Document MJ2aBzmMdkG1J2wYo9byNJzxV

To; Interoffice Communication From: Dote: Subject; V. Messick D. Penney l~~y\ September 16, 1993 VIS1A Union Carbide report of Pancreatic Cancers in a PVC processing operation I spoke with Dr. Jane Teta of Union Carbide about a.report of an increased risk of pancreatic cancer in workers involved in PVC processing. Dr. Teta said that Carbide had recently reported the study to EPA, however, she was not willing to make a copy of the study available for wider distribution 'before it was accepted for publication. However, Dr. Teta offered to meet with the Vinyl Institute to discuss her findings. I told her that I would contact her if such a meeting was desired. Dr. Teta briefly summarized the study as follows. Twenty-eight male pancreatic cancer cases which were compared to 140 control cases with no pancreatic tumors were included in the study. Workers were assigned to work areas where both PVC and polyethylene were processed. Men assigned for more than sixteen years to these areas experienced Slightly over a seven-fold increased incidence of pancreatic cancer. No excess was seen amongst workers with shorter duration of assignments. Seven of the nine cases ofpancreatic cancer began working in this area in the 1940s. All but three cases had worked 20 years or more. While recognizing that the workers in this study were assigned to units in which both PVC and polyethylene were processed, Teta places most of the blame for the excess pancreatic tumor rate on the PVC processing. She believes this is because PVC processing practices of the time resulted in higher chemical exposures and involved working with more hazardous raw materials than polyethylene. Teta does not believe the increase of pancreatic tumors was due to vinyl chloride exposure. This is primarily because there were no cases of angiosarcoma of the liver. She instead points the finger at the phthalate plasticizers used in PVC, citing diethylhexyl phthalate being reported as carcinogenic in mice and rats. Teta also expressed concern for stabilizers, some of which contain cadmium and lead, which have been demonstrated to produce cancer in animals. ' Teta maintains that chemical exposure of workers during PVC processing prior to the 1950s was very high because materials were weighed and fed manually into a blender. Workers climbed inside the blenders to scrape off excess chemical residues whenever different additives were required for different vinyl products. She says that this occurred R&S 147664