Document MJjq0rygo2N08KM6bZV71pgGV

J^tvuju6J BIO -TEST JPcly$M&yw&, Sac. 1810 FRONTAGE ROAD NORTHBROOK. ILLINOIS 60062 23-MONTH STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 IBT NO. 663-03222 Subject tc - 0; "'r in Ross v. ....... ` - -V. -3 - 4337 Hth " ' - V Tvc-t Calcasieu i... -3-, 1- '_c^ar.a CMA 011640 CO Subject t: 7r Koss v. Cor.o'o 14th Judicial *- .Calcasieu Pc.r - -r * T . >A- iJ 7 n _ Iculjicina CMA 011641 !)<ufaMjsJ 31 0 - T E S T 1S10 FRONTAGE ROAD NORTHBROOK, ILLINOIS 60062 3nc. September 23, 1973 Dr. Milton Freifield Project Manager, Vinyl Chloride Research Manufacturing Chemists Association 1 225 Connecticut Avenue ~,V. ''.`.'ashington, D. C. 20009 Dear Mr. Freifield: Re: IBT No. 663-03222 - Chronic Vapor Inhalation Toxicity Study with Vinyl Chloride (Ethylene Derived) in Albino Rats, Albino Mice and Golden Hamsters We are submitting herewith our laboratory report prepared in connection with the above study. Very truly yours. JCC:bp J. C. Calandra President c:-: Sub3ooo to Hess v. - 14th Ju.Calcasieu 7 i CMA 011642 J*-4-~1 3 10- I TM 5 1 l^-C. 23-MONTH STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATIONCHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 13T NO. 663-03222 I. Introduction A chronic vapor inhalation toxicity study with Vinyl Chloride (Ethylene Derived) was initiated on September 10, 1973, and termi nated on September 10, 1974. Animals were then placed on observa tion. A summary of all data obtained through the twenty-third month is reported herein. Subject ic Ross v. Cc ' 14th jc ,, Calcasic- cwft 011643 HwLMt'Ual 3 I 0 - T i S T iM&vzijvuei, Ukz. 1 II. Summary Exposure of mice to Vinyl Chloride was terminated after 9 months of testing. At this time all surviving mice were placed under observation for the remainder of the investigation with the exception of the T-III group (2,500 ppm) which was sacrificed during the eleventh month. Rats and hamsters were exposed to Vinyl Chloride for 12 months before being placed under a non-treated observation period. Respectfully submitted, INDUSTRIAL 3IO-TEST LABORATORIES, INC. Report prepared by: Dennis C. Lindberg, 3.S. Assistant to the Manager Decatur Research Laboratories Report approved by: Lm W . Goode, Ph. D . nager Decatur Research Laboratories Florence K. Kir.cshita ,/Rh. ITT Technical Manager Toxicology & 7% M. L. Keplinge^PhTlk^ Manager, Toxicology crtft 11444 _C0 ' " Subject - Res3 V .. __ c 14th J--.ii Calcasi^ 1 -- .. >. -1 SruL*ciud 3 l 0 * T 2 S 7 Jz^>uzZ3rU44., jW. Ill. Body Weight Data The mean body weigh: data for albino rats, albino mice and hamsters are presented in Tables I, II and III, respectively. rVj ^, - Subject - Ross v. f - 14th J~" V ` CalcaoiwJ ; : CMA 011645 TAhU- TI-..ST MATLHIAI-; Viuyl Oiloi'idc ll-iliylenc Dnivi^lJ UkiiiDic Vjjmj* Uilialaliiin Toxicity Study - AJIjIimj Itati, Alkiinu Mice and u.lii.n ll.mi^iui'b SuiiHiuiy of Mean (indy Wciylilb - Album Jtatx Six (ilOU^I Male VC ti i ii im I'Viuatc kiC ii T II r in T IV _ .. Mean Itudy Wt'iyltlii (yiaim) a 1_ i _1 4 5 6 1 8 Month Numl^i . 10 II 12 LI 11 15 It. l i IB 11 20 21 22 21 205 163 456 448 SI! 53/ 54 1 5S0 554 641 671 684 642 108 111 74,9 7H2 t n 7BI 801 H12 B23 797 BI4 201 Ml. 441 441 S26 545 SS4 sti 541 651 640 610 646 104 112 753 Yh5 111 704 148 7BB 791 7Gb 700 201 110 4b! 440 522 549 St? 5b5 sas 681 661 646 7 It 140 164 7Ub m n\i 7Bt 181 749 - 2IHI 351 4bJ 444 524 500 St? Sit 581 621 624 680 118 121 164 7btt /MJ --~--- 160 215 2/S 24*1 IIS 120 126 144 156 112 166 180 148 111 424 343 4bl \ /> 491 Sll 527 520 527 557 168 212 214 247 110 JOB 121 148 161 151 161 114 }84 145 425 440 450 * ./ 4/2 4Hi 49 1 507 400 404 111 242 /ai IU2 111 116 124 142 158 its 162 186 (41 414 441 479 At** 1 HJ 150 484 494 - 16V 240 211 101 112 321 124 146 154 154 156 111 118 420 450 - -- -- IHI i'll tut 288 241 314 124 118 148 Itl 161 184 NA 145 NA J9J 421 - -- -- ___ ------ . ------- ___ ____ _ - f|i< muic animal* MmalnMtg Mi you|i, NA - Not a vallablc. 1 ^lianye fU9 551 _ - 39/ 31b - v i T V ! t ( I c I i. 1s*: V ft o CO wO r-* a1P Mop CO <\ c* l nn'D ia *J I -J r si n 3: > o 0*- 4- St* M.lit: Ji-lltdlt (ll ONJI in: T1 T II 1 III im: T1 i ii t lit TAMM-. II TIvST MAT'l-.IIIAI.. Vinyl CliMri.lu (Klliyl Cllt |)t:i IV1 ||J ^liiodit Viijiur IiiImIjIIuii iuKiuly Slixly - Allmio llal^, AIIximi Mio; jml i, SmiiMi.try ut M^iik Hotly Wti^lil^ ~ Ait**mi Min: __ ______ ____________ . Mtdll lltltly Wu||>llU (|I|U4I1) _ .. __________ Moiilli Nuuitien 0 l l i 4 S 1. / tt __ 7 JO __ U u M 14 IS ll> t i u 17 20 21 22 21 Cliati^c IS Hlk 41 41 10 ii 46 Si! 49 47 41 47 in 47 46 46 44 \ t 41 _ - _ n i'i 17 41 11 11 4/ 4S 47 47 4tt Itt 17 4tt ID SO 4H - - , - _ u* 40 \a M 41 42 46 41 44 46 17 44 46 - - it* ta 10 u 44 Itt 4S 41 41 4k 11 * - - . - 27 12 11 l*i it, IS tB 17 41 40 17 40 40 40 41 U JO 10 17 11 17 41 17 41 10 II 14 17 i't 1H 40 41 40 40 42 Ii U 41 44 17 itt - ik tl lb 17 16 Itt It* 40 v 10 40 17 Itt 40 itt itt 2H n H IS ii. IT IT 14 IT 19 27 --- _ 12 _ tin mult * w oM pp l--J o ctU o UI CO 03 C a1 < Cj. 0) o o03 K- rn 1 Cl c+ rmi -1 I- i s \ i r i t i n 3: > CK SI I i \ \ l t i m t 1 1 l i ui be* MjIc I'Viualc (noo^* ih: 11 T il T III in; T1 1 II 1 III TAiii.t: hi I LSI MA'JKItlAI.; Vinyl OtluiiUo (Ktliy true Durivul) Clnoitic V.ijm*! IjiImHiujii Toxicity iiludy - Albino Albino Mur .uni < l-i< lldii^iei b Stiitinuiy of Mean Hotly Wci^ltl* * Gohlrn lUniskr^ Mcm Hotly Wri^liH (^liiiib) Klimt I* Humi>ct, .IL__ ^ i _)_ _ 4 9 b -1 8 9 10 __iL J4 11 14 19 lb 1 IH 19 20 21 42 21 jj 98 HO 140 149 110 Hi 1 10 118 Ml 149 12b 149 1II 148 149 12b IH 1 18 141 HI NO 14) I4b 71 90 101 114 140 141 144 148 14b 118 119 no 119 141 144 144 149 l W 1 14 Mb 1 lb 1)7 14) ihO b) 89 V4 99 119 tna 140 118 144 1IV 119 11V 121 12b 111 149 HU 1 t1 1 14 1 14 in - bU 87 91 91 91 88 114 no II& 119 119 114 no 121 120 144 149 1 HI 12/ lib -- 77 711 104 99 lOtt 104 HU 114 140 118 121 118 124 144 149 1)0 12a 14b 1)1 12V 119 118 Mb no 117 M0 119 119 144 117 119 14) 119 122 1. 0 1 <J,j 118 124 114 III 141 12b - _ _ 71 Vi 99 108 107 106 114 114 lib 118 114 114 10V 114 lib III 144 12b 124 12tt 147 - - (,<> 94 100 nib 10b IIH 110 118 109 107 10) 99 101 109 109 114 9b " - - to* IIIHI'i- IMHllili.1 1 1 Hi.iMilliy in Uioiij), Iijnyc_ 71 79 - _ - OP O I 41. o CD !)KcLuiici 3 1 O - T i S 7 Sue. IV. Mortality Data The cumulative monthly mortality data are presented in Tables IV through VI. The following is a summary of remaining animal groups: Soecies Sex Groups Remaining Rats Mice her-stars Male Female Female : UC, T-I UC, T-I UC From mor tality data of the past 5 months of observation, the following estimations of death were obtained: Soecies Group and Sex Rats UC-M UC-F T-I-M T-I-F Mice UC-F Hamsters UC-M T-I-M Estimated Time of Death Months: 5 5 4 1 T 5 3 c SuVcr- ' Hess 7, r I CM* n '7 3 I 0 T E S T J.zJuyjzto-'U&i., jftC. Month Number 1 2 " 4 5 6 7 8 9 10 11 12* 13 14 15 16 17 18 19 20 21 23 TABLE IV TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Rats Cumulative Number of Mortalities at End of Month UC T-I T-II T-III MF MF MF MF 000000 00 20 10 n 1 r\ 00 00 4 024 30 235161 1 34 3 46 1 6 1 54 448262 65 4 5 9 3 10 5 10 8 4 6 10 4 11 5 16 15 5 7 11 7 12 9 24 28 7 8 13 9 14 19 34 52 13 14 19 16 21 37 58 66 16 17 23 24 26 50 73 83 19 21 26 30 33 63 85 36 21 23 28 37 40 75 94 89 23 25 31 45 46 87 100(4) 100 28 27 35 53 55 90 100 100 33 28 38 59 64 94 100 100 38 31 43 66 71 94 100 100 46 34 47 73 i--( mt 94 100 100 52 42 52 80 100(18) 100(4) 100 100 57 48 63 89 100 100 100 100 64 54 72 92 100 100 100 100 T-IV p 0 0 0 0 0 0 1 4 7 17 40 46 76 86 100(7) 100 100 100 100 100 100 100 * Includes 5 males and 5 females from each group excluding T-IV sacrificed for cytogenic study. () Indicates moribund or sick animals sacrificed. Sub;^--V Res; 7. I4~h / \ CMA 011650 , ?s-i.'-siuaJ. 