Document MJ1pO6v2ZDZ2JbdnL0pavyzGx

Industrial Hygiene Digest December, 1962 Lwi Weight# in Carbon Monoxide Dettht. M. Cregerien, Danish Med. Bull. 9. 59-60 (Apr. i962). (Danish Medici Bulletin, Ejnar MuaMgurd, Hoerregtd 6, Copenhagen K, Denmark*). MlUl and Camp* recently (1961) maintained that victims of rapid CO poisoning (mainly suicides) have higher lung weights than victims of more slowly-oecurring CO poison ing (mainly victims of accidents). The series of autopsied cases of CO suicides available to the author ai ae yet too email for statistical analysis. Experiments on mice and cats did not suggest the presence of a dif/erence in the relative lung weights of animals killed rapidly with a high concentration of CO and animats killed more slowly with a low concentration. Similar results were obtained when the lung weights were related to the "reduced" body weight (after removal of the gastrointestinal tract). The experiments indicated that the pulmonary edema In CO deaths partially developed post-mortem. A slightly higher CO saturation of the blood was observed in cats killed rspidly with a high CO concentration but this result, which was not confirmed In the mice, should be taken with some reserve. -- A PCA Abets. 1162 Toxicological and Physiopathologlcal Studies of Monobromotrlfluoromethane (CF,Br). C. Paulet. Arch, maladies profess. 23, 341-348 (June 1962). French, - Detailed studies on mice, rats, guinea pigs and rabbits showed that CF|Br had little acute or chronic toxicity. Above a threshold of 500,000 ppm some of the animate show ed drowsiness, tremors and disturbances of equilibrium, but there wore no deaths after 2 V i hours exposure at the threshold level. At 800, 000 ppm with an oxygen concentration of 20% there were still no deaths, but when the oxygen concentration was reduced to 15% some deaths occurred in animals exposed to 800,000 ppm of CF}Br, since hypoxia was added to the effects of the gae. When the gas was heated to 950*C, but not below that, it decomposed and became relatively toxic. The studies were made as the use of CFBr as a fire-extinguisher was under consideration. .. Bull. Hyg. L 1143 Metabolic Effects of Chronic Osone Exposure on Rats. J. A. Hathaway and R, E. Terrill. | | Am. lnd. Hyg. Assn. J, 23, 392-395 (Sept.-Oct. 1962). {'I 1; | Young male rats were exposed to 0.8-1 5 ppm osone 5 days per week for a period of 18 weeks, and various quantitative analyses of urinary constituents were done, A signifi? ' Cantly lower tit ratable acidity and a higher pH was found in urine from test animals than l.t from controls. Under a handicap o( having narrow openings through which to obtain food, f . mean food Intake and weight gain were consistently leas in exposed than in control rats. When ( ' the openings were made uniformly larger, food consumption and weight gain were comparable I 3 in both groups, -- Authors' abst. f/, 1144 Reaction to Toxic Beryllium Compound a; Terminology. Harriet L. Hardy. J. Occ. Med. 4, 532-534 (Oct. 1962)7 Knowledge at hand supports the concept that this disease (beryllium disease) is not I. exclusively a pathologic response in the lung to deposition of toxic beryllium compounds, and, t .* hence, not a pneumoconiosis. Stress is laid an the value ol using accurate nomenclature in describing the chemically-induced disease, beryllium poisoning. -- Author's summary 1145 Comparative Toxicity of Stable Rare Earth Compounds. II. Effect of Citrate and Edetatc Com Vs pleting on Acute'"Toxicity in Mice and Guinea Pigs. J. G. Grace, F. C. Davison and Joyce B. Feavel, Arch. Environmental Health 5, 437-444 (Nov. 1962). Intraperitoneal injections of rare earth chlorides, citrates, and edetatc complexes in mice and guinea pigs produced graded toxic reactions in the animals In doses from 25 mg. per kilogram to &00 mg. per kilogram. Chloride toxicity wan difficult to evaluate because of fair!: t i; i II ii u 11