earth. In case of spill, Hush away with water applied quickly to entice spill. (Neutralize (washings^ (spill area) f with soda ash or lime.) In case of spill, sweep (scoop) up and remove. Flush spill area with water. NOTE: See also 4.8.6. Substitute or add appropriate words in parentheses, tSelect applicable word or words. 13 AP00008752 AMERICAN NATIONAL STANDARD ZI29.M982 4.4.1 Metal Drums (for Liquids and Semiliquids) Keep closure up to prevent leakage. Keep drum out of sun and away from heat. Relieve internal pressure when received and at least weekly thereafter by slowly loosening plug. Retighten immediately. Drums should be grounded and bonded to receiving con tainer^) when being emptied. Do not drop onto, or slide across, sharp objects. Never use pressure to empty; drum is not a pressure vessel. Keep lights, fire, and sparks away from drums. Drum must not be washed out or used for other purposes. Replace plug after each withdrawal and return with empty drum. Do not expose drum to direct sunlight for long periods of time. 4.4.2 Glass Carboys Before moving carboy, be sure closure is securely fastened. Avoid rough handling or dropping. Loosen closure carefully. Keep carboy out of sun and away from heat. Never use pressure to empty; carboy is not a pressure vessel. Completely drain carboy before returning. 4.4.3 Wooden Barrels (for Uquds and Semiliquids) Keep barrel out of sun and away from heat. Store with bilge bung up. Never use pressure to empty. Drain completely. Keep barrel moist - shrinkage may cause leaks. 4.4.4 Plastic Containers With and Without Over packs (for Liquids and Semiliquids) Keep closure up to prevent leakage. Keep container out of sun and away from heat. Do not drop onto, or slide across, sharp objects. Never use pressure to empty;drum is not a pressure vessel. Keep lights, fixe, and sparks away from container. Container must not be washed out or used for other pur poses. Replace closuie after each withdrawal. Thoroughly drain containers and tighten closure before re turning. Do not use container as dilution or mixing vessel. Remove closure carefully to relieve possible internal pres sure. 4.4.5 Fiber Drums Protect from direct contact with water or excessive mois ture. Do not drop onto, or slide across, sharp objects. Do not store on side. Avoid creasing or impacting of side walls. 4.4.6 Shipping Sacks Protect from direct contact with water or excessive mois ture. Only those bags marked "May be used for open storage'' should be so used. Never store on ground. Keep out of sun and away from heat. Do not drop onto, or slide across, sharp objects. In case of puncture, use overslip bag and securely close. 4.4.7 Bulk Containers Never use pressure to empty. Container must not be washed out or used for other pur poses. Relieve internal pressure when received. Do not remove label until thoroughly cleaned. 4.4.8 Empty Container Warnings. When the kinds and degrees of hazards are the same for a full, partial ly full, and "empty" container, and all of the hazards are adequately dealt with in the label warnings, the label shall also state the following or equivalent: Since emptied containers retain product residue, follow label warnings even after container is emptied. The following additional statement, or equivalent, would be appropriate for vapors of a chemical that could explode when confined under certain conditions: Do not cut, drill, grind, or weld on or near this container. 4.5 Antidote Statements. While it is generally true that specific antidotes are known for very few chemicals and many of these can be administered only by a physician, there are some measures that may be used by laymen with benefit (see 3.11). Specific examples are given in 4.5.1 through 4.5.5. Others may be de veloped by the user of this standard for appropriate application to other chemicals. 4.5.1 For corrosive acid substances that are not toxic or highly toxic by ingestion: Antidote: If swallowed, do NOT induce vomiting. Give large quantities of water. Call a physician immediately. Never give anything by mouth to an unconscious person. 4.5.2 For corrosive alkaline substances that are not toxic or highly toxic by ingestion: Antidote. If swallowed, do NOT induce vomiting. Give large quantities of water. Call a physician immediately. Never give anything by mouth to an unconscious person. 4.5.3 For cyanides and cyanide-like substances: Antidote. Always have on hand a cyanide first-aid kit. Break an amyl nitrite pearl in a cloth and hold lightly under nose for 15 seconds. Repeat five times at about 15second intervals. Call a physician. 4.5.4 For soluble barium salts: Antidote, If swallowed, induce vomiting and then, if readily available, give on tablespoonful of epsom salts in a glass of water. Call a physician immediately. Never give anything by mouth to an unconscious person. 