310*1 is S T J.z^iaiyu&L, jW. a Month Number 1 L0* * 5 0/ 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 TABLE V TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Mice UC M Cumulative Number of Mortalities at End of Month T-I T- II F MF MF T-III M 00000000 o 0 0 3 0 0 0 0 0- i 1- 5 .j 4 4 8 2 26 0/ 4 2 8 7 12 2 30 6 8 3 , 10 o 18 5 31 11 9 12 13 23 18 5 32 14 16 30 30 46 23 8 38 24 37 58 56 "5 28 10 42 31 78 82 76 98 30 15 54 46 96 94 100 100 34 16 57 66 98 95 100 100 44 23 70 80 99 97 100 100 54 28 79 91 100 100 100 100 67 39 88 97 100 100 100 100 82 46 100 100 100 100 100 100 82 54 100 100 100 100 100 100 82 58 100 100 100 100 100 ICO 92 70 100 100 100 100 100 100 100 77 100 100 100 100 100 TOO 100 81 100 100 100 100 100 100 100 89 100 100 100 100 100 IDG 100 92 100 100 100 100 100 * `J 'j qma oil*51 v coiirirrv-T *t, : Subject to J_V ' : Hoss v. Ccr.' . ' '<n - JIndmiUol 3 I O * T S S T 2ziniahyu&i, Month Number 1 2 *1 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 TABLE VI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Golden Hamsters UC M Cumulative Number of Mortalities at End of Month T-I t-ii F MF MF T-III M r 54447525 8 11 10 12 9 16 10 ii * ~ <* rt j. "-- * * "X _ L 3 16 16 15 19 15 13 9 18 16 16 16 20 15 15 13 18 16 16 20 21 16 16 13 28 24 19 22 33 18 26 14 28 24 19 23 35 19 28 14 29 24 20 25 36 20 28 14 30 26 20 26 37 23 29 15 31 28 21 26 38 28 36 18 36 34 33 37 46 40 45 23 40 43 49 46 49 49 53 28 46 49 58 54 53 61 69 39 61 53 72 66 55 71 84 50 78 58 83 74 59 84 100 57 81 61 85 76 66 86 100 62 85 62 86 77 75 88 100 65 90 68 89 79 84 92 100 71 96 73 95 86 39 100(5) 100 71 100(2) SO 100(3) 100(13) 100(7) 100 100 73 100 82 100 100 100 100 100 78 100 85 100 100 100 100 100 () Indicates moribund or sick animals sacrificed. CMA 011652 Subject c: 7 . Ross v. Z~:z * . 14 th 7, i: Calc: si-;u 7_V.i -' . ' j. ID-43'7 : :'a 3 I O - 7 S S T ^^yiaiyued., jric. I1 V. Hematologic Data. Twenty-three month hematologic data are presented in Tables VII through X. ro-- 14th Calc CMA 011653 l TABLE VII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Group Animal Number Total Leukocyte Count (thousands/miu^) Test Month: 23 Erythrocyte Count (inillions/mm^) Test Month: 23 Hemoglobin (Concentration (g/100 ml) Test Montii: 23 Hematocrit Value (%) Test Month: 23 Untreated 1 t Control 4 5 7 15 17 18 |w m|m g* 1M. C5_u* o. `"lo ' 1 H 19 22 27 28 34 37 : I -i 1 l 40 41 42 47 O 49 > 52 o 53 J-L tK Mean wKr . 9.0 11.3 8.7 9.8 13.0 16.0 11.5 14.8 8.0 10.8 15.6 9.7 11.6 15.0 0.0 8.8 7.9 9.2 11.6 10.4 11.0 8.03 8.89 8.97 7.30 5.30 6.91 8.52 6.40 7.79 0.57 6.14 8.17 7.88 8.19 7.84 8.55 8.44 6.65 7.84 8.70 7.65 14.2 16.0 15.6 16.1 11.5 14.0 15.7 14.8 15.2 15.4 14.8 15.2 15.6 16.2 10.0 15.9 17.0 14.0 16.0 16.2 15.3 48 53 51 50 40 48 54 40 50 50 45 48 52 52 51 50 55 44 50 52 49 v t- i o -I ni ts> TABLE VIi continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Group Animal Number Total Leukocyte Count (thousands/mm^) Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 T-l If g> po rfr*1 M [j. (MaVj M + ^ 1 ^* :J cna>T i !o V- 1 ' ' '1 ,1 O, , * cl i 1 1 i - ( 1 i j ^ .V 201 20 V 20l) 212 214 222 223 225 226 227 228 232 213 231 2 18 211 246 250 255 268 Mean O 3 > oh* h* uCil 9.8 . 1*1.6 12.4 12.4 8.7 9.2 10.8 14.8 11.8 5.4 7.6 9.2 10.4 7.3 10.5 12.2 13.7 18.6 6.4 8,7 10.7 6.54 6.54 3.82 7.26 6.91 6.38 6.44 6.4*1 7.83 6.57 7.83 7.80 8.19 8.45 7.75 9.37 6.77 7.47 6.95 7.18 7.12 12.4 14.0 8.6 14.4 14.3 13.7 13.8 10.4 15.2 13.7 15.2 14.3 15.8 15.6 15.4 16.4 13.6 14.0 13.8 14 .6 14.0 . ------------ 40 44 30 46 44 42 46 38 49 42 47 44 50 49 48 52 41 45 42 44 44 V. L to O ni in TABLE VIII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rats Group Animal Number Total Leukocyte Count (thousands/mm 3) Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 Untreated Control ltd 0 Jn. g|wj o' 1 re 11 f ! l: o1 ') ::J ,j j - .! iH i> s-s:i 2 102 105 107 100 111 112 in 117 118 119 J 21 123 124 125 127 130 131 132 133 134 Mean 3 > 2 * ta O'- 13.0 9.1 7.8 15.3 8.3 15.6 10.3 3.6 6.1 11.1 9.0 14.4 10.8 6.1 5.8 20.0 5.0 5.9 8.1 7.0 9.6 5.02 6.78 6.38 7.15 5.29 4.49 5.49 7.26 5.80 5.43 6.10 4.90 6.25 7.27 7.10 2.69 7.18 7.60 6.54 7.30 6.10 12.0 14.9 13.2 14.6 10.4 9.1 12.2 14.6 12.0 12.2 13.6 10.0 13.2 14.8 14.0 5.7 14.6 14.4 13.5 14.4 12.7 40 48 42 46 34 30 38 46 38 38 42 35 40 46 43 22 46 45 42 45 40 B IO -7H S 7 K. 1 r i- Group T-l TABLE VIII continued TEST MATERIAL: Vinyl Chloride (Ethylc.i : Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rats Animal Number Total Leukocyte Count (thousands/mm^) Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) 1'est Month: 23 Hematocrit Value (%) Test Month: 23 315 322 326 337 352 354 363 Mean 9.6 8.4 24.6 9.0 28.4 14.9 5.9 14.4 7.11 6.95 2.01 8.24 6.28 4.42 8.60 6.23 13.2 13.6' 4.4 13.8 10.8 8.8 13.5 11.2 43 43 17 49 36 30 46 38 'Jo 1p-- o p Efl H* O P- cT ty c-i r: i-i. \ PM |to <i * 1o3 I1 O CQ G CC_jf. (T> O Hcf O o o M 'J !i A <J A i o >3: & \J V- W o rn in -- Ot ^ruzudiivil 3 I O T ES T Calc.-. Group Animal Number Untreated Control 17 28 40 T-l 250 TABLE IX 1 ES*1 MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rat ... Ring* Differential Leukocyte Count (number of cells per hundred) Neutrophils Band Segmented Lymphocytes Monocytes Eosinophils Month Number: Month Number: Month Number: Month Number: 23 23 23 23 Basophils Month Number: 23 52 41 52 0 10 0 52 37 0 11 0 40 48 1 0 1 0 0 0 0 10 0 11 79 0 0 0 4 Several of the ring -form neutrophils were twisted like a figure 8. "2S' n '< ocd -n- fHI. 1i l,-i o o 3: > O(0.01' Group Animal Number Untreated Con trol 108 112 117 130 T1 326 352 354 TABLE X TEST MATERIAL: Vinyl Chloride (Ethylene Derived) I it to Chronic Vapor Inhalation Toxicity Study - Albino Rata, Albino Mice and Golden Hamsters O Ring* Hematologic Data - Female Ran. Differential Leukocyte Count (numht r of cells per hundred) Neutrophils Band Segmented Lymphocytes Monocytes Eosinophils Month Number: Month Number: Month Number: Month Number: 23 23 23 23 Basophils Month Number: 23 in to --l 71 14 0 70 11 1 34 62 30 34 52 5 31 1 63 .0 54 0 1 2 0 0 0 0 0 0 11 0 35 53 i 0 0 13 0 31 54 1 1 0 90 32 57 2 0 0 -* Several of the ring* form neutrophils were twisted like a figure 8. > *-* --!/ V-* O' 01 O Cn.* aj n ^ .-Jn 'o -,, i.n ld3? -in.-i 3 I O T C S 7 JljJuyuiiiyue&, Due. 13 VI. Gross Pathology Tables XI, XII and XIII present suspected treatment-related tumors based on lessious found during gross necropsy. These lessiuns will be evaluated by histopathological examination to determine their true value. Tumor Key C ESC P PMA S = cannibalized = escaped = postmortem animal = valid evaluation precluded by postmortem autolysis = sacrificed animal A = antmai stm alive CMA 011660 Subject : Eos5 v. ", CiiOo-biCLL F uta fridmitisl 3 I O T H S T IsJMyiatfrtigA,, 9hc. 10 TABLE XI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1 Control 2 - 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 557 -^ ^ 372 411 504 556 564 532 590 331 656 681 712 609 607 424 645 712 611 402 138 365 146 612 P :d A A P A P PMA P PMA PMA PMA P A P A A A P P A P P p SE A A oL PMA p o im PMA A PMA PMA X X A X a: cm ev SubjC; l; Boss v. 14 th ; Calcus: . j- CrtA jruLtiluzl 3 I O - T S S T JliuyuzZyu&i, 2tvs. 20 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal GrouD Number Days on Test Mortality Data Liver Sdeen Lune Skin Misc. Untreated 37 Control 38 continued 39 -iO ' 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 A 660 P 360 ; A X A A 667 SE X 702 PMA 524 PMA X 619 P Kidney A 703 P X A 673 P 204 P X A A 360 S 360 S 692 P X A 641 P 347 PMA 463 PMA 272 P A 456 P X A 572 P 581 P CMA 011662 511 P A 360 S X 626 P 578 PMA A jnxri--:oiAL Subject to I': - M'T ,, Ross v in ---- 1 --0. 93-dTi7 14th- Judicial y3V,,t c,,ur`t ---------------- CaIca$ifiu Pariah, Louisiana----- i'Jsil B I O * T i 5 T JaJtcyta&yu&t, $hg. TA3LE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 73 A Control 74 continued 75 599 P 541 p 7 6 5uo C i -i 77 675 ? 78 A 79 A 80 A 81 A 82 685 P 83 603 P 84 360 S 85 699 P 86 595 P 87 587 P 88 713 PMA 89 384 P 90 302 P 91 706 PMA 92 507 P 93 415 p 94 409 p 95 384 P 96 591 P 97 168 P 98 474 *o 99 496 D 100 710 P X X X X X cNA 011^63 Subject "c Ross v. Cone cc, _ ' , _ 14th Judicial Sic.ct Calcasieu Parish, Louisiana B I O - T E S T fM3Ao&u&t, Jrtc. D > TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. 