Document MJ7z6JynoJwGX4BVxb3xgDZby

R&S 110406 BIO-MEDICAL RESEARCH DOCUMENT DESCRIPTION FORM 63 68 69 75 Duplicate in all cards:--> ft?&` 'ear as-1961- File number [Right justify [Numeric only] Author(s), as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 20 21 40 41 /L<r,r cv 77 78 Sub-Index Code 60 61 62 11 12 13 Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms, separated from each other with comma-space. Avoid other punctuation; do not abbreviate. 12 61 62 21 /ST ,^-v .'.z'-J-e,- ^Vi?. ^ / ' -'t /C,.: .- / 22 23 24 Source (Journal, Vol., Number, Pages, Date) 12 7> y ^ c nr 1 / f <> r- 9/f v 61 62 31 32 Brief Summary 12 10 SUMMARY: 61 62 61 62 63 64 teristic of mercury treated rats. construed as evidence for a primary animals treated with BP, 2-hydroxy- Decreased balancing ability and oxidant induced pulmonary lesion. benzo(a) pyrene, and 11-hydroxy- crossing of hind limbs suggested The mechanism of BHT induced lung benzo(a)pyrene. A five-week latency altered motor coordination. Rats changes may not be related to the an period before the appearance of the treated with mercury often exhibited tioxidant property of BHT. since first tumor was observed after the ap decreased body temperature, matting vitamin E, n-propyl gallate.. ethoxy- plication of either 2-hydroxybenzo(a)- of fur about the eyes and perineal quin, N.N'diphenyl-p-phenylene- pyrene or BP, whereas a slightly longer region, apparent vision impairment, diamine, and the structurally similar latency period of Seven weeks was ob decreased body weight, and diarrhea. compound, butylated hydroxyanisole served following application of 11- (Authors' abstract) did not appear to produce the gross hydroxybenzolaipyrene. The time re anatomical or biochemical lung quired for 50% of the animals to Brain and Blood Lead in Acute In toxication. H. Savolainen and J. Kilpio. Scand I Work Environ Health 3:104-197, j 1977. Dept, of Industrial Hygiene and j Toxicology, Institute of Occupational I Health. Haartmaninkatu 1. SF-00290 ] Helsinki 29, Finland. Administering lead acetate in drink ing water to adult male rates resulted in an elevated lead content in blood changes observed with BHT. (Authors' develop tumors was 13 weeks for abstract) animals treated with BP and 15 weeks A--^-D--o--m--i-n--a-n--t--L-e--t-h-a-lvS--t-u-d--v'--i-n---M-o--an-l-e-e-R-,rajts'iyAffc -----hf-o-y-rdraonxiymbaelnszot(rae)aptyerdenew.ith(Au2t-hoorsr' 11ab ter Repeated Exposures to Vinyl Chloride stract) or Vinyiidene Chloride. R. D. Short, |. L. Minor, J. M. Winston, and C. C. Lee. / Toxicol Environ Health 3:965-968. 1977. Pharmacology and Toxicology. Midwest Research Institute. Kansas C:ty, Mo. Cellular Attachment to Implanted For eign Bodies in Relation to Tumorigenesis. D. ). Ferguson. Cancer Res 37:4367-4371. 1977. Dept, of Surgery, University of Chicago. Chicago. IL 60637. and brain during 11 subsequent days* Male CD rats were exposed six The brain and blood lead contents \ hours/day for five days/week to 0. 50. were proportional to each other I 250, or 1,000 ppm of vinyl chloride or although the interdependency '.55 ppm of vinyiidene chloride. Starting changed according to the cumulative on week 11 of exposure, these males dose and equilibration period. The were mated with untreated females. present data indicate that the per There was no evidence of either pre meability of the blood-brain barrier to implantation loss or postimplantation wards inorganic lead may be dose loss in pregnant females that resulted dependent and saturable with high from these matings. Consequently, it doses of the metal. (Authors' abstract) was concluded that these exposures did not produce germinal mutation, as Effect of Butylated Hydroxytoluene and i manifested by a dominant lethal ef- Other Antioxidants on Mouse Lung i feet, in male rats. (Authors' abstract) Metabolism. 