Document Mo4RZpnawbygaE2B8RE0QjOnz

FILE NAME: Saranac (SAR) DATE: 1949 Jan 31 DOC#: SAR001 DOCUMENT DESCRIPTION: Report by Saranac Lab - Asbestosis CONFIDENTIAL AS9XSTOS7S Jta&mtomHBr' ---- i * W i ? ,r , 'jOOVWNMENT EXHIBIT JU - o /2 I *yt 3 ?. Ifttrxluctiar 2 3. Asbooles Uixm'i.iS {L>* ? r . ****T^9 rT,;,* A rw oes I H t *"tt 5. txpm rizcr.iil Urtheir 0I0 6. Snoclo* S u sccrtib ilit *c 7* reult&r C .vr rK ri tiu o' Ajboitoc $ 6 . Soto of f is sun Fx*ction to Aobwtoa fibsr* 6 Aaboetoaia todlM _ 7 x /r- I. 7 A iM ^ ry 4 C 12. Austin; lltio ria l e 13. Pari uKpotivi'j*. 8 11. Duct ConwnTtrotion 0 15. ftasctlen in A nln.s * 16. Guiuto Tics 9 17. Bait i6 Type of Routlon 9 IB. 11VJ 'INCjOG ID IP. Info .Meat Saladdect v tih Dost lA a ltliw 10 Jafeetiaa after loot Zeholotle n .21 AObootosls 12 .22 Babbits 12 23. Bats K Sit. %m&Ff and ZsitsTEraiation 13 11 to 1L D uctile "5 te r iil U 4 I * Iwot -capor i *;... ir ' *o **. 4# H i: 29. Siae-iPocum r/ o f TYrt 15 30. Saartlon l i iniaair 15 31. Oulrp; ;<:* 15 I 32. ani lere 9f Reaction 15 I 3?. Fro.'yaBr.ep. 17 y*. J.BkMTUM.'O.l* OUU 1C II X ' Sa' 4'<* T/".- o.' IS 37. Sots 19 m A J Sato a.*--1Cre of raetl.-.i 19 37. r .v ..c" 19 ?* 1a RahMto 20 ir. Jtotn end Tyro of Reaction 20 fc3. Aabesteolo Dsdtoo 20 Ui. end I-ntmerprretatiotnm tc&Lt hM * a 1no Per Coni B all n litf. fluoUne Itetorl&l 21 float Oanpealtlevi 22 (!* fluol Concentration 22- Siso-ft-oqusmey e f Dost 23 11 X W V * A m 5C. friction lr /.nlttls SI. ChtLafta Vies tot** ird Ty;* of Etc.;tier. SI. 55. 57. 5fcr-4i *. 6C. 61. 62. 61. a. 65. S t. 67. 66. 69. 70. 71. 72. 73. Ifsph frde loralTonont M M noiia Eodios Hits and t&ea 'JwtiiC :tetcri*l Soft Coaposltlon B u t Ooneootriuon S'-so-ft-ogooue/ of Dus. froc tIon la Animls ouiuM ri^s 1st* md Typo of fraetloe ftrejrcttlor. Iffrh frdo HwelTBMDt U b n tM lt ftodloo cots Bsto and Type of frictio n Ifiy Oianros Koto Bata end Typ* of frietian 1? SS 1\ 23 2) 23 2L 21 2k 2k 25 86 26 26 26 27 27 *7 27 8 9 % % *3 30 m 71. 75. ta tr tad Ifr* ef Hoarticn 76. Sim cr/ end Interpr*;*4.-.ou U/lflly it.. kl?LSXI7T. 73. Intrtr":*eal b p c riw ita 79. Coawriaor. of Flbroaa and Hon-fibroua 90* Garofirloar. of f&rleaa Lc:vTflbtr BisU ftU Caapartaon of *.ag-4*br and Shcrt^flbor ftt9 8?. TFrpvewwi feparlaanta 83. Xotraporltenaal Z^nriaantc io t v / offiT* ravrfSitarra -- - * y f ft i r "*"i 95o P*Ua6lla AcView. cf ila eS o n &8pc*j3ds 96. Pcrsattan I Artoatoaia Itedlaa uxm L T rap ^o^g^urr icnai @9. Safest!cc $C. Oaoacptlb ility te W w w i?w> Tnfw ii. a 91. aMopUMlMy as Q et*4tibstvaiem Xofcsaia j^ S s iC :V Z) Si 31 31 3? 32 32 33 3ii 31 35 35 35 35 37 37 % 38 39 bo bs - n 7 2 -7 5 I ASfesateslo 13 c pslsstosy dlosdpa J f f tho inhalation of eabaatoo dost. in ia 13 cjism torioo I Molar fibroaie ttoieh {(o a ro to s v sn ^ j^ c a tk e : ur Irritatio n of ftho ftieaeo b? oohecftoo fibers* 6t , SFOQOtlOBJ eft'll. f3n>0 ^PO Palfl1 the load fitens prodyo* a ftftftral fiwrft^Mrho IT!1-- til11ft o trratv* of "* Silos teW* On fibers ia an essential Xbcftor> Ln th i raehaslra of irritation^ d-character ieU e Uoroo reopens* era - ~ n e ~ 6 f f - * * -- ) Ira of e^ostoo draft t o w M f dees raft alter ol&aLCLeontljr the' r 1 oBbraftopia badjr, Ul^|tobsreelrala isAAf'ia,arf -pl-*. ^ * r lo * opeeifii eoneoalUnt of adbeataalo and fwra of the u b si m fiber into the Ians, p-ceaol^ further a to tho U an 4 b 7 the fib er rad tins fa H alt [^0TCMlon of (M rat K 0 psftcstioo zsyLsn agaim t the Uaow irrita tio n o f aafcsatoo fiber* as It that of quarts porftlelo 2. if % 2. IntroducilBr, ii < ,*r- r of a rirjlttnr, firm proloncKi Liffyilo* tie s f asbestos te s t. Tuc t&nn i. V utos, lito re lly anbumable,* id aei th at o? a partieal&r tt-noral but it> * ter* typUod to a HfiufrUi o f filffsroert d n sralo t3v>oe c'.:araelerlrtie /haters is a strocturo w p in rt o f boaCt p**- a lla l, f l e ? S f i b e r s , Vnia etruelurt u veiqm boarna ilia fibers ar oopablo of ropoatod longitudinal subdivision to d*s of aolaeular proportions. In length tha floors vw / froa a fe r d e m o to six or aors Inches. Soot tssplotlss era d if f e r then others k it osny a r%o affleiaatlr fin d Ms to no span lrto Varr and oovcn oi Modified ta c tile mchinery. 3. ascortra Miranda Tio odbMtos ninorala ar silic ate s of variable oasyas lt inp and bsloaf to *.ho ccrpmUxa ani ttw asstiibels poepo. Li*ta*5 bVsr sro the aoro sbsbbb verioilae. Aschlbols Orcup kAtertrlllte (Ue> Pa) ailioato Acphibela V*g ID eilloaU (ctj, Hg, p, h 3 as* n) autaatn fru sllt# ( b , % ) nllflaato A rtin o lito O^oeidolito (Ca, a s, Pa) tdHeats (Sa, Po) ailioato <pp dH eato Cerwetlno Crop sycntila tfc dllea&o (fcjparesa) % AltAourJi M bastoiir i " uu i t a chronic d la i r \ ; c* recrarea J t w l o do^oUpi i t i i paaeibla to reproduce in ena cr corr opeeico of opiasi e ta ra te ri ^ i e tiaeuo ehai& t which er? o iid li? to t-ha lo tlrru 0/ buoan aaboatecl*. bi^cr tha lifb < 7psn o? the etiwriaMjial oriaal in raHatiwly abe?t i t lo Eat poaslbla to isTclap ttea chareetcriDtic Issltno in mlflclo order th r bwbQ la d v u io i coo* (JitUBSi @3Boa<|uoot5jff Wo obtain U |i<l9 CTi. il.Ujb oi* to# t l i n t r a p c u i to Inhaled jjartlealoto end fibrcao ca U rla l, i t is rossasexy to aoooSnrato the m o tio n by c^ifl^ine hishw oneontratlonfl o f deal than m id ordinarily In caesaatored in infeaiiry. T.fcilo perditiona f aaqpojwt are Una* d ifferen t, tto Inforaation yielded to*/ tcpwlaenta idbn aniaale in lom laiblo In fem iihlnc a hotter Esdcrstandinc o f the reaction of tha Iraun topmI n to inholod aaboetoa 5, io o ria tn U l fcthodo Fcr SseogUe&ttng ttea biolofiefll reaction of th* w p c rte n lal --tool to tha v erltas eobacteo cdnarcla, too typoa of toetalqo hero boon aaplopod, aaoaly, tha UsholoMca earthed and the injection aettiad. In Inhalation e p e rle e ite , peep* o f onleals 9 to 100 or asm fvlnaa pig and M antiew a a d la r oadwro of rdbblto, eato, d sp , rate or nlva - eto Sept fe r d p t b a n a dap la a cubical Asst retab d *t foot in dixaaalon, in ehieh a akrri o f owboetea doct i& m iatainai. &% isfrem&m to fc jj ttes eaperieeat, a fta m lm lo era aacriflaad ead ta& biotas ABEadcad to tta csttcro aatwit. o f tho dart rsaatlcae essitalo ore gCTfffirwl fer periodo ^ to iters peart* tha la ja e tic s ap arlaaeta, &a ** tha d a ft, a itie r 6 y cr a a p M la O sid, is tn rad M d Into Wo otfaoi tin jSatoEwcaoaj, SstssB^crltessal car istralrasStsal pseoadaro, era c&sttss? cr oat a ^ rtlecSsr dest Isa a pstaatAsl os^n&ty to praSaso fetiymr> pssabia. \ / * the synthstie fibsr* af *ol