Document MM4mKxYOvENkn7gK8GkJvYB7V

w,bVoi. (ii>, 4509 > - toxicology ami Air Pollution 10 llicmuglnlim 70% satil. with CO) in 10 rings (expiring O umii-r A kail. Veil., Bratislava). F.ndnerinnlngy 76(1),. 151-5(1905) hyperbaric I'KiiditiiiiiN. With 7', CO* ,'imiii hi tin- supplied O, (ling). Ally). I-. nliiiK-v.ni.it., adiuiuixurnl m single doses of till- Cu wax Ilmimab-d marly twiei fast as wluu pure O was 2 to 4 lllg. iliprisseil sigmlic.uitly tin r.iilmimliin- uptake by rat r(.spirit). Of 22 pjlKiits with cikiI gus (unsuuing. the respiration thyroids. The administration of ally I isollnoeyanate to rat--for f O at 2 a*,u. pressure led lu'recuverylno fatalities). All pa OH days, in doses corresponding approx, to the total content of tients recovered consciousness 30-90 min. after inhalation of 0 a mustard oils m cabbage, caused changes in the thyroid similar to under pressure began. Of 70 other severely coal-gassid patients, those following cabbage feeding. RCFN only 3 did not recover. The results demonstrated that hyper The physiological properties of aerosol propellants. Hans baric O should be administered as soon as possible in CO poison Kuebler (hpruhuchuik C.m.b.II.. Reinfelden, Ger.). Aerosol ing. Data are given on 1 patient with barbiturate poisoning who Age 9(4), 44, 47-8, 50, 90-1( 1964)(ling). A discussion of the recovered from respiratory and cardiovascular depression under _physiol, limits for many aerosol propellants was presented. hyperbaric 0 when ollur method* failed. Other reports indicate Hats. mice, and guinea pigs were exposed for 2 hrs. daily for 100 that there arc no advantages in giving 0 at more than 2 atms. days to 0.5, 1.5, and 5.0', vol. of the propellants, v inyl chloride pressure. At higher pressures, toxic effects of 0 appear, per (I), and mixts. of trichlorofluoromttliane (II) anu dichlorodi- haps resulting from the presence of CO in the blood. fluoromethane (III) (50-50 and 10 90). The animals showed no W. C. Tobie reactions to the mixts. at any concn. or'with pure I to 1.5%, Diagnosis of salt poisoning in animals. M. Bohosicwicz b With 5% I the animals first showed increased mobility which was (Wyzsza Szkola Rolnicza, Wroclaw, Poland). Zesxyty Xauk. then gradually reduced. Upon autopsy no histol. damage was U'yzsrej Szkoly Rolniczej U'rodawtu, W'eterynarxa 11(42), 3-43 seen. Mice under a plastic cover were sprayed with a shellac- (1962)(Pol). Administration of high N'aCl doses (3--1 g./lcg.) based hairspray with I, II, and III propellants for 30 sec, daily caused acute intoxication in mice and pigs. NaCl poisoning was for 5 weeks at a distance of 20-25 cm. There were no histol. noted when Na''' values in the brain and liver exceeded 150 mg. changes in the lungs. The thermal decompn. was detd. at 1000". % and those of Cl- 180 mg. % in brain, 70 mg. % in muscles, One g. I yielded 39.5 mg. CO, If mg. COClj, and 102 mg. HC1) and 250 mg. Sc in liver. The loss of water m brain, muscles, 1 g. II (1.5, 7.0, and 94); 1 g. Ill (1.5,2.4, 79); 1 g. sym. dichloro- and liver amounted in mice to 3.8, 7.5, and 9.2%, resp. In tetrafluorocthanc (0.8, 12.0, 59); and I g. methylene chloride pigs this decrease in brain, muscles, and in liver amounted to (15.2,18.0.81). BKJN 4.5, 9.2. and 8.7%. K. Belzecka Concentration on molecular sieves as preliminary determina- Toxicity of the olernder leaves. Symptoms, pathological tion of trace components of mine air. Jerzy Muzyczuk (Glowny anatomical damages, and methods of glucoside identification. Inst. Gormctwa, Katowice, Poland). Chcm. Anal. (Warsaw) C. E. Eliakis, E. C. Eliakis, and A. S. Coutseiinis. Ann. 9(4', 671-82(1964). Trace components of mine air, such as Med. Legate Criminal,, Police Sci. Toxicol. 