Document MXrRMLDLJVxkxXqJQra7vmky
CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE PREFACE : Acknowledgments, significant changes and comments
REVIEW DATE 1 JANUARY 1986
1. The new cases in the Register are the following :
France Germany UK
18 23, 2lt, 25, 26, 27 11, 12
2. There are amendments from the previous Register against the following cases:
Germany 21, 22
US 36, 38
3. I would like to thank Dr De Sloover, Dr D M J Williams and Dr Friedel for informing me of new cases.
k. For the case corrections I would like to thank Dr Friedel, Mr J T Barr and Mr R W Frase.
5. For other corrections and information, thanks to Dr D Forman, Mr J T Barr, Mr T II Sutherland and Mr N F Humphry.
6. I should be very grateful If all recipients of the Register could continue to keep me fully informed of any new cases, or, if they should hear of other Companies who have acquired a case of ASL, it would be much appreciated if I could be notified by the appropriate person.
It is extremely helpful if new information is supplied in tabulated form, using the headings in the Register as far as possible.
7. I would like to thank the many people who have suggested research topics, and should be grateful if I could be kept up to date.
8. I shall be happy to supplyto any recipient of the Register a copy ofthe Paper "Exposureto Vinyl Chloride andAngiosarcoma of theLiver: a report ofthe Register ofcases" by Dr David Forman,myself, DrJohn Stafford and Sir Richard Doll, published in the British Journal of Industrial Medicine, November 1985 (**2: 750-753)
Dr Brian Bennett Medical Department Imperial Chemical Industries pic
Hillhouse Site P 0 Box 6 Thornton-Cleveleys Blackpool FY5 ^QD England
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February 1986
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IMPERIAL CHEMI
INDUSTRIES PLC
UPX/ASL_2 - LA
Index
LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1986)
Table Sequence Belgium Canada Czechoslovakia France Germany Italy
Page 1 2-3 4 5-8 9-14 15
ASL Case Numbers by year of Death (Table 6)
ASL Case Numbers by year of flrBt exposure (Table 7)
Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8)
USA PVC Producers - Start-up DateB vs ASL Cases (Table 9)
Japan Norway Sweden
16 Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10)
17 East European PVC Producers - Start-up Dates vs ASL Cases
18 (Table 11)
UK USA Yugoslavia
19-21 22-28 29
Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12)
South 6 Central American PVC Producers - Start-Up Dates (Table 13)
Incidence of Cases per annum (Table I)
30
Australasian PVC Producers - Start-up Dates (Table 14)
Distribution of Cases
by Country
(Table 2)
31
Pattern of Cases by
Factory
(Table 3)
32
Latency Periods (Table 4A)
33
Distribution of Latency Periods (Table 4B-4JI)
34-40
Annual Geographical Incidence (Table 5)
41
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CASES,4
Page 42 43 44 4 5+46 47
49 50 51
Pa 30
TAP I.
(Review Date - 1 Jan 1986)
Incidence of ASL Cases Per Annum
By date of death
1955 ........................................................................................ 1
60
7 ......................................................................................... 1
8 ......................................................................................... 0
9 ;...................................... 0
1960 ......................................................................................... 0
1 ......................................................................................... 1
2 ......................................................................................... 1
3 ......................................................................................... 0
A ......................................................................................... 2
5 ......................................................................................... 0
6 ......................................................................................... 0
71
0 ......................................................................................... 5
9 ......................................................................................... 3
1970 ......................................................................................... 2
1 ......................................................................................... 3
2 ......................................................................................... 5
3 ......................................................................................... 8
A ......................................................................................... 5
5 ....................................................
11
6 ..........................................................................................11
7 ......................................................................................... 9
8 ..........................................................................................10
95
1980 ..........................................................................................10
1 ......................................................................................... 5
2 ......................................................................................... 2
39
A ......................................................................................... 5
5 ....................................................................................... ^_2
Total
117
N.B. I Does not include Italian 01 but does include Cerman 03.
(if? //7-
2 The 1977 total Includes US cose 2A which is a Cholangiosarcoraa.
3 The 1982 total does not include US 33 and F 15 who are alive.
A The 1983 total does not Include US 36 who is alive.
WPX/ASL_2 - bANGIOCASES,35
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W*
31
Distribution of ASL Cases by Country
TABLE
(Review pate - 1 Jan 1906) 2
USA W Germany France UK Canada Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway
35 *** 3L
26 ** 18 *** 11 10 13
5 **** 4 *****
4 * .5
2
23
2 1
Total
120
* Omit ItOl - atypical case of PVC bag extruder. ** Includes CE03 aerosol can filler.
*** Includes case US 2k which was diagnosed as Cholangiosarcoma & US 33, and 36j and F 15 who are alive **** Includes one monomer worker. ***** includes two monomer workers.
i.e Western Europe North America Rest of World
67 A5
8
WI'X/ASL_2 - LANCIOCASES, 36
Total 120
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32 Pattern of AST. Cases by Factory (a) W Europe
ABLE 3
(Review Date - 1 Jan 1986)
Of tlie 67 cases in W Europe, 57 have occurred in clusters at 11 factories. Of the 26 Cerraan cases, 23 have occurred in clusters at A factories.
ASL Case8
Dynarait, Troiedorf, Germany
Chloe Chimie (Formerly RP) , St Fons, France BP, Barry, UK Wacker, Burghausen, Germany Kemanord, Sundsvall, Sweden PCUK, Brignoud, France CWU, Marl, Cermany ICI, Ilillhouse , UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jeraeppe, Belgium
11 8 8 7 5 5 3 3 3 2 2
57
NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America
Of the A5 cases in N America, 38 have occurred at four factories out of a total of 5A factories:- In N America A3 plants have not had ASL cases.
BFC, Louisville, US BFG, Shawinlgan, Canada UCC, S Charleston Coodyear, Niagara
ASL Cases
IA 10 10
A
38 NB: There are 28 pre 1962 PVC plants in N America; 11 of these hove had ASL cases (Ref Tables 9 6 10) (c) Rest of World
The 8 ASL cases are believed to be in 1 cluster of A and 2 clusters of 2 cases, WPX/ASL_2 - LANGIOCASES,37
1-16600 ssy
33 (Review Date - 1 Jan 1986)
Fable 4 a
Latency Periods (Years from first Exposure to Diagnosis)
W Europe
Country Belgium France Germany Italy Norway
No of Case3 2 18 26 4 1
Total Years 35
459 495
74 22
Average 17.5 25.5 19.04 18.5 22
N America
Sweden UK
5
ir ' 67
122
254 1461
24.5
23.09 21.80
Rest of World
US Canada
35 886 25.31
10 204 20.4
45
1090
24.22
Czechoslovakia
2
30 15.0
Summary
Japan Yugoslavia
2
4
39 19.5
85 21.2 154 19.2
W Europe
67 1461 21 .80
N America
45
1090
24.22
Rest of World
8 120
154 2705
19.2 22.54
* Of the countries with >* 10 cases, France, UK and USA have an average latency period above below world average.
WPX/ASL 2 - LANGIOCASES,3B
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