201 A 202 462 P _ -j j i 46 204 668 *D 205 361 s X 206 642 p 207 A 208 701 PMA 209 A 210 536 P 211 189 p 212 A 213 703 P X 214 A 215 145 P 216 568 P X 217 599 P X 218 718 P 219 529 P 220 101 PMA 221 541 P 222 A 223 721 P 224 668 p X 225 A 226 A 227 A 228 A 229 675 P 230 74 PMA 231 719 P X 232 A 233 A 234 A 235 324 PMA 236 645 P X X X C'V" Subject :: Ross v. Ccr.o'. 14th Calcasieu P .. i CMA 011664 jAO*vU/'MiL SIO-TSST J.zmaataM&&., 9me. 23 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Grouo Number Days on Test Mortality Data Liver Soleen Lun? Skin Misc. T-I 237 136 PMA continued 238 A "'3 0 6 46 13 240 261 ml 241 722 P. 242 693 P 243 669 PMA 244 611 P XX 245 595 P 246 A 247 695 P X 248 703 P 249 526 P 250 A 251 A 252 508 P X 253 113 P 254 693 P 255 A 256 361 S X 257 634 PMA 258 34 PMA fN 259 581 P c^ ^t 260 617 ? X r, p S ^o - 2 261 624 P n\- ^ 262 275 PMA r: " 263 274 P t-- 264 361 S .'3 / ' -1 * * 265 693 p . j ' *H 266 318 ? X ',:i six 267 662 P -- 1! O_ C, 1 ii <OH 3^ 268 A o' ^iip-P r[\5l1'h^p *r^Pa 269 642 ? X X o> > jP= rj llr" PhJ 270 271 272 99 534 640 c P ? ' Thymus Kidney X X Kidney X CMA 0116&5 K:dney A . ucr.ey SttGidliisl 3 I O * T 5 S T jftc. 24 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Grouo Number T-I 273 continued 274 27o 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 Days on Test 690 661 - * 1 120 388 569 361 383 85 204 670 665 547 531 43 438 412 541 573 224 89 94 249 361 547 Mortal: Data P SE PMA P P S P ? A P P A SE PMA P ESC P ESC A P P P PMA PMA PMA S P Liver Spleen Lung X X Skin X X Misc. CMA 011666 , - Subject tj ' Mossi v. Con.; 14th fcdZz n. - ' Calcasieu Paris:/, i -n T.J7 a SIOTCST jVfci 26 TABLE XI continued TEST MATERIAL : Vinyl Chloride (Ethylene Derived) Chronic Vapor Inh alation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Susp ected Gross Tumor Observations in Male Rats Animal GrouD Number T-II 437 continued 438 '.JO 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 Days on Test 473 381 474 626 134 616 451 535 626 576 449 482 501 507 532 626 626 502 452 626 466 526 361 577 333 575 485 626 465 239 547 395 361 224 626 t^o-1* -^1 Mortality Data Liver Soleen Lung Skin P P T3' f ^ 5 PMA PMA P PMA S P P P P P PMA S S PMA P S P PMA S PMA p PMA PMA S P PMA P P S P s p X X X X X X X X X X X X X X X *' X X X X X nr7 Subject Ross v. "I" 14th :1 Misc. CMA 011667 * 7, ' . 1 `7 : DtuiH.&Mil 3 I 0 - T z S T 2^JiOAci0A4^, jrtC. 25 TABLE XI continued TEST MATERIAL : Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal GrouD Number Days on Test Mortality Data Liver Soleen Luna; Skin Mi sc. T--II 401 495 ? X 402 505 P If)? 626 X X _^ 404 361 405 474 p X X Pancreas 406 534 P XX 407 527 SE X 408 555 P X 409 535 P 410 340 PMA 411 485 PMA 412 631 S X X 413 631 S 414 506 D X X 415 64 P 416 597 P X Mesentery 417 506 P X X 418 631 s X 419 574 P X 420 415 p X 421 604 p X 422 449 PMA c 1* I P ^34 423 424 108 341 PMA P X cO o3 H " O 425 589 P <r" o ^ o 426 626 S X -- 427 529 PMA +OJ rM +> M . <2 m 5 423 429 626 611 S P y X to Pro Conoco, mb 430 626 S * 3O *- 431 297 D X sO O i3 432 317 PMA ( -tOOH-3 >* ^ 433 434 361 617 S P X X W32 nCoO s 435 626 S X W 436 626 S X X X Thymus CMA 011668 S l O * T H S T -thuo-iai&uei., 2kc. TABLE XI continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study .Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number T-II 437 continued 438 '.30 4*0 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 Days on Test 478 381 626 134 616 451 535 626 576 449 482 501 507 532 626 626 502 452 626 466 526 361 577 333 575 485 626 465 239 547 395 361 224 626 244 Mortality Data Liver Soleen Lung Skin Misc. P P O' f x 5 PMA PMA P PMA S P P P P P PMA S S PMA P S P PMA S PMA p PMA PMA S P PMA P P S P S P X X X X X X X X X X X X X X X X X X X X v r -- Subject to ^. -floss v, Conner , tuu. -M. i'O - 4337 I4th Judicial-!) strict r.ourt Calcasieu Purio b Louloia.-a CMA 011669 3 I O - T S S 7 J.zaosmt&xi&i., jv^. TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal GrouD Number Days on Test Mortality Data Liver Soleen Luna Skin T-II 473 502 P continued 474 r < i P ,,- C 476 229 p X T '' ** 477 374 P X 478 196 PMA 479 590 PMA 480 231 PMA 481 525 P X 482 569 P X 483 596 P X 484 626 S 485 468 P 486 513 P X 487 223 PMA 488 223 PMA 489 361 S X 490 359 PMA 491 626 S 492 432 P 493 465 P * r 494 612 P X 495 536 PMA 496 480 p X 497 446 P X 498 429 P 499 129 P X 500 480 P X X X X X Misc. Prostate Seminal vesic Lymph nodes V 'Subject L: - lnoss-v. . : 14th ju-l*.'^ 1 Calcasitu CMrt 011670 ?rUZ^iiucd 3 1 0 - T 2 S T J.zotyuzovUea., 23 TABLE XI continued TEST MATERIAL Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Soleen Luna Skin Misc. T-III 601 355 SE 602 247 PMA L^ ^^ p 6 0 4 402 "D X X 605 366 P X 606 242 P 607 344 P X 608 384 P X X 609 361 s 610 439 p 611 390 p X XX Mesentery 612 236 p 613 394 p X 614 400 p X 615 411 p X 616 496 p 617 250 ? X 618 498 s X 619 426 p X 620 470 p X 621 371 D i. X X 622 244 p V 623 292 p 624 362 SE X X X 625 341 SE X XX 626 344 P X 627 353 p X 628 448 P X 629 389 P X X 630 424 P X 631 452 PMA 632 341 SE X CMA 011671 X 633 341 P X 634 455 P X 635 177 D4i r ................... L 636 392 P X _ r ' ^t Pcs:3 V, ;Calebs!"? j - . ~ 1 ' -1" 1 5 I O 7 S T sJt&\G&vu&, !)*ic. 1Q TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin T-III 637 405 P continued 638 412 P 6?Q 361 s X X 0*iU 459 P A 641 359 SE 642 208 PMA 643 293 P X 644 498 S X 645 340 P X 646 373 P 647 258 P 648 314 P 649 402 SE 650 318 PMA 651 372 SE X 652 386 P X 653 281 P 654 452 P 655 343 SE 656 428 P X 657 148 P 658 427 PMA i" I')1 ^ "', -*-5 - oCu r3 659 660 453 92 P P X 661 299 P X - -J x '3 662 339 P ; t *3 663 361 S -J. pCQ * 664 373 SE Z : Q -h 665 274 ? 666 382 P X X X 667 383 SE X 668 361 S X 669 377 P X 670 366 P X O 671 383 SE PS 672 310 SE X X X X X Misc. Kidney Brain Brain Brain CMA 011672 c t to P.,, . Conoco, J u d ic ia l ;a s ie u Par j3 1 0 * T E 5 T 2zbo>\ctvuelL, S*c. TABLE XI continued -- TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations m Male Rats Animal Group Number Days on Test Mortality Data Liver Stsleen Lun^ Skin Misc. T-III 673 321 P XX continued 674 335 PMA -i 676 342 p X 677 297 SE X 678 304 P 679 428 P X 680 273 PMA 681 314 P X 682 296 SE X 683 338 P 684 359 P X X 685 374 P X 686 360 P X 687 498 S X 688 443 P X 689 308 P X 60 393 PMA 691 413 P' X 692 408 P 693 157 PMA 694 361 S X 695 455 P 696 311 p X 697 364 P X 698 383 P X 699 332 P X 700 143 P CMA 011673 Subject Ross y. 14th J.': Cal" ~ - 3 ! O - T H 5 T J^MyuiUues, ?*a. TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study .Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal C-rouo Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 101 661 SE Control 102 A * A " i p 104 649 P 105 A 106 360 S 107 A 108 A 109 513 PMA 110 704 P 111 A 112 A 113 A 114 573 P 115 673 P 116 386 SE 117 A 118 A 119 A 120 619 p 121 A 122 575 P 123 A 124 A 125 A 126 563 PMA 127 A 128 313 P 129 557 P 130 A 131 A 132 A 133 A 134 A 135 492 PMA 136 A X *- X X X X X to CO *3 IC <o7i ci < M> X p M poo oP & o O o -p <' cu 'ir 1 PJ .-4 -p o X CJ<0 *-3 > x: & p CO \ ^ i--t .i CO o pH CMA 0X1674 tot 2ivL*UrU&L 3 l O 7 E S T ync. TA3LE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats GrouD Animal Number Days on Test Mortality Data Liver Soleen Lung Skin Misc. Untreated 137 A Control 138 504 ? continued 129 " ^ `w ' 140 ."V 141 612 P 142 A 143 A 144 619 P 145 718 P 146 A 147 452 P 148 A 149 360 S X 150 A 151 113 D* 152 715 P 153 A 154 71 P 155 704 P 156 656 P 157 596 p 153 A 159 652 SE 160 360 S 161 357 D 162 691 PMA 163 616 P 164 499 p 165 544 ? 166 A 167 129 PMA 168 607 PMA 169 296 P 170 698 D ' 171 272 PMA 172 A X X X X X *Yh c|-H u- *VV I ' ' hTM1 ZZ ^ <u ' ,, X ^ c-i 7* 1; , -- P-N -fm . V--l ! > c ._ o; 'T A : CMA 011675 ____ Hi: 3 I 0 7 S 5 i 2sJxvuztiyu&, 23 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Soleen Lung Skin Misc. Untreated 173 169 P Control 174 v * - -a r? T- A *3 17o A 177 611 D* 178 361 S 179 640 P 180 A 181 660 P 182 A 183 A 184 665 SE X X X Adrenal gland 185 616 P 186 669 P 187 A 188 614 P 189 631 P 190 199 PMA 191 A 192 241 PMA 193 461 PMA 194 596 SE 195 A 196 A 197 495 ` SE 198 699 ? 