Document Mod7bGJGaD3ooBvJD7ZZmXe8x

Ir.dustr-.a. r.cr.,. ao,e. Measurements ":'>sc .n c ( . r .e r I'.'.tir. > oaf.y .r.v<*. ....s a*.*: :a . r. v constant from year t' year ar.d has varied :r*:v. place t- r.ace b<.rween i ar.d .- particies ? :c 100 microns iong anc at teas: tnree tirrei as .cr.c as they v/pr" '.vine' pc-r e.c. ci air. Chrys--.- tile was used predominant:*- in inn factory. but smail a mounts oi crocidolitt were also pro cessed at all relevant perices. Death rates have been reccrned for all the Hit men who were employed for at least <20 years in the scheduled areas since the first mar. ccmp:e:ed 2C1 years' exposure in 1916, and for tne 53c men and 220 women who were employed for at least 10 years in the scheduled areas but were never employed in these areas before I'il. The results show a substantially increased mortality :cr mer. who were exposed for 10 or more years before i,:,3; (48 deaths from all causes against 1 expected). The increased morta.lr. a-nonc these men can be accounted tor by ar. increased mortality from cancer the lung (.2 deaths against ! 2 expected) and from diseases of the respiratory and circulatory systems associated with asbes- tosis. Men employed before 1-35, but for less than 10 years, showed an increased mortality from lung cancer (5 deaths against 2-t expected), but no significant increase from other causes. Men and women who were exposed cr..y since January 1, - -33. have had a mortality experience close to the national average. Analysis of the trends ir. mortality shows 111 a decrease ir. mortality from lung cancer and other deaths associated with asbestosis with reduction in length of employment before >a53. and (2) an increase in mortality from lung cancer and other deaths without asbestosis with age. Twenty-three cases of lung cancer occurred in men who had been employed in the scheduled areas for at least 20 years. One was regarded as a pleural mesothelioma and the rest (approximately 18 in excess of expected) appear to have been ordinary bronchial carcinomas. Four other mesotheliomas have been diagnosed since 1963, all in men and women with less than 10 years' exposure, one with only seven months' exposure, and one in a man who had been employed In the scheduled areas only since 137. The results provide grounds for believing that the occupational hazard of bronchial carcinoma has been largely- eliminated, but the data are insufficient to estimate the extent of the risk which may remain. --Authors' abst. 80 Fibrous and Mineral Content of Cosmetic Talcum Products, L. J. Crallev. et al. Am. Ind. Hyg. Assn. J. 29, 350-354 (July-Aug, , 1968). With the exception of 4 of the 22 cosmetic talcum products analyzed, the levels of free silica, cobalt, nickel, chromium, and manganese were generally of a low magnitude and within a narrow range. It is not known whether the four products represent a significant proportion of sales in the industry or to what extent the sources of the talc ir. these four formulations are the same as sources of talc specified for use in other talcum products in the competitive market. The levels of silica, chromium, and nickel in these four products are sufficiently high, however, to be of concern in their potential to cause disease. All of the 22 talcum products analyzed have an appreciable fiber content, ranging from 8 to 301 by count of the total talcum particulates, ar.d averaging l9ro. The fibrous material was predominantly talc but probably contained minor amounts of tremolite, anthophyllite. and chrysotile as these are often present in fibrous talc mineral deposits. Cosmetic talcum products should be included as a source of the fibers, from which may be derived ferruginous bodies observed in the Lungs of humans. The meaning of the presence of these ferruginous bodies, however, is uncertain. Industry has the know-how to safely handle fibrous material as weil as toxic metals such as nickel, chromium, cobalt, and manganese once adequate criteria have beer, established. Unknown significant amounts of such materials in products that may be used without precautions may create ar. unsuspected problem. For this reason continued research ar.d investigations ar.d communication oi findings are neces sary ir. this area. There are 24 references. --Authors' conclusions 8 L Ferruginous Bodies ir. H.'.mar. Durrs. Prevalence a; Random .Autopsies. M D. Utld ,ar.. ?. Gross, ar.d?.. 7. P. ceTre-.-i-.e. Arch. Zr.viromv.er.ta. Ht-a.tr U7 l Z~ -12 5 (Seat. Reprints available frtm Industrial Kyriene Foundation, 3231 Centre Ave , Pittsburgh e s o:n- s a~t ir. o: . ' a_::;.ti,rs" 'err The v-iuncest su-:;ec: srr :Vrru.-::: era.lv more ab_rdar: :r. tr.s .ur.es :: -r.a.irr.ar.t cisoascat r-: .* a relative ecu.-.dar.ee rr.nr.- er.tral c:.-,. or ec : ores ir rt t: mer. and 2 sodies was a 24-vear-o.d .'.-man. r.tr b-dies v.-rre -" ` : men. Thiriv-t--o oatier.ts ir. this ;erie= had some apnarer.c assreiatior -.etwee.-, tr.e ma.irr.ar.cies ar.d the =. T tere wc.-c r-v- cases orinarv cam er ir r'r M