Document MMjZqkydarb334OvZqvzBZ9Ly

GENERAL in s t r u c t io n s f o r s u b je c t s Q ?-'LE A D IN H A LA TIO N STU D Y Th e r e aso n for th is stu d y is to obtain in for m ation on th e m e tab o lism of lead w h ich is v ital to a c le a r e r u n d er stan d in g an d b e t t e r con tr ol of in d u st r ial e xp o su r e to th is m etal. Th e p ar t you p lay in th e stu d y is of th e u tm o st im p o r tan ce. Th e u ltim ate v alu e of th e w ork, tim e, an d m on ey sp en t by oth er m e m b e r s of th e lab o r at o r y st aff is d ir e ct ly depen den t on how h on estly an d c ar e fu lly you do you r p ar t . In acce p tin g th is jo b you ac ce p t th e r e sp o n sib ilit y of b ein g a r e lia b le su b je ct . Sch ed u le D u rin g th e p er io d of e xp e r im e n t al e xp o su r e to le ad you w ill be exp ected to spen d 7 h o u r s p e r d ay , 5 d ay s p e r w eek (M on day, T u e sd ay , W edn esday, T h u r sd ay an d F r id ay ) in th e ch am b er . Satu r d ay m orn in gs w ill be left fr e e fo r n e c e ssa r y w ork ou t sid e of the ch am ber o r for m ed ical exam in ation s, t e st s, etc. . Th e d a ily se v e n - h o u r p e r io d fo r o ccu p an cy of th e ch am b e r w ill be 8:30 A . M. 12:00 Noon , 12:30 P . M. - 4 :0 0 P .M . T h is a llo w s th e n o r m a l o n e - h alf h o u r fo r lu n ch an d a llo w s t h e p e r i o d s fr o m 8 :00 A . M . - 8 : 3 0 A . M . an d 4 :0 0 P .M . - 5 : 0 0 P .M . fo r ch an gin g cloth es, bath in g and car r y in g out an y oth er n e c e ssa r y d u ties o r p r ep ar ation s for the d ay 's w ork. N e c e ssa r y su p p lie s an d equ ipm en t fo r c a r r y in g out th e d a y 's w ork sh ou ld be kept on h an d by th e su b je ct an d in so fa r a s p o ssib le , th e w ork sch ed u le fo r th e day , sh ou ld be an t icip at e d in o r d e r th at co n fe r e n ce s w ith o t h e r s o u t sid e of th e ch am b er w ill be k ept at a m in im u m . W hen it is n e c e ssa r y to com m u n icate w ith p e r so n s o u t sid e of th e ch am b er th e telep h on e sh ou ld be u se d . M a t e r ia ls, p a p e r s, et c. w h ich can n ot be obtain ed b e fo r e en terin g th e ch am b er , o r w h ich a r e n eeded b e fo r e th e end of th e w orkin g 2- - d ay , sh ou ld be d e liv e r e d an d c alle d for by m e sse n ge r o r oth er p e r so n n e l. Th e su b je ct can m ak e ar r an ge m e n t s by teleph on e fo r su ch d e liv e r y to an d fr o m th e ch am b er , Cioth in g Cloth in g to be w orn in th e ch am b er w ill b e p rovid ed by th e Lab o r at o r y . Th e cloth in g is to b e kept se p a r a t e fr o m th e su b je c t 's r e gu la r cloth in g an d sh ou ld be lau n d ered se p a r a t e ly . A lo c k e r o r r a c k fo r a la b o r a t o r y co at (to b e w orn o u t sid e th e ch am b e r ) w ill b e k ep t a t a con ven ien t p lace in th e la r g e room in w h ich th e ch am b er is in st alle d . T h is co at can b e lau n d er ed w ith th e lab o r at o r y co at s of o th er m e m b e r s of th e st a ff, i. e. in th e r e g u la r lau n d r y . Th e lo c k e r s a r e to b e u se d (1) fo r th e st o r a g e of th e su b je c t 's st r e e t clot h in g d u r in g th e d ay ; (2) fo r th e st o r a g e of cle an e x p e r im e n t al clot h in g; an d (3) fo r th e st o r age of slip p e r s an d bath rob e at n igh t. Th e cloth in g w orn w ith in th e ch am b er is n ot to be w orn o u tsid e th e Lab o r at o r y bu ildin g, an d th e su b je ct 's st r e e t cloth in g is n ot to be w orn in sid e the ch am b er at an y tim e. M iscellan eou s A p p r o xim ate ly on ce a w eek t e st s w ill b e m ad e to d et er m in e th e su b je c t 's "le ad reten tion . " T h is in volves b reath in g in to sp e c ia l ap p ar at u s fo r a sp e cifie d tim e. O th er te sts of sim ilar n atu re m ay be m ade from tim e to tim e. It is exp e ct ed th at th e su b je c t w ill b e co m e th orou gh ly fa m ilia r w ith th e a p p ar at u s n e c e ssa r y to d eterm in e the lead con ten t of a ir an d th at o ccasio n ally h e w ill be provid ed w ith su ch equ ip m en t w ith w h ich h e