Document MJyyxpp2nJ7KJdK9nE5emgMqk

FILE NAME Brakes BRK DATE 1985 DOC BRK090 DOCUMENT DESCRIPTION Medical Report Describing Asbestos Found in Lung Tissue SINAIS j MSM SINAIS / MSM MSM ' MEDICINE SCHOOL MEDICNE MEDICINE OF UNIVERSITY C C~ ,x THE MOUNT SINAI MEDICAL CENTER ONE GUSTAVE L. LEVY PLACE NEW YORK NY NY 10029 Mount Sinai School of Medicine T he Mount Sinai Hospital March 20 1985 - Blatt and Fales 1611 Allen Street P.O. Box 365 RECEIVED RECEIVED RECEIVED MAR 25 1985 BLATT &FALES ATTN Tom Hart Esq t Environmental Sciences Laboratory Cummings Basic Sciences Building 10 East 102 Street New York New York 10029 212 650-6650-6173 173 Dear Mr. Hart Re Patient Harry Shimada This will report men of the lower the results lobe of the of mineralogical left lung of the analysis of a speciabove patient The specimen was removed from the paraffin block paraffinized dissolved in potassium chloride solution washed and the inorganic lung burden residue was then analyzed by transmission electron microscopy including microchemical analysis Analysis of the specimen at 10,000 x magnification shows no asbes- tos fibers but when the magnification is increased to 20,000 x many chrysotile fibers are visable shorter then 0.5 ...min length Thus virtually all fibers are This is consistent with our studies of brake drum dusts in which it was shown that 80 of the chrysotile present is shorter than 0.4 um in length The large numbers of fibers found in the tional exposure to chrysotile asbestos tissue indicate an occupa- Please call me at 212 650-6183 if there are any questions ANR Very XN truly yours yours \ oN, on A, Arthur N. Assistant Rohl Ph.D. Professor - Mineralogy o~ os ALBERT EHRLICH M.D. One Horizon Road Fort Lee New Jersey 07024 201 224-6126 NOV 181985 ECEIVED NOV 181985 181985 Mr. Gary Galiher Galiher & Associates Suite 800 Melim Building 333 Queen Street Honolulu Hawaii 96813 11/9/85 Board Certified Anatomic and Clinical Pathology College of American Pathology American Society of Clinical Pathologists Dear Mr. Galiher Re Harry Shimada Second Report On 10/11/85 I recovered lung tissue from a paraffin block RML of the lung which on H & E section showed interstitial fibrosis with anthracosis The paraffin was dissolved with xylene The recovered lung tissue which weighed 0.1 gram was digested in % potassium hydroxide The sediment after centrifugation was placed on a slide and examined by light microscopy Over 19 asbestos bodies were found in the 0.1 g of lung tissue I estimate that there are over 200 asbestos bodies present per gram lung tissue Thirteen of these asbestos bodies were photographed The findings of numerous asbestos bodies in addition to parenchymal and pleural fibrosis in Mr. Shimada's lung confirms the histological diagnosis of asbestosis The finding of asbestos bodies with chrysotile asbestos is uncommon I used a method of concentration of lung digest for Page 2 -Shimada second report demonstration of asbestos bodies different from the commonly used Naylor 1 method My method is much more sensitive and will soon be submitted for publication I conclude that demonstration of asbestos bodies in chrysotile asbestos is due to 1. The increased sensitivity of my method or 2 The presence of some amphibole fibers in Mr. Shimada's lung in addition to large amount of chrysotile fibers 1 Smith Naylor A method of extracting ferruginous bodies from Sputum and pulmonary tissue American Clin Path 58 : 250-254 1972 Transparencies will follow Photographs will follow Sincerely yours AE ee Albert Ehrlich M.D. Pathologist