Document MJqDV0aObjQK0oKOyqqZewGoy

HduttrUl Hygitnc Digest Murch, 1961 autopsy label of emphysema is relatively eunimon, Using (ho whole-lung parchment and th supplemental techniques ot corrosion castings, post-mortem bronchoanyiography, serial his* tologic examination of the diseased lungs, and wentricular-supta) weight ratios of the associ ated heart specimens a more penetrating analysis of this distinctive form of emphysema has bsen possible* The subject is discussed under the following headings: materials and methods; macroanatomy of the secondary lobule of the lung; mucroansiomy of centrilnbular emphysema; microanatomy of centrilobutar emphysema; and cardiovascular lesions. .. Authors' summary SKIN DISEASES AND BURNS 242 The "Toxin-Antitoxin1* Phenomenon in Burned and Injured Human Subjects. S. R, Rosenthal, J. B. Hartney and Wilma S. Spurrier. J. Am. Med. Assn. 17-4, 957-969 (Oct* 22, I960). The presence of toxins in the blood of burned or otherwise injured patients was in dicated by the demonstration of cytotoxic effects on HeLa cells, cytolytic affects on red cells of other burned or injured patients, and prccipitogens against serums from pstients with healed burns, Sueh serums were shovbn to contain antltoxic-antibody-HVo substances by demonstrating (heir ability to neutralise the cytotoxic effect on HeLa celts and by demonstrating the presence of hemolysins and precipitlna* In preliminary clinical trials and transfusion of blood or plasma from donore with healed burns to critically toxic burned or Injured patients was followed by prompt improvement. Serums obtained from the recipients after such transfusions were no longer toxic to tissue eulturea. The authors recommend further clinical trials of antisera of known titer from persons with healed burns. -- Authors' abst* Plhydroxyacetonet A Suntan-Simulating Agent* H, I. Maibaeh and A. M. Kligman. Arch* Dermatol. 62. 503 (Oct. 1960). A recent cosmetic development indicates the possibility of acquiring a suntan with out exposure to the sun. Dlhydroxyacetone, the active agent in these suntan-simulating pro prietaries, is a triose sugar, which is an intermediate in the metabolism of carbohydralss in higher plants and animals. Dlhydroxyacetone is a colorless substance which wae found to com bine with eomt mainly water-soluble component on or near the surface of the ekln to bring about brownish discoloration of the horny layer. This is a chemical staining reaction which does not involve any normal phyelologlc activity of the ekin as synthesis of melanin, encymic reactions, r microbial action. Some vitiligo patients found It a useful concealing agent. It did not act as a sun screen, nor were sensitisation or toxicity noted. - - J, Am Med. Aeen. Absts. Cutaneous Porphyria In Turkey. R. Schmid. Now Engl. J. Med. It), 397 (Aug. 25, 1960). About 5,000 cases of cutaneous porphyria hsve occurred In ths Turkish provinces ince 1959. The syndrome resembles porphyria cutanea tarda and consists of bullae and epi dermolysis of the exposed skin, hyperpigmentailon, hypertrichosis, hepatomegaly, end por phyrinuria. Epidemiologic studies incriminated hsxachlorobentene, a fungicide used treatment of seed wheat. The wheat had been used for human consumption Instead of for planting purposes, laboratory studies showed that 0. Z9 hexachlorobenzsne, when fed to rats, produced urinary ex cretion of uroporphyrin end coproporphyrin. -- J. Occ, Med. Abets.