w ill ob tain sa m p le s o f th e a i r of h is h om e fo r lead determ in ation . H ygien ic in stru ction s T h e se in st r u ct io n s a r e in ten ded to sim u lat e t h o se w h ich sh ou ld be issu e d in an 3- - in d u so ia l p lan t in w h ich w ork in vo lv in g e x p o su r e to le a d d u st o r fu m e is d on e. T h ey a r e d esign ed not p r im a r ily fo r th e safe ty of th e su b je ct , but fo r th e avoid an ce of m in or but th e o r etically im p ortan t ty p es of exp osu re to lead oth er th an th ose actu ally in ten ded Th e su b je ct sh ou ld b ath e a t th e en d of each d ay sp en t in th e ch am b e r . T h is i s n e c e ssa r y so th at no m e asu r ab le am ou n t of le ad d ep osited on th e sk in of th e body o r in th e h air sh all r e m ain th ere to be c a r r ie d abou t, d istr ib u te d in to th e a ir an d b r eath ed by th e su b je ct o r by o t h e r s. Th e am ou n t av ailab le fo r th is p u r p o se w ould b e so sm a ll a s to b e n e gligib le , in a ll lik elih ood , but good exp e r im e n tal tech n iqu e c a lls fo r th e avoid an ce o f even th is m in ute so u r ce of exp o su r e. It is ap p ar e n t a lso th at c a r e sh ou ld be e x e r c ise d in se ein g th at th e cloth in g w orn in th e ch am b er is n ot brou gh t in to con tact w ith th e clean cloth in g o r w ith th e sk in of th e body aft e r bath in g. Th e tech n iqu e of h an dlin g th e clean an d u n clean cloth in g an d keepin g t h e se e n t ir e ly se p a r a t e fr o m each oth er sh ou ld be c a r r ie d out fa u lt le ssly at a ll t im e s, a s a good exp erim en tal p r o gr am . W hen th e su b je ct le a v e s th e ch am b er fo r lun ch w ith in th e Lab o r at o r y or fo r an y o th er p u r p o se (w ith in th e La b o r a t o r y ) d u r in g th e c o u r se of th e d ay 's st ay w ith in th e exp e r im e n tal r o o m , h e n eed n ot bath e an d ch an ge a ll cloth in g, but sh ou ld w ash h is h an ds c ar e fu lly so a s n ot to con tam in ate h is food o r an y oth er o b je ct . T h is sh ou ld b e don e a ft e r th e r e m o v al of th e La b o r a t o r y coat w h ich is to be w orn at a ll t im e s w ith in th e ch am b er . T h is co at is to b e put in it s p r o p e r p la c e w h en th e su b je c t le a v e s th e c h am b e r . A n oth er lab o r at o r y co at , k ept o u t sid e th e ch am b er , sh ou ld be put on o ver th e oth er cloth in g w orn w ith in th e ch am b er , so th at th e h an d s w ill be p r o t e ct e d a g a in st con tact w ith cloth in g w orn in sid e th e ch am b er. Th is coat m u st be lau n dered freq u en tly . 4- Lu n ch can b e st be eaten in th e a r e a p r ovid ed w ith in th e la r g e r o o m in w h ich th e ch am b er is in st alle d , bu t n ot w ith in th e ch am b e r . (O th er ar r an ge m e n t s can b e m ad e in a m an n er th at w ill not d istu r b the exp erim en t o r d iscom m o d e the su b je ct. T h ese, when a gr e e d upon , a r e to be se t down in w r it in g.) Lu n ch sh ou ld be tak en , u su ally , w ith in th e Ket ter in g La b o r a t o r y bu ild in g, so a s to m ak e it p o ssib le fo r th e su b je ct to avoid bath in g and ch an gin g cloth es gom p letely at n oon , fo r th ese p recau tion s m u st be taken if h e goes o u t sid e th e L a b o r a t o r y . W ith th e p r o v isio n fo r w ash in g th e h an d s an d ch an gin g th e lab o r at o r y co at h e can tak e lun ch in so m e d esign at ed p ar t of th e La b o r a t o r y b u ild in g. Th e clean lin ess of all lo ck er s sh all be m ain tain ed at an excellen t level by the frequ en t u se (at le a st tw ice p er w eek) of a vacu u m sw eep er. Th e flo o r , d e sk , ch air , an d a ll oth er o b je ct s w ith in th e ch am b er a r e to be clean ed d aily by th e su b je ct in acco r d an ce w ith th e in st r u ct io n s given u n d er H ou sek eep in g. Collectin g sam p les So f a r a s p o ssib le r o u t in g sa m p le s (food , fe c e s , u r in e ) sh a ll b e c o lle c t e d d u r in g th e h ou r s spen t o u tsid e th e ch am b er by th e su b je ct . Th e lu n ch , if b r ou gh t fr o m home, sh