arjAfooty ir. tec lafijcdble to pus o u H j throuch the nose, ph*r/nx, traehcu And bronchi end stldon reaeh the terminal brenchiolas and alveo li. Inhaled partlcalato xattor cease to root thm-^hrut the ten d aal a ir opeoee (alveola? doct, s tria , alveoli) in d l parts of ths 1m m inhaled osbtotea fiber* era f ir s t rot&ioei in tsa respiratory eroneujoiBSo ffteot very s ta ll tubas am laM distaly d ista l to bronchioles lived by eiU atcd opdihalloa. fb slr n n w t l a l Mules 10 a lew Ubeidal type of splthcllea bat, as tfcslr itsao liy llo a, they actaally ftooetior. in reerlro^ion thrrwph la tera l alveoli given off os ponchos oleas tto ir vails* Cither tbsce pourdwo, or the abrupt ehsnga la tha abaraetor o f tho o p ltte llia , or tha daaraase in disaster of tha M b , ar portia^iii ths sMaefcion o f a ll throa nsetaro in responsible far k i.l reUsnUsa of the iohalsrt fiber* Only after eatosteslQ Is oll established re CCTroUblc KBbara of f lo boro carried Into the care peripheral a ir spaces. 0* isto of Tiaons Bsactlon to dSbortoe F ib re *b rato ef t&acuo reaction to asboetoo Is aaeh aoro ropiil then to cm eetive daaft Uha gaarta. Srldssioes ef tiroes rvspooso appear aa aeon aa fibers base ls w lliw l is n fA e ls it osaeaBtratlan la specific areas. 2d ra ts resolving cjtb--tao fibaro by IsVroleoota&l imjestloo th is evtdenco Is viribl** as ecrly es tw lo a lte r la&etlemj for quarts dost ths laten t period s i# it hs t o sar.ths sr f t s Mhsv&sr of tho Meets relation to iA elsd dost sftsr ths tessdM&lea of rngpoesaro Is set t&a esas la o&UsoeSs as la e& satesls. % Glli<MBl0e teas pae^ asAdea haana larpers Is tsfcastosiop poos sear ja y (* fsmsdpeaa- fspcste s s l tasesaa oso doso test tbo ares of Ic^oSseosot decreases la sirs'* Xf * c^aaearo to cafesotsa ficst 2o terstostga oftas* a brio f p rted 9 tbs pcrnit274cbals4 iai ~.~g wsua*-' atom by m arro* count o f 0*b edliior, far portlalaa proofes than 10 lierooo. Aftor fcto istalatlcn ocpsriiasit tod tow m tor ray 6w stoefc tm jmtgfi, tos o p tti o f t&a pjtaUE2 paddLs in tfca daatics Kadhlns tea iasreaced and ftr tfco w nalalag 9 cr 10 rootha of tbs opcrlesat eoasltoroo]? w ro g o t w s dispersal late w ateseptars. Awrc$o Cast eswfca Star iapiiyar cssptos csllo sito afto? tM s tea?* vsra 53.7 id llio n fbr tin nrar' UirhUfioM Bribed, end 1.6 Minitan fir partlela s larger tton ID r i o r a . l$ < Aw4^ra ta Inhaled "tloc'o floata* AgtoftosJhft. Baaolta af tto t r e t ig a iiw , briefly sam rissd la tto ls J, I t o to il lahalat i n ef Elsg'e flaatc asbestos dust predated a typ isal psrthraMMnlsr fibrosis 4a pigs but w t la rtobits or rata. l . Pulses fig s . Sorw groups of gainst pigs avrs #ed. In t t r p*w > the o ffact of a contl imbus and o f ao iaU cn ytsd dost tao studied) la too otter groups tee ralaoleeship bstMon iiT ca U n cal tz s l eyonrru aa inmostIgated. TH roaaiaiag fees groups vers la fs e tln esatrols 17. tote sad frem of toeetten. Ondnos pigs lifiallag Milo to st for paristo p t 32 eastte tortlapad a W w w tcrtatls ffJLtesoio eaesrriag la esidaol paUtos tosat tbs vaspinitevy t m eifclelii BarlEg i H cast raasticai feto flfe n u olaasafco rsaalfssd fffcafl e% feto d t e f arlglaal cad taro ea lfia dotested la to ZysphsU tosm, r --luj t o S o farads la too ospta m o toaarsto cwZsr tfiaa Safbstlcj craylfjsh&to t o piiiisnn After c apsaaM of eppradm laly a p w r, o B a ll castot o f pesaUea bad tosa predated toast easy rraplsafesiy ts^w abiato. a Ga*o Cad esa Is&aSto, fl& ccstAcasd to caszzaiato la tao em** Vw m* erd lefts? ctegeo o f 05a ^ wbmmi ( 1 ib m . tan lM T , of th*M tL tt fra* intorcw onv pncvaoMt. M a tty t* w eulto toto as follow * 1C m o iled seoe ewldsrve# of 0proid or tha toboroolmi* ppgcojgi la 6 of U ast i t <ot> cdufliod to tho Ib ii* and in Ha lU o f it ths efedea&nal viscera also va*ro Involved. Usually a Gllght local extension o f tho t<&nculoui Infection hod octvred hut subooqocnt hotline had re n ilM in fi* to ta ls *r bath the pulaanury lu elcrj srJi~:n ism:/!??? 1ro!*v in ether or**.3. Tho haalad polaanary lesions inraod oore flb/aoio than ir characteristic of eith er tuberculosis or odbeatesis alone. Ths 9 -- <"in Qhieh verr o tlU alive after too rears o f dost wpoauro ear* sa crifice d at icte rtsls darirj the following y**r. In it of thse the priotr/ foci o f infection had hoalod with fibrosis and eve?, calcificatio n and Uwro w ns Gvidanes of prep w i t i . In the other $ the tuberculous fool thtsed n U a m of 0 having previouslr sfraad locallyt in h of lh*s i t had haded, b f Uva tin s of w to p ar, with a m a tiv e fib ro sis1 In tbo ether arvlaal ttiero aos a (ansrollsod chronic tabereuloua pnousenia in one lo ts and isolated priaary tuborclas, ahieh vsurc s t i l l oetivo bat had not spread^ in the ether lobes. Brldonea o f oetooslon of the ln ftclio.i cm ft rot soon after 7 Booths of Cast inhalation) d v ia e tho nort 8) osnths asm than h alf of tha o d aals shceod m a c tiv e ly spEmdiia; tuLcrculooia and in 3 o f ihss n a i l e x v ltln had developed. Sur&ss tho loot 6 Booths as at&aala axhihlted m y w th w n of oetivo iafsetion dt& soah la h a lf e f then tho fcaalad fibrous s o n o f pw riw a n H r*ft e a m ah v is a s . S laty fo r east o f tha guinea pdgo d th opnadiag pdooenry tafesrealoaia utwmmil tehornriilimln c f tha epleon and liv s r . SO. Infoction Supsrtspoaod W*>n an isUMlohod U hootoals. lbalvs Guinea p&@2 dfher in k^Mag oobestoj duct t o ccc^ly 4 DsnthaBtcro located c&th ttbcralo cad thca paasved to cereal oir. ffeo sUSpifflurd tabaroloo fla t&j dasstsd wtiraSn varo n 1 ,,*T frtiwr-rgtf**..--- bo bbto amorous tSon in norndui^d controls, but a egeeldenbln a s te r so rt feead in tSs dsptw of tha lunj about feci of osbastsals. Tfca reaction to infta bles chesad en lj clight local cstsnsier. About tha e rlfirn l Bitoe is tha la g s esA tFoshsotecocbiel Sytph nodes. The aM odrul vieosra sore involved ia oelj c^3 c alm l. fiascatica tsas fbtaa In tubercl&a 1-1/3 seetho eld but b7 *1/2 osatha i t hcd ca^platol? dLe^pjnom), la&viiV' onl/ eoar tiw u a . Tbs la tte r o tiU persisted in the la st odffld, t&ich et_ kUled 1L esavta a lte r lafeetlsB) 21. ishostoBin Bodies. Moderate o u te rs ef adteeteela bedLao eeewred is tha leafs ef Uu fuisea jd fs, hew in g ear* oaenM* sad bops d istin ctly sepwnted in loUrr eonUo. 