199 531 P 200 361 3 X X Adrenal glanc X X X X X A.crerai glanc CMCS 011676 .COUFlpv^ T_A t, Subject tc -Ross vs - . 14th J - ! CiIt. - ' '37. ?ru*su&l 3 I O - T S S T 34 TABLE XI continued TEST MATERIAL : Viny 1 Chloride (Ethylene Derived) Chronic V'apor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters S'.:spected Grossi Tumor Observations in Female Rats Anima 1 Grouo Numfae r Days OR Test Mortality Data Liver Soleen Lune Skin T-I 301 460 P 302 652 SE X - - --c\1JI ,j '-A ' o i+o> 4 -' c \ ri ?3' O 303 361 S 304 604 4O. ;; X 305 569 D X 306 174 PMA 307 479 PMA 308 238 P X 309 651 P X XX 310 512 P X 311 555 ? X 312 595 P X X 313 404 ? X 314 516 P X 315 A 316 283 P 317 630 ? X 318 247 D 319 41 ?MA 320 388 P 321 460 P X X X 322 A 323 641 P X X 324 691 PMA 325 522 D 326 718 ?? 327 616 P X X X X 328 451 D 329 614 O X X X x 330 413 tm X 331 661 SE 332 617 P X V 333 621 P X X 334 577 DH 335 656 SE X V X Misc. Adrenal gla CMA 011677 Acrenai si; 3 1 O - T 2 5 T Jz*MVuz&ueA, jrte. 35 TA3LE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inn alation Toxicity Study Albino Rats , Albino .\ lice and Golden Hamsters Susp ected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-I 336 524 P continued 337 333 A * -- T5 *k 339 o07 ? 340 632 p X 341 180 PMA 342 214 P 343 588 P 344 760 PMA 345 573 D 4. X 346 180 PMA 347 116 PMA 348 427 P 349 361 S X 350 466 P 351 597 P 352 A 353 300 pi. 354 A 355 540 P 356 449 PMA 357 449 ? X 358 531 P s 359 49 PMA C J 360 51 PMA " ' T ^ 361 547 PMA - .4 '' %i 362 493 p 1: ' (r-- . - \ ` 363 A 364 333 PMA 1 * 365 454 PMA 366 476 P ' V 367 523 ? 368 428 P > +J ^ . 369 361 S X 370 521 PMA .51 > _J 371 277 P X s <j 372 437 ? "If X X r * X X X X X X XX X X X X `X CMA 011679 C 0 TTp J T>7'j TTT T A T* 3I 0 -T S ST IvtC. 56 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , .Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Grouo Number Days on Test M ortali ty Data Liver Soleen Lung Skin T-I 373 <->.*- t-i trued iT- 84 P -- X x' 375 542 376 642 SE X 377 381 ? 378 198 PMA 379 494 P 380 419 PMA 381 361 S X 382 656 SE 383 513 P X 384 519 ? 385 337 P 386 356 PMA 387 654 P 388 400 PMA 389 283 P 390 584 PMA 391 127 PMA 392 556 PMA 393 387 PMA 394 576 P 395 593 P X 396 346 PMA 397 361 S 398 703 p X 399 532 ? X 400 591 p X X X X X XX X *v X X AX -v Misc. Ki dr. ey L'terus Adrenal gland CMA 011679 y;": :' CC:T~T-' Subject t: Ross v. Ct - 14 th J Cal-- ; ; I ;\L jruL-^-uai 3 I O - T H S T Jstj&ial&u&i., Urtc. 5" Grouo T-II .cr. 'V- TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters SusDected Gross Tumor Observations in Female Rats Animal : umber Days on Test 501 473 502 341 D > ' T -71 504 483 50 5 384 506 360 507 438 508 433 509 327 510 395 511 626 512 348 513 295 514 624 515 377 516 377 517 515 518 208 519 356 520 360 521 143 522 626 523 480 524 361 525 466 526 392 527 364 523 471 529 515 530 420 531 488 532 414 533 389 534 437 535 238 536 509 537 508 Mortality Data Liver PMA D r D P P P PMA PMA PMA SE DL PMA P P P P P P SE P S P s PMA P P PMA PMA P P P P P PMA P D X X X X X X X X X X X X X X X X X X X bxin X X X X X X X X X X Misc. Kidney ml4 -- C A** * ^ v-- CMA 011680 SruLt&i'^ol 3 1 O T H S l jtiC. TABLE XI continued TEST MATERIAL: Vinvl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Sus pected Gross Tumor Observations in Female Rats Animal Grouo Number T-II 538 ccntinu.ed 539 5-`, 5-41 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 553 559 560 561 562 - 563 564 o. O! ^ - s S u b je c t > V,( ;n j r-'l ^ ------- 565 566 567 568 569 570 571 572 573 Days on Test 377 316 35341 2S1 306 356 487 428 373 396 303 361 336 335 427 500 461 399 626 496 393 321 314 314 452 402 626 366 429 361 443 417 363 416 Mortality Data Liver Soleer. Luns PMA p\ f f - ? P P P P P P ? S PMA P P P PMA P S PMA P D ? D o p p s p ? s p ? D ? X X X X X X X X X X X X X V X A^ r x X X X x X X X X X X X *A X -.V Skin X X X X X X Misc. Pancreas Thymus Xidnev Adrenal Mar.d CMA 011681 3 I O - 7 S S 7 IzJt&vztiyUed., Is- TABLE XI continued TEST MATERIAL: Viny 1 Chloride (Ethylene Derived) Chronic Vapor In halation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Susp ected Gross Tumor Observations in Female Rats Animal Group Number T-II 574 continued 575 578 579 580 581 582 583 584 585 586 587 538 589 590 591 592 593 594 595 596 597 598 599 600 Days on Test 276 325 V< 7 345 468 234 262 395 411 309 505 306 429 420 419 402 311 311 388 387 361 357 429 417 454 361 335 Mortality Data Liver Soleen Lun^ p P PMA D P PMA P P P P P P P P P PMA P PMA PMA S PMA P PMA P S PMA X _ V X X X X X X X X X X X X X X X X X X X X X - Skin X X X Misc. Lymph nodes CMA 011682 ec t ' `' 3 I 0 * 7 H S T 2zmag&um, jne. TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats -1J3? Group T-III u c- A > Cj \ Animal Xurr.be r 701 702 703 . M-: 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 720 721 722 723 724 725 726 727 723 729 730 731 732 733 734 735 736 Days on Test 366 262 ' ?Z> ' 2 443 373 346 375 306 240 333 303 261 405 312 353 361 383 405 224 211 317 374 296 438 321 303 361 381 443 319 361 334 32 361 316 Mortality Data Liver pX P r Spleen Lung Skin p p p PMA SE P P PMA pt. P P P S P P P p SE P ? p P D S P D PMA S SE PMA S PMA X X X X X X X X X X X X X X X X X X X X x X Misc. Thymus Salivarv 2land CMA 011683 310-THS T Inc, table XI continued X C I MATERIAL; Viny 1 Chloride (Ethyl ene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross T umor Observations in Female Rats Animal GrouD Number Days on Test Mortality Data Liver Soleen Lun^ Skin Misc. T- III 737 378 PMA continued 738 295 D _k 740 362 5E ,TVT 741 311 P 742 361 S X 743 325 PMA 744 367 P X 745 351 PMA 746 368 SE X 747 235 P X 748 347 P 749 379 *D X X 750 336 P X 751 82 PMA 752 82 PMA 753 377 P X 754 371 P X 755 277 P X 756 348 P X 757 374 P X 758 383 PMA c '59 82 PMA -- - 760 320 P X S- 761 354 SE X hi!/: 762 256 P X '' 763 365 P X '^i-- 764 290 P X frj! ' 765 322 ? g|o 766 311 SE &fri1c: o 7- 767 768 326 SE 311 ? X v O ]-op 7, #^rT> > x: -" 7^o- 9Q 770 113 268 PMA P X fgj'So "1 286 ? X "4 "2 330 p X X X X Pancreas X Thymus X X X Kidney CH* 0U684 _ * ' _ i a ' 0-7ES 7 jV.c. - -\ TABLE XI continued TEST MATERIAL: Viny 1 Chloride (Ethylene Derived) Chronic Vapor In halation Toxicity Studv A .bmo Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal C-ro uo Number Days on Test .lortalit y Data Liver Soleen Luna Skin T-III 773 314 P continued 774 343 P --* o X X T" 7"c 284 X 7" 365 p X 773 299 c 779 325 PMA 730 353 SE X 781 389 ? X 782 322 P 783 303 SE X . 784 372 PMA 785 283 ? X 786 113 PMA 787 113 PMA 788 113 PMA 789 324 P X 790 113 PMA 791 401 P X 702 339 4o A^ r 793 274 ? A^ * 794 271 ? aVa 795 113 PMA 796 78 ESC 7Q7 78 ESC 798 348 p X 79 78 ESC 300 78 ESC XX , X Misc. Salivary gland Cervical lymph nodes Kidney CMA 011685 Subjec-TTrrrBoss v. r.-~, ` ' 7- C- 4 7^ T A T in'O'-! ' '.'7 3IC-7SS 7 Xz&yuzt&u&i, jrtc. 43 TABLE XI continued TEST MATERIAL: Viny . Chloride (Ethylene Derived) Chronic Vapor In halation Toxicity Study Aibino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Grouo Number Days on Test Mortality Data Liver Snleen Lung Skin T-IV A W ^ S- . __ ' m . , iM C3O - \ ^' ^,\J */ 2401 2402 .TV J ' 2404 2405 2406 2407 2408 2409 2410 2411 2412 2413 2414 2415 2416 2417 2418 2419 2420 2421 2422 2423 2424 2425 2426 2427 2428 2429 2430 2431 2432 2433 2434 2435 2436 379 350 JiL 345 411 405 310 398 434 268 473 349 434 496 261 498 346 351 352 398 498 342 379 434 498 489 457 366 382 297 372 429 311 264 342 484 P PM A. A ? 