Document Mo68ekDbjGdXeaK5p3jGN3KM

Inter* organization Correspondence TO Dr. M.N. Johnson PfltOM D.W. Ward fllU) POINT ON AKRON BBPANTMEMT * MM, NO, Akron - D/0022 - B/5H nci-B POINT Oft AXAON OCPAATMSHT ft ILM. NO. 1 Avon Lake Technical Center usjkct Iota'' 2 Dermatitis Induced by Geon 130X17 \^RFCoodrich^' OATS YOUR CSTTSN ATS THIS LITTUI Sept. 19, 1973 In early May I discussed a problem with dermatitis from one of our never plastisol resins with Mr. E.B. Katzenmeyer. Later I sent samples and a description of the problem (Memo of 5/18/73). In more recent discussions, I learned that no testing has started and that the materials have been turned over to you. Will you please initiate some action to help us determine if a problem does indeed exist with this material or tell me how to proceed. My concern is with our external as well as internal liability since this is a standard production material used in an industry which traditionally considers plastisol resins innocuous. DWW: jms cc: F.E. Krause B.M.G. Zwlcker E.G. Schwaegerle E.B. Katzenmeyer D. W. Ward 23438017 RMH4 MCV. 11/TO UTHO. IN U.S.A. BFG25587 ...//* Am F. E. Krause D. W, Ward PICI.O fOIMT ON JIKHON DUAKTUIMT * BL0O. NO. Avon Lake Technical Center FIKLO POINT ON AKMH BCNAJtTMCNT KM. NO. Avon Lake Technical Center oatk tmm ucttkii 5-3-73 Dermatological Implications of Geon 130X17 Re our conversation yesterday, I called Wally Bachtel at Akron to find out what we need to do to check out our suspicion that Geon 130X17 is causing dermatitis in paste group personnel, Wally said that he would check with Dr, Johnson (who is Bill McCormick's interim replacement at the Medical Center), Ed Katzenmeyer or John Born and let me know how to proceed. Messrs, Katzenmeyer and Bom are industrial hygienists in Akron. Plastlsol technicians who have worked for a prolonged time with Geon 130X17 and Geon 130X17 plastisols have complained of peeling skin on their hands (especially the finger tips), Although there is no apparent lasting dermatological problem (the lesions seem to heal when exposure stops), we need to consider potential problems with dusting in our plants and in our customer plants and potential problems with plastlsol contact in our customer plants. I believe the first step should be parch tesMnp within our organization with* both plastlsol and dry resin. DWW/sp ce: E. G. Schwaegerle R. W. MacCuspie W. A, Bachtel S. C. Alten j&JL D. W, Ward 2343801Q IN) --i MV, |ir*l UrMO. IN BFG25588 .../m G.B. Katzenmeyer D.W. Ward PICIO POINT Off AKRON OCPAJtTMCKT O OLD*. NO, Akron, Dept. 0022 - Bldg. 5H F1KLD POINT Off AKRON OCffAffTMlfCT ft SIDO. NO, Avon Lake Technical Center Geon 130X17 - Dermatitis May 18, 1973 I'm sending you samples of Geon 130X17 resin and a Geon 130X17 plastlsol. The plastlsol Is a simple stir-in mix of 100 parts resin and 80 parts DOF. I've described the apparent skin problems which our technicians have from 130X17. This resin is a copolymer of 2.5% acrylic acid with vinyl chloride. Other than the co-monomer, 130X17 is very much like our FDA acceptable Geon 121. Our analysis shows that the finished Geon 130X17 con tains about 2.7% carboxyl as acrylic acid. There is less than 0.1% free poly acrylic acid or acrylic acid monomer removable by hot water washing Geon 130X17. The process of using Geon 130X17 involves dispersil% at room temperature in DOP or other plasticizer by means of a planetary type mixer. The dis persion is then spread on a substrate using common laboratory applicators and fused in a circulating air oven at 300 to 350F. Many tests such as viscosity are run on the liquid and we often handle rags, etc. wet with the liquid. After heating, a 130X17 film is formed (sample enclosed). We have much occasion to handle such films. Our operation is extremely clean relative to those in our customers' labs and especially relative to their plants. We have minimal exposure to resin dust during mixing and to contact with the wet plastlsol. We probably handle fused stock as much as our customers do. Since Geon 130X17 is going into plastlsol applications and since simple resin/DOP plastisols have for years been considered to be Innocuous, I think it is important that we find out if 130X17 is not Innocuous. If it is not, we should use appropriate handling techniques and we should at least warn our customers. As far as hazard in end use is concerned^ *his resin poses little problem since it is usually used as an adhesive between vinyl film and a substrate. 234380X9 DWW:jms cc: F.E. Krause B.M.G. Zwlcker E.G. Schwaegerle ftFQ-*CV, ll/W LJTMO. IN U.ft.A. D. W. Ward COMPANY CONFIDENTIAL BFG25589 GEON 130 X 17 RESIN AND PLASTISOL - HOMAN REPEATED INSULT PATCH TEST. There Is an error In my report to you dated 6/17/74. The first sentence, last paragraph on the first page should read: "Based on the incidence and severity of the reactions, Geon 130 X 17 resin and Geon 130 3C~17 plastisol would not be classified as a skin irritant, as normally defined." The word "not" was left out of this sentence. Please make the correction in your copy of the report. elc cc: F.E. Krause B.M.G. Zwicker E.G. Schwaergerle tf.C. Bachtel 23436020 m min *. unw. im u.