4.5.5 For cholinesterase-inhibiting compounds that are highly toxic: Antidote. Atropine is an antidote. Consult your physician about obtaining a supply of 0.6-mULigratn U/100-gxain) tablets for emergency use, if symptoms include blurred vision, stomach cramps, or tightness in chest, take two tablets at once and call a physician immediately. Do not take atropine unless symptoms of poisoning have occurred. # 14 AP00008755 4.6 Notes to Physicians. Physicians may not always be familiar with specific antidotes forgiven chemicals or with specific practices found useful by experts in the management of some poisonings. It may, in certain cases, be desirable to acquaint the physician with an antidote or with a specific form of medical management through a Note to Physicians on the label (see 3.11). Specific examples are given in 4.6.1 through 4.6.4. The user of this standard may wish to discuss with his medical consultant the need for or appropriateness of a Note to Physicians in the labeling of his products. The Note to Physicians should be prepared by physicians. 4.6.1 For soluble arsenic compounds: Note to Physicians, if swallowed, give gastric lavage follow ed by saline cathartic. Force fluids. Give cUmercaprol (BAL) in recommended dosages as appropriate. 4.6.2 For cholinesterase-inhibiting compounds that are highly toxic: Note to Physicians. Warning symptoms include weakness, headache, tightness of chest, blurred vision, nonreactive pinpoint pupils, salivation, sweating, nausea, vomiting, diarrhea, and abdominal cramps. Give atropine intravenous ly, depending on severity of poisoning. 2 to 4 milligrams every 15 minutes until fully atropinized as shown by dilated pupils, dry flushed skin, and tachycardia. Twenty to 30 milligrams, or more, may be required during the first 24 hours. Never give opiates or phenothiaztne tranquilizers. Clear chest by postural drainage. Artificial respiration oi oxygen administration may be necessary. Observe patient continuously for at least 48 hours. Allow no further ex posure to any cholinesterase inhibitor until cholinesterase regeneration has taken place as determined by blood tests. 4.6.3 For cyanides and cyanide-like substances: Note to Physicians. If patient has not responded to amyl nitrite, inject intraveneously 10 milliliters of a 3% solution of sodium nitrite at a rate not greater than 2.5 to 5 milli liters per minute. Follow directly with 50 milliliters of a 25% solution of sodium thiosolfate at the same rate by the same route. Keep patient under observation. If signs of poisoning persist or reappear, repeat nitrite and thiosulfate injections 1 hour later in one-half the original doses. 4.6.4 For methemoglobin-inducing compounds: Note to Physicians. Absorption of this product into the body leads to the formation of methcmogtobln that, in sufficient concentration, causes cyanosis. Since reversion of methemoglobifl to hemoglobin occurs spontaneously after termination of exposure, moderate degrees of cyano sis need be treated only by supportive measures such as bed rest and oxygen inhalation. Thorough cleansing of the entire contaminated area of the body, including scalp and nails, is of utmost importance. If cyanosis is severe, intra venous injection of methylene blue, one milligram per kilo gram of body weight, may be of value. Cyanocobalamin (Vitamin Bjj), one milligram intramuscularly, may speed recovery. Intravenous fluids and blood transfusions may be indicated in very severe exposure. 4.7 Other Useful Statements of Hazard 4.7.1 Inhalation INHALATION MAY BE FATAL OR CAUSE DELAYED LUNG INJURY HARMFUL IF INHALED AND MAY CAUSE DELAYED LUNG INJURY AMERICAN NATIONAL STANDARD Z129.1-1992 HIGHLY VOLATILE VAPOR EXTREMELY IRRITATING EXTREMELY IRRITATING GAS AND LIQUID UNDER PRESSURE GAS EXTREMELY IRRITATING MAY CAUSE LUNG INJURY AND BURNS - EFFECTS MAY BE DELAYED REPEATED INHALATION OR SKIN CONTACT MAY, WITHOUT SYMPTOMS. INCREASE SUSCEPTIBILITY CAN CAUSE DEATH IF TOO MUCH IS BREATHED 4.7.2 Contact RAPIDLY ABSORBED THROUGH SKIN CAUSES SEVERE BURNS WHICH MAY NOT BE IM MEDIATELY PAINFUL OR VISIBLE MAY CAUSE RASH OR EXTERNAL ULCERS MAY CAUSE BURNS OR EXTERNAL ULCERS LIQUID OR VAPOR CAUSES BURNS WHICH MAY BE DELAYED CAUSES SEVERE BURNS - EFFECTS ON EYES MAY BE DELAYED MAY CAUSE BLINDNESS MAY CAUSE PERMANENT EYE INJURY MAY CAUSE EYE INJURY - EFFECTS MAY BE DE LAYED DESTROY CONTAMINATED SHOES/CLOTHING IN A PROPER MANNER 4.7.3 Reactive 4.73.1 Gas Liberation SPILLAGE MAY CAUSE FIRE OR LIBERATE DANGEROUS GAS CONTACT WrTH WATER OR MOIST AIR LIBERATES IRRITATING GAS CONTACT WITH ACID LIBERATES POISONOUS GAS CONTACT WITH METALS LIBERATES POISONOUS GAS CONTACT WITH WATER OR ACID SLOWLY LIBERATES POISONOUS AND FLAMMABLE HYDROGEN SULFIDE GAS LIBERATES HEAVY GAS WHICH MAY CAUSE SUFFO CATION LIBERATES POISONOUS GAS 4.7.3.2 Fire Hazard CONTACT WITH WATER MAY CAUSE FLASH FIRE MAY IGNITE IF ALLOWED TO BECOME DAMP HEAT, SHOCK, OR CONTACT WITH OTHER MATERIAL MAY CAUSE FIRE OR EXPLOSIVE DECOMPOSITION CONTACT WITH OTHER MATERIAL MAY CAUSE FIRE OR EXPLOSION, ESPECIALLY IF HEATED REACTS VIOLENTLY WITH WATER, LIBERATING AND IGNITING HYDROGEN POWERFUL OXIDIZER MAY FORM FLAMMABLE DUST-AIR MIXTURES 4.73.3 Explosive Hazard MAY FORM EXPLOSIVE PEROXIDES FORMS SHOCK-SENSITIVE MIXTURES WITH CERTAIN OTHER MATERIALS MAY EXPLODE IF WATER CONTENT IS 10% OR BELOW MAY FORM EXPLOSIVE DUST-AIR MIXTURES 15 AP00008754 AMERICAN NATIONAL STANDARD Z129.1-1982 4.7.3.4 Pressure Hazard CONTAMINATION MAY RESULT IN DANGEROUS PRESSURE LIQUID AND GAS UNDER PRESSURE EXTREMELY HAZARDOUS LIQUID AND VAPOR UNDER PRESSURE WARNING - CONTENTS UNDER PRESSURE 4.7.4 Miscellaneous MAY BE FATAL OR CAUSE BLINDNESS IF SWAL LOWED CANNOT BE MADE NONPOJSONOUS REPEATED ABSORPTION MAY RESULT IN BLADDER TUMORS EXTREMELY COLD 4.8 Other Useful Precautionary Measures 4.8.1 Eyes and Skin Ordinary rubber protective