0 * P PMA P P P P P SE P PMA S P P ? O S PMA' PMA Ou S P P P 0 * P PMA P P P 0 p A V X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Misc. Mesentary CMrt 011686 p 6 ii 3I 0 -T 3 S T jhc. TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Ini':alation Toxicity Study Albino Rats , Albino 1 lice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal C-rouo Number Days on Test Mortality Data Liver SDleen Luna Skin T-IV 2437 contir.u ed 2438 4- n-- o'- 1 1 . t m oo >. ,c `vj , -p M S n Vv <3 w o,5 u H K 2439 2440 2441 2442 2443 2444 2445 2446 2447 c 4-i3 2449 2450 2451 2452 2453 2454 2455 2456 2457 2453 2459 2*60 2461 2462 2463 2464 2465 2466 2467 2463 24o9 2470 2471 2472 385 306 265 394 306 3S1 473 352 385 385 340 325 370 426 426 365 331 423 220 330 392 375 387 365 498 326 375 318 411 356 365 432 424 361 383 414 PX SE -X ?MA P PX X D DX PMA P PX PX X PX PMA X PX PMA PMA p X PMA PMA ? *V* X PX ?X X PMA SX X SE X X PX PMA p p X ** A X V k PMA P ?x pX X PMA pX Misc. Cervical lymph Lymph nodes 011^87 ?*sLui'~d 3 1 0 - T E S 7 45 TA3LE XI continued TEST MATERIAL Viny 1 Chloride (Ethylene Derived) Chronic V apor Inhalation T oxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal GrouD Number Days on Test Mortality Data Liver Stsleen Luns Skin T-IV 2473 continued 2474 ~- ill 3 2477 2478 2479 2480 2481 2482 2483 2484 2485 2486 2487 2488 2489 2490 2491 2492 2493 2494 2495 2496 2497 2498 2499 2500 447 431 3T -- 443 469 363 407 417 323 398 316 314 250 348 476 440 344 403 390 379 415 498 355 368 356 285 422 432 PX X PX :: *X T3 X PMA P.MA P X PMA P P XX PMA SE P P o* PMA X X PX PMA PMA PMA S PX PMA PMA SE P PX X X X X X X CMA 011*88 Misc. o--- -- z Cvary Kidney Me= enter" W ------ y Subject Eoss v. c. ' ' " *7 r,, - 3IC-TlS7 J TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal C-rouo Number Days on Test Mortality Data Liver Soleen Lune Skin Misc . untreated SOI Control 802 304 805 806 307 803 809 810 811 812 813 814 815 816 817 313 319 320 821 322 323 824 325 826 827 328 329 330 331 332 833 834 335 560 429 --i 428 371 301 429 502 329 452 204 428 197 190 388 505 148 305 474 568 187 94 568 134 418 122 134 321 340 200 570 462 401 94 ?i.;a ?MA rt 4* , ..1 K * ** * Vm ?MA FMA P p p ? P PM4. PMA PMA D p PMA PMA D PMA p p ? o PMA PMA PMA PMA p PMA pi.; a D p ? r-r- *."tn Cal' m CMA 011689 3 I 0 - 7 i S 7 J^Myiaiyuei, Jus. TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study .Albino Rats, .Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal C-roun Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated Control ---------------J 3 3 H . ' j .'i -j , A ^ 836 837 v73 33? 340 841 842 843 844 845 846 847 348 849 850 851 852 853 854 855 856 357 853 859 860 361 862 363 364 365 366 367 868 369 870 116 178 T `1 3 -- T* 383 279 302 213 390 451 390 575 461 271 527 497 441 161 255 255 261 174 564 148 178 178 435 496 272 376 409 564 454 351 349 PMA p '"` r or l or f ' >*.. ?MA PMA PMA ? PMA P P PMA SE PMA P P PMA PMA PMA p PMA PMA o * ? PMA PMA P PMA P O PMA P SE D CMA 011690 3 I O - 7 z S 7 ASMloLsyiui, Jnc. TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. Untreated 871 Control 872 i 176 567 - -^ PMA ~3\` v ^ i t 276 p 875 152 PMA 376 466 877 450 878 371 P p PMA 879 500 P sso 411 P 881 431 P 832 423 883 406 PMA p 884 380 885 381 P p 886 459 P 387 292 P 838 376 P 389 431 1 p 390 275 PMA 391 316 392 530 ? p_ 893 94 PMA 894 409 895 378 P p 396 262' PMA 897 428 898 354 399 277 P p PMA 900 424 PMA CMA 011691 ---- Subject t7 Ross v. ' -L- - <J Ca : - - ' '7 "f DK^LmiiiaL B l O - T E S T J.alta\aloAie, !}hc. 49 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortal! Data Skin Misc. T-I -c ^^ - C^tf ?A 5 5 ^1 j> -, . `--i> o < - --i O j CJ ^ C O ? 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 1022 1023 1024 1025 1026 1027 1028 1029 1030 1031 1032 1033 1034 1035 149 445 392 362 492 421 130 309 498 332 79 79 85 85 85 309 378 136 92 290 121 437 121 498 498 367 413 137 332 498 115 346 115 173 281 P P PMA P P P C PMA S PMA C PMA C C C P P C c P c P c s s PMA P P PMA s P P P PMA P X X Prostate X X Mesentery Mesenteric nod CMA 011692 2tidasiUai B 1 0 - T E S T J.3Ji&iata/tieA, j*- 50 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lune Skin Misc. T-I 1036 continued 1037 . 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 c J o 3 * 1059 1060 1061 .A < ` * vo4 ' p, 1062 1063 1064 13 1065 L- "i `'4 .i `H 'Si ' %* V: H 1066 1067 1068 1069 1070 CO t-l 407 150 373 196 265 205 275 377 378 123 145 247 149 498 243 389 121 196 118 196 149 145 85 121 346 165 271 121 104 498 121 332 286 434 121 P PMA P ? P PMA PMA P P PMA PMA P P S PMA P P P PMA P P PMA C c P PMA PMA C PMA S P P P p c X X . X X X X X X Mesenteric nod? CMA 011693 B 1 0 - T E 5 T 2aiia\aityued^ j*- 51 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Mis c. T-I 1071 continued 1072 . 1073 1074 1075 1076 1077 1078 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 446 316 294 377 386 386 401 311 319 437 406 362 448 498 432 406 407 407 275 410 267 332 380 293 369 432 386 353 446 365 P PMA PMA P P P P P P P P PMA S P PMA P P P PMA P P P PMA P P P P p* P X X X X X X X X X X X Mesenteric node X X X Kidney Kidney X CMA 011694 ccr.. i Subject te " - - _ * n Ross v. C:" . - . . 3 - 17 14 th ;. .. . ' 'j Calcasieu f_.i. i, I . ' ' : . .< B I O - T 5 S 7 2sJtateiZyU&&, 9hc. TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Grouo Number Days on Test Mortality Data Liver Soleen Lung Skin Mi sc. T-II 1201 : 202 TO 3 1204 1205 1206 1207 1208 1209 1210 1211 1212 1213 1214 1215 1216 1217 1218 1219 1220 1221 1222 1223 1224 1225 1226 1227 1228 1229 1230 1231 1232 1233 1234 1235 320 277 324 225 274 296 254 291 275 309 286 331 351 331 322 359 293 318 272 291 226 235 291 225 269 374 299 295 234 310 276 311 290 297 308 P P ? p P P P P P P P SE P~ SE PMA P P SE P PMA P P P P P P PMA PMA P P P SE P P P X V A V X X X X X X X X X X X X X X X X X X X X X X X X X X X V X Mesenterv X X X X X X X X X Mesenteric r.oc X X X X Kidney X Lymph nodes X x X CMA 01X695 CCIIFTT)''" 7 TAX, Suh1fsn+ fn y r. - ~ "JMr in jJoss v. CcriT " - 14th JuiT ' - - j - -3o7 - 1 - u 4, Calcasieu IT; . jr'Audi'ual 5 1 0 -TEST Jzhyiayii&i, jfas. 53 -- TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethyl ene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Soleen Lung Skin Misc. T- II 1236 348 continued 1237 340 1238 317 1239 268 1240 292 1241 143 1242 368 1243 303 1244 302 1245 310 1246 389 1247 268 1248 288 1249 300 1250 340 1251 290 1252 258 1253 258 1254 271 1255 282 1256 264 1257 401 1258 - fCrO* 1259 3 - d ^ ga 1260 < OC7i wO CHQ 1261 1 ^ jj -d 1262 . ' 1i o> ^O* S3 -_p 1 1263 1264 3 1265 , _rt ` ^` p"-4* 1 5 /Oo1 c ^ H3 c3 ^^ 1266 1267 1268 C3 l -oT1 ^ O >^. m 3 ncfl ,+Si 3<d 2 .... 1269 1270 292 303 304' 287 313 383 244 299 276 249 180 302 303 CQ o p= ' PX X PX PX X P PX X P PX PX PX X PX X P PX PMA PMA . PX PX X PX X PMA PX P. X X PX X PX PX X PX PMA PX X PX X PX X PX X PMA P PMA X ' X P PX X PX X Kidney Mesenteric no CMA vl1696 A w B 1 0 T E 5 T lal&uit&uei-, Dfic. r< TABLE XII continued TEST MATERIAL : Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lunsj Skin Misc. T-II 1271 continued 1272 1273 1274 1275 1276 1277 1278 1279 1280 1281 1282 1283 1284 1285 1286 1287 1288 1289 1290 1291 1292 1293 1294 1295 1296 1297 1298 1299 1300 283 258 339 324 317 218 261 273 288 288 265 289 289 286 145 277 248 284 197 305 91 91 255 306 253 214 298 234 294 294 P PMA D P P P P PMA P PMA PMA P PP PMA P P P P P ESC ESC D ? P SE PMA P PMA P X X X X X X X X X X X X X X X X X X X X X X X X X Lymph nodes X X XX X X X Kidney X X X Salivary glai X X CM* 011^97 C\ - Subject v; Ross v. C-.- - 14th i"'- - ' ' "i - - - -7 - Calcasieu leju --1 Ltuioiam Dndwiiual B 1 O - T E S T J.aluyiata'U&i,' Dwe. 55 TABLE XII continued. TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test T-IH !> ^ =b o o3 - 3 o V 1-3 .) i j -pH -> 9. i+> P o* ^ > 33 ij -P ^ --ta I 1401 1402 1403 1404 1405 1406 1407 1408 1409 1410 1411 1412 1413 1414 1415 1416 1417 1418 1419 1420 1421 1422 1423 1424 1425 1426 1427 1428 1429 1430 1431 1432 1433 1434 1435 143 248 276 264 169 93 219 130 208 306 304 312 277 312 221 273 248 280 255 239 237 274 288 220 245 234 274 236 282 127 290 211 291 235 254 Mortality Data Liver Spleen Lun? PMA P ? P P C SE PMA P P P S PMA S PMA P SE P P P P P P P P P P P P PMA P P P P SE X X X X X X X X X X X X X X X X X X X X X X X X X X X X _X X X X X X X X X X X X X X X X X X X Skin Misc. Mesentery CMA 011698 jticLvUual B I O * T E 5 T JaA&icAyu&i, Dnc. TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number T-IH 1436 continued 1437 143S 1439 1440 1441 1442 1443 1444 1445 1446 1447 1448 * 1449 1450 1451 1452 1453 1454 1455 1456 r ^ 1457 u r. a iS - ^ /! c- ' . -J? 1458 1459 1460 1461 ; * ' " -, ^ 1462 '^7 : ` i 5 , ,, J h . * O 1 ` ' a O/ r ; ~ A .