Document MJ12LByEY9GN48Ny7qLb2rZRj

To: From: LEAD INDUSTRIES ASSOCIATION 420 LEXINGTON AVENUE NEW YORK 17, N. Y. Dr. Kehoe Manfred Bowditch Further on the Chinese baby. CO 035 COPY .r June 1, 195$ Mr. Manfred Bowditch Lead Industries Association h2Q Lexington Avenue New York 1 7 , N. Y. Dear Mr. Bowditch: I was most interested to receive your letter and enclosures concerning the Cninese baby that Dr. Byers ana Dr. kaloof studied. From the data as given I do not find sufficient evidence to be absolutely sure of the diagnosis of lead poisoning. However, this does not prevent one from searching for possible sources of lead. The two main sources, of course, would be assimilation of lead either through the respiratory tract or the intestinal tract. It is hard for me to believe that the baby could get suggifient lead from the mother's milk without the mother having marked evidence of lead absorption. Therefore I feel that one ought to look more towards a common source of exposure, in particular a respiratory exposure, however, the data as given do not give me any clue and I am sure that Dr. Maloof has made an extensive search in this direction. Therefore I am afraid that I cannot really help out in this case. Sincerely, /s/ Hugo Dunlap Smith Hugo Dunlap Smith, U. D. HDS/bp J. B, H *rPNIR,PH ISlO lNT M . B O W L B Y , VICE PRCSIOtNT K. C. BROWN BLU, ViCK PRESIDENT J , A. MARTINO, VICE PRISlDlNt ROBERT LINDLEY ZlIOPKLD, SECRETARY-TNIAIUNIN ( 4 2 0 LEXINGTON AVENUE N E W Y O R K 17.N.Y. Robert A. Kehoe, M. D., Director Kettering Laboratory of Applied Physiology University of Cincinnati College of Medicine Eden Avenue Cincinnati 19, Ohio MANFRED BOWDITCH orD I R E C T O R H E A L T H AND S A FE T Y May 31, 195$ Dear Bob: These are just a few lines to express my gratitude for your thoughtful and very helpful letter of May 2Uth. Just before receiving it on Friday, I had dictated a letter to Randy Byers in which a number of seemingly pertinent questions were posed, and I think I will await his replies to these before deciding just how to pass on the additional com mentary you have provided. My association with Randy has covered quite a few years and I have on more than one occasion had evidence that he is rather more touchy than some of us* Hence, I have thought better of my initial impulse, which was to have your letter copied verbatim and send it along to him. I hope you can find the time before long to give me in a couple of paragraphs your thoughts on that extraordinary Australian proposal re ferred to in my letter of May 16th. It may interest you to note from the enclosed what Drs. Craneh, Johnstone and Mayers had to say about it. I'll be looking for you in Atlantic City, where I'll be parked at the Ritz-Carlton. I am sure Elfriede would welcome your charming spouse as a beach companion. May 24, 1955 D4NLM2eeir0rwa.edLcYMteIoonxarridnnkufogrsfCtetodHrintiyeeBAaso1lvAt7whesdnsaiutoneccdhiaStaiofenty Dear Manfred: tIwhhheaicvChehwienxoeausmlediinsneefdeamntth,teoainnbdefoahrlmethlpaotfuiuoglnh. Isuhpapvleiesdevweitrhalyocuomr mletetnetrs otof Mmaayke1,9 ncoonneceorfning atteecIcshhaenarsdaepnrrniatioecsoobnrleocnuieanikeasooleleyrflitldnsmyyvttoikphhseuaeteearrybd(tyuattobhtebirtotemahsaitomanusmnrtIpcapatihtechyshltcolyieteeobinsofdnecesiccaiasldbmo)ipsnyfeeepoitrilsecifteooshaataftelorehldodteghtbdr,oiyeeeinbausbltfaguonsheebnoolmlrtsedohososausuysloiolngpuseffuhectotestirhhnafuhlcayinfaerlsraelairanataclaeictnydhcq.ttaacieuiellcalrdiynM,arsi.scseelbieotdspiupr-TcrtehtohonooafoIeovalrftcorfemihoenpurtenedah,nilftuasuyihnttrrs,hynoumiaenotanmrihenletd,ehhafosoyyceyaurragmnbembsnidstieep,uganbtttnmlohneiticiomsoiafansnwidoalo-le,ioftysofilnogy