22. Babbits. Babbits safroaod tbs sdbostes dost te r ycrlada ep to 19 aeetftf developed los-frade fureign^odjr if.es wf rear lion W. s A breelo. lltKoufh lhair lane* eenUiaed pertloalate elaaorto e f bhs te st, flfcara scro art prssa-i, is tts e tia f that the tn -rr resyj r sUwy aotfartes of ts rdfabit is adequate to exels** fibrous iTsreifn bodies, tee rabblU i after latalias te s t fSr 6 sad IS osfltfcs, lived is tom al a ir for aare th is tea soars, fit catopjj s a ltte r osteal Mieaad aqr evitenet o f eallo lar raaeuen or fU roeto la tea U reia a l feroafetelcs car o p s there o r ssbaetoaia bodies. S3. Beta. 21 fibs ehito rate had aaqpirad ea tefeotlco, rm lb te s la the dpparastly, o essa hey atass abstracted iksdr W m M that vary fto fibers (309 gdQcrcd Used? la a fj. 2a o fo e c f r.*~> refiOf m a sb a e to io a^ay c&o diaa^ acd tat than cas e fib ro sis. 12K*y^T~ecc-arr 1L. s*t ftU nrttoH on P f J n h ^ l g L t o r i a s t with Mm i F la ts P u t, TVatOnn to>W spurtaani tth ttct'o f la t s dufl can bn a v - throo totdinft* A. Effect of the inhaled dual a w r a l a n ta ls. ftos Kim 's O m U a K r is tie prv'iWvirtrJolGr Hteresie in etcUva* pigs te t 894 in cefcfcito a* H.te?c3ia id not prop-osa aftor U* dost m poar* a s disc a t l a s t and too fftrfjnes pies tr a n s f m d Ut carnal Air* D. Iffset ef tla inhaled dust cm tdtor*~f p ia a M ie. la i*es fdcs 1- ftoetod lt* otUoocUd ttoerels u u d lli a d t i n plats* la lbs tost \ rasnl&e a r e o n furiibla then xs usual la a asperitnot i f this tree* ^ f a a idea cf^rcy s sinci in a t i e f t o a thsrs a s aiasae* of pregrosiiea nil* sobeequeat baslla*! la a s a l a l H a s a s a s t ln a * praSKssoisQ Os totto. la saotrast, unen galeae d a s, after being Infettod, are Mqmgjrfl t<o quarts instead ef sebistri dust, tho Inf ec tla a preeses eeetisue# t* p r e y e s cad e?cntaally aiiais tKs death of tfcs eadsels. flft tto fila r Sad, atp e a a e f Infected a t a la to a ta n lses d a i like ealslte er y p a n dess a t la d to e*gr p rasF w ia of toa infection, flnina ids* Inftetod eito dVsasWd teafesrola h*&m fOUadat toe toraln&tlem ef dfea& too f a n ' nrpaeru to afbato C zzi did a u Csvolcp ggeyaalse d la ssn .* f t s o l f w d lflarttw i f toe loftsstlna nag ia it s Isaali&e&ka* a fis tu c llll balm retained a toa fibrous tandaal teaafhieilea sad flossies ttoaelea ttaro la aidit&aa ts t o a o s l fee l taadta toe 2a v im e f Ma U iV toa s c^aag-Ttls a of dac&fes &3 I s to s s r a a t d ata** ffl/rrn CO to ttuj SaflEM Of tofeadESSt a c f too suspense aad toa B flo fteia tost daflnlto toa ososaa c f tobssataas fiafbstieii cro o s t jcstof&sd. 1 43- ^ '* - I2SSS9E3EBR Siess kosa^ so d o ts tote csv asst effeatlvo 1it psodmifiif flteo sia tSa iha portielw cfo 3 stareas osd Isca to elsa, ca lahalst& d oepcrlocBt taa essriod ea to detcralas chatter tten aud ition is in s also far adaitoo Coat, i t m a ttaasht tote 6y wine o d srtotfltar e& tatos date eonrtteln e lu te ca llrely o f f t o o p erile lsi o a lla r tten 3 tibovra oa b-- lernlad t la n s m y n sdfht to cs en adnaced raatetoo atoataad ia a d m lis a . fha pawlaoa Stitolatlea es^irieart vlth K iss'o flsato a d u to a , d is h oaettewd fStera I*** 1 eta. to 1 a&eron a* 1<wp In Xencth u w all aa a crate deal o f partisalato a d ta r cad d i d ypcdaaed a typical p rU reech lelar fU roela la <oqjnwm fainsa pigo, C'-iT^fd os a tesla of aa^arisas* $. $fes dcitjjac m U rlsl for th is ospsrisHBt oas ftamrdsd ftea tbs M&nrllba plate of the fcOrw tonm in Corporation. Zt mm tte n b Im a f Ltero caltestod la date lia s after o cardiac aporetlsa m d eeracasd to pass 900 and* 01c o tte GDterlol ca m aito d ocateiBsd m ay tool fib ers, to ss p m d la o tea t B&5UL to aetewgsjy p oatlacU y g&s. ca^ partdalao to 9 fiaraoa e? la d o o . aa ssd <to> la a fltoadspd So ttas v sM za t tola flstSpb&octe estaator? AfmA*4 to yrd to tte bspysg enid 2,t fcraaan Bsaoaffly to CM OQtoBB o f the gpeasd d t o tkrsa --s*"*-- c f tte dtood to faH toto o ctetadtetcry dote QjgTVSo S Cftdlttoa Cd? too arOU <psatdCy c grigpewni y|Opfftrfiy riyq wmffiws&ema&a t^ag?gg) & c s t e d tte o3 reteH o. wt3*&3jr tte o le ? tssste 'e? rtestlca tote c o d o to fcte lacs filters to too pfefcan oSteaa tte afisa f e u I f iKlfl flfp riam l do not jv w t '.e pelnt, 87. tto eoaBoaltlar of the ahart-fiber acbsotoa as w aived is dlesloced by tea ekselcal ea petrographic analytes glean la ftb ls fa/ ftaplea U tean ta f e n ce3 cfter gpiwiittj ylolAd shoot tfo ossa m inus ca em lytdo, Isafilcstlrv; V e t t w * w ** e^tcolnatlea ftw ths B ill or 1m s of M ter content. 10. Sha dost aenotatratlon varied aeocOtat during the anpariMBt aad ligh t fle K ecert-o <Vw trtmspwric asrgOaa eallaetad laalde tha animal a im ttth `tha impdj^vr ^paralus rnoipd frou S3 o illic r to 182 irilllsn . tha M anga ef oeonta g* 1)0 td lllo n for tte fir s t jeer e f tho catperlwrtl, SJfa adllllaB fo r U s rear sd IfaO mUllM far the third raar. 25o Clte-fnaa nancy BBasonaaants of ot $ ngnlflaatlon ef 1300X t ie las (fable 5). Ramrly 5^ parr om t sf the a frast i the e f Ana pm 33. foaeilan lr. Sntamls to labeled fta rU M b f iabaatea Beat, four irpenlaa ef m lw lfl guinea plga, ehita n te n t i and rabUte ears tend xjh th is aa^ariaant. ffca revolt* ef tha foot crp-joure, rtiiah are eaamarlaad in Eeblo 6, t i l l fes tm tiM stA aoro la d e ta il bale*. U Padnea P ig . gatowi fig s nsro erfgtoaMy plmaad la the to st real m i tsm sd teM M of . e f t&a S a tts fo tr a s ta il cr died m m m m iX S, a ffte totes Gassed fce to st for 80 %> 0 o S3. Bate aad 7 f ef foeetlan. Sto type of fetessa sessAlaB te the <r -15ami'ii 'iita^fflCTiwau' > h c rW ib tr tfbaatoc u am;M.iaUr 1ft* * " thAt tlm d y chwr t i ) la tha oKpcriaont rath War'a float* <ubfeU. Dm rata et m o tio n olxa cms appm i - cately tha aan bat the aartent of involvuaar.t with tha abort-fiber dbist u vary ess* k s s rad after 2A to 2t awtha of capoanre only a vary fo r aaall fact of m s tla n , whlrfi ganarolly raqairaO nlcroaeoplc airaalnation far detection, wwra predwoee la the ettirte* j.is <. Qtttll mfry-f Hfta bad aonlirwed C.r approriLaatoly a&o yoor, there wao l i t t l e tawto iey far dint nantatnlx phUoqrteR to eeUoet Into eluape* y turnbe tftMgwptea bod baron to co llect about tha walla of a fa t of tha respiratory breo- atdalaa with a lit t le proliforatlor. or in filtra tio n of iriiw-- aicilnar ealla la tbaae walla* Share won alaa aowe anltlttucUatad ealla but thay wara alwayv o f tha Im r t foreiisrfcodr tm * i t 22 to 2L cratha tha aeliu lar eliapa wore aasatiaao ^ site aarVH and msattaoa chanren in tha oplthallm rwaultad in tha adiw-- i Mira a err "odaneoateld* appanra&oa prarloualy daaeribad in fac t ion 17* In woat o f tha enhewapmt Bsatssre o f tha eerlea, tha raactloa reaalaad rel l al ar In type. Za a fgsr, hswwor, flbreus alaan ta dominated tha picture. In tha U tta r root, tha aoliaffOB was ja la in ealer and tenuous with no heavy ewUUn h y lfrla a ila u * da la tha rate daoerlbad balsa, tha alveolar walla a id it ha nada wp o f a Had of aUagcn sappertlas o layer of oplthollaa, but with ao aanfilnad aapIVaHan la tho tresaaebreaahUl lyaph aodaa the m o tio n woa aare praneansad la th is a ^ o 4 e a t tfe&a la tha { r s d s a oas vith king's floats adbaeteo, pmbably haaaaaa a f Who feTsaspotOoAiaa of ca enema of tie s partlelea to the aadaa la oatatls td u llm aheit f lb a aflbaatoa fe* -- Mt<. -- a -- n lirm rrr in raliailam . lalhai than o flfcw als, v ilh paaeon alien o f tha d g l c a l mStlo tateaaa tha tMehaaad cw tlw la r f l bara. Biffbaa dhrenio ploariay wltkowt cvidaaaa a f pdlanary lafaallaa c a fTcaent la o fa r caSaale. V t 33. 