clothing, including gloves, will not prevent skin absorption. Wear goggles; neoprene, butyl rubber, or vinyl gloves; neoprene shoes or boots; and clean protective outer clothing. Do not wear ordinary rubber protective clothing, including gloves and boots. Wear goggles; neoprene, butyl rubber, or vinyl gloves. Wear goggles or race shield and fire-retardant clothing when handling. Wear goggles or face shield, rubber gloves, and protective clothing when HandlingWear heavy rubber gloves and goggles or face shield. Wear goggles and DRY gloves when handling. Liquid penetrates leather shoes causing delayed burns. Use fresh clothing daily. Take hot shower after work using plenty of soap. Cali a physician at once in case of bums, especially to eyes, nose, and throat or if patient is unconscious. Flush eyes for at least 30 minutes. Hold eyelids apart and flush eyes with plenty of water at least IS minutes. In case of contact, immediately remove from skin with dry cloth followed by flushing with plenty of water for at least IS minutes; call a physician. Remove contaminated clothing and wash before reuse. Skin: Remove sodium and flush affected area with water. Avoid prolonged or repeated contact with skin. 4.8.2 Inhalation Avoid breathing dust or solution spray. Avoid breathing dust or spray mist. Avoid prolonged or repeated breathing of vapor. Avoid exposure to vapor. Avoid breathing dust or vapor. Do not enter places where used or stored until adequately ventilated. Use only with adequate ventilation and in closed systems. Use NIOSH/MSHA*-approved respiratory protection.. * National Institute for Occupational Safety and Health/Mine Safety Health Adminiatration. 16 Always wear a self-contained breathing apparatus or fullface alr-Une respirator when using this chemical. Have available emergency selfcontained breathing appara tus or full-face air-line respirator when using this chemical Have available emergency gas masks approved by NIOSH/ MSHA* for bromine service. This gas deadens the sense of smell. Do not depend on odor to detect presence of gas. In case of inhalation or suspicion of inhalation, move patient at once to fresh air and call a physician. Keep patient absolutely quiet and start oxygen inhalation through suitable equipment. 4.8.3 Ingestion Do not swallow. Do not taste. Do not induce vomiting. 4.8.4 Fire In case of fire, smother with soda ash, dry sand, or carbon dioxide. Dispose of by flushing away with a large volume of water under adequate ventilation. 4.8.5 Reactive 4.8.5.1 Fire Hazard Keep away from contact with oxidizing materials. Keep away from contact with clothing and other com bustible materials to avoid fire. Drying of this product on clothing or combustible ma terials may cause Are. Spills on ciothing or combustible material will cause fire. Contents packed under water and will ignite if water is removed. Avoid friction or rough handling because of fire hazard. Keep wet in storage - dry powder may ignite by fric tion. static electricity, or heat. Prevent contamination with readily oxidizable materials and polymerization accelerators. Do not add water to contents while in a container because of violent reaction and possible flash fire. Clothing and vegetation contaminated with chlorate or its solutions are DANGEROUSLY FLAMMABLE. Remove ciothing and wash thoroughly with water. Keep persons and animals ofT treated areas. Keep away from fire. Static charges can accumulate during shipping, unloading, pouring, or conveying. To avoid fire or explosion, ground and bond container and receiving equipment (and ground personnel) before transferring material. To dissipate static electricity during transfer, ground drum and connect to receiving container with bonding strap. 4.8.5.2 Explosive Keep from contamination from any source, including metals, dust, and organic materials. Such contamination can cause rapid decomposition, generation of high pres sures, or formation of explosive mixtures. Do not add to hot materials; do not grind or subject to heat or shock - explosive decomposition may result. Do not allow to evaporate to near dryness. Addition of water or appropriate reducing agents will lessen peroxide formation. NOTE: Suck-back into cylinder may cause explosion. Under no circumstances should the cylinder entry tube be inserted in a liquid or gas without a vacuum break or other protective apparatus in the line to prevent suck-back. Fire or high temperatures may cause explosive decomposi tion if confined. 4.8.5.3 Pressure Hazard Avoid contamination from any source including metals, dust, and organic materials. Such contamination may cause rapid decomposition, generation of large quantities of oxygen gas, and high pressures. Do not puncture or incinerate container. Loosen closure cautiously before opening. Do not expose to heat or store at temperature above 120*F (49 C). 4.8.5.4 Handling and Storage Glacial Acetic Acid freezes at 62 F (17C) forming hard lumps (hat may break carboy when moved. Store in area maintained above 62F (17*0. If frozen, thaw by care fully moving carboy to warm place. Keep dry and handle only in suitable equipment to prevent metallic contamination. Consult manufacturer. Keep container tightly closed; flush container clean before discarding. Keep drum in upright position. Do not roll drum on side. Keep away from heat. Keep away from adds and heat. Keep away from acids. Store in dry place. Never return unused HYDROGEN PEROXIDE to container. Dilute with plenty of water and discard. 