Document MJ00MGgKyO0k2Bb5EJzgxeo5j

33 ft (/) cn CJ1 (0 co l/C meun of epithditi origin were histologically similar to the types of lung can cer found in human pathology. The dose of benzo(a)pyrene was found to af fect the histological structure of the cancer cells observed: smaller doses of the carcinogen were related to a lower frequency of squamous epithelial lung carcinoma and a trend towards the development of tumours of the adenoid type. WS65) CIS75*1399 Use of anaphase studies for estimating bone-mar row chromosome aberrations in the hygienic assessment of the mutagenic effect of polymer building materials Ospol zovame anafaz* noQO metoda ueta hromosomnyh perestroek v kostnom mozge pn gigieni* fieakoj ocenke mutagennogo ftffekta poiimernyh stroitel'nyh materialov), Sok ov AAI* Gus*kove SJ.. Guskov E.P.. MasTto V.l. Cigmna i sannehja, Moskva. USSR Aug. 1974. No.8. p.17-20.6 ref. {In Russian) Literature review and results of animal experiments concerning the chromo some aberrations induced by exposure to polymer-containing concretes end putties. It was found that polymer concretes which produced no chronic toxic action in animals had no cytogenic effect Polymer putties containing unsaturated hydrocarbons, patrol, divinyl and xylene caused changes characteristic of certain toxic effects end an increase (by a factor of almost 2) in the number of chromosome aberrations as compared with a control group. <035*0 CIS 75-1400 Polychlorinated biphenyls. Storage, distribution, ex cretion, and recovery: liver morphology after prolonged dietary in gestion. Burse V.W,, Kimbrough R.D., Villanueva E-C-. Jennings R.W.. Linder fi_, Sovocoot G.W. Archives of Environmental Health, Chicago. USA, Dec. 1974. VoL29, No.6. p.301-307. Illus. 16 ref. (In English) Rats were fed 6.6 to 3.89mg/kg/day of various Aroclors. and organs and tiss ues were analysed after 0.5 to 10 months' exposure. PC3s were highest in ad ipose tissue where a steady state was reached in 4 months. Little PCS-derhr-d material was excreted in urine. Enlarged liver cells with vacuolated cyto plasm and inclusions were noted. Aroclors 1015 and 1242 were less persist ent in the rat and have less effect on the liver than Aroclors 1254 or 1260. ' 3573) CIS 75-1401 Laboratory results of some biological measures in workers exposed to lead, Secchi G.C, Alessto L Archives of Environmen tal Health, Chicago. USA. Dec. 1974, VoL29. No.6, p^51-354.20 ref. (In Engish) Erthrocyts ALA-dehydratase (ALAD) activity and blood lead values were stu died in different groups of subjects not occupationally exposed to lead and compared with values for exposed workers. The results lead to the conclu sion mat measurement oi mlmu acuvuy ts ntom u&diui mi waiu4!iiy poaawv exposure of general population groups to minimal quantities of lead then in the surveillance of workers in the lead industries. BM7 CIS75-1402 Load poisoning and multiple sclerosis. Westerman M.P.. Braetman M_ Pfitzer E. Archives of Environmental Health. Chicago. USA, Dec. 1974. Vol29. No.6. p.355-356.14 ref. (In English) 5 individuals with typical clinical findings of multiple sclerosis were evaluated for lead poisoning using current in vivo methods. These included measure ments of lead stores, mobilisable lead, and blood and urine levels. The results showed no association between lead poisoning and multiple sclerosis and suggest that multiple sclerosis in humans is not a result of lead poisoning. yyyw CIS 75-1403 Haemostatic phenomena in vinyl chlorida disease (Himostaseologische Aspekta bei der Vinylchlarid-Krenkheit). Bachner U.. Etzel F.. L;n&e CE. Marstsllar HJ.. Valtman G. Deutsche meduiruseke Wochensthrift. Stuttgart Garmanv (Fed.Rep.). 22 Nov. 1974. Voi.99. No.47, p24092410. The authors examined 70 workers employed inth^olyvinylchjonda industry and not*'' that m ZQ'U of the cases observed^BHlHMH^ constituted the ear! -- -nd of exposure to vinyl chloride monomer. The ino of flpQS^^ncressed n proportion to the degree of thrombocytopenia (nftrwnum values 17.000/mm3). Results of laparoscopy, his tological analyses and haemostatic function tests. A check-up made one year after termination of exposure revealed a tendency to persistent thrombo cytopenia. especially pronounced among a group showing varicosity of the oesophagus and reduced plasminogen levels. tttSSu CIS 75-1404 Chemical products and carcinogenesis (Chemicaiien en het ontstaan van kanker), Henderson P.T.. Ssutter-tisrlaye F. Njtuuren tschtuek. Maastricht. Netherlands. Apr. 1975. VoU3, No.4, p.210-227. Illus. 2 ref. (In Dutch) After an introduction on xenoblotics (substances which are foreign to the hu man body) and the uninhibited proliferation of the cancerous coll, the authors study the question of carcinogenesis due to chemical products: carcinogenic Constituents of t.v (polycyclic aromatic hydrocarbons), tjronnticjrnunes lam- and dy*s containing azo compounds) v<nyl_^^~rt^'t^'ngiosarcnina oLiheJuiiU. nurses and mtroso-ammes. In a chapter rldvnred"unnatural subsiinc**-* which are carcinogenic, the afhtoxms and cycasm on; given as uxam* p!