1 ; Wio iJ-j/*. aouUi* fo llo rirv tt*r (tm llo ; of 20 m tUm' i '-ann-' l* I'ur.t. prop*eaaioa o f diuu<, i net d tfu it* ^ dMxr.trttd tout' nolt. eralc U \# 4bluU3jr ilfp fm d , rin| to tki n r l'* liilitjr of tho rcot*nc in difi'oront. .--.JwLo. At Wts end of Wt duet a v a m t t f fO eaaUia too pi^o owo retd ea o end e v ta t* , Moaj tko SJ'pem sd fpcaa fa rt ts fiw atny oro vfi^eh\pi In J? the ro&etlca $5 U i b U M j Sa 3 at CCS > 1 m J fit oat ij and fin eno enlaal fit caa f t ia f d to ttto lk lo fife* Vimo p iw Wa c m o ^ c J cksutca lesd da^alepdl aesfa resstlca than t3 resatiw do* ^ t&a tfiea aqraasaa eracad. G ian Ike esto wnBm "fatotoM t aar v i ^tr> dlreH ;' end boro co rolatlerahip U tbo loaclb o f U t> tfW r rataatto i of eqw- ms tAo diffrsnu3 tana oltilbju*d i t W U U a fit IkdlfMhil tm p tlttlllp * VMq vlc?ar resolved eurr*** f m to Moale&L an alftat flafcla 7J t ilt h ofu*. f> '.ealrd eoapcrabl: BBtp of ofih and H it* la la tfo v lth vtd tIf O lfla re a e m e u cl tie s ta tntnrv. f- smkjwo to ca> td e filiu trtlw u t a r t qulio eU U ar t v Ul*o* nlm 'js n rust ; aonvt ,t t*mt in t a i l nil mmImo, r* Ho Li- cr;r ro aetia fta* pro a 'v.i >*. i, fee anaViar, oj M l ftar ta t th ird , M.1,* 3'.. ^ssaevasla Sadlct. ?v- M hM U ai neditt tat fit fir s t t- vrr? pops ofcsrt trol; lis ite d . A.*Ur 5 BSBtha' fap u rn i tl/ ecu10 bo fto sf ocsrJJjr im ld t of c a lls . druEd tfca ffiaart IfiiraeellulA r parUelfa to: dofaaltc tartar tto M td s ? 00 tka aotesttoala bo^r. D^oovne o f cjt ysa* hod psm lttod ea aeweafiAklm o f Bca& b n p r ffitero xbiv*JLth t^.a *sSts3tsafi4it07 coeUuf; d f ttb f o l. ta& o f t tn o vse^a etlU c fw t crata^. to to 27%cJy e r oatlrafijf ltk&a ffMawiijIli'ii a ^ L ). Cy Iks *dh o a t* or * *?ftafVsQ, t o y o p t caparadvafi^ m ayw B o&ttaqft to r n r b q 2j> er^portoco vim thr &a Uo fifiax'o fXcakg aq^onant. 17 Dr* 3$. ffM ti Rato. 3or*BtjMhara tfrilt* rot* trar ecposad to eteMpberle o tw tfibor asbestos dust ftr ported* op to 32 sailha. iacrt gaping the f ir s t 10 aoaths w ro a d c tdaonthl? end te r U rm tlM * of the a p artaaat at Isos ^eqwtat iut^ryaU. $6* Rato pad Trr* of 2oactlos. The dsac a lio tsrtil 6 norths iwro vide!/ pcsttorad cad codsted la Ibel coir oparail- eaUy. leeeHea to m ilaM L l ollgtit thLehsadtaga d the aejsta abort of dart c o lls, la a Sm vets at 10 oontho, there w a aof- orlx fibraalo hot ^ ebaago act ao ollgrt that &t mold jWhtblr ha aithoel the a la ? o f ia d c a lls to attract attvtLaa to U a a m . Od? 10 ad jo in dpecei firm 12 to Jf norths, ia coot af that the loan of mllrio^nif fibres!e dUtrlbotad U h that of actod oo ia ta t vlthort cdoctac&o bodies. Tha Ladens, risib le oalj i t ggrtflcotton i f 150 dlsastan or noro, oomlotoi o f fsAclwc alon* drooler ioetc ia th&ah tho to lls c f tea d r 090000 aasa f o r UtLok, i a a oaollm a lla c a firawoork. Ce'nertlvo l a 7 tod lo a llr Ortrtia t a oollaca ano a thia lapor of epithelial calls # fela did tflt w n a ib the Ndmeateid" d o nga rtarartarlnltr a gdaco jig tsstoo&o. f t ylaarior d o froeont. Saar tho laainnc tho d r ogoaa aero fille d ttth ghWMgtaf ooBkhtadag p a? ta yd la o p p tisd a to tart a d a m o long u M do tsa tnnrtr,stirmrill nil taritea d m i a g o i h o d m U m Kcsi o f aaa qptlo aefils at 13 n h a a d t t GOo o tla , a n llflta a ttU ta h g of tho eaSiaflatt. So a fisa cc&s thw o a icfirtfta CteeaSa olaog the aargim o f tho ga> /gsa'gs&radawg fieSa radcaM sal esaoto tlacoo. toogarad i t t tso vwpmm C3 estfico <Ssa&3 Mhw gao^ta ot2 chart Cfcs poaotlen gbsr&^&fear cdtactsa a s cagldiiH oo -1 5 - tesuT.* of cbrrlc.J, a*j ri i ' 1 j*>v}*o w*vit* rc.tr urr fivcn In Tibia 8 end ths fd rife valued h*"'' tabulatti In Tikla f fhr ccatartsai with s ls lla r values tor ra ti iz^-alir.* other dusts. lb t concentration of atsovpbfflfi particles to vhldi Vfcr mro exposed ma approadnaWly the m ss to rteofcwte3 cad quarts; fop the gypses*quarts $dztvrc, i t m* about Ivies ee hirh end fOr ehrrt fis o < &3 Lifh. It r i l l b? th tt t v ???esatafftft fo r cehsotea era leeor thca fe r quarto or ehtrt bstf. c v o ia ilrr tc them to r the cjrfom qu*te d x te re , in efcleh etoDsphorxe ar.fjiotinatiOB leaded to io Ium Utt inowit o f dart Ssftoled. St Bd|bt bs inferred that the to ta l qaa&tity o f asbestos dust inhaled uw Iso cr that i t had tom olinlnated froar or dissolved elth in tea I m p . 2c tte p m aet ctata o f oar tasaalodgs cvslM tlon o f them hypotheses is eat ynoslhls. 37, Cate, ftrartty eets w v ** In this lrhsletloo eperinset uith the efeorb-flbsr ooheatos. Eighteen mre hspl in the dual rooa u t i l dsoih tfc cqpaawM period renting ftrea aao uonth to aasrty lb i/i p a r t , ead too# after a dtft of 3)- 1/2 *ere rw w itl to norml a ir . One o f these tsas aaerifteod %Boatho, and the other & aeotho, lo to r . J6. la ta aod free e f Bosctioa. B e m o tio s m s essen tially that to m Inert dart, area a fte r nor* then fc p e n e f a p e - t oaroe fho tissue seopmae la this speeles m s oshflnod to titosooopls to d cf j&tassia la tfeo m ala c f o f eabplwral a lv e o li, mtfcsr thee la Ids p srl- t^aaialala? cress* & ess the c h a p m s actaM&ve a a o p to ho v ita lis e d a p uco o f the csst&on. SPo jM ^Q agges. ^ cedsol tilth tbs Impest wthbiii i did the reveal Oeflmitcfly ehrnm il shedsm. d ftar 85*3/1 ftpwSiwa tho p&6tSBO VB3 t3S08tltO| Ofto* J# r~^a**ga G firiat fS ttllS g CCdM ta Qj353j^eat fcstei lo g s . At aa&opsy, 0 earths t&aro too caly depcasspie IZ3!.n,ir-fl^ , ......... " ............................ I r * fibroeia L-i the r.rnleur*'. so?.:* p3y< .'v.y I^v-^cr/tic ia fJlt-atlo n about aw ll bronchio les. I 2:0. AcboutftH* Bodfrs* Or. tro' mrad eraroh a fe* jrallse atypua'l Aobeetwrlf b riic ;, cav^b end without haustMtiono, w c fbttod i tro crim la caposci fr* enr- t.v* n y^cr. Id . Rcbblta. Elftht rabbits -aero arpocad hs dart for pariads osWadlng trot. oae to coro than f ir s psara. fha last l a l a u waved fra tha dual roes and lo ft la earaa?. a ir 6 aoatba bafare balaf aaarlflead. k2 Bata and free of Eaaetloo. thara aoe aarcr aooa|t flbroaia to ba da* Uctod graadly and tbtrs m bo ekrtrir oihailvop3ourUr Hicreacepie orli-nee of alveolar e a ll u fl/a t daUctad After iboat 3 jpaore of oepnerro and a n a w la A ll five "<<-- minad fearaaftar* Za cat a a L * l t!**t died * f psralydfi after Beer)* fw r poosra tb> w stlO B ma ttU n d ra eaoach to be rirdble on froao lnopactico of tlaaae eoeticne. w poeatbUUy of pabaoaary Infbstieo la tblo OBtaal eeold aert ho ceaiadad. Is o m r, la aaother aolM l dpiag too p are later the f0Al flbroaxi usa yot naorly as ebrlous or aa advanced. Araa i o f Is t t lw a s t j atdah war* Jtopaly viflealiesd baoaaM of yhapoeytle ranrtlnr altfcla the A ir Apeem, tAdtd rOmratiffli^MlV to beane aero Obroaa < th tha pawafo a f lia r bat there aao w w aeah lanraairtaiHi it ppaa the loncn af a ir apaeaa aad tha enfclteslBM of the cdmlWi thet tad feesa bedtoa aero tart dateeted la rabbits btat died early la tha aqpeaiaBfflt bet aero la nil ts tha dost ter acre thoa ihnso pears. -do* t*m*jrr ae Ipt'irprrtiftipn. 0 She art fin al jvrpoar, or to? erjv rin n * m s to ovalsato tfcc ebealeal to ea y e tha patVcoiccia o.' asheoiocis. I t oo f a it that i f tho tlsaus tloo to eabaatoo taco ehaoiatl la crl& n ca aeoalsrstod or ooaouluoto woaLS rooult troa c tpoourr to fin d y -d l'id c i aotostoo, so la tho e w with quarts. Thio ccparlaent, la toloh the rosettes w s olooar and lass OKisnlvo than ttto Siax o flo at*, ixrfleat&s tbrt tiw raaetioa i* not p rln rlly ohcnieal la l/ aatoro. Of tho floor opodoo arpoocc in ttdo aopanunot N l f tho (tin s* p ic tad ra t roarlorT r ilb characteristic poribrrr.ehidltr fib ro sis. the oat m ated with atypical ootoptoercl fU roaia aad la too rabbit tho fib ro sis fideh w w rrr i could Bet bo pool*tool/ attributed to Uw uui I m w m T a abroad p ossib ility of M a n o r? lnfoetleo. ip ^ s p !^ i2 t Xa too Inhalation oxperinnt with afcort-flbar duet a quantity f aurmriri adbsfteo was aland o ito froand aatarlal la order to prodsoa a ouitabl* f ia t clood. t o n orldonoo of a dost r s a e tln qjpaanod la too pdaoa plgo dnriaf C a omportantti i t was wot clear whether th is vac a tiaooo rwopnnai to tho aoall ffia&ar e f Laos O tero la too n r w r i aSbsotoo or woo a doliyort a ffca t of too aoro dtoalcst f i n dost* C fisseqnU y, soattor id o la t ia i aoportaoBt vac started la ` tfib fi eo inaeroaal a sta ria l was u n i* B 8 b dvattog aotorlal taa too p u d ohorW lbtr a b a ter oood la too pcvles* faftpiUatlCT g p jrim rl Cat ra tapw nd aatarlal woo alaod oito 1&9* ebtoia a caiLdcal e m a t of c a o o |ta rle f ia t, toe daoi*n of too darttae s^oretao choasad to on opaa typo c fcsjqssr **** flrafii dost css daily. CMn.* to tho tend:.:-.j* ' t: tc f a i o r J l st-i-'.J*s n .irh prevontod mch of t> fibrous p : l:J" fror fica* in.; ov*. of th* hopjtr, th* dia^oroal of the dust vac sot cr.tirol;' ua'Jafaetcry nr.:* f.rU : ? omtha of operation, tho dust ing m ehiat cas racor.crtrO to its cri^irvil di .<71. To provont Spilling * or tho fcreation of etherulos of r j- 8to*, ctr.el viro bruchss *a?o a tt a c h to tho io - ddo surface of the hopor and to the rotating saddle. This n rraarw n t row eatIj foelory romJ.tr and - acd for tho resainlr.- 21 e^nths of the erp srisrct. Ii7. The coB-osj cior. o f tho rv notorial {shert-fibnr asbostos) and of ataaspherfc duM liberated f r t i the b*llcillld product in tho dusting Bo chins le pivon in Table 10, T.taac values are bated upon potropraph-e study and Jt-rv diffraction analysis. Th: atnccphorle ox^rlc vac celleettd udth an elec tro sta tic prorioitatev a lter a irs bruehas had bean installed in ths dusting aehlM. Previous to thin., tho c.j'/sctilc- content af tluc air-iusponded m terio!. M w^oubtedly less than the IS' per cent value fi-a i' In Table If). In an 1uter is; report, it *ta state! that the tir-h orr: dust err* ; i **4 abcut 5 par er-.t or etffTBotilo boforo thr wire brashes w r t uaad u d up to par cent aftcnaardi, but these values vers TTCbevl;' la v. OrnsrHUMv* >trim*too o" b a ll-a llie d esbeatot dust a y la eoacvU&t iraecurate beeauso i t in d iffic u lt to datersiBo brw aa:h of & dust sanpla in fibrous ohrjnsotDe and her mtch is nan-fibrous serpentina. bS. She duet ooncontratAen fo r the f ir s t ? eedthe ef tbo es,w isnt van dbeVt SCO perticloe per euhlo foot ef air* After the vira (gratae bed teen installed, the duet eouefca vwo a lit t le higher and the e m a il range ft? tha f ir s t jnaar v u 106 n111inn. Sta cvmroco e f counts fer the second j^ssr oaal3 end for ths th ird poor IL5 H illinn.  4 9 1$. 5Sc slio-rroj.;. of t'.e ecsrr.rant* o1 ataaspheric dual collected laaJdb th* -mlr il te `*s *1'- the elactnoatitic apparatus la reported In table U* teo are *1m r:rc uiten, ora baforo the t>irc brashes ver Installed end one after. Zt d l l bo rote! th at oA ar the vir* ferr.ehee oro in oh a greater ^oportion of vary fir# particles end alto of lenjor fibers * u released Into the a ir. $0. laaetion in AnlasL: to Inhaled IX Par Cent Ballhllled lab--toe Imat. Oolites pigs, rate and aleo vaso tnad In tin lsfcaletiec aarerlaant vltfc tho I X par oont Uall-olUcd eabootos dost. fho raaults aro euaenrlaed la Table 12. SU ri* e . fha acparlaaot oss started d th 100 p iM i pdg. Aa tha dust asporire pvooaadad, thart vara 39 aeddental deaths, 32 of puwfcwHtA in an epldraie. After 28 sonth* of dostInf tha 16 tu rrlrln f gtdaaa pigs w e tranafn-red te naraal a ir. $2. late and Type of Haaciiop. For tha f ir s t fear of aapaaara practically tha s e lf raartlon to tha dast aas tha yra- Sanaa af scattered phagocytes and an eeoadsoil d a rts aabastesla body* At 16 cad >0 w rths cs gross response ma v isib le an tha tiaaoa aaetian bat d eiesesp ia allj garlhreoehlalar fe d of irflfanatinry s a ils aould ha aaan. At 2b santha there aas m i l oe change lares aaough to ha scan d th a hand laaa althoafr dereeeopie rvoealad i^a.iat.