^A M_3Q CO /, woj ^+^J 'i'fj 1463 1464 1465 1466 1467 1468 1469 1470 Days on Test 257 121 310 312 258 179 220 121 254 288 287 230 165 108 144 278 311 252 290 295 254 311 267 241 215 258 252 248 274 312 302 255 281 310 277 Mortality Data Liver Sdeen Luns P PMA 5E S P PMA PMA PMA P P P P PMA' PMA PMA P P PMA PMA P PMA P SE P PMA PMA PMA PMA P S P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Mis c. Kidney Mesentery Kidney CMrt 011699 9*dndtual B l O - T E S T -fsLvwivuei, !}*uu Di TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Soleen Lun^ Skin Misc. T-III 1471 continued 1472 i 473 1474 1475 1476 1477 1478 1479 1480 1481 1482 1483 1484 1485 1486 1487 1488 1489 1490 1491 1492 1493 1494 1495 1496 1497 1498 1499 1500 243 240 "1 4 ' i'll 263 260 302 265 198 226 250 260 287 283 231 224 312 266 276 236 229 148 230 306 194 241 312 325 262 221 224 PMA P P P PMA PMA PMA PMA PMA P PMA PMA P PMA PMA S PMA P PMA P PMA PMA PMA P PMA S PMA P P PMA X X X X X X X X X X X X X X X X X Mesentery Cervix X X X .X X X CMA 011700 C^T^THT 1'L Subject to - ''' ' "t r* 4 ^ Ross v. Ccncco 9rtd*uZ'*iJ- B I 0 TEST 58 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Grouo Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 901 428 Control 902 308 903 345 904 266 905 266 906 390 907 522 908 511 909 511 910 641 911 912 564 913 616 914 435 915 313 916 564 917 405 918 664 919 325 920 508 921 392 C^ C -.5" S; -e ^3 ccad , r ' 1 -- H10 -* - - ;' ^--~ '^5O -. ^,. # : 1 ^i 922 571 923 364 924 202 925 579 926 702 927 647 928 511 929 665 ` ,-J H " " , P-1 u s CJ- _. tj `r, -h= 3 O -P ril p9 ntfj lia^ w M1 l 930 547 931 669 932 367 933 392 934 935 511 - PMA P P P P PMA P P PMA PMA A PMA P-- PMA PMA PMA PMA PMA PMA PMA P P PMA PMA PMA PMA PMA P P PMA P SE PMA A PMA -- x 011701 ------- 3 I O * T 5 T J.2&yu2icyUed., jnc. 59 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Group Animal Number Days on Test Untreated Control continued e^ -^ ,, 5* I 5 5 , t- <71 CJ ^ ba o a ! i "5 >-< ' -- - z> - ij ./ re o Si.2 3 i-- O .,, -P O i h--j CQ o, p> jj r'1 Tj. ea w g re u re 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 99 209 427 271 582 326 492 511 374 572 511 666 579 709 321 471 440 423 579 551 432 209 371 315 486 672 578 714 450 574 322 575 Mortality Data Liver Spleen Lung P PMA O P PMA P P PMA P PMA PMA P PMA A. PMA PMA A P SE A P PMA PMA P PMA P P PMA PMA P PMA P P PMA P Skin Misc. CMA 011702 iv 1lu .iit Jiiio o Jr'Auli'Ual B I 0 - T E 5 7 d., 9*c. 60 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc Untreated 971 Control 972 *_cn,**4^L*ed 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 569 449 300 508 526 408 416 526 300 572 405 374 434 500 579 372 667 504 573 452 522 429 94 547 598 666 662 577 439 467 P P fA 4D- PMA PMA PMA PMA P PMA PMA P PMA PMA P PMA PMA P PMA P PMA P P P PMA P PMA PMA PMA P CMA 011703 __ "o. 00- 337 u i- !)ndu6i'UaL 3 1 O - T S T !)*&. 61 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal GrouD Number Days on Test Mortality Data Liver Spleen Lunt* Skin Misc. T-I r N. V L . ^C o O3 * .o ) ,> d -h ~ o , "h M ,-.4 > , - *H * --i V Cl . - cv, 1 ,: d ;o , ' - -H -a .d >^ o -pH vWra|f ri ou o| 1101 1102 1103 1104 1105 1106 1107 1108 1109 1110 1111 1112 1113 1114 1115 1116 1117 1118 1119 1120 1121 1122 1123 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 271 435 375 307 338 329 380 359 316 192 354 498 414 368 377 402 264 262 196 374 343 423 323 333 396 249 349 354 462 308 416 329 360 85 382 PMA P P P SE PMA P P P P P S P P P P PMA SE P P P P P P PMA PMA P P P PMA PMA P P C P X X X X X X X X X X - XX X X X Mesentery XX Kidney X X X Kidney XX X X Mesenteric nod* X X X X Kidney X X Kidney X Uterus X X Kidney X XX X 011704 CMA 'Jfcje c O-TEST Jlz'j&ushyuei, Jrtc. 62 TABLE XII continued TEST MATERIAL : Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number T-I 1136 continued 1137 1138 1 j. 39 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1153 1154 Days on Test 325 246 137 232, 353 340 444 351 236 370 309 398 450 356 429 380 54 388 353 r ;? % aj ' ~c ' ' ` r- ^ r o* - -o3 . -^ -V - 7) - - 1 -. I-1'w*1 C' J^ |, rJ , , -- *OH --O3 ^s,. Jj rHv^ "2 cnl 6f j^ wgH 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 388 260 388 382 294 309 416 416 253 320 347 373 283 380 449 55 - Mortality Data Liver P PMA P ^* * \ X X P SE P P P P P P PMA P P P C P P X X X X X Spleen X Lung X X X X X PMA SE P P P P PMA PMA P P PMA P P P PMA C X X X X X X Skin X Misc. X X Mesenteric nod Mesenteric nod Mesentery X Mesentery X X X Mesentery Mesenteric noc Kidney X Kidney X Stomach X X * Mesenteric ncc CMA 011705 jtuLal'wzl 3 I O T E S T Jal&ui&yUei, 9*c. 63 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Susp ected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Soleen Luna Skin Misc. T-I 1171 continued 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 55 304 416 355 319 218 428 341 320 341 290 342 295 397 373 284 295 355 343 339 261 305 308 309 247 . 323 416 123 498 202 C SE ?MA P P PMA P P P P P P P P P PMA P PMA PMA. P PMA PMA P P P P PMA PMA S P X X. X X X XX XX XX X Ovary X Uterus X X Kidney XX X X Kidney X Kidney, Cervix X XX Uterus XX X Mesenteric node Kidney XX A T. ir in _.0 . 3-4337 14th Juiir: u Cr-t Calcasieu Pir 3h, Louisiana ', COTTFITTTT T AL t; Subject to Fi'ot= Ross v. C~"-~~ ' C' ' CMA Oil706 3 I O - T E S T JsA&iat&Ued., 2m. 64 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. T-II fcr to CO JJ ^ E ttf S ' o3 10 _> -H aao - -J. H ^ .1 :: ! :: ^ 'X H --i S-l :^ , ^i 3O i , -H i F-, W -c 2 txoa M O 1301 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1312 1313 1314 1315 1316 1317 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1330 1331 1332 1333 1334 1335 95 259 253 240 290 226 228 296 190 265 231 327 373 214 270 257 278 270 255 333 236 237 316 278 275 277 230 250 218 276 299 222 258 278 278 P P P P P P P P P P P PMA P PMA PMA P P P P *D P P P P P P PMA P P P *u P P P P X x X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Lymph nodes X X X X X X X X X Mesenteric r.od X X CMA 011707 9ruLutual B I 0 - T E S T Dkc. 65 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Soleen Lung Skin T-II 1336 continued 1337 1338 1339 1340 1341 1342 1343 1344 1345 1346 1347 1348 1349 1350 1351 1352 1353 1354 1355 5 ~ 1356 c 7 !' 1357 .V -71358 t?/ O ~ ~ 1359 i J o 1360 ^ ^ - . 1361 1362 C - - V 1363 1364 +> o' -~ o 1365 1366 1367 1368 J 1369 1370 227 214 230 305 275 206 285 179 270 220 275 177 298 261 208 216 315 274 252 271 307 224 241 278 264 245 259 430 244 310 269 335 287 258 276 PMA PMA D PMA P P P PMA P P P P P P P P P P P P P P P P P PMA P P P P P P P P P. V* b X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X XX X X XX X XX X* XX CMA 011708 JrVUiiiUZ*. B l O - T E S T lawstivu&i, jrtc. 66 -- ' TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal GrouD Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 1371 continued 1372 1373 1374 1375 1376 1377 1378 1379 1380 1381 1382 1383 1384 1385 1386 1387 1388 1389 1390 1391 1392 1393 1394 1395 1396 1397 1398 1399 1400 293 316 230 322 322 262 316 234 256 369 278 205 232 275 176 217 340 273 295 251 256 183 272 297 329 498 277 498 212 448 P P PMA PMA P P P P P P P P P PMA P P P P PMA P P P P PMA S P S P PMA X X X X X X X X X X X X X X X X X X X X X X X X XX X Kidney X X X X Kidney X X X X XX CMA 011709 Subject J?OSS v. Hr ' ' - 14th . .. Calcas-f " ` *~ -,-` ` - Tu : TL :t --jna j^L*diuaL 3 I 0 - T E S 7 J.sltonato4ie6., jrtC* 67 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-HI c^ , r 'o-lo5 t; * t. J - c.v *o3* ' ' .. / * Hi ;.