Document MMmj3dGNbeGM9g62DkeeB3vEj

CRI NUMBER R & D REPORT DOW CHEMICAL U.S.A. RESTRICTED: for use within The Dow Chemical Company only. DEPARTMENT Toxicology Research Laboratory -*. (2^ - /tfi-C&t) P*/ LABORATORRYY RRCtRROORRT CODE _HET K-1688__-_(_2__1__)_____REV BATE IlfUED gjgj December 8_j_ 1977 ns. .mo PROBLEM NO. 1--1 I I I 1 ACUTE PERCUTANEOUS ABSORBTION POTENTIAL OF TWO SAMPLES OF ACRYLONITRILE AUTHORS) P. A. Keeler, L. L. Calhoun AUTMOR(s) SIONATURF.fi) \2 -j 'I 1 -ij/f y/*/ ; //, X ^ Vfi REVIEWER S SIGNATURE K. J. Olso ,, L >L X Cd.jjUHx, This report is: DATA REFERENCES (book and page): I INTERIM 0 FINAL and mainly: None (Refar also to earlier related reports and publications.! PATENT STATUS: I I disclosure submitted I DESCRIPTIVE SUMMARY WITH CONCLUSIONS: I case filed I I no petent action required PAGES IN FULL . REPORT 1 Qnew review The acute percutaneous absorption LD50 for rabbits for acrylonitrile has been reported in the literature at 220 mg/kg and, then again, greater than 1600 mg/kg. A clear colorless liquid sample of acrylo nitrile dated 3/15/77 was submitted to the Toxicology Research Labora tory for toxicological evaluation by acute percutaneous absorption. A comparison to methacrylonitrile was requested. Using 2 male and 2 female New Zealand albino rabbits per dose level, the LD50 was determined to be 63 mg/kg for undiluted acrylonitrile. A similar test was conducted on a duPont production sample with identical results. The acute percutaneous LD50 for rabbits for undiluted meth acrylonitrile was between 12.5 and 25 mg/kg (see report HET K7773-2). Both of these materials are highly toxic by this route, with meth acrylonitrile being more toxic than acrylonitrile. Exposure to either material requires immediate thorough flushing of exposed areas and removal of contaminated clothing, including shoes. Then, prompt medical attention should be obtained if a gross exposure occurred. j DISTRIBUTION: See Back Page 00 541050 confidential