ou ld be put up in two id e n t ical p a c k a ge s, on e o f w h ich is to be eaten , th e oth er to be in trod u ced in to a se p a r a t e ja r w h ich is p r o p e r ly lab e le d fo r id en tification . T h is is to be don e w ith in th e room in w h ich the lun ch is tak en , so th at by h an dlin g th e two d u p licate lu n ch es in a s n e ar ly id en tical a m an n er a s p o ssib le an y p o ssib le co n tam in atio n of on e (w ith h an d s o r o t h e r w ise ) w ill in vo lv e th e o t h er . -3 correspon d in gly. W hen u r in e is to b e void ed in to th e con tain e r d u r in g th e d ay tim e (spen d w ith in th e ch am b er ) th e su b je c t sh ou ld r e m o v e h is in sid e la b o r a t o r y co at , w ash h is h an d s c ar e fu lly , go o u tsid e th e ch am b er an d to th e p lace a t w h ich th e con tain e r is k ep t, an d void d ir e ct ly 5- - in to th e con tain er , tak in g m eticu lo u s p r e cau tio n s a ga in st an y u n n e ce ssar y m ovem en ts of body o r cloth in g th at m igh t d ist r ib u t e d u st fr o m th e cloth in g in to th e a ir o r in to th e con tain er. T h e se sa m e p r e cu at io n s sh ou ld b e tak en in co lle ct in g a sam p le of fe c e s d u rin g th e d ay tim e . A ll su ch sa m p le s sh all be lab e le d c ar e fu lly w ith th e tim e at w h ich th ey w er e co lle ct e d . O p eration o f th e Room ,. A ir Sam p lin g, etc. In gen e r al th e ch am b er w ill be op er ated by a tech n ician oth er th an th e su b je ct h im se lf. H ow ever, it is exp ect ed th at th e su b je ct w ill b eco m e acq u ain ted w ith th e m ech an ics of op eratin g the room an d th at he sh all (after in stru ction ) ch eck p er io d ically cer tain of th e in str u m en ts an d m ak e m in or ad ju stm en ts. A lso he w ill be in str u cted and r e q u e st e d to h elp in tak in g c e r t ain a ir sa m p le s w ith in th e room fr o m tim e to t im e . H ou sek eepin g In ad d ition to th e n o r m al clean in g an d d u stin g it w ill be n e c e ssa r y to m op the flo o r of th e ch am b er each day b efore closin g down. Th is is an in tegr al p ar t of th e e xp e r i m en t to p reven t accu m u lated du st fro m ch an gin g th e estab lish e d con cen tration . It can n ot be don e by ja n it o r s, an d it is expected , th e r efo r e , th at th e occu pan t w ill do th is w ork. Doors Th e d o o r s o f th e ch am b e r sh ou ld be k ep t c lo se d wh en th ey a r e n ot ac t u ally in u se . Th e vestib u le d oo r s sh all be closed im m ed iately on en terin g, an d not m o re than one v e st ib u le d o o r sh a ll b e open ed at th e sa m e t im e . T h e- e m e r gen cy d o o r sh ou ld n ot be u se d o th er th an in an em er gen cy . LogrBook A log book sh all be kept an d en tr ies m ade each day th e room is occu pied . Tim e out o f th e ch am b er exeeedin g--5 m in u tes sh all be du ly n oted in th e log book. T im e of 6- - en tran ce an d tim e of exit sh all be en tered . In th e lo g book, d r if p r e fe r r e d in a r e co r d book kept in th e cu stod y o f th e su b je ct, oth er in fo r m atio n sh ou ld b e list e d d aily , a s fo llo w s: ' a. Food and b everages taken at each m eal, item ized; b . An y u n u su al c ir c u m st an c e s o ccu r r in g in th e co u r se of th e day, th e effect of w h ich m igh t in flu en ce th e exp e r im e n tal r e su lt s; c . An y even t o r in cid en t w h ich act u ally d id in flu en ce th e d u r ation o r c h ar ac t e r of th e e xp o su r e w ith in th e ch am b er th at d ay; d. Any e r r o r of sam plin g or of oth er beh avior, an y lo se of sam ple, or failu r e to obtain on e; e . A n y illn e ss w h ich in flu en ced sa m p le s o r p e r fo r m an c e , su ch a s a cold , a d igestiv e u p set o r an y oth er p h y sical d ifficu lty . (T h is is a con fid en tial r e c o r d , w h ich w ill n ot be se en excep t by d e sign at e d p e r so n s, n or u se d in su ch m an n er a s to e m b a r r a ss o r p e n alize th e su b je ct . It p r o v id e s ce r t ain h igh ly n e c e ssa r y e xp e r im e n t al d ata an d sh ou ld n ot be tak en ligh tly . )