41(July-Aug.), C?H, CjHt, and n-CiHio, were eoned, on a mol. sieve of 5 A. 367-88(1961 )(Kr). Decoctions (10.150) of oleander leaves, tvpe at 0 and 30 and retention times were measured. Prod eontg. 3 X 10~* g. of neriin and 4.5 X 10'* g. of oleandrm, were ucts of desorption at 300" were analyzed in a gas chromatograph used. Rt values of 0.65-0.70 for neriin and 0.96 for deendrin -- with a conductometric detector. In some cases addnl. concn. were found'by means of paper chromatography (Whatman No. 1, w-f.s used. The method makes it possible to increase the sensi ascending, undimensional, 3-1.3 EtOAc-HOAc-HjO). With tivity of the detn. of C|H, CjH,, and CiHi 10-100 times. The the same method, very similar values were found for digitoxm, results of the detn. of traces of gases in a sample of mine air are lanatoside, and other glucosides. No abortive effect could be given. The effect of concn. can be estd. from the retention vols, detected on pregnant ruts. Twenty ml. of decoction (coned, Z. Kurtyka to </() resulted in the appearance of toxic symptoms in rats after d Permeability of newborn rat akin to a volatile hydrocarbon, 20-60 min. The oleander components seem to affect the central `V.-labeled p-eymene. Guillaume Valette, Yves Cohen, and nervous system, esp. parts related to the telencephalon and Jacques Wepierre (Fac. Pharm., Paris). Compt, Rend. Soc. :erebellum, the symptoms resembling those of decerebration Bint. 158(5), 950-4( 1964)(Fr). The compd. readily diffused paralysis, according to Sherrington, also displaying tendency to through the hairless skin and was detected in various organs. A total or partial disintegration of cerebellum. In rats, which _special app. was used to prevent any inhalation of the vapor which received 3 ml. of decoction intraperitoneally 9 times every other mignt invalidate the findings. Since the hair follicles had not day, congestion of the parenchymatosic organs took place. yet been formed, they are not indispcnsible for penetration of a Damage to kidneys, liver, heart, and peribronchial inflammatory volatile hydrocarbon, L. E. Gilson congestion and atelectasis of the lungs was detd. microscopically. Flue gas from plants manufacturing synthetic fatty acids and From CZ 1963(24), 10175. MWCR alcohols. F. I. Dubrovskaya (F. F. Erisman Sci.-Res. Inst. Use of the chicken embryo in the assay of aflatoxin toxicity. e Hyg., Moscow), Gtgtena t Sanit. 26(1), 7-10( 1961 )(Russ). M. Jacqueline Verrett, Jean Pierre Marliac, and Joseph Mc Results are reported on the investigation of 1252 air samples Laughlin Jr. (Food & Drug Admin., Washington, D.C.). (580 m March/April and 672 in June/July) collected 250-5000 J. Assoc. Offic. Agr. Chemists 47(6), 1003-6(1964). Preliminary m. from factories manufg. fatty acids and fatty ales. In all results of an investigation of the general systemic toxicity of samples in the spring, hydrocarbons (max, 56 mg./m.*) were aflatoxtn (1) in chicken embryos are reported. The studies are detected; fatty acids, in 54% of the samples (same max.); and not complete enough to verify if any I produces any specific unsatd. hydrocarbons, in half the samples (max. 13 mg./m.*). pathol. lesion in the embryo. Injections of test solns,, in pro In the summer, 70% of the samples contained hydrocarbons pylene glycol vehicle, were made, before incubation, in fertile (max. 63-90 mg./m.