atmshnigeidsnsbniefloeidcocadetnosoftsoiqtrmyupaaonunfyrtitpthtyoiemsoeafespslpeobalfiydcdacihtfaifaoresnerfebuonefletinatahnlaeddbceisraoxigrptnbeeroeridisoei.nsn.coWefdethpheeaovcpeolensceteeonndtrtohautebiotdntihaogefnuloetsailidistyin sTahide tahnaatlythtiecaml ointhfoerrm's abtiloonodincotnhtias insistuaat"ihoinghisnnoormt vael"rycoconncevnintcriantgiontoomf lee.adI.t is nepsJovohumiresdmtneeowwnamlhth".eaentironItefnhm,aei-tbylaioensbvvdeoneoliottkhrisdemsoiimageslns,enianfoinitotethnssasottaisrhgtmaneotdniaft,llyhyvaerannivledsuagkejlauu.toeisrvtAfedowsauchnnlsaigdunteciiirchssa.oiwltfinisbitfishogeirnanrdirnfeteihorcdelraimfnnnrecaooelrmi,mm(pstpaihhlonyircsrstaei.ions"lgohnegi,ogitch) It is also said that the m other's m ilk contained no lead, and (sic) by spectrographic an alysis. It is hardly possible to make a spectrogram of human m ilk that does not contain certain of the more sensitive lead lines, if one uses a satisfactory method of preparing and examining such a sample. I am forced to conclude, therefore, that someone lacking in information or experience carried 0 3 5 o7 Mr. Manfred Bowditch - (2) - May 24, 1955 out this examination. Iotf itshealusroinseaiodf, twheithcohuiltd,stathtiantgVtehresernanegheaps finledaudcecdonacnenintrcarteiaosne/iinn itnhietiaclonsacmenples tthraetinoonrmofalleraedspinonthsee utoriVnee,rsreenpee.at/edUy. I can only ask why pot, since this is / btIhohitsahvecerhenidloda,dbvoouuipbttIsoosfmttihlelemae3yxkspjfteoer'pireitonhucese psaronoudorfacesotfuotftheleneaeddsisaagobnfsoothsripes^tiyob/lnien,fiocar/a'neldwI Igoershkt oadulolldnhebofteoargnladd to offer our services apd equipment for obtaining phd analysing duplicate sam ples of the blood pf the child, and for that m atter, of the mother and father as w ell. May I say here, that there is no reaspn whatever ior believing, and pisnoomitshoeeneimnvgiidl,ke,ncacwne^tiipoledsuauclpw'spaoyrstddskpemoepisotonincsiitnsrmgab,ilnet,haant tinhmfeoarnmet,.ilt/khTaonhfelaickmoenolyctehtneortrbwaetiitloohnwfrouafnnldkeaelrdeaadll circum stances. This, therefore, is an unlikely source, and in a mother with a "i^igh normal" blood lev el, a preposterous source, of significant lead absorp- tion\ / // Now, op'th\e ot/her side of the coirj,' lead is so nearly ubiquitous in the /norm al neneevdironnomt.beentu, ttaenrdlysofrusustbrjaetcetdtoptinncortefainsde ining tihtse aprrteicfiicseialsoeunrvcieroinnmaelnl ti,nsthtaant coense. I have had several baffling experiences of this type. At least two that pome to mind rathe^ dramatically, kave involved adults one of whom was a hpusewife. The so u rcesvof the poisoning of several children have eluded us com pletely, despite the rather considerable effort* made to unearth them. Jhe case of a nursing infant is a bit m ore difficult to understand, but even so, this is not always possible/^ I confess to a certain sense of frustration^hea we fail to find the source, principally because of the threat that remains undisclosed and thus uncontrolled, ^ the child that has become ill and toothers in the same environment. However, this is not something so remarkable as to be a marvel, in view of the ubfquity ^f lead. Certainly this is not a/unique situation, and esp ecially should I be captious in dram atizing it unt^l' and unless I had the proof of the diagnoses, which, s^ far as I am concerned,/has not been furnished. hfoy. I sugges/t to you, and if\yqu cjan do so without/offense to D r. B y ers, since I mean only to oe helpful and wquld shrink from giving offense, that it is of im portance that the analtyical methods and thp diagnostic criteria, which we and others have employed over a period of yyars., should be used generally in the study of cases of this type. I fail to ^ee how our colleagues in Boston can bring them selves to deal with their diagnostic and therapeutic problems pwofaittphieroneucttsis,thioaennb)demwneeitfahintosuotfotfthhdeeepteenhrtymisriieonlliyonggriectlhaialebbclaeocnk(cwgerintohturinnadticotonhmaotpflweleotaeuldlydipnernetahdbeilcebtaltobholedemloiftmo its interpret such results with an alm ost absolute degree of certainty. It is a source of considerable sadness to me to find that there are comments and implied questions in this correspondence, which ought not to be uttered in view 1/ ft Mr. Manfred Bowditch - (Z) - May 24, 1955 out thi3 examination. ttIohrtfaeittshinoeaonlrusmoroifanslleearaiodedfs, ptinhwoenitthshceeohuiutlotdri,sVntateeht,riasntregenVpteehe.raesteerndanelyg.heaosIfcinlaednaudocnecdloynaacnesknintr"carwtehiaoysnenoinitn, i"tnhisetiinaccloensactmhenispliess aftbIsooasohrmtoawhftvpehfeerelileersln.sdoocouhadMfbriolotaduhsuyb,eettrIbbsvousolfiaotmcoyteIhdeshes tmoeaiefrnlxyledtpsh,ateeeestrqkrhicuieahofintpoiulcrmtdseh,teeshanroanetenuddfprioascrfreosontooruoofbfttotrehlafeneaiaanetthsdsimonsengaadibntawistvaneohogdrraln,pvtaoteeonisvdofaiesnltir,yn,hsfebitoanhenmrgfedobodcrtIelheulisienpheIrlivoicgciuaaenanltldgtdea,wbfloalaernthkghdoleadtrdoanned attpcshioioore"mincshm.oueignmiheilnkvsngt,idao ercnwamnchnceaiesllie."ntdoabTullswcohueoapidsylp,esolaetrddhvteeepmsrlko,eoeifsnapoosrtnptiercir,naiesgbpimsloien,sa, tneatihrnsuaontmiunlstifohkareseneoltmyu.thrislacoTkneuh,orleifcokecafeo, lsmnyiagcnotenodtnhiftbieirncreaatawlniootimwnthloeuotaffhnrddaelerneaarkbwdsalioetilnhlrapd nmIeNTnehhoievnewadidvr,seonoronouhantmatrhdbtceheeenerssteu,dovotttraefheanrtremadhlryleassbtofpiiradocufseaifussllotilobnrynfjag,eitntchehegtedxatovpocafeeotirisninnienec,ovvnrteolecerfleaviaanssedldedoicinfiahsngdtilhsutdiohitlrstsenestnapeyoarrpnhtreeeialc.fyviiocseufAeiabwetlislqhuoleeuodunamiertvsdocitewuruotsawsinnsiomncaa,oetlmnhthlhteoipa,nultnesstothetcareowamlnmtyicfa,oeeenl.ste.o despite the rather considerable efforts made to unearth them. The case of a fotineeanihnslfunwupvdrtvsheaisireiectyunohwisnnadgecmlpiolaisoyofnoegnsfntuntsashrthrnoie.obcotsleuluilieseH,lbs,.ddiopq,awwIruIhtbibeionctiivecytocethinhcmrop,af,efaeouslsltcrtleohshyieaoiiftsdulbdaod.seirifsactfiaahinCnccsuaueoedtsIrtlrerhtttaasaaatoommioisfnmnaubltceythsneoiteezchdtnnihoietncnsmhiregesgsrretenioiastsaefinoltdufndlr,tnro,ahuettnhaimbsldaatturaastrutanroennektdmivoiaooqutebatnunnhbileneelwesesresoahssinuss,teuninfntItaudohwthrtiiihbnasseocdeeinfsilos,ahtashsiaenaleemdmnodt.doptaearronvodefl, taiMImhnmeadpyesooatIrtunthsdaeuoynrngcsolgeyfehtstcahotavatesbtoeeteshymhoeoepufal,lptonfhyaauinelslyddattinyoicfdpvayeelwro. muoaueIcltpdfahaenorisdlhidostrodoiansnoskoedf efwyrtheiohtaemhorwodsugiotaisvughoirnofnfougceslnodtolsilcfebef,eeactngorusuisDteeeesrdr-.iiagtnhBeawnBytheeoirristcasthoills-nywoseciifnannce bring them selves to deal with their diagnostic and therapeutic problems owfitphroeuctisthioenb) emneefaint sofofthdeeetenrtmirienliyngretlhiaebcleon(cweinthtrinaticoonmopfleletealdy ipnrtehdeicbtalobolde loifm its patients, and without the physiological background that would enable them to iismnotuperrlicpeedreotqfusceuoscnthisoirndesesruianlbttslhewissiatchdonarernsesaspltmoonomdsteenatcboesf,oinlwudthetihcdhaetogturhgeeherteonfaorcteetroctaobimentmuyt.etnertIsetdai,sndain view 03539 Mr. Manfred Bowditch - (3) - May 24, 1955 of the state of our present knowledge. Sincerely yours, Robert A. Kehoe, M. D. RAK ef Pcsot.anSlt.lridbIouwtmeadys tubonetsahtbelteoatcroteisbvpeitoianetds thtoofe ytAhoe.uSrS.Ausub. b-Cmseoeqmeutmeinnitgtt,ceeaalnoldsn tothnhuems lefeaafrdorIsthhaaenvldpea.nrodItss. aIny needed now.and if so, what? R.A.K . 03590