5. T, Omaye. K. A. Reddy, and E. Cross. I Toxicol Environ Health 3:829836, 1977. California Primate Research Center. University of California, Davis. Calif. Skin Tumor-Initiating Activities of the Twelve Isomeric Phenols of BenzMa)pyrene. T. |. Slaga. W, M. Bracken. Toxic doses of outylated hydroxytol uene (6HT), a phenolic-antioxidant commonly used as a food additive, are S. Dresner, et al. Cancer Res 38:678-681. 1978. Biology Division. Oak Ridge National Labo-atory. Oak Ridge. TN" 37830. Previous experiments demonstrating a reduction of tumorigenicity by roughening the surfaces of plastics im planted in rodents, or by increasing the pore size of cellulose f'iter im plants, were repeated with observa tions on cellular attachment to these objects and to filters strengthened and made impermeable by bonding to plastic. Round 13 mm discs of methylmethacrylate implanted s.c. in A8iF/F50-t- mice produced sarcomas in 12% of mice at 64 weeks. Tumor in cidence increased to 60% (p < 0.001! in mice receiving discs to which cellu lose filters with pore sizes of 0.025 to 0.1 fi m were bonded. No tumors oc curred with discs covered by C.45 /1 m filters, followed up to 83 weeks. Vinyl coverslips 15 mm square also produced no sarcomas when covered known to produce lung damage. In The skin tumor initiating activities of by 0.45 jim filters -- plain vinyl this study, three days after a single ip the 12 isomeric phenols of benzofa.'py- produced sarcomas in 40% of mice at injection of 62.5, 215, or 500 mg/kg rene (BP) were determined in mice by 64 weeks (p < 0.001). Sanding of vinyl BHT in mice there was a dose depen use of a two-stage system of surfaces reduced tumorigenicity (p dent increase in lung weight. This con tumorigenesis. 11 -Hydroxy Lenzo-a; py < 0.05). Permeability, fragility, and centration dependence with injected rene was moderately active, whereas storage capacity of filters are ap BHT was accompanied by increases in 2-hydroxybenzo(a)pyrene and BP were parently not related to tumorigenicity. lung DNA and nonprotein suifhydryl strong tumor initiators when applied Surface roughness probably is related. levels and in whole lung tissue enzyme topically to CD-I mice and followed Cells, mostly macrophages, were activities of glutathione (GSH) by twice-weekiy applications of the densely and uniformly attached to peroxidase. GSH reductase, glucose-6- promoter 12-0-tetradecanoylphorbol- nontumorigenic surfaces from 24 hours phosphate dehydrogenase, and 13-acetate. 1-, 3-, 4-, 5-, 6-, 7-. P,-. 9-, to two years after implantation but superoxide dismutase. The increased 10-, and 12-hydroxybenzo(a)pyrene were distinctly fewer and not unifor enzyme activities are considered to had less than 5% of the tumor initiat mly distributed on tumorigenic sur correspond to inflammatory and ing activity of BP when the data were faces. Topology favoring attachment proliferative pulmonary changes expressed as papillomas per mouse. was inherent in 0.45 jrm filters and resulting from acute lung cell injury After 30 weeks of promotion, the num was produced in plastic by gouging and necrosis, which have been ber of papillomas per mouse was 8.4. irregular excavations 10 to 15 /rm desrribed previously, and cannot be 8.5 and 2.8, respectively, for the deep. -- R .. R&S 110407 208 Selected Reviews from the Literature r &S 110408 BIO-MEDICAL RESEARCH DOCUMENT DESCRIPTION FORM 63 68 69 ,, 76 Duplicate in all cards: -- year as-196l- File number [Right justify [Numeric only] Author(s) , as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 1 . .. - . 