^s Oth*r subjects ifetiU vnth include the activation and inhibition of uaremo* 1J8 genic substances (rale of enzymes). mutagenesis (insertion of carcinogenic molecules in the ONA helix) and prevention of cancer. HSMSI -- CIS 75-1405 Effects of chlorine dioxide (CiOz) on rats (disconti nuous exposure) lAction du bioxyde de chlore (CIO.'I sur le rat cn exposi tion discontinue). Peulet G-. Oesbrausses S, Archives des maladies profess* onnelles. Pins. France. Sep. 1974, VoL35. No.9. p,797-B03. Illus. (In French) The authors investigated the effects on animals of short (ISmin) and repest- ed 12 to 4 times s day) exposure to atmospheres conteining 5.10 and ISppm CIOi. The results of the exptnments showed that discontinuous exposures of 15min did not result in lung damage in the case of concentrations below 5ppm, which are considerably higher than the concentrations found in facto ries where this gas is used- foasaat CIS 75-1406 Contribution of infrared thermography to diagnosis and supervision of disorders due to exposure during vinyl chloride polymerisation processes - Table No.52 (acroostaolysis) of the Schedule of occupational diseases lAppon de la thermographic infrarouge au diagnostic et i la surveillance des affections consecutive* aux oper ations de polymerisation du chlorure dt vinyl- - Tableau 0*52 Ucro-osteolyse) des maladies professionnellesl. Retv J-. Lazsrd P., Berrod J-, Schmitt M, Archives des maladies professionnelles. Pans. France. July-Aug. 1974, VuL35. N0.7-8. p.733-738. Illus. (In French) The use of thermography in examining 3 persons with rxdiologicallyvisible se- roosteoiysis, one person with comoiateiy recsicifiad bone lesion and 2 heal thy controls brought to light certain vascular disorders among the 4 first-- mentioned subjects: it was impossible to ascertain whether these vascular disorders preceded and had a causative effect on the bon* damage or not. In frared thermography would apoear to ba of considerable use in studying the pathogenesis of this disease, end from the forensic point of view, es well as assisting diagnosis if the syndrome precedes the bone lesion. UK$ct CIS 73-1407 Morphological changes of th, blood end bone mar row in chronic experimental poisoning with mercury vapours in rab bits (Zmisny morfologiczne krwi i sioiku w przewlsktym doiwiedezainym zatruciu parimi rteci u kr6lik6w), Koimider S-. Wegial A.. PigOn-VVfgief A. Medycyrta pracy. Lode Poland. 1974, Vol.25. No.6, p.525-531.22 ref. (In Polish) Results of experiments in rabbits exposed to concentrations of 2-Z5nvjr'm3 metal mercury for 3h per day over 12 weeks. The authors found no apprecia ble change in haemoglobin levels or red blood cell, granulocyte or lympho cyte counts in the peripheral blood. Thera was however larger proportion of erythrablasts in the bone marrow than in controls and an increase in the met-j- ration index of the calls of the erythroblazt line. Megikanocytes showed no pathological changes, iha ciscrepancies in tne results ODtameo can be ex plained by the relative lack of precision of morphological examinations and differences in individual susceptibility. U3S9 it CIS 75-1408 Elements of industrial toxicology (Elements de toxicoith gie industrieile). Well E, Published by Masson. 120 boulevard Saint-Germain. 75006 Pans. France. 1975.347p. Klus. 64 ref. Price; FF.167.00- ISBN 2-22540403-8 (In French) This general work, which explores occupational toxicology in its complexity by following tne fate of the substance down to cell level, utilises the latest re sults of physicochemical, biochemical, clinical, analytical and therapeutic re search. It is composed of 6 main sections: the poison and ~.the atmosphere: -the organism; ...the clinical examination; laboratory tests; ^.preventive measures; .-the antidote. Metabolic breakdown processes end conjugation mechanisms are clearly presented, and the complexity of the toxic effaces (which depend chiefly on the dose or concentration, the nature and chemical properties of the substance involved, duration of exposure, etc.) brought ouL A large piace is devoted to interpretation of analytics! results-and to the corre lations between different chenvcsl end biochemical parameters. The part dealing with prevention refers to tha relevant French regulations. 32 tables, the last of wmch mdicotes physicochemical properties, synonyms. Soviet and U.S. TLVs, hazards and effects of the principal industrial toxins, are ap pended. Alphabetical index. KOSSM 130 OCCUPATIONAL PATHOLOGY CIS 75*1409 Occupational medicine survey in personnel exposed to oil mists lArbeitsmedizmische Erhebungan bei olnebetexponierten Parsonen). Drasch H.. Fin tel L. Martschei H.. M*y*r R. Zontrathlatt far Athens* msdmn und Arbeitsschvte. Heidelberg. Germany (Fed.Rep.). Oct. 1974, Vpi.24, No. 10. o.3Q5-3l2.20ref, (In German) Results of a survey on tha incidence of respiratory symptoms (cough, expec toration, dyspnoea) rn 443 workers wth year-long exposure to cutting oil mists 140- 150mg/mh and a control group. A review of the composition of cut ting oils and of the published literature on the bmlogicjl effects of od rnisLi is followed by a statistical analysis of the results: smokers and non-smokers, aye, duration of exposure, frequency of colds. No irritative efrect of oil mists was obseived. and indeed the possibility that they exert a protective effect on the bronchial system is debated, tottioi