-:r'/ .. ^ C, g O Ctf i> > +J ^ col v * sr 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 1522 1523 1524 1525 1526 1527 1528 1529 1530 1531 1532 1533 1534 1535 205 225 258 221 206 157 294 229 220 258 272 215 284 283 295 256 302 293 312 263 275 312 222 277 312 312 256 252 265 276 195 179 228 222 210 P P Q P P PMA P SE P P PMA P P. P P SE PMA PMA S P P S P P s s SE P P P P P P SE P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X X X X X XX XX XX X X X X X X X X X X Misc. Mesentery CA 011710 B I O T E S T JzS&ia&yued., 9rvz. 63 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-HI 1536 continued 1537 1538 1539 1540 1541 1542 1543 1544 1545 1546 1547 1548 1549 1550 1551 1552 1553 1554 1555 1556 1557 1558 1559 1560 0 ca 1561 1562 r- D 1563 1564 "H ._, . aJ . 3CJ W*H r-'-j 3<S 1565 1566 1567 1568 1569 1570 276 263 173 227 232 247 253 208 208 312 208 276 263 276 260 282 295 269 267 224 254 278 273 261 275 294 180 235 298 206 240 220 309 191 312 Mortality Data Liver Spleen Lung P PMA O P P P P SE S S P P P P PMA PMA P P PMA P SE P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X P PMA P P P S X X X X X X X X Skin Misc. Mesentery X X X X X Ovary Kidney X X Ureter Mesentery Cvarv CMA 0117H Siib.Jc^ jIridudi'u&L B 1 0 T E S T 2~JGAat&Uai., Uric. 69 . TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Grouo Number Days on Test T-III 1571 continued 1572 1573 1574 1575 1576 1577 1578 1579 1580 1581 1582 1583 1584 1585 1586 1587 1588 1589 1590 1591 1592 1593 1594 1595 1596 1597 265 257 255 194 221 243 212 250 269 273 259 290 272 299 295 239 239 197 264 248 226 113 202 240 236 118 240 1598 1599 1600 190 268 264 Mortality Data Liver Spleen Luns Skin Misc. P P SE P P P SE SE P PMA PMA P P P. PMA PMA P P PMA P P PMA P P PMA PMA P P SE P XX XX X XX XX XX X X XX X XX X XX XX XX X X X X X XX X X Salivary glands X X XX XXX CMA 011712 C'....... '"VITAL Sn'bjert \~j Ecso v. Oriinr in C 3. CO - 4357 Pnurt Ci2 s? s.'.--i ^ciislana - B I O - T E S T Aalvit2&yUe, jttc. 70 TABLE XIII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1601 Control 1602 1603 1604 1605 1606 1607 1608 1609 1610 1611 1612 1613 1614 1615 1616 1617 1618 1619 1620 1621 1622 1623 1624 1625 1626 1627 1628 1629 1630 1631 1632 1633 1634 1635 447 391 591 452 529 492 596 565 591 64 8 697 46 649 536 698 107 107 44 186 151 83 51 96 54 A PMA P P P PMA P SE P A P A A ... PMA A A C P C A A P P A P A PMA PMA PMA PMA PMA PMA C PMA C (1 Su"b" c"1Ross v L A.1 . Ceiled ji CMA 011713 BLO-TEST J.3JkUzi&U&L, jHC* 71 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Untreated 1636 Control 1637 continued 1638 1639 1640 1641 1642 1643 1644 1645 1646 1647 1648 1649 1650 1651 1652 1653 1654 1655 1656 1657 1658 1659 1660 1661 1662 1663 1664 1665 1666 1667 1668 1669 1670 99 99 136 207 199 199 40 66 123 123 88 201 177 157 541 363 157 395 61 2 169 688 2 14 524 591 55 14 363 11 576 519 708 Mortality Data Liver Spleen Lung Skin Mis c. PMA PMA PMA r4 .. PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA A P PMA C P P C PMA A P P PMA C P C P PMA P c '\.:. Subject co 7-'- Ross v. 14th Z ' ' 1 ,! _-'t Court L:-_^lana CMA 011714 B 1 O - T E S T 2z*iOA<it&U&6.r 9*VZ. 72 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality Test________ Data Liver Spleen Skin Misc. Untreated 1671 Control 1672 continued 673 - 1674 1675 1676 1677 1678 1679 1680 1681 1682 1683 1684 1685 1686 1687 1688 1689 1690 1691 1692 1693 1694 1695 1696 1697 1698 1699 1700 695 243 701 686 479 593 436 575 325 511 651 246 108 108 529 430 530 467 319 503 121 303 P P A A P P PMA P P A P A A PMA P P PMA PMA PMA P P A P P PMA P P A PMA CA 011715 c_o: Subject t' Ross v. 7 - 14th :r Calcasieu La ial B I O - T E S T lalMMat&U&L, Dti&. 73 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 1801 A 1802 A 1803 666 P Kidney 1804 61 C 1805 59 C 1806 85 P 1807 44 PMA 1808 382 P 1809 371 P 1810 589 P X 1811 100 PMA -- 1812 100 PMA 1813 533 P 1814 575 P X. Lymph nodi 1815 1816 622 631 P P X Kidney 1817 137 PMA 1818 191 PMA 1819 148 PMA 1820 100 PMA 1821 65 PMA 1822 164 PMA 1823 111 PMA 1824 1825 175 607 PMA P Kidney 1326 523 PMA 1827 51 C 1828 1829 375 649 PMA P X Kidney 1830 A 1831 607 P X CMA 011716 1832 377 PMA 1833 1834 1835 1836 108 108 108 108 PMA PMA PMA PMA r r------- ' Subject Ross ' 14th 7. : " " t, ` 'r '~i . . j. 70- !Jj7 :.c- i ' " 7rift jncLiAC'ual B I O - T E S T Jaiuyuz&yU&i, !)n. I -i TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin_______Misc. T-I 1837 continued 1838 1839 1640 1841 1842 1843 1844 1845 1846 1847 1848 1849 1850 1851 1852 1853 1854 1855 1856 1857 1858 1859 1860 1861 1862 1863 1864 1865 1866 1867 1868 1869 1870 1871 1872 614 108 11 696 386 14 64 420 373 635 47 47 47 572 574 531 72 248 77 94 109 141 196 101 632 206 206 206 206 312 570 202 55 P PMA A C A PMA P C PMA PMA PMA P PMA PMA C PX PX X Kidney P C PMA PMA PMA PMA PMA P PMA S XX PMA PMA PMA CMA 011717 PMA P PMA A PMA PMA _c:.; Subject Boss v-. Czz" 14th Jc:U' PalngsifiU . . . - z57 fcirt a. Louisiana BIO*TEST 2&UVUzt&UM, 9*UZ. 75 TABLE XIII continued - TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 1873 64 PMA continued 1874 24 C 1875 485 P X 1576 29 1877 460 P XX Kidney 1878 684 P 1879 A 1880 684 P 1881 A 1882 711 P 1883 611 P 1884 A X Kidney X 1885 A 1886 279 P 1887 555 P 1888 597 P X 1889 616 P X 1890 A 1891 45 C 1892 45 C 1893 576 P 1894 587 P 1895 310 SE 1896 A 1897 289 PMA 1898 A 1899 347 PMA 1900 A CMA 011718 /** Subject t : Eoss V. ' 14th .': : Calc_3l,,- J _i.h, ' -t ~ :-:~t I .. j i Htuiaitual B I O - T E S T JtaboAattvtiel, Hue. 76 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______________ Misc. T-H 2001 2002 2C03 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 2033 2034 2035 2036 107 36 298 201 101 162 86 95 113 48 24 6 109 48 424 632 100 203 40 186 129 83 61 111 100 100 100 100 100 594 100 100 632 632 590 589 PMA PMA PMA P PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA S PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA S S P P CMA 0ll7|9 r: ^ . - Subject -o Ross v. _C: ' 14th Calcg.sl.-j. _______ , - - ;-i : J.57 :7 z -I jlur.a____ Jttdii&ULcl B ( O - T E 5 T Jialionattvu&L, 9*c. 77 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin______ Misc. T-H 2037 632 S continued 2038 90 C 2039 370 P 2040 238 P 2041 208 PMA 2042 225 P X 2043 107 PMA 2044 64 PMA 2045 238 P 2046 85 C 2047 288 PMA 2048 486 P 2049 46 C 2050 249 P 2051 415 P X 2052 561 P 2053 532 P 2054 632 S 2055 244 P Kidney 2056 576 P 2057 588 P 2058 9c 2059 10 PMA 2060 41 PMA 2061 33 PMA 2062 9C 2063 12 PMA 2064 221 PMA 2065 221 PMA 2066 7C 2067 10 C 2068 632 S 2069 171 p 2070 391 p XXX 2071 108 PMA 2072 108 PMA CM* 011720 . yO - 43 C.'.- ' ! .j : . , l i o S ubject 1. > i -L 0 -T->r ir Ross v. !)ridruJ/ud B I O T S S T Hite. 73 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lune Skin T-II 2073 632 S continued 2074 2075 469 44 P n X 2076 632 s X 2077 7c 2078 632 PMA 2079 101 PMA 2080 101 PMA 2081 127 P 2082 632 S XX 2083 93 c 2084 632 s XX 2085 107 PMA 2086 100 PMA 2087 44 PMA 2088 158 PMA 2089 44 PMA 2090 590 P 2091 582 P XX 2092 632 S 2093 632 S XXX 2094 9c 2095 388 P 2096 32 c 2097 528 P X 2098 535 p X 2099 632 s 2100 99 p Misc. Kidney CMA 011721 C Subject b. Boss v. ' 14th r Calc..,., CruLtiual B I O - T E S T Jsluyta&vu&i; 9*tc. <9 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. T-III aCcttff 'HcCOj .H) -J o1 ,^c _oI 2201 2202 2203 2204 2205 2206 2207 2208 2209 22X0 2211 2212 2213 2214 2215 2216 2217 2218 2219 2220 2221 2222 2223 2224 2225 2226 2227 2228 2229 2230 2231 2232 2233 2234 2235 348 54 405 192 219 434 231 101 206 417 350 108 367 422 582 179 552 422 219 196 386 346 346 346 496 365 100 305 330 441 377 189 422 340 16 p c D PMA P P PMA P PMA P P PMA PMA P P P P PMA PMA P PMA P PMA PMA P SE P PMA P P P P P P C X X X X X x Pancreas x Thymus St!>3 CMA 011722 SrtditAi'MiL 5 ! 