4.8.S.4.1 Handling Use only dry, clean utensils In handling. While making solutions, add slowly to surface to avoid violent spattering. Do not attempt to loosen ot remove material from con tainer with any tool. Put nothing else in this container. When empty, rinse thoroughly with clean water before discarding. (Do not use this statement on returnable drums.) Handle under inert gas atmosphere in DRY equipment. Keep from freezing. Open container carefully and only in dry oxygen-free or inert atmosphere. Do not heat cylinders. When empty, drain thoroughly. REPLACE BUNGS SECURELY. (Use this statement only on returnable drums.) Avoid spillage and contact with moisture or combustibles. Do not use air pressure to transfer. AMERICAN NATIONAL STANDARD L129.1-1982 4.8.5.4.2 Storage Keep from contact with oxidizing materials, halogenated solvents, organic compounds containing reducible func tional groups, or aqueous ammonia. Solidifies at about * F ( *C1 and may break container. Store in moderately warm place. Keep from any possible contact with water. Do not allow water to get Into container because of violent reaction. Keep container tightly dosed and away from water or acids. Do not put in stoppered or closed container. Store in original vented container. Keep container tightly dosed. Do not store near . Store separately from, and avoid contact with, dehydrating agents and other materials. Store in cool dry place. Store in a cool place in original container and protect from direct sunlight. Keep container closed to prevent drying out. 4.8.6 Spillage. For additional statements of hazard, see Table 3. Sweep up spillage. Do not flush to sewer which may con tain acid. In case of spillage, keep wet and remove carefully. Clean up spillage immediately. Clean up spillage, flush with plenty of water, and remove contaminated articles. Spillage may cause fire. Do not get on floor. Sweep up and remove immediately. Dispose of according to local, state, and federal regulations. 4.8.7 Miscellaneous POISON with skull and crossbones vignette. Keep out of reach of children. (Consider for use on small containers) DO NOT HANDLE OR USE UNTIL SAFETY REGULA TIONS RECOMMENDED IN TECHNICAL BULLETIN NO. ` HAVE BEEN READ AND UNDER STOOD.*1 No known antidote. Treat symptomatically. Before using, read Material Safety Data Sheet.1 * Identify technical bulletin precisely. 1 Good hygiene practices may justify one or more precautionary measures without a statement of hazard on the label. 17 AP00008756 Appendixes ('rhM0 Appendixes are not a part of ANSI Z129.1-1982, but are included for Informational purposes Appendix A Illustrative Use of Precautionary Label Texts Al. General This appendix is included to illustrate the arrangements of the various elements of precautionary label texts, and sets forth suggested labels for those chemicals that present the specific hazard or hazards listed above each text. (See also Tables 1 and 3 and Section 4.) Product identification (name of product and/or hazardous com ponents) should be included on the label (see 33). A2. Labels for Chemicals with Single Hazards HAZARD: Highly Toxic by Ingestion DANGER! MAY BE FATAL 1F SWALLOWED Wash thoroughly after handling. POISON Call a Physician FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an unconscious person. m HAZARD: Highly Toxic by Inhalation DANGERI MAY BE FATAL IF INHALED Do not breathe (dust, mist, vapor, gas).* Keep container closed. Use only with adequate ventilation. POISON Call a Physician FIRST AID: If inhaled, remove to fresh air. If not breathing give artificial respiration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. `Select applicable word or words. IS AP00008757 HAZARD: Highly Toxic by Absorption DANGER1 MAY BE FATAL (F ABSORBED THROUGH SKIN Do not get in eyes, on skin, on clothing. Wash thoroughly after handling. POISON Call a Physician FIRST AID: In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.)t (Thoroughly clean shoes before reuse.lt APPENDIX HAZARD: Toxic by Ingestion WARNING! HARMFUL IF SWALLOWED Wash thoroughly after handling. FIRST AID: If swallowed, induce vomiting Immediately by giving two glasses of water and sticking finger down throat. Call a physician. Never give anything by mouth to an unconscious person. HAZARD: Toxic by Inhalation WARNING! HARMFUL IF INHALED Avoid breathing (dust, mist, vapor, gas.)* Keep container closed. Use with adequate ventilation. FIRST AID: If inhaled. remove to fresh air. If not breathing, give artificial respiration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. Call a physician. *Select applicable word or words. fUse phrase when appropriate. 19 AP00008758 APPENDIX HAZARD: Toxic by Absorption WARNING! HARMFUL IF ABSORBED THROUGH SKIN Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. FIRST AID: In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Call a physician. Wash clothing before reuse. (Destroy contaminated shoes.)+ (Thoroughly clean shoes before reuse.)t HAZARO: Corrosive, Eyes DANGER! CAUSES (SEVERE)t EYE BURNS Do not get in eyes. Avoid breathing (dust, vapor, mist, gas).