Document MojDx5p83eQonD0MDdqR8815M
AR226-2899
FOR DO FONT USE ONLY
4 E. I. i Font de NeBOura and Coapany
Haskell Laboratory for Toxicology and Industrial Medicine Elkton |load, Newark, Delaware 19711
HASKELL LABORATOR1f REPORT NO, 541-81
ftBHHBU
r 1 ^^^totcrlaiyiitea.^
Study Initiated/Completed
6/8/81 - 6/23/81
'
-TO^ Baikell No. [ -- r ^ ww^^^^^--^
^^Hyi^rProduets Department
ExDeirf^encal Station 353/318
11
i
1-
. ORAL LD50 TEST-IN'^S^
Procedure: The test aaeexial , ail an aqueous auapension, was ;- nistered by incragastric intubation in ai agle doaa to 6 gro^p? of 10 young adult Crl;CD*
nale rats. A Range Finding S tudy wan coaducted to'determine the initial dose level for the LD50 teat.** T ie surviving rats we're weighed and observed
during a 14-day recovery peri yd and then sacrificecl. The LD50 value was calculated froa the aortality data using the BetlBa of D. J. Pinney.***
Reaulta:
T
Dose
(ng/kg)
3,700
Average Body Weight (g)
251
Suspi insion (i !)
^0
Average Dose (BL)
2.32
Mortality
Ratio
10/10
LD50**** 2,196 mg/kg
3,000
240
40
1.80
5/10
2,500 2,000
. 241 243
^0
1.51
^0
2.43
6/10 5/10
1,500
236
1,000
241
^0
1.77
2JO
1.21
3/10 0/10
-
1 -
,
l
Company Sanitized. Does not contain r<t^^ ^
Clinical Signs:
it /tec and/or atained periaeal area, weakness, scained face and weight loss
all dose levels. Chronodacryorrhea at 3,700 and 2,500 mg/kg. Tremors c
3,700 ing/kg. Lacrimacion at :!,000 ag/kg. Congestion ac 2,500 ng/kg. Stained
underbody at 1,500 ag/kg. Lethargy at 3,700, 3,000 and 2,000 ag/kg.
Diarrhea at 1,000-2,500 ag/kg^ All death* occurred within 7 days after
dosing*
ay/kg of body weight.
is moderately coxic when administered
cs in single doses; its LD50 is 2,196
Clinical signs observed at most dose levels included: wet and/or stained perineal area, weakness, stained face, weight loss and diarrhea. All deaths occurred within 7 days jafter dosing.
*** ****
A Range Finding Study alhowed deaths occurring at 2,250 mg/kg when
administered at 670 andj2,250 mg/kg, 1 rat per dose level.
Finney, D. J., Probit Analysis3, rd Ed., 1971, Cambridge University
Press.
:
952 Confidence Limits;
Lower: topper:
Slope;
1804 ag/kg - 2652 Bg/kg
4.94
2 -
.CompanySanitized. Does not contain TSCA CB
^' ^'^C^- Report by; J^^L--7------John E. Henry / Technician
Reviewed by;
Study Director
o^^t AFpproved by:
>f. K------( <>
- 'W^id L. Rennedy^-J^.
Chief, Acute Investigations Section
JEH:jrg:WP:l2.6
J
Date laaued; September 23, 19(81
'Report No. 5A1-81
3 -
Pompany Sanitized. Does not contain TSCA CB?