0 - T S S T 2aJ*yiatoAi&L, Sue. 30 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal GrouD Number Days on Test T-IH 2236 continued 2237 2238 2239 2240 2241 2242 2243 2244 2245 2246 2247 2248 Ns. c^ -3 +> d u' 33 ^O O rn o - ,-t rj OI-2 ' 5 -p ^ 3 o 6-' -, ' -d * w " ' r-' - f 1 -4 d. _ 2249 2250 2251 2252 2253 2254 2255 2256 2257 2258 2259 2260 2261 2262 2263 2264 2265 2266 2267 2268 => 7> 'Bf*5 3 -T-' ^ 3 CO I 1--* 2269 2270 s4 339 591 529 478 270 517 590 591 100 477 484 139 404 147 373 46 137 149 278 295 361 395 547 591 591 508 46 408 474 270 373 372 39 176 351 Mortality Data Liver P S P FMA PMA P P PMA PMA P P PMA P PMA P C P P P P PMA P PMA S S SE C P PMA PNLA P PMA C PMA P X X X X X X X X X X X X X X X X X Ski n Misc. Kidney CMA 011723 BlO*TE$T 2*tc. 81 TABLE XIII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal GrouD Number Days on Test T-in 2271 continued 2272 2273 2274 2275 2276 2277 2278 2279 2280 2281 2282 2283 2284 2285 2286 2287 2288 2289 2290 2291 2292 2293 2294 2295 2296 2297 2298 2299 2300 324 54 338 411 591 569 323 155 85 85 85 64 85 64 385 286 26 360 330 448 438 438 326 359 591 211 285 38 155 99 Mortality Data Liver Spleen Lung P C D ? S PMA SE PMA ESC ESC ESC ESC ESC ESC P P C p PMA P PMA P PMA PMA S PMA PMA C PMA PMA X X X X X X X A X Skin Misc. X Kidney Mesentery CMA 011724 'Subject t. Ross V . C' 14th C-. ' - ' ' 'T 1 T. ` jndnii'Mzl B I O - T E S T 2a<uyiatiyue.4: 2aa. 82 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study .Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1701 Control 1702 1703 1704 1705 1706 1707 1708 1709 1710 1711 1712 1713 1714 1715 1716 1717 1718 1719 1720 1721 1722 1723 C *r-- - t 2 C T *' '' w. n 1724 1725 1726 1727 1--: i--4 ,j ir ~ I ^) --' r+ cf :!1 -o" r ] 1 -p O 0} , --* n '` a t-4 > fM & wjU. o p 1728 1729 1730 1731 1732 1733 1734 1735 oJ..................... 1 632 632 23 43 414 426 559 108 95 137 95 7 7 68 104 116 137 505 591 629 495 130 589 404 91 131 128 410 127 127 454 23 70 104 271 S S C PMA P P P PMA PMA PMA PMA C PMA PMA PMA P PMA P P P P PMA P P PMA PMA PMA PMA PMA PMA P PMA C PMA PMA X Kidney CMA 0U725 _ B I O - T S T ^zJxyuiiyu&i, jVi S3 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1736 411 PMA Control 1737 103 PMA 1 1738 411 ?> [A 1739 97 PMA 1740 611 P 1741 168 PMA 1742 351 PMA 1743 79 C 1744 415 P 1745 52 C 1746 1747 54 592 C P 1748 530 P 1749 118 PMA 1750 186 P 1751 65 PMA 1752 30 C 1753 233 PMA 1754 1755 53 194 C PMA 1756 373 PMA 1757 1758 59 595 PMA P X 1759 208 PMA 1760 147' PMA 1761 147 PMA 1762 1763 89 307 PMA PMA 1764 1765 53 582 C PMA 1766 541 P 1767 567 P 1768 575 P 1769 47 C 1770 367 PMA 1771 116 PMA 1772 116 PMA Ovary CMA 011726 r" -T " Bert Cc.: ' : M ;.7 '- jKcLuiuaL B 1 0 - 7 E S T J.sJuyiaiyuei., !)*&. S-i TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lunq Skin Misc. Untreated 1773 Control 1774 cor.w*nu3C* x < to 1776 1777 1778 1779 1780 1781 1782 1783 1784 1785 1786 1787 1788 1789 1790 1791 1792 1793 1794 1795 1796 1797 1798 1799 1800 193 198 ^ a 267 283 114 190 362 340 314 38 200 587 27 341 43 571 464 193 435 14 400 542 536 506 539 547 531 P P PM A PMA PMA PMA PMA PMA PMA C P P PMA PMA C P P PMA P C PMA P P P P P PMA X X CMA 011727 4 ;/ _f ' Subject ;. Ross v. fvy l4tn * Calcasici ; ... L, jruLi^i'ual B I O - T E S T JzuaAC&Uei, StHO. 35 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. T-I I 1901 1902 10 03 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 104 187 188 141 394 153 200 57 84 200 113 201 108 120 131 164 580 49 49 131 106 311 119 119 119 133 61 52 127 572 578 94 81 74 126 191 PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA P PMA PMA PMA PMA P PMA PMA PMA PMA P PMA PMA PMA PMA PMA PMA PMA P P PMA PMA PMA PMA PMA X X r' Sub' :-cv K'V. -errfrr Kidney X CMA 011728 B I 0 - T E S T JzM^aivuetl. ,tta. 3a TABLE XIII continued TEST MATERLAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal C-rouo Number Days on Mortality TestData Liver Spleen Lung Skin _____________ Misc T-I 1937 continued 1938 193 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 191 180 135 DO 473 553 417 54 493 435 451 608 47 53 83 467 476 313 47 51 59 578 632 544 632 40 56 86 174 33 31 107 178 592 397 411 PMA PMA PMA PMA P P PMA C P P P P C c PMA P PMA PMA C PMA c P s P s ESC PMA c PMA c c PMA PMA P PMA P X X X X X X Ovaries CMA 0H729 Subject" to " Ross_ v. C ' 14 th i Calc?. \ SriOUdJ/'iiai B 1 0 * T E S T JzkylG&yU&t, ?+tc. 37 1 TABLE XIII continued TEST MATERIAL : Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Grouo Humber Days on Test Mortality Data Liver Soleen Lunu Skin T-I 1973 continued 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 524 14 467 31 371 487 86 577 581 494 424 542 94 128 207 193 65 389 55 488 493 24 191 632 33 144 603 88 P C P C P P PMA P P P P P PMA PMA PMA PMA PMA PMA C P P C P S PMA PMA P ESC X x Misc. Ovaries Ovaries CMA 011730 C'''"-' 7*" Subject t; _Eoss v. C 14 th , Cal ~ - B l O - T S T 2zltOKit&U4i., 33 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc T-U i 2101 2102 2103 2105 2106 2107 2108 2109 2110 2111 2112 2113 2114 2115 2116 2117 2118 2119 2120 2121 2122 2123 2124 2125 2126 2127 2128 2129 2130 2131 2132 2133 2134 2135 2136 602 P 9C 486 P if i if r: 476 PMA 553 p 451 p 392 p 514 p 578 p 570 p . 336 PMA 52 C 476 P 632 S 529 P 52 C 632 S 87 c 60 c 39 ESC 509 PMA 632 S 39 ESC 446 P 221 P 562 P 576 P 286 P 513 P 129 PMA 495 P 173 PMA 208 P 447 P 413 PMA X X X XX X X Stib'Jec-Kafis - 14th i Cal- X Kidney Kidney X Mesenterv X X X Cervix X CMA 011731 3^eU*di/uai BlO-TEST 2zivyia&yue&, !)nc. 39 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Luna; Skin Misc. T-II 2137 continued 2138 2139 2140 2141 2142 2143 2144 2145 2146 2147 2148 2149 2150 2151 2152 2153 2154 2155 2156 2157 2158 2159 2160 2161 2162 2163 2164 2165 2166 2167 2168 2169 2170 2171 2172 29 47 359 29 39 522 68 36 36 522 104 603 46 628 426 307 632 614 207 542 632 564 614 473 96 96 96 534 541 200 485 196 468 632 409 383 C C PMA C C P C C C P PMA P C P P PMA S P P P s p p PMA PMA PMA PMA PMA P P P P P S P P X X X XX X X XX Thymus Ovaries X X CMA 011732 coiifitt:! i;' j X Subject .to ?\o 'r ' " '" Ross v. C: `.t ' 14th Jj . Calc^'. ---------- B i O T sST j?alvy%6&LU,, Jruz 90 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal GrouD Number Days on Test Mortality Data Liver Soleen Lun$ Skin T-II 2173 456 P continued 2174 489 P 2175 541 P 2176 -too r 2177 462 SE XX X 2178 492 P 2179 53 C 2180 566 P 2181 570 P 2182 9c 2183 514 p XX X 2184 520 p 2185 202 PMA 2186 470 P 2187 261 PMA 2188 212 PMA 2189 194 P 2190 245 PMA 2191 541 P X X 2192 536 P 2193 29 C 2194 193 PMA 2195 508 SE X X 2196 625 P X 2197 596 P 2198 632 S XX X 2199 558 P XX 2200 547 P X Misc, Kidney Cervix Ovaries CMA 011733 Subject to Boss v. 14th Jo' Calc - -- B'J O - T E S T Jlsh&ialoAied,, 2na. 91 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-m 2301 2302 2303 2304 2305 2306 2307 2308 2309 2310 2311 2312 2313 2314 2315 2316 2317 2318 2319 2320 2321 2322 2323 2324 2325 2326 2327 2328 2329 2330 2331 2332 2333 2334 2335 9 74 149 591 320 309 314 304 201 118 206 201 390 64 247 300 318 315 249 207 360 381 403 361 350 498 390 354 448 354 398 498 496 411 89 C PMA n s p PMA PMA C C PMA PMA P PMA PMA PMA PMA P PMA PMA PMA PMA PMA P P P S P P P P PMA S P PMA C X X X X X X X X X X X X CMA 011734 CONFIDENTIAL Subject to Protective Ross v. Conoco, !no_. , -o. .0 14th Judici' ^ Calcasieu F-i-Ji:, ^_ S hO-T S S T iyu&i, Httc, 07 TA3LE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal GrouD Number Days on Test Mortality Data Liver Spleen Lune Skin Misc, T-III 2336 continued 2337 2333 2339 2340 2341 2342 2343 2344 2345 2346 2347 2348 2349 2350 2351 2352 2353 2354 2355 2356 2357 2358 2359 2360 2361 2362 2363 2364 2365 2366 2367 2368 2369 2370 442 405 399 ST 409 490 219 236 403 332 419 403 8 41 54 96 118 244 359 8 353 43 385 207 352 96 100 96 96 96 96 305 439 591 407 P PMA P C P D PMA P P PMA PMA PMA C PMA C PMA PMA PMA P C SE C P PMA P PMA PMA PMA PMA PMA PMA PMA PMA P PMA X X X X XXX X X XX Stomach C^' - - * Subject Poss v ^ - X 14th j CHJ 0N o 1 ` . - - -1 .m i 011735 3IO-TSST JftfwirtfiyAj-BA-! 93 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. T-III 2371 continued 2372 2373 2374 2375 2376 2377 2378 2379 2380 2381 2382 2383 2384 2385 2386 2387 2388 2389 2390 2391 2392 2393 2394 2395 2396 2397 2398 2399 2400 367 383 V? */ AV 379 61 68 53 264 207 49 38 279 279 306 378 387 364 207 194 325 38 364 29 243 361 29 41 84 397 208 PMA PMA PMA PMA PMA PMA C PMA PMA PMA ESC PMA PMA PMA P P PMA PMA PMA P C P c P PMA C C PMA PMA PMA X X X X CMA Oli736 CONFID^ITTIAL Subject to Protect 3 1H Ross v. _C*-.oto, Inc. ::o. 90-4337 I4th Julici ?.l District Court Calcasieu Parish, Louisiana