* Keep container dosed. Use with adequate ventilation. Wash thoroughly after handling. FIRST AID: In case of contact, immediately flush eyes with plenty of water for at leasr 15 minutes. CaJJ a physician. HAZARD: Corrosive, Eye and Skin DANGER! CAUSES (SEVERE)t BURNS Do not get in eyes, on skin, on clothing. Avoid breathing (dust, mist, vapor, gas).* Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. FIRST AID: In case of contact, immediately flush eyes or skin with plenty of water for at least 1S minutes while removing contaminated clothing and shoes. Call a physician. Wash clothing before reuse. (Destroy contaminated shoes.)t (Thoroughly clean shoes before reuse.}t 'Select applicable word or words, fUse phrase when appropriate. 20 AP00008759 HAZARD: Irritant, Eye WARNING! CAUSES EYE IRRITATION Avoid contact with eyes. Wash thoroughly after handling, FIRST AID: In case of contact, immediately flush eves with plenty of water for at least 15 minutes. Call a physician. APPENDIX HAZARD: Irritant. Eye and Skin WARNING! CAUSES IRRITATION Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. FIRST AID: In case of contact immediately flush eyes with plenty of water for at least 15 minutes. Call a physician. Flush skin with water. (Wash clothing before reuse.)? HAZARD: Strong Sensitizer, Skin WARNING! MAY CAUSE ALLERGIC SKIN REACTION Avoid prolonged or repeated contact with skin. Wash thoroughly after handling. FIRST AID: In case of contact, immediately wash skin with soap and plenty of water. HAZARD: Strong Sensitizer, Lungs WARNING! MAY CAUSE ALLERGIC RESPIRATORY REACTION Avoid breathing (dust, mist, vapor, gas).* Keep container dosed. Use with adequate ventilation. *Select applicable word or words. tUae phrase when appropriate. 21 AP00008760 APPENDIX HAZARD: Physiologically Inert Vapor or Gas CAUTION! (VAPOR) (GAS)* REDUCES OXYGEN AVAILABLE FOR BREATHING Keep container closed. Use with adequate ventilation. Do not enter storage areas unless adequately ventilated. *Select applicable word or words. HAZARD: Extremely Flammable Liquid DANGER! EXTREMELY FLAMMABLE Keep away from heat, sparks, and flame. Keept container closed. Use with adequate ventilation. NOTE: See Table 2 for selection of appropriate fire-extinguishing statement. HAZARD: Flammable Liquid WARNING! FLAMMABLE Keep away from heat, sparks, and flame. Keep container closed. Use with adequate ventilation. NOTE: See Table 2 for selection of appropriate fire-extinguishing statement. HAZARD: .Flammable Solid WARNING! FLAMMABLE Keep away from heat, sparks, and flame. NOTE: Sec Table 2 for selection of appropriate flre-extlnguishing statement. AP00008761 HAZARD: Combustible Liquid CAUTION! COMBUSTIBLE Keep away from heat and flame. NOTE: See Table 2 for selection of appropriate fire-extinguishing statement. HAZARD: Pyrophoric Chemical DANGER! EXTREMELY FLAMMABLE CATCHES FIRE IF EXPOSED TO AIR Keep away from heat, sparks, and flame. Keep container closed. NOTE: See Table 2 for selection of appropriate fire<exttnguistiing statement. HAZARD: Strong Oxidizer DANGER! STRONG OXIDIZER CONTACT WITH OTHER MATERIAL MAY CAUSE FIRE Keep from contact with clothing and other combustible materials. Do not store near combustible materials. Store in tightly dosed container. Remove and wash contaminated clothing promptly. NOTE: See Table 2 for selection of appropriate fire-extinguishing statement. APPENDIX 23 AP00008762 APPENDIX A3. Labels for Chemicals with Multiple Hazards HAZARDS: Highly Toxic by Ingestion Highly Toxic by Inhalation DANGER! MAY BE FATAL IF SWALLOWED OR INHALED Do riot breathe (dust, vapor, mist, gas).* Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an un conscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration, prefer ably mouth-to-mouth. If breathing is difficult, give oxygen. HAZARDS: Highly Toxic by Ingestion Hi#\ly Toxic by Absorption DANGER! MAY BE FATAL IF SWALLOWED OR ABSORBED THROUGH SKIN Do not get in eyes, on skin, on clothing. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat Never give anything by mouth to an un conscious person. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.)t (Thoroughly clean shoes before reuse.lt Select applicable wotd ot voids. fUse phrase when appropriate. 24 AP00008763 APPENDIX HAZARDS: Highly Toxic by ingestion Toxic by Inhalation DANGER! MAY BE FATAL IF SWALLOWED HARMFUL IF INHALED Avoid breathing (dust, vapor, mist, gas}.* Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If swallowed, Induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an un* conscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration, prefer* ably mouth*to*nnouth. If breathing is difficult, give oxygen. HAZARDS: Highly Toxic by Ingestion Toxic by Absorption DANGER! MAY BE FATAL IF SWALLOWED HARMFUL IF ABSORBED THROUGH SKIN Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an un* conscious person. In ease of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.)t (Thoroughly clean shoes before reuse.)t Select applicable word or words. fUse phrase when appropriate. 25 AP00008764 APPENDIX HAZARDS: Highly Toxic by Inhalation Highly Toxic by Absorption DANGERI MAY BE FATAL IF INHALED OR ABSORBED THROUGH SKIN Do not breathe (dust, vapor, mist, gas).* Do not get in eyes, on skin, on clothing. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If inhaled, remove to fresh air. If not breathing, give artificial respiration, preferably moutfvto-mouth. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.)t (Thoroughly clean shoes before reuse.)t i HAZARDS: Highly Toxic by Inhalation Toxic by Ingestion DANGER! MAY BE FATAL IF INHALED HARMFUL IF SWALLOWED Do not breathe (dust, vapor, mist, gas).* Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If inhaled, remove to fresh air. If not breathing, give artificial respiration, preferably mouth-to-mouth. If breathing is difficult, Qive oxygen. If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an unconscious person. Select applicable word or words. fUse phrase when appropriate. 26 AP00008765 APPENDIX HAZARDS: Highly Toxic by Inhalation Toxic by Absorption DANGER! MAY BE FATAL !F INHALED HARMFUL IF ABSORBED THROUGH SKIN Do not breathe (dust, vapor, mist, gas).* Avoid contact with eyes, skin, and clothing. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If inhaled, remove to fresh air. If not breathing, give artificial respiration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. In ease of contact, immediately flush eyes or skin with plenty of water for at least IS minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.it (Thoroughly clean shoes before reuse.)t HAZARDS: Highly Toxic by Absorption Toxic by Ingestion DANGER! MAY BE FATAL IF ABSORBED THROUGH SKIN HARMFUL IF SWALLOWED Do not get in eyes, on skin, on clothing. Wash thoroughly after handling. POISON Call a Physician FIRST AID: In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes).t (Thoroughly dean shoes before reuse.)t If swallowed, induce vomiting'immediatsly by giving two glasses of water and sticking finger down throat Never give anything by mouth to an unconscious person. 'Select applicable word or words. tUse phrase when appropriate. 27 AP00008766 APPENDIX HAZARDS: Highly Toxic by Absorption Toxic by Inhalation DANGER1 MAY BE FATAL IF ABSORBED THROUGH SKIN HARMFUL IF INHALED Do not get in eyes, on skin, on clothing. Avoid breathing (dust, vapor, mist, gas)/ Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: In case of contact. Immediately flush eyes or skin with plenty of water for at least 16 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.lt (Thoroughly clean shoes before reuse.)t In Inhaled, remove to fresh air. If not breathing, give artificial respiration, prefer* ably mouth-to-mouth. If breathing is difficult, give oxygen. HAZARDS: Toxic by Ingestion Toxic by Inhalation WARNING! HARMFUL IF SWALLOWED OR INHALED Avoid breathing (dust, vapor, mist, gas).* Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down-throat Call a physician. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration, prefer ably mouth-to-mouth. If breathing is difficult, give oxygen. Call a physician. '"Select applicable word or words. fUse phrase when appropriate. 28 m AP00008767 APPENDIX HAZARDS: Toxic by Ingestion Toxic by Absorption WARNING! HARMFUL IF SWALLOWED OR ABSORBED THROUGH SKIN Avoid contact with eyes, skin, and ciothing. Wash thoroughly after handling. FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Call a physician. Never give anything by mouth to an unconscious person. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Call a physi cian. Wash clothing bafore reuse. (Destroy contaminated shoes.lt (Thoroughly clean shoes before reuse.lt HAZARDS: Toxic by Inhalation Toxic by Absorption WARNING! HARMFUL IF INHALED OR ABSORBED THROUGH SKIN Avoid breathing (dust, vapor, mist, gas).* Avoid contact with eyes, skin, and clothing. Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. FIRST AID: If Inhaled, remove to fresh air. If not breathing, give artificial respiration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. Call a physician. In ease of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Call a physi cian. Wash clothing before reuse. (Destroy contaminated shoes.lt (Thoroughly dean shoes before reuse.lt Select applicable word or words, fUse phrase when appropriate. 29 AP00008768 APPENDIX HAZARDS: Strong Sensitizer, Skin Strong Sensitizer, Lungs WARNING! MAY CAUSE ALLERGIC SKIN OR RESPIRATORY REACTION Avoid breathing (dust, vapor, mist, gas).* Avoid prolonged or repeated contact with skin. Keep container closed. Use with adequate ventilation. Wash thoroughlv after handling. FIRST AID: In case of contact, immediately wash skin with soap and plenty of water. HAZARDS: Highly Toxic by Ingestion Highly Toxic by Inhalation Highly Toxic by Absorption DANGER! MAY BE FATAL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN Do not breathe (dust, vapor, mist, gas).* Do not get in eyes, on skin, on clothing. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh atr. If not breathing, give artificial respiration, prefer* ably mouth-to*mouth. If breathing is difficult, give oxygen. in case of contact. Immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Call a physidan. Wash clothing before reuse. (Destroy contaminated shoes.lt (Thoroughly clean shoes before reuse.lt Select applicable word or words, fUse phrase when appropriate. 30 m AP00008769 APPENDIX HAZARDS: Highly Toxic by Ingestion Highly Toxic by Inhalation Toxic by Absorption DANGER! MAY BE FATAL IF SWALLOWED OR INHALED HARMFUL IF ABSORBED THROUGH SKIN Do not breathe (dust, vapor, mist gas).* Avoid contact with eyas, skin, and clothing. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration, prefer ably mouth-to-mouth. If breathing is difficult, give oxygen. In case of eonteet, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Calt a physi cian. Wash clothing before reuse. (Destroy contaminated shoes.) t (Thoroughly clean shoes before reuse.)t `Select applicable word or words, fUse phrase when appropriate. 31 AP00008770 APPENDIX HAZARDS: Highly Toxic by Ingestion Highly Toxic by Absorption Toxic by Inhalation DANGER! MAY BE FATAL IF SWALLOWED OR ABSORBED THROUGH SKIN HARMFUL IF INHALED Do not get in eyes, on skin, on clothing. Avoid breathing (dust, vapor, mist, gas).* Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. m poison yt* Call a Physician m yff FIRST AID: If swallowed, induce vomiting immediately oy giving two glasses of water and sticking finger down throat Never give anything by mouth to an un conscious person. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.lt (Thoroughly clean shoes before reuse.)t If Inhaled, remove to fresh air. If not breathing give artificial respiration, prefer ably mouth-to-mouth. If breathing is difficult, give oxygen. Select applicable word or words. fUse phrase when appropriate. m 32 AP00008771 APPENDIX HAZARDS: Highly Toxic by Ingestion Toxic by inhalation Toxic by Absorption DANGER! MAY BE FATAL IF SWALLOWED HARMFUL IF INHALED OR ABSORBED THROUGH SKIN Avoid breathing (dust, vapor, mist, gas).* Avoid contact with eyes, skin, and clothing. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an un conscious person. If inhaled, remove to fresh air. I f not breathing, give artificial respiration, prefer ably mouth-to-mouth. If breathing is difficult, give oxygen. In ease of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.) t (Thoroughly clean shoes before reuse.) t "Select applicable word or words. fUse phrase when appropriate. 33 AP00008772 APPENDIX HAZARDS: Highly Toxic by Inhalation Highly Toxic by Absorption Toxic by Ingestion DANGER! MAY BE FATAL IF INHALED OR ABSORBED THROUGH SKIN HARMFUL IF SWALLOWED Do not breathe (dust, vapor, mist, gas).* Do not get in eyes, on skin, on clothing. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If inhaled, remove to fresh air. If not breathing, give artificial respiration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. In ease of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash cloth ing before reuse. (Destroy contaminated shoes.)t (Thoroughly clean shoes before reuse.) t If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an unconscious person. "Select applicable word or words, fUse phrase when appropriate. 34- AP00008773 APPENDIX HAZARDS: Highly Toxic by Inhalation Toxic by Ingestion Toxic by Absorption DANGER! MAY BE FATAL IF INHALED HARMFUL IF SWALLOWED OR A8SORBED THROUGH SKIN Do not breathe (dust, vapor, mist, gas].* Avoid contact with eyes, skin, and clothing. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If inhaled, remove to fresh air. If not breathing, give artificial respiration, preferably mouth-to-mouth. If breathing is difficult, give oxygen. If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an unconscious person. In case of contact, immediately flush eyes or skin with plenty of water for at least IS minutes while removing contaminated clothing and shoes. Wash cloth* ing before reuse. (Destroy contaminated shoes.lt (Thoroughly clean shoes be fore reuse .)t `Select applicable word or words. fUse phrase when appropriate. 35 AP00008774 APPENDIX HAZARDS: Highly Toxic by Ingestion Highly Toxic by Absorption Toxic by Inhalation DANGER! MAY BE FATAL IF SWALLOWED OR ABSORBED THROUGH SKIN HARMFUL IF INHALED Do not get in eyes, on skin, on clothing. Avoid breathing (dust, vapor, mist, gas)/ Keep container dosed. Use with adequate ventilation. Wash thoroughly after handling. POISON Call a Physician FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat. Never give anything by mouth to an un conscious person. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. (Destroy contaminated shoes.)t (Thoroughly clean shoes before reuse.) t In inhaled, remove to fresh air. If not breathing, give artificial respiration, prefer ably mouth-to-mouth. If breathing is difficult give oxygen. HAZARDS: Toxic by Ingestion Toxic by Inhalation Toxic by Absorption WARNING! HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN Avoid breathing (dust, vapor, mist, gas)/ Avoid contact with eyes, skin, and clothing. Keep container dosed. Use with adequate ventilation. Wash thoroughly after handling. FIRST AID: If swallowed, induce vomiting immediately by giving two glasses of water and sticking finger down throat Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. if not breathing, give artificial respiration, prefer ably mouth-to-mouth. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Call a physi cian. Wash clothing before reuse. (Destroy contaminated shoes.)t (Thoroughly clean shoes before reuse.)t `Select applicable word or words. fUse phrase when appropriate. 