Document MoyVKJn3zg1bRrEGy7892MQoM
FILE NAME Quebec Asbestos Mining Association QAMA DATE 1950 Aug 25
DOC QAMA045
DOCUMENT DESCRIPTION Letter from Dr. Lanza to Drs Cartier & Smith from M Archive & Met Life
August 25 1950
Dear Doctors Cartier and Smiths
sumer
and
meet On the basis of our
-ccsessob. - a.
further study of the problem we should like to
a)
meet
the following for your consideration
It appears that there are two distinct ware in which which
secure & more accurate understanding of the possible carcino-
ve my
of these is an picsaiolo
genicity of asbestos The first
The second is
evaluation of present and past exposed populations
animal testing of suspected materials
With respect to the first of these that is the
epidemiological study it is suggested that before definite plans
are
made
the
value
of
such
a
study
be
determined
by
a
visit to of
Thetford and Asbestos at which time the available sources
information would be reviewed with you
The second part that is the animal testing program
has several phases As you know there is now no technic by which
with certainty evaluate the carcinogenicity of materials
we can tissue Exposure inhalation in cancer studies has not
for lung by extensively
and is at the moment of completely
employed The
Institute is at this time laying plans
for the establishment of a range progres involving a busis
that we inhalation of carcinogens of many various types A study based on
inhalation of asbestos fibres in our opinion must be done It is
believed however that this study would be most effective if it were
made a part of the larger program mentioned above which would be
designed to test the validity of the technics employed using a and a variety of species For these
variety
of
known
sarcinogmas will
be
in
a
better
position
to
suggest
croenacsroentse wpelabneslifeovre inhalation studies in three or four months than
;
YO 4ZO BOY
There is however in the animal testing progres the necessity for subjecting the materials to screening tests such
as implantation with embryonic lung tisme and intratracheal injection
studies can be considered as indispensable preliminaries to may
These
miterial since they might might very
inhalation study planned on the sume
a basis for selection of miterinis for use in the pore
well provide
elaborate inhalation -tudies
These the Institute could get under
vay any time after September 1st
Buch studies would involve explor tory implantation and
-
injection
of
a
group
of
materials
to
be
determined
jointly
using which
technics as now employed by Dr. William H. Baith Such a study
would include a number of materials would some to about 10,000.00
for a one year study Such a project would be carried out under a
contruct of the type enclosed
i epidemiological study be determined on the best of 0 visit to your
| pleats 2 that definite plans for an inhalation study be deferred
, 4
for
three or
four months
3
that
screening
studies
by
implantation
-i and injection be started immediately
\
a
Sincerely yours
A.J. Lausa M.D.
Chairman Institute of Industrial Medicine
Smal C.C.1
Mr. J. P. Woodard
NEW YORK UNIVERSITY MEDICAL MEDICAL CENTER
OF A POKA LAY LENTI
:
i
POST GRADUATE MEDICAL SCHOOL
* FIRST AVENUE NEW YORK
...
08 9.3200
DE DE DE AZTRIAL AZTRIAL WISCINE
)
Augast 75 1950
Dr. Ienneth Smith
Manville Comptay Asbestos Quebec Cresada
Dear Doctors Smith and Cartiers
te bsis of cur discussics
summer and further study of the probles v
the following for your considertim considertim
with yourselves this should like to suggest
epidemiological that there are two distinct ways in which
It appears
unerstanding of the porcible aurcing
ve my secure ^ 2074 scourite
of rabecton The first of there tz en
genicity
emittios
of
present
and
prat exposed
populations
The second sa
animal testing of suspected mterials mterials
before before to the first of these that t
With respect
definite plans
pidemiological story it is sstuupdryentbeeddettheartmined by a visit to
are
made
the
mile
of such at bulch
tize
the available sources of
Yoetford uni Asbestos
information information would be revieved with you
. The second part that is the enizal tLeescthailn^g' pbyrowghriacRh
5 several plast~
you kosov there ja pov do
of materials
with certainty evaluate the coreisogenicity
ve can
has not
Utrue Exposure by inhlation in cancer studies
for lun
completaly extensively employed
and
is
at
the
comment
of
yes been
Institute is at this time laying plans
uninov^ reliability The
lovehring a busie
for the establishment of a nage progrez cancer arising ty
investigation of technics for the study of lung
m 'rious tyres
A study based on
int litios litios of carcinogenfeiborfesmaniyn our optalis optalis ustbe done It is
inhalation of asbestos
would be most affective if it were
believed however that this study tentionm above which would be
nede a part of thethelavreglerlaiptryogrofez the technics employed using a
derigart to test
Lad = v riety of species for these
ene muccest variety of known entrino
sill be in a better position to
terecht terecht we believe that te
twiles in three or four months the
innlition innlition concrete plans for
VO ATE now
however There reasing however in the unital testing progrem
the arteriels
screaming tests such
the ancersity for mubiemsettrionngie lung tiscue and introtrichorl infection
implantation ** implantation
with
e
e
; , ;
.
oe
ee
e These studies can be ecmaidered as indispensable preliaimaries to say
inhalatico study pimaed on the same mat^,rtssince they night very vell provide a mais for se'sculis of materials for us in the more
alatorsta inhalation rules Rose the Institute could
under
after get en wy any time
September ist
.
eee
ee
Suck studias voni~ involve exploratory implantation ami
he injection of a group of materials to be determined jointly using
tecimies za nov mpicyed by Dr. #Lillaz b Saith Swen a study vidch
would include a number of materiais vould come to shout 10,000.00
for a co year study Such a project would be curried out under a
Cea snstruct of the type meiased In sumary 1 bement bement that the kilit ymy on
opidoiological study be determined on the sis of a visit to ym planta 2 that definite plass for an inhalaties sindy be deferred
incntiataly implantatim implantatim for three or four months 3 that screening studies by
or
and injection be started
ware Sincerely yours
oe
ap4#
fete XLARGA
CRmrED Chairman
:
Institute of Industrial Nudisine
wea
Os
e
++
AFL
te
.
ew Encl
C.C.1 M. J. P. Woodard
+
Or. P. Cartles
-