Document MJo4o7yB1JRVeEGra7QxKoyKk

March 15, 1962 Dr. Maroua Key U. S. Public Health Service Division of Occupational Health 1010 BroadwayCine innati 2, Ohio Dear Dr. ..oy: Confirming our telephone conversation, I am forwarding a_copy of our Technical Bulletin No. PL-306 entitled 1 nArocjjor Plaetioizers." On pages 46 and 49, we have summarized our available data relating to possible skin effects if the Aroolors are misused. You will note that in the first paragraph under "Dermatology and Toxicology" on page 48, we state,"When Aroclor compounds are used at elevated temperatures, engineering controls must be applied, either by the use of closed systems or by effective local-exhaust ventilation together with general workroom exhaust." Again, in the last paragraph on page 48, we make reference to avoiding skin contact. In the section on "Safe Handling" at the top of page 49, wa again point out the necessity for avoiding exposures, particularly when the Aroclors may be used in applications where elevated temperatures are Involved. As I told you on tha telephone, : r experience and the experience of our customers over a period of nearly 25 years, has been singularly free of difficulties. To our knowledge, there have loan only three Instances where chloracne has occurred. In view of the millions of pounds which have been produced and used in many and varied applications, the low DSW 018361 STLCOPCB4004905 Dr. Marcu3 Key - fage 2 - .'(arch Id, 19o2 frequency of any difficulties has been gratifying, I am sure that the earlier problems with mixtures of the Aroclor and chlorinated napthalenes were in part, responsible for the subsequent trouble-free experience. Certainly we have attempted to provide sufficient Information to insure safe handling and usage. We have not in any case attempted to minimize potontlal hazard*. We iiave carried out screening toxicological tests on many of the lower Aroclors. We have, likewise, carried out extonsivo Inhalation testa on Aroclor 124c and 12L>4. Because of the physical nature of 44Jy and the fact that we had no reports of any exposures or difficulties, we ha<e not carried out any toxicological experiments on this compound. I would, however, assume that it lias the same toxic character as the lower Aroclors. Therefore, If sufficient material were inhaled, iiver problem* would develop. If you have any further questions, please let me know. Very truly yours. It. Qnmet Kelly, M. D. Medical Director Medical Department HEK:sg Enclosure CC: Mr. Jerry Molos U. S. Public Health Service Division of Occupational Health 1014 Broadway Cincinnati 2, Ohio DSW 018362 STLCOPCB4004906