Document MM2e7wo4OzDDRX2RyBNDaqOLL
AR226-2881
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S- I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine
Elkton Road, Newark, Delaware 19711
ORAL LD50 TEST IN RATS
lO^oun^adult'ch'R-CD^ale 2 S E
* * * * " * intubation in single doses to 5
level for the U>50 study*. The surviving animals were i g h e d i n d " o b s TM / * ! W3S nducte4 to determine the initial dose
a . LDSO value ... calculated f r ,, the eert.li?, data
SSS It^
*"a
Results s Dose
jmg/kq)
14,500
~
Average Body Weiqht (q)
254
'"
Solution (%)
oU
14,000 265
o CO
1
Average Dose (ml) 4.60
-- ------ ;
Mortality Ratio
6/10
4.63
10/10
____________
stained and wet perineal area,stained face, lacrimation, salivation, diarrhea, humped postutB, weakness, lethargy, and severe
weight loss. All deaths occurred within 4 days after dosing
10,698
Stained and wet perineal area, lacrimation, salivation, diarrhea, eyes half-closed, lethargy, and severe weight loss. All deaths occurred within 3 days after dosing.
r` rnofeonfain TSCA CBl
Results:
Dosa (mg/kq) 13,000
(C o n t >
Average Body Weight (q)
261
Solution (%)
80
12,000
252
80
10,000 258
80
Average Dose (ml) 4.24
Mortality Ratio
10/10
3.68
9/10
3.22
2/10
Clinical Signs
LD50***
Stained and wet perineal area, stained---- iF"69i
face, diarrhea, congestion, chromodacryorrhea, '
weakness and severe weight loss. All deaths
occurred within 7 days after doaing.
stained and wet perineal area, stained face,
lacrimation, chromodacryorrhea, salivation, diarrhea, weakness, lethargy, and severe -.-weight loss. All deaths occurred within 4 days after doBing.
Stainea and wet perineal area, stained face, -- ____and Severe wel91>t loss.
3=i
1 " ,iv"
y' D-
'` W i . 3 M . , 1971, Cambridge U,,lvsity P M .
95% Confidence Limits are not defined. Slope: 10.1
,
LH:jrg
28, 1980 Report N o ^ 58-8i^,wJi
Report by: Approved by:
-jf p f f j'J} 0t vLonnnniiee' Hinckl Technician
* .-- ,-J _________ Grald^L* Kennedy
Chief, AcSulttfrea ITnnv..Aeskt.iJ gatio__n__s_, Section
Cori O s a n t e * , Does
""' . ( n r s c d c e ,