*), 52% contained fatty acids, and 56% White Leghorn eggs either by way of the yolk or air cell. De contained unsatd. hydrocarbons. Acetone and formaldehyde velopment of the embryo was observed for the full 21-day in were found in only a few samples. From CZ 1962(47), 17163. cubation. Injection of solns. of pure I Bi and Gi, and of exts. y MRCR of I-producing mold cultures indicated that the chicken embryo ! Maximum permissible concentration of chloroprene in the was sensitive to these compds. The relation of toxicity of the atmosphere. A. V. Mnatsakanyan (N. B. Akopyan Inst. samples to mortality at time of hatching, exhibited a dose re Epidemiol, and Hyg., Erevan). Gigiena i i'oitit. 29(9), 13-18 sponse. Exts. of I-free peanut products were nontoxic to the (1964)(Russ). A concn. of 0.22 mg. chloroprene/m.* was the embryo. Addn. of 1 B, to such uncontaminatcd exts. produced threshold concn. lor decreasing the su'.fhydryl concn. in brain the expected toxicity. Injection of exts. from contaminated -- homogenates and increasing adenosinetriphusphatase activity peanut products resulted in a toxic response that correlated well in the livers of rats exposed constantly for 60 days; 0.08 mg./m*. with that obtained by injection of pure I B, solns. at same dose is considered a proper max. John Howe Scott levels, and in most instances the chcm. analysis was confirmed.- . Effect of dichlorobutene on the olfactory organs and ocular The presence of I Gi. B), and Gi had no apparent effect on the analyaors. G. V. Dcroyan (Med. Inst., Erevan), lev. Aiad. toxicity due to 1 Bi at the levels at which they occurred in the A'auk Arm. SSR, Biot. Nauki 17(7), 201--4( 1904)(Russ). The particular samples tested. Scpn. of 1 B, from contaminated 0 threshold concn. for a dichlorobutane (1) effect on the olfactory exts. by thin-layer chromatography, and its subsequent elution analysors was investigated with 15 patients and was equal to from the plates and injection into the eggs, confirmed that the 0.34 mg./m.* Effect of I on the visual center was examd. on toxicity of these exts. was due primarily to their I Bi content. 3 patients. The results indicated that in some cases 0.34 mg./ H. A. Lepper m.` of I produced harmful effects on dark adaptation. A concn. Electrophoretic and chemical studies on serums of swine follow- _of 0.34 mg./m,* of I in air was considered harmful. ig the feeding of toxic peanut meal. E. Annau, A. H. Corner, M. Charmandarian o. E. Magwood, and K. Jericho (Animal Diseases Res. Inst., Effects of- inorganic fluorides on animals. J. W. Suttic Hull). Can. J. Comp. Med. Vet. Set. 2g( 11), 204-8< 19G4)(Eng). (Umv. of Wisconsin. Madison). J. ,-ltr Pollution Control Assoc. The consumption of toxic peanut meal by swine leads to marked 14(11), 461-4, 4KO< 1964)(Eng), F" toxicity in cattle can re alterations in their electrophoretic serum patterns. Expts. car sult from the ingestion of forage contaminated by industrial ried out by chein. assays, moving boundary electrophoresis, A processes. Cattle are affected when F" levels in the compact and starch-gel electrophoresis showed a relative decrease in the bone exceed 5500 ppm. Marginal toxic effects are noted in albumin, oi-, ar, and fl-globulms. while y-globulin appeared to animals with F~ eonens. in these bones of 4500-5500 ppin. be considerably increased. Rudolph Scidcn The concn. of F" on forage that can produce these conens. in Goitrogenic activity of allyl isothiocyanate. A widespread the skeleton depends on a no. of factors. Air quality standards natural mustard oil. Pavel Longer and Viktor Stole (Ceslioslor based on atm. F~ levels are not feasible fur protecting livestock 009703