20 21 >0Bi <IS . 40 41 77 78 Sub-Index Code 60 61 62 11 12 13 Title of Report; end with space-hyphen-hyphen-space. Follow with IndexTerms, separated from each other with comma-space. Avoid other punctuation; do not abbreviate. , 61 62 21 - 22 23 - /A/'r?<77sA - Fl'C ~ 24 Source (Journal, Vol., Number, Pages, Date ) 12 / - - . -. 61 62 31 32 Brief Summary 12. 10 SUMMARY: 61 62 61 62 63 64 0: ^53 TOXICOL. APPL. PHARMACOL., 9(3): 501-504. Nov. 1966 " Chronic oral tonicity to rats of a vinyl chloride-vinyl acetate copolynsr. Smyth, H.F., Jr. Weilx C.S. R&S 110410 BIO-MEDICAL.RESEARCH DOCUMENT DESCRIPTION FORM 63 68 59 76 Duplicate in all cards: --> year as-1961- File number [Right justify [Numeric only] 77 78 Sub-Index Code Author(s), as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 1 20 21 40 7,P'-' 'A-S/P/ // f/necK-t <r A!r*ew' f pal yjr j/__________ STtrT/rt f'oj'C? J K U-'koO L-JZ&t'J'AZr 41 ______________ 60 /a 4 ! <A. . ! ' ZAA. < Wtri-'fC . 7 61 62 Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms, separated from each other with comma-space. Avoid other punctuation; do not abbreviate. 12 61 62 21 T7--: zr/ t - JZ*' ' .-A/ s>-u i 22_ 23 ./ 24 Source (Journal, Vol., Number, Pages, Date) 12 /f 7TT **hi.(. ^ (. fiftcl'/LtfC. 'So#?- il'iiaM- 71 i/ '< _ <^fo'?/ 61 62 .Si. 31 32 Brief Summary 12 10 SUMMARY: 61 62 61 62 63 64 ->X:4*:%<;dss,>ry7z'-x J*J- ' * -r -'.'.vT'/.-.j*,-, w ---\ `C- ilium ArnV'*-' tt - - r-'.l .* - * EXPERIMENTAL STUDfES ON THE CHRONIC TOXIC EFFECTS OF VINYL CHLORIOE IN RATS -?: J. A. SOKAL, B. BARANSKI, J. MAJKA, R. ROLECKI, S. MATYCH, G. a- OLCZAK, J. PALUS, J. STETKIEWICZ, I. STETKIEWICZ and K. WROBLEWSKA Institute of Occupational Medicine, Lod^, Poland In the experiment, male rats were exposed to vinyl chloride at the concentrations of SO, 500 and 20,000 ppm, 5 hours a day, 5 days a week, during a total period of 10 months. After 1, 3, 6 and 10 months of the exposure, blood and urine analysis as well as histopathological examination of internal organs were performed in exposed and in control rats. Blood analysis included hematology and the following biochemical determinations: total protein, urea, phosphates, citrates, calcium, alkaline phosphatase, alanine and aspartate aminotransferases, -f-glutamyltranspeptvdase and lactate dehydrogenase. In addition to the routine urine analysis acid mucopolysaccharides and hydroxyproline were estimated. After 10 months of exposure all rats were sacrificed, organ weights measured and the X-ray examination of the skeleton of some rats was performed. As a result of chronic exposure to vinyl chloride the following toxic effects were observed in rats: 1. depression in body weight increase 2. increase in the relative weights of liver, kidneys, heart, and spleen 3. biochemical changes in blood (mainly increased activity of plasma lactate dehydrogenase and alkaline phosphatase) 4. slight hematological changes 5. morphological changes of the liver Even at the concentration of 50 ppm some toxic effects were observed including morphological changes in the liver of some rats. The results obtained showed that the chronic exposure to 50 ppm of vinyl chloride causes systemic toxic effects in rats. m-wm R&S 110411 S'7lc T^/i7X /n~F7r/j/Te^n zf r/rs- s.is-rfs-TTsf! z f fftz/ft D /r- t'<4# ' Mrr I'&'V I2P\ 539 v j;. : t ', i! ,Tr . r * F V V.