36 i AP00008775 Appendix B Labeling Serious Chronic Hazards Bl. General Until definitions and test protocols for chronic effects are established, precautionary label texts for serious chronic effects should be used when there is generally accepted, well-established evidence that such serious chronic effects exist or when required by law. A chronic effect is an effect from exposure to a hazardous chemical resulting in either of the following: (1) A persistent illness or injury that develops over time from a single exposure (2) A persistent illness or injury that develops from prolonged or repeated exposure under conditions that would not produce the effect from a single exposure B2. Labeling Carcinogens When there is generally accepted, well-established evi dence that a chemical is known to cause cancer in humans, it should be labeled with the following state ments of hazard or equivalent:1 CANCER HAZARD OVEREXPOSURE MAV CREATE CANCER RISK CANCER SUSPECT AGENT (as required by government regulation) When there is generally accepted, well-established evidence that a chemical is known to cause cancer in animals and not known to cause cancer in humans, but where the animal data suggest that the chemicals would probably cause cancer in humans, it should be labeled with the following statements of hazard or equivalent: CANCER HAZARD BASED ON TESTS WITH LABORA TORY ANIMALS OVEREXPOSURE MAY CREATE CANCER RISK When there is generally accepted, well-established evidence that a chemical is known to cause cancer in animals, but not known to cause cancer in humans, it should be labeled with the following statements of ' hazard or equivalent: POSSIBLE CANCER HAZARD BASED ON TESTS WITH LABORATORY ANIMALS OVEREXPOSURE MAY CREATE CANCER RISK `When labeling regulated carcinogens, use CANCER-SUSPECT AGENTS or other statements of hazard as required by govern ment regulations. B3. Labeling Reproductive Toxicants When there is generally accepted, well-established evi dence that a chemical is known to be a reproductive toxicant, it should be labeled with the following state ment of hazard or equivalent: POSSIBLE REPRODUCTIVE HAZARD OVEREXPOSURE MAY CAUSE (FEMALE) (MALE)2 REPRODUCTIVE DISORDER(S)3 B4. Labeling Other Serious Chronic Effects When there is generally accepted, well-established evi dence that a chemical causes a serious chronic effect other than carcinogenicity or reproductive toxicity, the chemical should be labeled with one of the follow ing statements of hazard or equivalent: OVEREXPOSURE MAY CAUSE (specify the oiganfs)) DAMAGE3 OVEREXPOSURE MAY CAUSE (specify the diseases] >3 B5. Labeling Mixtures If a mixture contains more than one chemical capable of causing a serious chronic effect, the potential effects of each should be combined in one statement of hazard. B6. Signal Words Applicable to Serious Chrome Effects When a combination of acute and serious chronic ef fects exists for a chemical, the signal word required for the acute hazaros should be used. 1 Select applicable word. `Add the phrase. "BASED ON TEST WITH LABORATORY ANIMALS,if only animal data are available to substantiate the chronic effect. 37 AP00008776 APPENDIX B7. Precautionary Measures Applicable to Serious Chronic Effects Statements of hazard for serious chronic effects neces sarily require appropriate precautionary measures for avoidance of exposure. The precautionary measures shown in Table ! for-the most severe hazards of con tact, inhalation, and skin absorption should be used for protection against serious chronic effects. Additional useful precautionary measures may be found in 4.8. B8. Placement of Statements of Hazard for Serious Chronic Effects Statements of hazard for serious chronic effects should be placed after (below) any statements of hazard for which the signal word DANGER is required by 4.1 and before (above) any statement of hazard for which the signal words WARNING or CAUTION are required by 4.1. Statements of hazard for carcinogenicity or reproduc tive toxicity should be placed before (above) any statements of hazard pertaining to other serious chronic effects. HAZARDS: Known to Cause Cancer in Humans Irritant, Eye and Skin CANCER HAZARD OVEREXPOSURE MAY CREATE CANCER RISK WARN I NO I CAUSES IRRITATION Do not get in eyes, on skin, on clothing. Do not breathe (dust, vapor, mist, gas).* Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. FIRST AID*. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Call a physician. Flush skin with water. (Wash clothing be fore reuse.)t Select applicable word or words. tUse phrase when appropriate. 38 AP00008777 HAZARDS: Corrosive, Eye and Skin Known to Cause Cancer in Laboratory Animals but not Known to Cause Cancer in Humans APPENDIX DANGER! CAUSES BURNS POSSIBLE CANCER HAZARD BASED ON TESTS WITH LABORATORY ANIMALS OVEREXPOSURE MAY CREATE CANCER RISK Do not S^t in eyes, on skin, on clothing. Do not breathe (dust, vapor, mist, gas).* Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. FIRST AID: In ease of contact. Immediately flush eyes or skin with plenty of water for at least 16 minutes while removing contaminated clothing and shoes. Call a physician. Wash clothing before reuse. (Destroy contaminated shoes.lt (Thoroughly clean shoes before reuse.lt HAZARD: Known to Cause Cancer in Humans CANCER HAZARD OVeREXPOSUREMAYCREATe CANCER RISK Do not get in eyes, on skin, on clothing. Do not breathe (dust, vapor, mist, gas).* Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. HAZARD: Known to Cause Male Sterility in Humans REPRODUCTIVE HAZARD OVEREXPOSURE MAY CAUSE MALE REPRODUCTIVE DISORDER Do not get in eyes, on skin, on clothing. Do not breathe (dust, vapor, mist, gas).* Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. Select applicable word or words. tUse phrase when appropriate. 39 AP00008778