^e.s<Twiiwe mat tcradsal hroMhialas n d sany era aShaeteeld M is s , ch isflr vith ia a a lla . ftv d iii) aaalysae of tha fangs (Tibia 13) repeal that la spite af tha j United Ueses reaaUaa esoldsm blo dust ted teen rd d m d la the fang. | t i ^3* --'tea Sadie n 53. rofT**r.lor,. V.x lunfs e.' anLualc exposed for the fu ll dotting period C?f ***.he) and than livin g in narasl a ir tor 2 asnths re/eel* j Un changes described ebmo end alee very alight peribronchiolar fibro s is , After 8 mentha in noreal oil* tho fin d in g ear* e lc ila r bat at 12 sooth* 3 o f It an lm li ebsved groaolr-*lsIM ehereeterlatie porltreachlolar flbroela eivb ademmtoid change. f t . lertrh Bode lntolvosont. fh* traobwbirenchlal node* ear* eeeantlally negative w ill mpootro had baaa asntlmad to r mro than year and a h alf, Aaiaal* oscrlfLeed it 12 aentha and 2d aMtha revealed a tm adnata eellactiooa of phagocytes containing partlelea bat praoU o ally so fibers large vwugfc to be recogBlsed aa eoeh. After 20 oooths *f og aag e msff aaaeqpteo fllla d alth ftlla v g r la o ear* present. At 30 oath* there had beer, e flig h t lacreeae la reticu lar bet ae flb reala. he fhrthar Chang** occurred la the aetae. Aabwtode bodlee ere net eeea la the aaiet af ooj ef the guima pigs. 55. ASbaataela hedlea. KLarto oabeateel* bodlee a m Observed aa earl/ > ) loathe e fU r capooure began, but they did net be- sa a e r w instil 16 asath* tad elapood. fbo badlee ag o eh a* a d praeU cellr eH ear l*5paeellalar, eltheagh at 20 aantha aaoa eare laag aaeagh te frsje e t St la lu ir t aat to iaanmsc la the oi that after that la the la te r a-- tig e f ^ iiiw ri thmo sm a ef lam fibers te TO ato m s la laagU^la the ehorecterlatle lam 9S. S t k J lt o end Idea. & thia oB^arlaaat feO rate tore tip to SO moths ead f t e&gte r fc? periade to 22 .'M a fia < B E -- . nontha. Hoitfccr species dev-^rred <r/s\ a svrresUon i f caboetoais and reaction < u lislta d to ehacoevtosis of irJnlad p jrtisla s b; *ldslv*acattafad dust ealla ehleh renaiatd frea in d r ap'xcs or ware transported tr tha tracheobronchial Ipp h sodas. So cabastoaio bodies ware found in tho rats tu t In tha aiea tbero w vo e vot7 fa* o sU l non-haostraUd fares vlthin phagocytes. Zn Ti. notes lcsc* saetiwwd thrre *er J I v i n w of pnlaonarr crtaooaa (lh<), 57, tm e* -7 and Interpretation. The rearti on* ebaanred in th is asparleant ware aueh la st crtaDsira w d tlasrer in dm lopoant than in tha pro?lews lnrastlgatlon with Short-fiber tfbaatea. Since praco&ably thara wore faoar fibers longer than 3 adcrena in the m terio l oaad In th is trperiaont, U* results tsni to eonfira tha interpretation wx in Section tL m* the ehn-t-^ber wy r im nt that tha r--f t Ion ycM H jr la act jrlaaarlly tfttrelOAl in nature. Tha flndinr of lane asbaatoali bodioo in anisala irhalin - tha ballnKLllad tsta rln l io an osaaplo o f tna d iffic u lty of ooaplatoly ellalrw tln i long fibara free an aabaotos preparation. Zn regard to prc\,ruaio<i of reaction aftar rcavrsl fro s dust, tolsh was *b- earood in thio eaparleant bat not in the others, the folloeiac interpretation is efftrudt Wien the reaction is woil-deNnlopod at tha U m iration a f aapoave,tha eanterectlea af tha flbroan tiesua would obscure any passible fuwgreaaiciv. Xa this aapariaact, bsawrar, aijsa only tho ea rliest aiage a f raarttan waa yreoeat e t tha tia a o f r T r ia l fires S a t , lto cuboeqssnt procraes caa apparent. St should ba aatai that tha dagreo ef propeaoicn was eo d i g i t that i t can hare l i t t l e , i f cssy, p e s tte s l oicydCteanw. -25 - o fH T| 13 a illlo a . Ererinnt *n ef Un iopLvar aasplas with dark fluid illu a la atian dlseleari that m y fir* psrtielco less than eat rieren is sit* oeoeapaaled the larger p articlot and dark field counts wore, oo the sw a g s, about 5 or 6 tiy y i lar ger than ths li it field counts* 62, Ths alao-froqrmcy e2 oteospherle caaplm* uf tbe lo n cd b er asbaeUw Cast ta t ef ths L sll-M llsd dust is abeam in Table 16* Both acapleo taro collected uith tits o lcctroaU 'ie precipitator* I t w ill fen noted th at tbora was far aoro fibrous notarial in tbs louc-fibar dost. S3* Enaction In Anlnals to Inhaled lonc-Fiber Asbestos Bust. Odnsa pigs, so ls, rate and alas var* seplay*! in ths Inhalation experinest with 2eag<*flbar asbestos. leeu.Ua e f tbo aepsrlaaat, o isn rlssd in Table 17, a rt dsseribed in graater d e ta il bales* fii. Ocinao Biss* Tbs w y rrtautfit nos otertad with ICO fwlaaa pigs* After tad boon carried on far a pear, a of tree* Jn ths dust reea and about ono-tfcLrd of the o n tilo died os* esre tille d . To replccs t h s , 3d cars guinea pir.a ware added to tbe saroiring pep la the duet roon* i$ . oat* mat t^bs ef Been! ton. UleLologloel orairination rwvwolsd gpaMlg visib le lesions la tbo laags after 8 o f c ^ osggj to dest, esaalstieg e f n l l i t e ' ia lU b o U n t A n d tbo to n la a l fcrcaahialca. At 13 estates, ttesro m m fidsnsetaold ataagn in tie sir rpanwi and bg tta lAtb q doflnlts fibreeis uao present la half the caiaala* The filtaeaa laeiea eesld bo esea easmssepineUsr ta W ratahe* ffcua cadi* tior ca t&o resotica lEsraocd &a extent end in the carast of cflfflffgci tstsl -*?- IWTx rw PifJ. 'Jjr th# X.U. north, It. i\m.\ out lr.tr th poronr^.r*. 7ha lcnior-o *ra rtthar sharply lo celir ar the txworjie.u free iitto rte t broneMolta stomd bo Undoncr to Tuiot vm lr AnlaUi c/poori !br tha s o d a * period (3 y u r t) . Although Uu latrepolaonaj7 r Metier. sonatlnae roechad the pleura, thoro a. s do lorolvwmnt o f that acebrane. Ko acch/oam u Tiaibie at any point. Sam thlefeanioc of th* larger bronchi with a chronic x a fla m to rr in filtra tio n was rv> m i l d , but it probably me oo mro than would bo prodocad by a erpsevra to any dust. For th : fir s t f iwn4^ th? yrnsniwta* eonalatod of mnoeytM or r e y m a ll slant ew llaj la te r, slan t c a ll ijrw alio.t u aoro prm iaaal. Aftar 16 ooBths tha iant ca lls mro large, f t Hot with yt\lo*lfb>bywm plcw nt and scsstlacs m cuclatad. An c:caalonal anlnal ahoaed an A&dxturt o f polyaorpho- anclear xwdwytaa atii, Li kuIem pigs asr^aad fe r c ees^Iderable period, medaophilaa. Tho reaction ww at f ir s t entiraly oailalar bat by 16 mxi*Lo f i brous tlsaua fom atlea was daflnJLe. Roovrvr, I t nm.jr a tta 'nrd a eta;o c f Sqral3jueau.cn eucsoati** of A mazrato inditidaal variation oeevrred aooag tha mqpnaid a la a ls, beth la tbs rate of d m lrrln s lealona and In the stag* of dovalopm.t atU.eed at tha and of gapooura. Amlyma o f tha langa (Tibia IS) dladneol tw t although tha tle a * raapaeeo m a mcB frm tar la ttern gvLma pica than in them eapoeed to either ahett-ftbar cr bffUmlllfld edbaatca, tbo aaomt o f ainaral m ttar la the l a y aah me L a *. 