Document MGx2mjZ7kO5eXmYObDJ6QE8Xk

rr | AR226-1396 || | | | rev @ D cc: GB.. AWl. E. D. EI. 1. oouu PPoonntooftN aMi--e--mo&Cuomrpasny MjJ:.ALT. HASKELLLABORATORYFOR TOXICOLOGY C. F. Eucron ARNoDssI,NDMUeSTwRaIrAL, MDEeDcIaCwIaNEre 1971 RGL. EL.. CENTRAL RESEARCH ANDDEVELODPEPMAERTNMETNT HKaaprkrah,, LEReDg,al,N-1D1-4700300 C-4/AF Champaey, Jr., PPD, D-11070 SSSnmToi0otvkhe:,i1)P#P5Dp;h, 7CH.S!3D14- Doa15s 12 0 04 Staples, CRAD, Haskell Reinhardt, CRGD, Haskell Kennedy, CR&D, Haskell March 15, 1982 PERSONAL & CONFIDENTIAL AR&AG -- 1396 MENO TO: JP.PD,W. M-R5A6I2N5ES . _. mow co. cowensice EXHail REPORT OF FC-143 TERATOGENIC STUDIES TO EPA On March 12 Frank D. Griffith and William H. Pearlson of 3M and I reported results of teratogenic studies on three fluoro- surfactants to EPA. EPA by 3M reporting This was a teratogenic follow-up to 8e notifications to findings on a fluoroalcohol, a fluorosulfonate, and ammonium perfluorcoctanoate (FC-143; C-8). includTihnigrteFernankpeoKpolveer,frTomerrtyhe O'CBPrAyaOnf,ficJeoseopfhToSxeiicfteSrubs(taannciens-, house toxicology consultant), and Elaine Francis (a teratolo- gist) met with us for nearly two hours. Pearlson said that Sithough full teratogenic studies on the alcohol and sulfonate and a dosc-ranging study on FC-143 had earlier indicated that all three that none caused of the an eye defect in substances caused rat fetuses, this defect. 3M now believed He gave EPA copies of reports on two SH studies of FC.145 that were subse- quent to the 8c notifications, and said that no significant stueprpaotrotgeednichiseffpeocstistiownerebynogtievdi,ng inEPAtherepeoyretsorofelstehwehetrweo. I nega- tive teratogenic studies of FC-143 by Haskell Lab. I said that few substances had been so extensively examined for teratogenic effects as FC-143, with a total of four full-scale studies car- ried out in two laboratories in two species of mammal by two routes of administration; that although the eye had received more attention than usual because of the initial indications of eye defects, both skeletal and soft tissue had been thor- oughly examined for teratogenic effects and then none had been and finding their eyes normal. efxouanmdi;nintghatthetheeyeasbseonfcejuvofenielyee defects had been reinforced by rats born of exposed mothers 5 SETTER THINGS FOR BETTER UviN... aRouoH cxemisay EIDOTI0S 000184 PERSONAL CONFIDENTIAL 3. W. RAINES -2- March 15, 1982 tanetrsa,toPgeaenandr,lscoo3nnMcleruxedpeelxdaaimnitenhdeadthottwhh,eeydaafdttiadernoonFtC-t1hc4ea3usowetahseeryeshtdwooewfnefcnltoustorotaosfutrebfreacaatl-l a(thehipgohinteexdposouutrethlaetveltsh)e. alcAohfoelw it hatd to understand how highly ocfaustehde EdePfAecptesoplien positive findings osteheemredortgoanfsind with good dose- rsIkedesoppnto'intcsse tbhryienlkatthiePioernasrhlriseposnpocnoasuneld,d Gwrshiufibfcsihetqhuienncctollmuypdeldettuertnlhyeoucftoancvttoio rncbeeodfnebtgihaaetsive. ptSehvoripodlueegnhcesenoettmheatdexatFomC-i1na4ig3nrgeeistwheiathtSleirtdahetesogcebonln,icnldus.soimoenHewnetcrheea,t heatslhitethraoenutgihs abntooheutgEoPodA aeygereedienfgecttshatintrheatotfheetrusetsw.o fluorosurfactants had not caused ing anEPASeofnfoitciifailcsatisoanidorthaftorthEePrAe toisdneoclamreechaintisnomt foar cwaiutshedrfaowr- cFoCn-c1e4r3n.willHowbeeveprl,acetdhein3Mtahned sDaumePofnitlereapsortthse Bofe should anyone ask about the Se notice on FC-143, snottuidciee,s he will oannd be told about the conclusions of the reports. : BOWbId EIDO71706 000185