*.a. BFG25590 MMKT GEON 130 X l? RESIN AND PLASTISOL - HUMAN REPEAT INSULT PATCH TESTS. Due to skin problems, thought to possibly be encountered by the technicians work ing with Geon 130 X 17, samples of Geon 130 X 17 resin and Geon 130 X 17 plastisol (80 phr OOP) were submitted to Industrial Bio-Test Laboratories for human repeated Insult patch tests. Fifty human female subjects (in general human female is more sensitive to irritants than males), 22 to 50 years of age, were employed in the simultaneous investigation of the test materials. The technique used was the standard human repeat insult patch tests calling for nine 24 hr. induction patches, followed by a two week rest before application of the 24 hour "challenge" patch. After removal of each 24 hour Induction, the skin was graded for irritation. After the 24 hour "challenge" patch was removed, the skin was observed and checked again at 24 and 48 hours for irritation. Approximately 0.03 ml of the plastisol or enough of the resin to form a thin layer on the gauze of an oval shaped adhesive patch was used. There were a total of seven reactions noted with Geon 130 X 17 resin during the induction period. Six of these occurred on the 8th application, the other on the 9th application. Of the seven reactions noted, five consisted only of very slight reddening of the skin, one in addition to very slight redding of the skin consisted of very slight edema. The remaining reaction was moderate reddening of the skin. On the "challenge" application five reactions were noted which all consisted of very slight reddening of the skin. Only one of these occurred on a subject who previously experienced a reaction. The Geon 130 X 17 plastisol produced a total of 25 reactions. Two subjects showed a reaction consisting of very slight reddening of the skin on the fifth application, most of the reactions occurred on the eight application, these consisted of very slight to mild reddening of the skin. There were two reactions on the "challenge" application which consisted of very slight redding of the skin, one of the subjects also had slight edema. It is interesting to note that of the twenty people Who had a reaction to the plastisol, eleven had also had a reaction to the resin. The incidence of reaction to the 450 induction patches of each material applied was 1.6Z for the resin and 5.6Z for the plastisol. arBased on the incidence and severity of the reactions* Geon 130 X 17 resin and Geon 130 X 17 plastisol wouldclassified as a skin irritant, as normally defined. However, these materials do show some slight irritating effects. One could expect, therefore, that there will be individuals.who may be sensitive to these materials particularly after prolonged contact. For these people, precautions should be IW * MV. II/* IITMS. IM U.6.A. BFG25591 23438021 2 AVON LAKE June 17, 1974 taken to avoid skin contact. Geon 130 X 17 resin and plastisol showed no evidence of skin sensitisation (l.e. allergenic response). elc cct F.E. Krause B.M.G. Zwicker E.G. Schvaergerle ~X.L' V.C. Bachtel 23438022 BFG25592 B.F.GQODRICH CHEMICAL COMPANY TECHNICAL REPORT ,'iri.e Geon 130 x 17 Skin Reactions AUTHOR LOC A TION D. W. Ward REQUESTED BY; LOCATION ALTC SUMMARY OATS 9 July 74 project no. 3032 All of the technicians in the Dispersions Group have complained of skin problems from working with Geon 130 x 17 plastlsols. The problem seems to be one of loss of layers of skin with discomfort coining from the increased sensitivity of the raw area. We asked the Akron Environmental Lab to have formal tests made to determine if Geon 130 x 17 was actually the culprit and if so how severe a problem existed. Their report is attached. It says, in essence, that Geon 130 x 17 is a slight irritant causing reddening and swelling in some subjects and the plastisol is more irri tating than the dry resin. Geon 130 x 17 is not a skin sensitizer. The formal tests at Industrial Bio.-Test were patch tests with little abrasion of the exposed skin area. As a result, skin reddening and swelling were mentioned but no skin loss. The technicians in our lab habitually remove plastisol from affected areas by wiping it off, then washing with soap and water, and they repeat this procedure many times a day. My opinion is that the acid resin acts like salicylic acid used to remove corns and callus tissue and that our different experience is a result of prolonged exposure and the abrasion of the affected skin area. Since neither the independent lab nor the dispersion technicians report any permanent damage, I feel that we can consider Geon 130 x 17 relatively innocuous on a short term basis. It is worth noting that 5% gels of Carbopol in deionized water produced the same type of reaction as Geon 130 x 17 in the Human Repeated In sult Patch Test and that Carbopol is used in many cosmetic formulations. D. W. Ward 23438023 - LOG BOOK REFERENCE: DISTRIBUTION! F.E. Krause J.A. TePas K.W, MacCusple B.M.G. Zwlcker E.G. Schwaegerle J. Kobylak BFS-tttlO 4/T1 L.B. Lydick W.H. Scott J.R. Russell B.K. Mikofalvy W.C. Bachtel GROUP FILE ACO> NO. 1937 BFG25593 PPMNTSO INU.I.A.