Document MJBQamv6qdB1xRw81rky1Meqa

71 F Industrial Hygiene Digest INDUSTRIAL HEALTH NEWS LITERATURE ABSTRACTS MEDICAL engineering CHEMICAL TOXICOLOGICAL LEGAL decision* and trend* SEPTEMBER, 1936 (Vol. 20, No. 9) .s. :. -*i i \Vy-y,- \<: ! INDUSTRIAL HYGIENE FOUNDATION MELLON INSTITUTE 4400 FIFTH AVENUE PITTSBURGH 13, PA. PLAINTIFFS :_.EXHIBIT#||il 4 FOUNDATION FACTS FunOatlan Facta la a maathtr Mm*WMr(iiiM to tntfwtrlat wiwnw ntotnbmlil? | Intfuttri*! Hyjl*** PwMMtoa. TK F*u*dU, to Mnpr*K Mototton at Indu*tri* tar ttw av4M*mnt at htaWifal wrtrfclitf renditions. Volume 18 ' September, 1956 No. 9 21ST ANNUAL MEETING OF INDUSTRIAL HYGIENE FOUNDATION Detailed program information for the 21st Annual Meeting of Industrial.Hygiene' Foundation, to be held at Mellon Institute on November 14 and 15, 1956, appears on sub^V-T' sequent pages of this Issue of Industrial Hygiene Digest. '-y!" '. ' . . `. :-:.T - " . . The Foundation Is proud to present such a dlstiogulshed roster of spealcerii^^ . ^ . . from industry and.the professions to discuss the mauagexheqt, medical, ;leg^;;;es^`iader^ug,Y;f*-- aad.chemical-toxicological aspects t>f industrial heMth probiems;^AUof ihe^;r^tt)pi. "** n &-, - cometogether at the!Management Conference and a Joint Technical Copterehte^Sr!1^ ' WMmxmmmimssa.beiogheld for the first time this year. *:: - .* >. X-' ^Member companies of the Foundation are invited to ^e'nd^xepfeiphtativef. J*S*&**\%. p .the'handling of these meats were conducted in order^to p^ldf^^ectuai inforniatibn on which?toi>a*j| of the eye hazards that might he assoclaiedwith die use of detergent oil, c A second purpose Vas to detertainethe nature and.extent of cornei produced by instillation .of the detergentadditives into the eye..*. The USP white pU peas used alone as a control and a . %. ............................. flakes was included for comparison,^- The detergent additives'apparently-dld not eplm'ttcdrthe^.-'r^ V ' action of the USP white oil as indicated by the fact that the degree of r.espohsejpl^ddc^^yj^;v\j .: the test substances compared favorably with the response prbduped by^ji The instillation of the soap solution caused an Immediate irritation Whl^ Wis iz^r4Jieveiie'.--'.c. 'C '' * than that produced by the other test materials. recovery was complete when dosing was terminated. In general,' the corneal response produced by the detergent additives was .relatively mild considering experimental procedure. It seems unlikely that any appreciable^' by accidental contact provided that adequate first-aid measures T.V. ftr^ggtrial Hygiene Digest September, 1956 * 1188 A Study of Respiration la Pulmonary- Asbestosis. H. Baatenier, H. Deaolln, A. de Coster, and M. Englent. Arch, maladies profess. 16, 546-553 (1955). French. In order to test the respiratory value of lungs affected with asbestosis nine cases were closely studied. The seven men and two women had been exposed to asbestos dust, 1,000 to 2, 000 particles per cu. m., for 18 to 30 years. The patients displayed definite symptoms of asbestosis with troublesome cough and dyspnea, and all showed x-ray shadows like ground glass extending over both lungs. No tubercle bacilli were found in any case. A definite reduction was found in vital capacity, but the maximum expiratory volume was satis factory. Breathing, however, was accelerated by hyperventilation. At rest breathing was sufficient and satisfactory, but on exertion dyspnea appeared, varying considerably accord ing to the pathological lesions in the lungs. These functional changes were in no way differ ent from those seen in other cases of pneumoconiosis. , Varying emphysema was found, but no special strain was thrown upon the heart. -- Cond. from Bull, Hyg. 1189 Asbestosis: Report of a Case. E. R. Wiese and W. E. B. Hall. Diseases of Chest 30, 229, 230 (Aug. 1956). : The history and autopsy findings in a fatal case of asbestosis are reported. Conditions described include: absence of the middle lobe of the right lung; greatly en larged heart; wide spread, sharply demarcated development of fibrosis; and degenera tion of collagen in extensive irregular fields. These and other conditions are described fully. Fine needles representing the original asbestos fibers were seen. Small asbestos bodies were seen in a few areas of focal fibrosis, although they had not appeared in the sputum. 1190 New Viewpoints on Pulmonary Cancer in Asbestos Workers. H. BohligandG. Jacob. Deut. med, Wochschr. 8T[ 231-233 (Feb. 17, 1956). German. The following distinguishing features have been attributed to the lung cancer that has been recognized as an occupational disease of asbestos workers: (1) increased inci dence; (2) development at an early age; (3) dependence on duration of exposure to asbestos dust; (4) a latent period between onset of exposure and the appearance of the cancer; (5) the localization; (6) the histological structure; and (7) the mrJ.ticentral origin. The authors discuss each of these points, and show that there is little clear evidence to support any of these assumptions, with exceptions noted. Women workers in the asbestos industry have lung cancer more often, and at an earlier age than do other women, but the same is not true of men. Malignant growths of the pleura seem to occur more often in asbestos workers than in other persons. The multicentral development is observed also in workers exposed to cobalt and to chromates. The study of the pathogenesis is still in the state of hypotheses, and the theory of mechanical pathogenesis is given most consideration. Microtraumas and asbestos bodies are always found in the pulmonary cancers of asbestos workers, but the authors feel that'this does not necessaTily^provex^i*tijefchaiiicai`ti*cory. They "C-i'te*eeva2&al. factors that speak against a purely mechanical pathogenesis of asbestos cancer, but they concede that the development of so-called asbestos warts proves the irritating effect of asbestos on human tissues, -- Cond. from J. Am. Med. Assn, 1191 Nasal Penetration of Particles of Small Inertia in Experimental Animals. Gabrieile Asset, 1.. E. Gongwer, and Stella Ryan. Arch.Ind. Health 13, 597-601 (June 1956). Experiments were carried out to determine the nasal penetration of particles of small inertia in dead rabbits, dogs, and guinea pigs. The heads of the animals, or the entire bodies, were exposed in a wind tunnel to an aerosol consisting of particles of 1.3 microns with density of 1.2 g. per cc. and moving at a rate of 2,5 mph. The concentra tions of the aerosol entering the nasal passages and of that leaving the nasal passages were determined. It was found that there was a significant difference in nasal penetration be tween the guinea pigs, on the one hand, and the rabbits and the dogs, on the other hand. Wind direction had no influence on the nasal penetration of droplets of low iaertia. -- Authors' summary .29