66. Braaraaalm. In catena pigs cacpaad t* tha Bast fa r 10 m otto a&d tins paaamd to sara&l a ir , there m a Baited tmdamgr h r t o flamutary p e a t la to Blear, ThAs e ffe e t, omwagmilcd by Ma&mettm f the flbroa* tlMwa, r e s u lts la e d1atirichins otoo o f the fm a l Isviam . Bsoa -.m v nrM V if Umm urilml*, hilled ' vw'.ajt poritJt ,-n to XU r l u Sttr a p o m , m a ile d ltild n i u U r ;i is t' i*- '/no jrrJT. sacrificed at the m i of the f04M ih ^ M 'F I pcr)0d Of ttia ' In c/A'clr rhich rcitinod in the dust rooa for w c th e 20 reathr. fpia'ic^n aftnr 6 n t oepoturo ceased, the feed I21 fear of ths nix rvrJjiiis~ pifte rare 00 omV. that they wore Tlalblo Only &th a haid Lena. fioaetloa la tho grecr espoead for 27 Booths and then transferred to a n a a sl aSaoe)hase e u qolt* a la i-x to tno reopenso la tho 80-orath oqpeewe irnlaalo fears. Earrror, ors i-} fw-4 -vra aliara risib le so | tom inspection of aectlons of a ll y^ne* pir: c f 27-death ooriee bat la ao instance aa there evidence of sarUtasior of the reaction. 67. leach lode Irsolvnant. Rea-'.Ion in the treoheobreaeMal 1/eph aoCee as fir s t r t s it ls at the third aenth e f ea- poeere. At the 6th Moth patenct ef cellule* coansetlve tleees began to appear in the eedulle end hr the \lth eenth K>et o f the node hud been replaced by cellu la r oweetivt tleeue. Thia picture, ehlch reeeabled th at la early B illeeeie, pareiatad to the end sf the wcprrlaent. Soee anlaelr, ae a earlart* tfm ed beery oneote of ALffium -cnscyts: *** lvrge active g lin t cello bat there eoe eerer ey eecresle cr hyullxw IU*tion. The spindle-chspcd t r r cells w e jelloeiSh In color free fine pdgemt granules that etadeed fa r lreo . lo flbere er WO 63. Asbcotoela Bedlee. Althoefe asbeetesla bodice enra eee^es early 03 one m Ah a fte r e e in w betas* they e v e vera cad bard to fle d . At 9 seethe esra w e tls lb la , ehiofly oeiled teetae gleet ce llo , sad a t fi Booths bobt bodies w * free n ecaneetive t la eee. they beeaee fa ir ly 03 w e e v e psepeeeed althBafe in esae la ter aatanle the adhaetceda bodies C2ly - * * 6?i Get9. Four otts IrtA ltc the lon^-fibar M buW i dust ib r periods of 1L, 2$, V; and IT sssnlhB, rerpectlrtly, aad vara tamwIUlnly c&crlfto&i. tvs other e*tr, after baine spaaed to fast far IS Months, Sired in O Marvol QtoBaphorq br on cf-dltiaaal 2L coaths. TO, ?.a+ on* typ* &pom*ro fa r U Months mbs su fficient to produce o ellsiar aoew ulatlem a f ptegmijrtw opcmsl tom laal bronchioles cad peripheral M tcrlelas together adth saapect sol* In e tlm of slal'sc* sells in the tracheobronchial lyqpb Modes. At th at tin s thare a a s bo lypioal ssbestasis bodies, bet Booth pointed yellor fiber* ears bob aery rare ly . * ith eoctlBed esr-oenre, ap to t f sonCta, reaction la the lorstjens Bated progressed to the *orwiM"n of eallu lar connective t i eme vhich Bads aall^afL aed QbaMbhs shout the raaplratory branehlelaa wd Mrterihlee, narked Ijajiinlil hyperplaaia and lycgtoid in filtra tio n of bronehiolor v a ils. IHo tronebiolar epdU- ollan aas lav Mad fla tte n e d , giriag the to&es a Booth oodteor. typlaol i d s it a- e ls bodies vare not (bread olttangh there m s an occasional y ello r, B eethr painted fib e r, Ko plaarisgr m s present. fee roaetieM eae **** 1m ImsmUb te th at la the galaae pigs, bat fth reats mo BSh aim er In dsvalspBnt Mod had aot readied ths ssao dogra af B b arlty. iju m^be^SmLi beostgsMBgraaa o f periods ef ?$, 33 ead kS m aths, bat to be TSo Kate, flthcagh SO rate esse placed 1m tha fa st caadLo ad osre sot M dU tlr f t r Mtaf t . flr a n l a d i , o f o s capaatgd f tr I f oantha sad f e e f t r t$ Baatho, vsro ftaa ftea jalMNwy Saferfe&ca esd attar a bods far 7). R*U and T r Eaactlon. i l l foer inin&ls sacrificed at 2* aontha shooed a c e ll awtrsd perlhrenehlalar flb real*. 2a the 19-canth znlntl, reaction u Just b ejim ias. Aaboateaia bodies cere p w tU a lly abeanl at both 1? and 2? aontha altheagh two aaall aaooth bodies cere fOord in tbe 19 a anth aniaal after c lo r- serreh. thaa, these amiaalc adtfhlted fib ro sis without aShaotoai* bodies. lu, Mice. Oul of 20 1uU a ic t usai in thin aaperiaent, XXX ltti a year or acre in dust and died or ta re k illed d th o u t tfwadae an a w eiabla dope* of pnlaanazy infoction. 75. bate eeel Type o f U actio i.. Inaction caa United to phagocytosis by awnmclaar c a ll* . ItoaalX? thsee cere wide ly oeattesrod through the a ir epaoeej a Hurttad e a te r a w greepod abotri the to r- 76. l a w j asd lu U iia oU tieB. Tba larpnau a f thia a p o ria n lsM to seolaato the lapcrtsnae i f te c O tero la the tinaes vttfoam to iehelad cobeofcaa. #fha rseutto indiaato otrsagly * that tag filters arc chiefly rac^saolbXa h r tte pubMiw. ttaoe la gsdsxa fl& vocstlsa CordXejsl earlier cal boosts tars csfisaalsia ttea la fretim o oqpslcaste la cplto of o <Mttsca4ratl*$3 of otB$3|*8S7lo dsot ead o lacc? oie^sX sa tact in oha Xa^a. JWthsrcsro, a typical flbraote csts gretesssfl -3 1 - & le u . At t.h* tier `.y w ci :iv?~ v vi z-rrpmtink f * c / ) ty ta r la ie ti Qiiftf latrowrltcpoal Taohnlito. fia rarolto tS iaJaetlflD aqtortoaato alto too latrapo. ltoaaol fftaa la Ttolo 23. Xt v lU bo satod that toa tooc-fltor Oasta pradaMd a vmbU oi to lls d a te m ap w l o f p allelM 3 bUn m a d loot la olao a a d a i r ea la r t t i p o f te ip a n . f beoa c fv t a N ls todftaolo olao that too fthraola todtlaUd hr toa Irrltotlao o f aabaatot fibaro la oat raatrlatod to too ca a a tannr37 aaaaead, but oaa bo p r ta id la tha p a ll r fcK fc* mm. J T O .fflW !.J ffW * A o f aM ltdaral aapartarata ooro aaafaolad to ttro r aero H t as o f too 0$. aoU old al If to il-- of ta a a ia of a o f lane flhar ahrroottla to vftlco that too a H lllia o f tba fld a t too tlaaao la c ito tln oapoaaa to tha lajoeto* flhraaa / # \ tos laat lajaatlao o f too foot 00. Pm M m d lto a o to o to totiaa tbs l i a la too irotolm o f too bloat er tloaoo olaassto a d oat, a gQ llw iioq nrtkartmraa lojootlao of t o a @0 t a d fwwMOwttf 2 par too CtogStSSlfl r yytj to bo d r ived o f t o M a t o o ton p t o o c f o i tba other 2 p r cost fogOy flt bOto gffyf '1 Gf ftwffaflOfiMt v r1 -35 - An attoapt to ftraAaei cabastoola bodlss la p iM plga Vf ta flM U lia f Ursa ni2k toga seeUdalag fltoeua tfuTOotUo aa nausasaa!tal. Ona lag gilainlart tobsataastoly la too Mdrains! an il M ig y w u li Urn sttor too tags, fliaad la tin y a lta a n l m K j i fniaaar a ttttkr A w igt f w e t la ta t as astostoals todlas la a jaer. Xatrolrachoal iajoetien isto gntaa j^c* o f aStoatatls todlas w aw a r i f r a toon 2aag tlawn fkUad to producs too t f p la l tlaaoa raaatlan to Mbaotoa fltora. tha lajaotsd u ta rla l toa dbtal&od to dlgaatlag ^ to aailna IgfMMarlto Mitotan t a g t t a t o raaatod at (Otopqr ta n aa aSbastoo sartor. fto Mtoatasla todlas ascld to a m la too gtoaaa plga for at l a i t a ytor aftor lajaetlan* f t l i a p a ia s t t o a tto t ton actootoa1* tody too a lottor w r trta t aatolag AIM la aat tort* ./ad to aadooto topoAlorlto to w ta to aad toy to mlatalasd la i t f i Ito a m r ar ta g a r. & __ V' Of u x zrzz. y * ] r ^ yM yA W ^ eraa or t a m y * ^ n aiii!iTr to aapl&la too lavitotlaaaal itr S alto alto tills t a t t o toto t t a e a tlia a la a ffcaa tto t ta tada t o I t t o s t o t o a t i i odtooiBfTta a d d to f t t o o t i t o 't o r t o l I t ia y a t o M s i (I) d to f lto o , t a i a tad a o U ia sato tol of o d | 0.90 fa r l , casaad a Utooslo U2o tto t ysatooad to tto aSbastso Btaamloj CS) t o s d t t w yartlalaa ficsTeaao la pstcasy co toa fsto lrlo alas twaaaae t a a , t o t aAasti c& srto t o a sto at 10 to SO oUreaa a o a t a t l v t o taasaaaai (9) Jfr* lyrtirwld* nsratrAllee:: the irriu tiry ; of quart! but net of aObootoo) (L) aorpantino haj the t ic chenlcul ew^ositien as lot^-flber ehrysotile bet it data not jrodoeo th; ca?4 !&*: of tirni" meticr.i (rJ thoro la a fids ronco la the atomical eoapoalUon o f the airerala tMeh do cause asbaatoaia (aee Table 21i). & vicar of thio evidence i t e&ans aero ltiooly that oeboetoo la ia nanoed by on ucaroal oeehm ical irritatio n tr m lone oobootoo flbera? N M f b*w4 ^ th is ir r lt d ic a fcsVelaUd to thx peculiar filaaooted steuatoro o f the CUar a d the ftMOdjelcrt f la s it ilit y , v t d * art poaoeomd bgr no i t t r foreign ba^r. ** SBEEzplOf ignition o f ehryooMlo fibers ehtoftd th eir etroeWre acd o d e tte s inart ch ile the sano fibers, > fire being heated, vttkd prodse^flbrotia (lo t Table 19) Farther support for the theory of mchaitfeal irrita tio n is that a ib c m iu tcetrs in ao oifen of hi*!i atuLliity - the lunc and that a flhroos rotation eas bo produced by injection ol aebeetoa fiboro into the p o r lte M , ttero is also a degree of ro b llity , bu%t not la otter ottrapolasnary fb * u x m i u o^p y y u p^w s Ths cxperlssstal iavestigatisa sith atboetos d s tra la m concerned fria a rlly sdth the effoet o f the doat oa eoraal tisene but acae attantien vat given to ether phases, cadi es ooseeptiblUty to infection and ooe w a o ef MaS&Ba. The SBaary lafbotloa iB tJa fm rlSlr&t offpst Of istoslsd studied w tho f ir s t iriirJailea St io, pafeapa, caffertessbo tbs* IdaU tica 57- Sogctpilbllity U Tubfculmu Infection. Th dmlopB&t of * tdtor- i oont. Thli lr*ldnUl o riJ r u r.-rtrcn '.ne -o ea ib ilitj' of an offoe*. of oaboato* d n t oo eon-Oabercolr^e in fe rio r. bovertw iri*, oinco nueh opldnies oro not naanon la tarn a tio n ox^orlwnts oivh o-nar dual* and ores In Um eolary of m b I ealsala, i t If fe ll U at t w. iahalatio.i of adbooto* tfuat daoa not aaart a elpO fioani affect u tho awcc; t i t l il t " to aaa-t*em llm * fnlantny Infection. 52. I* opadCLe arptmaar.t was c^iluc**! Ui ahsthsr the jteialati-r* of faroro the fowlopaant/tf SKoplastlc jboMbbci c irta la baorraticni eu th is aob>etioro recorder in the w r-lia *itf th proposed aoa.,rtpb *n u b e sto ili mfcrtLttod by ih* la te Dr. L ./ . Qc^dsar t y ` eb ro r^ lfU 3. So :\ ha tailed a tte v tian to the hlfb laeldtocr A? in h k w aio^ iw a d u Itia-ri'^ar 2b hi* afparlaan4a l n & c s / Y o ^ d f o r r r d Vo thaaa laaiaca u adaoesa*. la ar. feceta ^ . diatiHAetlon botwsor adcnaoA and cancer tMcb. abavlf V clear. A eanohr i f a t o r , or a t e p a s , aaptiu- v f ie ta l in **ieu J~ XyaphaUoe cr blmu dBlop. 1bi A lahW hiblU it la a a^ tha o ia i ' to c la rify tha d ^ et satuna o f thaee ftagtoal oaks1 iA Sa oarsfeAly n m la a d .'^flaae It ia fa it banoflt IcrcOA'o jadgeeol, a r^ la * of the data la w ill a fte r bis ro tim f e n tafcfpt. Rather than delay tfc* aalVo te th e r dtecsoclea d l l bt m n rtd feA a eupplmcnt to to V -5 9 - T.r conronlor.t to state t* C , A. VtriTif firs-* ' lu - y/ fur >* j*5js * rr.U, *.ts ant) robhiia hut not o f alec and dtp*. Bo*h t'f'dMfr rry* irji-.-viu*. ocnw-rlBonto provldo support for triifc 1j s. : t.jtm 5 a-J 6 oho* th* reaction to tuo dlf.'rvrt V n a. Thu iw:# of .letxor" >* Acoer. o.< ndncral. ## rctUr thsr. c).sslssl lr. aa^.rrr. - y F-*7 Ths fartdc^ct lr nAvrli 5n acttio i 1X7.\\:T. fim res I, 2, 3, i and i>* ir4 tfti* .t psir.ts. Iho ntrooo filiarntv.) Btnretur* of orbeotdii^ew rexl^ p i aa oosontial part In the irrita tin ', action, inc* tr-u aollc' Abe.** of class wool do not prodnoo flbr.oJa C. Short oabootoo Ahsro r;.. jx k). U. rot rredssc fibrosis sp U ti lr. ths rideiwo soatloood la para- ertfn B srvr*. fa ^rii^nta ahleb fnrthar aopiort this finding lr. fi >l*f 71 and 21. E. Typical fifar>sli can bo produced br rr ateeeeherle ooopoaston o f aoboBtos dtat cental urc oalp an axtrsn&lj m ail proportion of lo af flo o r s . Za lahalatiet ospcrlaent with 100 por cent bcll-odllod . n ` '* bdbootoo luot l ferpieal, thcuchdelayod, fibrosis aa ItO* v V * o t U is c J '8 '? - ,t ! i l e a U i ' . 1 per e o n i o f tVe i t i i t , V .rl: c i*l to: v'$vc: -f ''.brrd ie:::r ihar. 10 nic-ona, re i* 3`;t "i *.i 1n>c 1". In c/slrost, the ie tra i trae'ical in v c `.>n experlaont with fln^ asorrtca drt oo- tcinins nc lez ; flb<*T*. fcj.lsd ir prodjjr Jibroais, ****?*!* 1 o a f Ar Inhalr.'m o: tit*;toe Jun*. e y arwa ei y dice not alter eiKniflnentlj the miw of er e r - in iw ujbi'rr'ilr-cit #iwn^**c^pti*r'*eSe juBaa-**i*'j**' This io i'n U ti-* tlrer vf*. rrldeneo or. etilA it la baaed :*. w oonfrt. v*it5i cur il erperieoca. Refer- :<ee to Title J w ill then that whan Lrtftctiao m aainctdcrt rii-t oiie* tit tl**'. ib,vi e Uierw W .^ a r y i*v.reriw*. u f ,S .'ier. w<*' `.H-oi r^w> n run initiated tfvrr 2 i 3/fc rorliw of dtst exporvjM tht enwnt o f the tuJc*N.olo it Uiua.it war not afTrectatly altered. Zn contrail, i t has beer observed In acperlaeuia 1 it r alaeU dueta omt.Mr.ine qa** Vi*tt I f inert is %ilirh t rocreaslor o f the iuherm- lo ile tf*.. iaftetior. as i fast uq 3icv are cotacid this effect la earkac (instead o: leer, as w&th eshertoi} when infection la injtlaUU after a ? rivS o f dor* 70 This aooelwelon eoaoemlng the a feet o f ifftelad tfeot m M b m l e i i i oeexs J u t l ied hooasae i i the eenal- blew %Mt (infection initiated a ter a oirlod o f dust otpoeure) there wee no npyrertahle t*rr*i' In eweoeptlMlit* to the tobereulova infection. :lower*r, ilnae the Hading-) in the asbestos ritrtr do not eonfsm wi-^ previous 'I